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The map label for this gene is fabH2

Identifier: 28378361

GI number: 28378361

Start: 1523253

End: 1524239

Strand: Direct

Name: fabH2

Synonym: lp_1671

Alternate gene names: 28378361

Gene position: 1523253-1524239 (Clockwise)

Preceding gene: 28378360

Following gene: 28378362

Centisome position: 46.04

GC content: 49.85

Gene sequence:

>987_bases
ATGACAACTAATTTTTCGATTTTAGCGAGTGCTAAGGCACTGCCGACGACCAAAGTCACGAATCAAGAACTAACGCAACT
GATGGCGACTTCTGATGATTGGATCAAGCAGCGAACGGGAATTCGTTCTCGCCACGTCGCGACCGATGAGACAACGACGA
GTTTAGCTGTTTCAGTTGCCCAGCAGTTGTTGCAGCAAAGTCGGCTAGCGGCGACGGCGATTGATTTGATCATCGTGGCA
ACCATGTCACCGGATTATTTGACACCGGCGACGGCTCCTCAAGTACAGGCAGCAATTGGGGCTGAAAAAGCAATTGCCTT
TGACATTAATGTTGCCTGTGCGGGCTTTGTTTATGGGATGCAGTTGGTTCACCAATACTTACAACCGGGCCAGACCGCTT
TGTTAATCGGTAGCGAGACCTTGAGTCGGTTAGTAGACTGGCATGATCGTAGCACTGCCGTTTTATTTGGTGATGGTGCG
GGTGGTCTATTGATTACTGCTAAGCCTAATACGACCACTGGGCACTGGCTGGGCGGTCATTACGCGACGTTTGGCGCTGA
CGGGCATTATTTAACGGCGGGACAGCAACCTCAGGTGAATCCGTGGTCGACACGGACTGATGGTGCAGATTCTAACCGCT
GGGCCTTTCAGATGAATGGTCGGCGGGTTTATGACTTTGCCACTAAGCAAGTGCCGCACTCAATTGAGCAGGCGTTGATG
CAGGCACGGCTCGAGTCGAGTGATATTAAAGCATTTGTGCTTCATCAGGCCAACGCACGTATTGTTAAGAGCGTTGGTCA
AAAATTAAACTTAGCTACGGAACAATTACCGATGAACATTGCACAGTATGGCAATACTGCGGCAGCCAGTGAACCGATTC
TATTTGCCGAAATGGTTGCCCAAAAGCAAGTTCAACGTGGTGACAAGCTGGTGTTTACCGGTTTTGGCGGCGGATTATCC
GTCGGTAGTGCCGTAATTGAGTATTAA

Upstream 100 bases:

>100_bases
TCGTTGGTGCAACTGATTCAAAATAGAAAGGTGGTAATGGCAATTCGGCGATTGTCGTTTGGGAAAGTTTTTTAAAAGTA
TTGCCGAATTGTAACCAACC

Downstream 100 bases:

>100_bases
TTGATAACTGAAATCAAGCATTTAAAATTAATTTAAAAATTCTGGAGGAATCAACAATGACTAAAACTGAAATTTTTGAC
CAAATTAAAAAGATGATCGT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 2; Beta-ketoacyl-ACP synthase III 2; KAS III 2

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTTNFSILASAKALPTTKVTNQELTQLMATSDDWIKQRTGIRSRHVATDETTTSLAVSVAQQLLQQSRLAATAIDLIIVA
TMSPDYLTPATAPQVQAAIGAEKAIAFDINVACAGFVYGMQLVHQYLQPGQTALLIGSETLSRLVDWHDRSTAVLFGDGA
GGLLITAKPNTTTGHWLGGHYATFGADGHYLTAGQQPQVNPWSTRTDGADSNRWAFQMNGRRVYDFATKQVPHSIEQALM
QARLESSDIKAFVLHQANARIVKSVGQKLNLATEQLPMNIAQYGNTAAASEPILFAEMVAQKQVQRGDKLVFTGFGGGLS
VGSAVIEY

Sequences:

