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The map label for this gene is fabD [H]

Identifier: 28378363

GI number: 28378363

Start: 1524548

End: 1525480

Strand: Direct

Name: fabD [H]

Synonym: lp_1673

Alternate gene names: 28378363

Gene position: 1524548-1525480 (Clockwise)

Preceding gene: 28378362

Following gene: 28378364

Centisome position: 46.08

GC content: 49.3

Gene sequence:

>933_bases
ATGAAAACGGCAATCTTATTCAGTGGTCAAGGACAACAGTTTGCCGATATGGGGGCCGATCTTTATCAAACGTTACCAGC
GTACCAAGCCACGATTGACGAAGCTAATCAAGTGTTGGACTGGGATCTGCGGGTAACTGCTGATTGGATCGATGATGCTC
AACGGATGCCGGTTGCAATTACAGCGATGAATATGGGGTTATATCGTGCTTTAACAGCGTTGCTTAATGAGTGTCCGACC
GTGTTAGCAGGATTGAGCCTTGGCGAGTATGCCGCATTGATTGCAGCTGGCGTCCTGCCATTTGCTGATGGCTTGAAGTT
AGTTGCCGATCGGGCTAGATATATGCAACGAGCGGGATTACAGCATCCCGGGGAGATGGTCGCGGCGTTGAAGGTAACGC
CGGCACTGGTTGCAGCCGCTTGTCAAAGTGCCCAAGCAGTGGGGGTTGCGTATCCCGCTAATTACAATCTAGCTGATCAA
ATTGTTATTGGTGGCGATGCAGCTGGTATTCAAGCTGCGCGAACCTATTTAAAAACACACGGCGTTAAACGGGTGGTCCC
ATTAGACGTTGCGGTGGCTTCACACACGCCGTTAATGGCAGCAGCGAGTGAGGCGTTGGCGCAACGATTACGATTTGTTA
ATATTGCAGCACCCCAAATTCCGGTCATCAGTAATACGACCGTGACCCCCTTTAGCCAGGAAACTGTCAAGGAAACGTTG
GTAAAACAGTTAGTATCGCCAACGCACTTTGCGGCCTGCTTACAACGAATTGCGACATATGAGGTCGATGAGATTATTCA
AGTTGGACCGGGGCATAGTTTAGCAACTTTTGCCAAACAAACATTGCCAGGGGTAAGGGTTTGGTCAATTGAAGATGTGA
CAGATTGGCAGAATTATTGTCAGGATACTGAGGAGGTACGTGAGCGTGGATGA

Upstream 100 bases:

>100_bases
CGAATATGATATCGAAATCGAAACGGATGACGCGTTAGCCACGGTTGGTGATTTAGTTGATTATGTGGCGACTCATCAGG
AAACTAGCGAGGACTAAGTT

Downstream 100 bases:

>100_bases
AGTGATTTTAGTCACTGGAGCTGCTAAGGGTATTGGTTTGGCAACAGTCAAACGGTTGGCAGCTCAGGGGGCCAGCGTTA
TTTTAAACGTTCATCATGAA

Product: [acyl-carrier protein] S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKTAILFSGQGQQFADMGADLYQTLPAYQATIDEANQVLDWDLRVTADWIDDAQRMPVAITAMNMGLYRALTALLNECPT
VLAGLSLGEYAALIAAGVLPFADGLKLVADRARYMQRAGLQHPGEMVAALKVTPALVAAACQSAQAVGVAYPANYNLADQ
IVIGGDAAGIQAARTYLKTHGVKRVVPLDVAVASHTPLMAAASEALAQRLRFVNIAAPQIPVISNTTVTPFSQETVKETL
VKQLVSPTHFAACLQRIATYEVDEIIQVGPGHSLATFAKQTLPGVRVWSIEDVTDWQNYCQDTEEVRERG

Sequences:

>Translated_310_residues
MKTAILFSGQGQQFADMGADLYQTLPAYQATIDEANQVLDWDLRVTADWIDDAQRMPVAITAMNMGLYRALTALLNECPT
VLAGLSLGEYAALIAAGVLPFADGLKLVADRARYMQRAGLQHPGEMVAALKVTPALVAAACQSAQAVGVAYPANYNLADQ
IVIGGDAAGIQAARTYLKTHGVKRVVPLDVAVASHTPLMAAASEALAQRLRFVNIAAPQIPVISNTTVTPFSQETVKETL
VKQLVSPTHFAACLQRIATYEVDEIIQVGPGHSLATFAKQTLPGVRVWSIEDVTDWQNYCQDTEEVRERG
>Mature_310_residues
MKTAILFSGQGQQFADMGADLYQTLPAYQATIDEANQVLDWDLRVTADWIDDAQRMPVAITAMNMGLYRALTALLNECPT
VLAGLSLGEYAALIAAGVLPFADGLKLVADRARYMQRAGLQHPGEMVAALKVTPALVAAACQSAQAVGVAYPANYNLADQ
IVIGGDAAGIQAARTYLKTHGVKRVVPLDVAVASHTPLMAAASEALAQRLRFVNIAAPQIPVISNTTVTPFSQETVKETL
VKQLVSPTHFAACLQRIATYEVDEIIQVGPGHSLATFAKQTLPGVRVWSIEDVTDWQNYCQDTEEVRERG

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=319, Percent_Identity=28.5266457680251, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787334, Length=290, Percent_Identity=33.7931034482759, Blast_Score=147, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71984332, Length=291, Percent_Identity=30.2405498281787, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=302, Percent_Identity=25.1655629139073, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24665753, Length=299, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 33309; Mature: 33309

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAILFSGQGQQFADMGADLYQTLPAYQATIDEANQVLDWDLRVTADWIDDAQRMPVAI
CCEEEEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHEEECCEEEEHHHHCCCCCCCEEE
TAMNMGLYRALTALLNECPTVLAGLSLGEYAALIAAGVLPFADGLKLVADRARYMQRAGL
EEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QHPGEMVAALKVTPALVAAACQSAQAVGVAYPANYNLADQIVIGGDAAGIQAARTYLKTH
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHC
GVKRVVPLDVAVASHTPLMAAASEALAQRLRFVNIAAPQIPVISNTTVTPFSQETVKETL
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHH
VKQLVSPTHFAACLQRIATYEVDEIIQVGPGHSLATFAKQTLPGVRVWSIEDVTDWQNYC
HHHHCCHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHH
QDTEEVRERG
CCHHHHHHCC
>Mature Secondary Structure
MKTAILFSGQGQQFADMGADLYQTLPAYQATIDEANQVLDWDLRVTADWIDDAQRMPVAI
CCEEEEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHEEECCEEEEHHHHCCCCCCCEEE
TAMNMGLYRALTALLNECPTVLAGLSLGEYAALIAAGVLPFADGLKLVADRARYMQRAGL
EEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QHPGEMVAALKVTPALVAAACQSAQAVGVAYPANYNLADQIVIGGDAAGIQAARTYLKTH
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHC
GVKRVVPLDVAVASHTPLMAAASEALAQRLRFVNIAAPQIPVISNTTVTPFSQETVKETL
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHH
VKQLVSPTHFAACLQRIATYEVDEIIQVGPGHSLATFAKQTLPGVRVWSIEDVTDWQNYC
HHHHCCHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHH
QDTEEVRERG
CCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]