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The map label for this gene is galM2 [H]

Identifier: 28378412

GI number: 28378412

Start: 1568652

End: 1569665

Strand: Direct

Name: galM2 [H]

Synonym: lp_1731

Alternate gene names: 28378412

Gene position: 1568652-1569665 (Clockwise)

Preceding gene: 28378411

Following gene: 28378417

Centisome position: 47.42

GC content: 49.11

Gene sequence:

>1014_bases
ATGAGGCGTACGATTTCTGCAGTACCATTTGGTGTGTATCAAGGCGAGTCAGTCTATTTATACACGATTGAAAATATCCA
TCATAGCAAACTAAAAGTGTTGAGTTATGCGGCAACGTGGTATGACTTCGAAGTGCAGGTCGACCGCCAGCCACAATCAT
TAGTGCTTCACTTTGATAACTTGGCGGATTATATCGAGACGCCTTATCAAGTCGGCAAAACAGTGGGTCGAGTTGCTGGC
CGAATCGGTAACGCGACGTTTTCCTTGAATGGGCAGACATACCACTTACCGCCAAATAACGGCCGGCATTTGCTACACGG
TGGCGGTCATGGCTTACAAACGCATAATTTTCGAGCCCGTTTTGATCCTGATGGCGACACTGTCATATTGACGACAACGC
TAGCGAGCGCTGACGATGGGTTTCCAGGCGACTTGACAGTAACTATAAGCTATACGTTAACGGCCGATGATGAGGTTCAA
ATCAGCTATCACGGGGTGACCACTGCTGATACGTTATTCAATCCGACCTGTCACGTTTACTTTAATCTTGATGGTCAGGC
CGCACTGATTAATCCCCAGCAATTACGTATCAACTCGACCAAGCTAGTTCATACGAATCACGAGAAGGTTCCGACCGGCG
TCTTCTACGTCCCGTCACCAGCGTATGACTTTCGTGAGCAGCCAACGATTCAATCGCAGCTCGATCGATTGATCCAAGAA
ACTGGCAGGACGGAATACGATGATTGCTATGTGCTTGACCACCAGGATGAACCCGCTGGCGTGTTGGCAACGACTCACGG
GCGACTGCTCATCAACACGGATCGCAATGGTTTAGTTATCTTTACCGCTAATCCCGAACGAACGCAGCCGTATCGTTTAG
GGGACTACCATGCGCTGGCCGTAGAATTGCAAACCTTGCCGGATGCTATTAATCATCATGGCTTTGGCGATGTTGTTCTA
CGGGCTGGTCAGCCACGGACGTACGTGAACCGCTACCAATACGTGTCAAAATAG

Upstream 100 bases:

>100_bases
GACTTTGAAGTTGATTGCCGGGGAACCGATTGATGTTCAAGTGGATGGTACCACGCAAACATTGACACAGAACTAGTTCA
ATCCGCACTGATCGAAGGGA

Downstream 100 bases:

>100_bases
CAATCAATAGATGATGGAAATTATTTTCTTTACCACGATCAAAAAGCAGTGCTTGCCATAGGGGCACACTGCTTTTTTGG
TGTACTTGGTTATAACAAAA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRRTISAVPFGVYQGESVYLYTIENIHHSKLKVLSYAATWYDFEVQVDRQPQSLVLHFDNLADYIETPYQVGKTVGRVAG
RIGNATFSLNGQTYHLPPNNGRHLLHGGGHGLQTHNFRARFDPDGDTVILTTTLASADDGFPGDLTVTISYTLTADDEVQ
ISYHGVTTADTLFNPTCHVYFNLDGQAALINPQQLRINSTKLVHTNHEKVPTGVFYVPSPAYDFREQPTIQSQLDRLIQE
TGRTEYDDCYVLDHQDEPAGVLATTHGRLLINTDRNGLVIFTANPERTQPYRLGDYHALAVELQTLPDAINHHGFGDVVL
RAGQPRTYVNRYQYVSK

Sequences:

>Translated_337_residues
MRRTISAVPFGVYQGESVYLYTIENIHHSKLKVLSYAATWYDFEVQVDRQPQSLVLHFDNLADYIETPYQVGKTVGRVAG
RIGNATFSLNGQTYHLPPNNGRHLLHGGGHGLQTHNFRARFDPDGDTVILTTTLASADDGFPGDLTVTISYTLTADDEVQ
ISYHGVTTADTLFNPTCHVYFNLDGQAALINPQQLRINSTKLVHTNHEKVPTGVFYVPSPAYDFREQPTIQSQLDRLIQE
TGRTEYDDCYVLDHQDEPAGVLATTHGRLLINTDRNGLVIFTANPERTQPYRLGDYHALAVELQTLPDAINHHGFGDVVL
RAGQPRTYVNRYQYVSK
>Mature_337_residues
MRRTISAVPFGVYQGESVYLYTIENIHHSKLKVLSYAATWYDFEVQVDRQPQSLVLHFDNLADYIETPYQVGKTVGRVAG
RIGNATFSLNGQTYHLPPNNGRHLLHGGGHGLQTHNFRARFDPDGDTVILTTTLASADDGFPGDLTVTISYTLTADDEVQ
ISYHGVTTADTLFNPTCHVYFNLDGQAALINPQQLRINSTKLVHTNHEKVPTGVFYVPSPAYDFREQPTIQSQLDRLIQE
TGRTEYDDCYVLDHQDEPAGVLATTHGRLLINTDRNGLVIFTANPERTQPYRLGDYHALAVELQTLPDAINHHGFGDVVL
RAGQPRTYVNRYQYVSK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=318, Percent_Identity=29.2452830188679, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=26.3313609467456, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557428, Length=293, Percent_Identity=29.3515358361775, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115533334, Length=293, Percent_Identity=29.3515358361775, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319493, Length=306, Percent_Identity=28.4313725490196, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322004, Length=337, Percent_Identity=26.4094955489614, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583720, Length=326, Percent_Identity=28.8343558282209, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24659048, Length=334, Percent_Identity=27.8443113772455, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24668278, Length=329, Percent_Identity=27.0516717325228, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24641876, Length=347, Percent_Identity=25.6484149855908, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24668282, Length=335, Percent_Identity=26.5671641791045, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37789; Mature: 37789

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTISAVPFGVYQGESVYLYTIENIHHSKLKVLSYAATWYDFEVQVDRQPQSLVLHFDN
CCCEECCCEEEEECCCEEEEEEECCCCCCCEEEEEEEEEEEEEEEEECCCCCEEEEEEHH
LADYIETPYQVGKTVGRVAGRIGNATFSLNGQTYHLPPNNGRHLLHGGGHGLQTHNFRAR
HHHHHHCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCCCEEEECCCCCCCCCCEEEE
FDPDGDTVILTTTLASADDGFPGDLTVTISYTLTADDEVQISYHGVTTADTLFNPTCHVY
ECCCCCEEEEEEEEECCCCCCCCCEEEEEEEEEECCCEEEEEECCCEEHHHHCCCEEEEE
FNLDGQAALINPQQLRINSTKLVHTNHEKVPTGVFYVPSPAYDFREQPTIQSQLDRLIQE
EEECCCEEEECCHHEEECCEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
TGRTEYDDCYVLDHQDEPAGVLATTHGRLLINTDRNGLVIFTANPERTQPYRLGDYHALA
HCCCCCCCEEEEECCCCCCCEEEEECCEEEEEECCCCEEEEECCCCCCCCEECCCEEEEE
VELQTLPDAINHHGFGDVVLRAGQPRTYVNRYQYVSK
EEEEHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRRTISAVPFGVYQGESVYLYTIENIHHSKLKVLSYAATWYDFEVQVDRQPQSLVLHFDN
CCCEECCCEEEEECCCEEEEEEECCCCCCCEEEEEEEEEEEEEEEEECCCCCEEEEEEHH
LADYIETPYQVGKTVGRVAGRIGNATFSLNGQTYHLPPNNGRHLLHGGGHGLQTHNFRAR
HHHHHHCHHHHHHHHHHHHHHCCCEEEEECCEEEECCCCCCCEEEECCCCCCCCCCEEEE
FDPDGDTVILTTTLASADDGFPGDLTVTISYTLTADDEVQISYHGVTTADTLFNPTCHVY
ECCCCCEEEEEEEEECCCCCCCCCEEEEEEEEEECCCEEEEEECCCEEHHHHCCCEEEEE
FNLDGQAALINPQQLRINSTKLVHTNHEKVPTGVFYVPSPAYDFREQPTIQSQLDRLIQE
EEECCCEEEECCHHEEECCEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
TGRTEYDDCYVLDHQDEPAGVLATTHGRLLINTDRNGLVIFTANPERTQPYRLGDYHALA
HCCCCCCCEEEEECCCCCCCEEEEECCEEEEEECCCCEEEEECCCCCCCCEECCCEEEEE
VELQTLPDAINHHGFGDVVLRAGQPRTYVNRYQYVSK
EEEEHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1694527 [H]