>Translated_328_residues
MTTNFSILASAKALPTTKVTNQELTQLMATSDDWIKQRTGIRSRHVATDETTTSLAVSVAQQLLQQSRLAATAIDLIIVA
TMSPDYLTPATAPQVQAAIGAEKAIAFDINVACAGFVYGMQLVHQYLQPGQTALLIGSETLSRLVDWHDRSTAVLFGDGA
GGLLITAKPNTTTGHWLGGHYATFGADGHYLTAGQQPQVNPWSTRTDGADSNRWAFQMNGRRVYDFATKQVPHSIEQALM
QARLESSDIKAFVLHQANARIVKSVGQKLNLATEQLPMNIAQYGNTAAASEPILFAEMVAQKQVQRGDKLVFTGFGGGLS
VGSAVIEY
>Mature_327_residues
TTNFSILASAKALPTTKVTNQELTQLMATSDDWIKQRTGIRSRHVATDETTTSLAVSVAQQLLQQSRLAATAIDLIIVAT
MSPDYLTPATAPQVQAAIGAEKAIAFDINVACAGFVYGMQLVHQYLQPGQTALLIGSETLSRLVDWHDRSTAVLFGDGAG
GLLITAKPNTTTGHWLGGHYATFGADGHYLTAGQQPQVNPWSTRTDGADSNRWAFQMNGRRVYDFATKQVPHSIEQALMQ
ARLESSDIKAFVLHQANARIVKSVGQKLNLATEQLPMNIAQYGNTAAASEPILFAEMVAQKQVQRGDKLVFTGFGGGLSV
GSAVIEY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=330, Percent_Identity=33.030303030303, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH2_LACPL (Q88WG8)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785253.1
- ProteinModelPortal:   Q88WG8
- SMR:   Q88WG8
- GeneID:   1064006
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1671
- NMPDR:   fig|220668.1.peg.1387
- HOGENOM:   HBG649927
- OMA:   MSPDYLT
- ProtClustDB:   PRK09352
- BioCyc:   LPLA220668:LP_1671-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 35279; Mature: 35148

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 255-255 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNFSILASAKALPTTKVTNQELTQLMATSDDWIKQRTGIRSRHVATDETTTSLAVSVA
CCCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QQLLQQSRLAATAIDLIIVATMSPDYLTPATAPQVQAAIGAEKAIAFDINVACAGFVYGM
HHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEEECHHHHHHHHHH
QLVHQYLQPGQTALLIGSETLSRLVDWHDRSTAVLFGDGAGGLLITAKPNTTTGHWLGGH
HHHHHHHCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
YATFGADGHYLTAGQQPQVNPWSTRTDGADSNRWAFQMNGRRVYDFATKQVPHSIEQALM
EEEECCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHCCHHHHHHHH
QARLESSDIKAFVLHQANARIVKSVGQKLNLATEQLPMNIAQYGNTAAASEPILFAEMVA
HHHCCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHCHHHHHCCCCCCCCCCHHHHHHHH
QKQVQRGDKLVFTGFGGGLSVGSAVIEY
HHHHHCCCEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
TTNFSILASAKALPTTKVTNQELTQLMATSDDWIKQRTGIRSRHVATDETTTSLAVSVA
CCCCEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QQLLQQSRLAATAIDLIIVATMSPDYLTPATAPQVQAAIGAEKAIAFDINVACAGFVYGM
HHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEEECHHHHHHHHHH
QLVHQYLQPGQTALLIGSETLSRLVDWHDRSTAVLFGDGAGGLLITAKPNTTTGHWLGGH
HHHHHHHCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCE
YATFGADGHYLTAGQQPQVNPWSTRTDGADSNRWAFQMNGRRVYDFATKQVPHSIEQALM
EEEECCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHCCHHHHHHHH
QARLESSDIKAFVLHQANARIVKSVGQKLNLATEQLPMNIAQYGNTAAASEPILFAEMVA
HHHCCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHCHHHHHCCCCCCCCCCHHHHHHHH
QKQVQRGDKLVFTGFGGGLSVGSAVIEY
HHHHHCCCEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566