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The map label for this gene is npr2 [H]

Identifier: 28379083

GI number: 28379083

Start: 2269594

End: 2270949

Strand: Direct

Name: npr2 [H]

Synonym: lp_2544

Alternate gene names: 28379083

Gene position: 2269594-2270949 (Clockwise)

Preceding gene: 28379082

Following gene: 28379098

Centisome position: 68.6

GC content: 48.75

Gene sequence:

>1356_bases
ATGAAAGTTATTGTCGTTGGTTCTTCTCATGGTGGTTATGAAACGGTTCGCGGTATTTTAGCCGCTCAACCAGATACTGA
AATTCAATGGTATGAAAAAGGTGATTTTCTGTCATTCCTCTCATGTGGGATGCAATTATACCTCGAAGGTGCCGTTAAAG
ACGTTAACTCCGTCAGCTATGCCACTCCTGCTGGCATGCAAGCCCAAGGCGTCCACGTTTTTGTAAATAGTGAAATTAGT
AAGGTCGACCCTGCTAGTCACAGTGTGCACGTCATTGACCACGCCACTGGTGACGAACGTGATGAAACTTATGACAAACT
AGTCCTAAGTGTCGGCGCGGTACCATTTGACCTACCAGTACCCGGCCATGACTTAGCCAACATCTACGCAATGCGTGGAC
GCGACTGGGCCATCAAATTAAAGGCCAAGACCGTTGACCCTAGCGTTAAGAATGTGGTTGTCATTGGCTCCGGTTATATT
GGAATTGAGGCGGCTGAAGTCTTTGCCAAAGCTGGCATGCACGTCACGGTTATCGACCTATTACCACGTTTACTTAGTCT
TTACCTTGATCAAGAATTCACGGATATCTTGACTAAGACGATGGCCGATCACGGCATCTATGCTGCAGTTGGCCAAGGTA
TTAAAGCGTATGAAGGTGTTGACGGCCACGTCACCAAAGTAGTGACCGATCAAGGCGAATATCCAGCTGACCTGGTCGTA
ACTGCCGCCGGGATTCGGCCAGCAACTGGCTTCTTGAAAGGCGTTGTCGACTTAGATGATCACGGTTTGATCAAGATCAA
CGACCACCTCCAAACGAGTGACACTGACATTTACGCCGTCGGGGACGCGACCTTAGTCCCATTTGCCCCAACTGGCAAGG
ATAACCGCATTGCGTTAGCCACTAACGCTCGTCGGCAAGGTCGGATTGCCGCTAAGAACTTACTTGGCGAAAACGTACCA
ATGCCTGCTGTTTCTGGTTCATCCGCACTTTCCGTCTTTGACTACCACTTTGCTTCCACTGGTGTTAAAGAAGGCACGGC
TGACAAGCTGGGCGTTAAGACGGCATCCGTGTTAGTCACCGATACCATTCGGCCTAAGTTTGTCTCTGAAGATGCTGGCA
ACACCAAAGTTTGGTTCAAACTAACCTTTGACCCAACTGATGGTCGCGTGCTTGGTGCGCAAATCATGTCGAAGTACGAT
GTTACTGCTAACATCAACGCCATCTCAGTGGCTATTCAAGCTAAACTGACTGTTGCTGACTTAGCTTACACGGACTTCTT
CTTCCAACCAGGCTTTGACCGTCCTTGGAACATCATCAACGTCGCTGCCCAAAAAGCAGCCGCAACCTTAAACTAA

Upstream 100 bases:

>100_bases
ATAATTTAGAATAATTACAAACTGCCCTTGCCGACAAACTTAGTTCGTGTTATATTCTATTTAGAACAGTTCTAAACTAA
AATTTGGAGGCTTTACAATT

Downstream 100 bases:

>100_bases
ATCAATTAGGCCTTAATTAAGCCATGAAACATCAAACGGATTCCTCAGCCACACATCGCTGAAGAATCCGTTTTTAATGC
ATCAAAATGCTAGCCATCAA

Product: NADH peroxidase

Products: NA

Alternate protein names: NPXase; Npx [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKVIVVGSSHGGYETVRGILAAQPDTEIQWYEKGDFLSFLSCGMQLYLEGAVKDVNSVSYATPAGMQAQGVHVFVNSEIS
KVDPASHSVHVIDHATGDERDETYDKLVLSVGAVPFDLPVPGHDLANIYAMRGRDWAIKLKAKTVDPSVKNVVVIGSGYI
GIEAAEVFAKAGMHVTVIDLLPRLLSLYLDQEFTDILTKTMADHGIYAAVGQGIKAYEGVDGHVTKVVTDQGEYPADLVV
TAAGIRPATGFLKGVVDLDDHGLIKINDHLQTSDTDIYAVGDATLVPFAPTGKDNRIALATNARRQGRIAAKNLLGENVP
MPAVSGSSALSVFDYHFASTGVKEGTADKLGVKTASVLVTDTIRPKFVSEDAGNTKVWFKLTFDPTDGRVLGAQIMSKYD
VTANINAISVAIQAKLTVADLAYTDFFFQPGFDRPWNIINVAAQKAAATLN

Sequences:

>Translated_451_residues
MKVIVVGSSHGGYETVRGILAAQPDTEIQWYEKGDFLSFLSCGMQLYLEGAVKDVNSVSYATPAGMQAQGVHVFVNSEIS
KVDPASHSVHVIDHATGDERDETYDKLVLSVGAVPFDLPVPGHDLANIYAMRGRDWAIKLKAKTVDPSVKNVVVIGSGYI
GIEAAEVFAKAGMHVTVIDLLPRLLSLYLDQEFTDILTKTMADHGIYAAVGQGIKAYEGVDGHVTKVVTDQGEYPADLVV
TAAGIRPATGFLKGVVDLDDHGLIKINDHLQTSDTDIYAVGDATLVPFAPTGKDNRIALATNARRQGRIAAKNLLGENVP
MPAVSGSSALSVFDYHFASTGVKEGTADKLGVKTASVLVTDTIRPKFVSEDAGNTKVWFKLTFDPTDGRVLGAQIMSKYD
VTANINAISVAIQAKLTVADLAYTDFFFQPGFDRPWNIINVAAQKAAATLN
>Mature_451_residues
MKVIVVGSSHGGYETVRGILAAQPDTEIQWYEKGDFLSFLSCGMQLYLEGAVKDVNSVSYATPAGMQAQGVHVFVNSEIS
KVDPASHSVHVIDHATGDERDETYDKLVLSVGAVPFDLPVPGHDLANIYAMRGRDWAIKLKAKTVDPSVKNVVVIGSGYI
GIEAAEVFAKAGMHVTVIDLLPRLLSLYLDQEFTDILTKTMADHGIYAAVGQGIKAYEGVDGHVTKVVTDQGEYPADLVV
TAAGIRPATGFLKGVVDLDDHGLIKINDHLQTSDTDIYAVGDATLVPFAPTGKDNRIALATNARRQGRIAAKNLLGENVP
MPAVSGSSALSVFDYHFASTGVKEGTADKLGVKTASVLVTDTIRPKFVSEDAGNTKVWFKLTFDPTDGRVLGAQIMSKYD
VTANINAISVAIQAKLTVADLAYTDFFFQPGFDRPWNIINVAAQKAAATLN

Specific function: Peroxidase whose active site is a redox-active cysteine- sulfenic acid [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=264, Percent_Identity=27.6515151515151, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI21389617, Length=264, Percent_Identity=27.6515151515151, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI226437568, Length=264, Percent_Identity=27.6515151515151, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1789065, Length=313, Percent_Identity=26.517571884984, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082354, Length=169, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789765, Length=272, Percent_Identity=25.7352941176471, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=250, Percent_Identity=30, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281359715, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281359713, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639250, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI18543267, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639252, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639257, Length=218, Percent_Identity=28.8990825688073, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.11.1.1 [H]

Molecular weight: Translated: 48256; Mature: 48256

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIVVGSSHGGYETVRGILAAQPDTEIQWYEKGDFLSFLSCGMQLYLEGAVKDVNSVSY
CEEEEEECCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCHHEEEEHHHHCCCCCCC
ATPAGMQAQGVHVFVNSEISKVDPASHSVHVIDHATGDERDETYDKLVLSVGAVPFDLPV
CCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCC
PGHDLANIYAMRGRDWAIKLKAKTVDPSVKNVVVIGSGYIGIEAAEVFAKAGMHVTVIDL
CCCCHHHEEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEHHHH
LPRLLSLYLDQEFTDILTKTMADHGIYAAVGQGIKAYEGVDGHVTKVVTDQGEYPADLVV
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHHCCCCHHHCCCCCCEEEEEECCCCCCCEEEE
TAAGIRPATGFLKGVVDLDDHGLIKINDHLQTSDTDIYAVGDATLVPFAPTGKDNRIALA
EECCCCCCCHHHHEEEEECCCCEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCEEEEE
TNARRQGRIAAKNLLGENVPMPAVSGSSALSVFDYHFASTGVKEGTADKLGVKTASVLVT
ECCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCEEEEEEEE
DTIRPKFVSEDAGNTKVWFKLTFDPTDGRVLGAQIMSKYDVTANINAISVAIQAKLTVAD
ECCCCCEECCCCCCEEEEEEEEECCCCCEEEHHHHHHHCCCEECCEEEEEEEEEEEEEEH
LAYTDFFFQPGFDRPWNIINVAAQKAAATLN
HHHHHHEECCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVIVVGSSHGGYETVRGILAAQPDTEIQWYEKGDFLSFLSCGMQLYLEGAVKDVNSVSY
CEEEEEECCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCHHEEEEHHHHCCCCCCC
ATPAGMQAQGVHVFVNSEISKVDPASHSVHVIDHATGDERDETYDKLVLSVGAVPFDLPV
CCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCC
PGHDLANIYAMRGRDWAIKLKAKTVDPSVKNVVVIGSGYIGIEAAEVFAKAGMHVTVIDL
CCCCHHHEEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEHHHH
LPRLLSLYLDQEFTDILTKTMADHGIYAAVGQGIKAYEGVDGHVTKVVTDQGEYPADLVV
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHHCCCCHHHCCCCCCEEEEEECCCCCCCEEEE
TAAGIRPATGFLKGVVDLDDHGLIKINDHLQTSDTDIYAVGDATLVPFAPTGKDNRIALA
EECCCCCCCHHHHEEEEECCCCEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCEEEEE
TNARRQGRIAAKNLLGENVPMPAVSGSSALSVFDYHFASTGVKEGTADKLGVKTASVLVT
ECCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCEEEEEEEE
DTIRPKFVSEDAGNTKVWFKLTFDPTDGRVLGAQIMSKYDVTANINAISVAIQAKLTVAD
ECCCCCEECCCCCCEEEEEEEEECCCCCEEEHHHHHHHCCCEECCEEEEEEEEEEEEEEH
LAYTDFFFQPGFDRPWNIINVAAQKAAATLN
HHHHHHEECCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1719212; 12663927; 2501302; 1942054; 8425532; 8756456; 9214307 [H]