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The map label for this gene is pepP [H]

Identifier: 28378296

GI number: 28378296

Start: 1451818

End: 1452879

Strand: Direct

Name: pepP [H]

Synonym: lp_1595

Alternate gene names: 28378296

Gene position: 1451818-1452879 (Clockwise)

Preceding gene: 28378295

Following gene: 28378297

Centisome position: 43.88

GC content: 49.06

Gene sequence:

>1062_bases
ATGAGTCGAGTTGAACGGTTACAAAATAAGTTTGATCAGTTAAAAATTGATGCGTTCTTAGTTTCAGATGGAGCTAATCT
TCAATATTTAACAGGAATGGTTGATATGGCTGGCGATGGTTATCTGCTAGTACTGGCACAGGAAGCCTATCTGATTACGG
ATGCCCGTTATCAGACAGCTTTTGCCGGTCAGTATGATGACCAGCACCTAGTCATTACACGTGATTATCTGGGGGCCGTT
TGTGATATTATTGCCAAAACCGGTACTGGGGTCATGGGCTTCGAGGCCGAGATTCCATATACAGCCTACAGTTACTTAGA
TGAGAACTTGGTCAGCGATTTGGTTGCGTTACCAGACGTGGTCGATGAGTTGCGCATCACCAAGAGTGTTGATGAGATTG
ACCGGCTACGAGCGAGTGCACGTTTGGCGGATGCTGGTTTCGAATACGTAACGAGTATCGTGCGACCAGGCATGCGTGAA
ATCGACGTTAGCAACCTGTTAGACGCGTTTATGCGGACGCACGGTGCAAGTGGGCCGTCGTTCACGACAATCGTACTTGG
TGGTGCACGAGCGGCTTTACCGCATGGGACGGCTTCTAAAGCGCTCTTAACTGCCGGGCAACTTGTTACTCTTGATTTTG
GTTACTTTTTGGACGGGTACACGTCAGATATGACACGGACGTTTGCTTTAGGTACTCCGGATGACAAGTTGGTTACGGCC
TACCAGGCGGTGCAGGCTGCTCAACAGGCTGTGATCGATCAGGTCCAAGCAGGTGCAGCCACTGCTCAACTGGATGCAGT
TGGCCGCGATTTGCTGACAAAAGCGGGCTATGGTGACGCCTTCAATCATGGTATGGGTCACGGCATTGGTCTTGCCATTC
ATGAAGGCCCGTTGATCTCAAAAAACACGACTGGCACCTTAGTTGCAAACAGTGTGATTACTGTTGAACCCGGGGTATAT
TTCCCAGATTTAGGCGGAATGCGGATCGAAGATGATGTCTTAGTGACTGCTGAGGGCCATGAACGACTGACGACTGCAAC
TCGTGATTTACTGATTTTATAG

Upstream 100 bases:

>100_bases
ACGTAATTGATTGACGAATGGCCTTCAATAAATCATTACCTTCAGTTTTTGGAAAGTTTGGTATAATGAAGCGTGAGGTA
ATGATGGGAGTGACGAAATA

Downstream 100 bases:

>100_bases
TTAAGACAGTTGCCACAGCGGCTCGGTCTTGTTATAGTTATAAAGATATATTTGAGGAGGATTTTTAAAAATGATTTCAA
CTGCAGATTTTAAAAATGGT

Product: Xaa-Pro aminopeptidase (putative)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSRVERLQNKFDQLKIDAFLVSDGANLQYLTGMVDMAGDGYLLVLAQEAYLITDARYQTAFAGQYDDQHLVITRDYLGAV
CDIIAKTGTGVMGFEAEIPYTAYSYLDENLVSDLVALPDVVDELRITKSVDEIDRLRASARLADAGFEYVTSIVRPGMRE
IDVSNLLDAFMRTHGASGPSFTTIVLGGARAALPHGTASKALLTAGQLVTLDFGYFLDGYTSDMTRTFALGTPDDKLVTA
YQAVQAAQQAVIDQVQAGAATAQLDAVGRDLLTKAGYGDAFNHGMGHGIGLAIHEGPLISKNTTGTLVANSVITVEPGVY
FPDLGGMRIEDDVLVTAEGHERLTTATRDLLIL

Sequences:

>Translated_353_residues
MSRVERLQNKFDQLKIDAFLVSDGANLQYLTGMVDMAGDGYLLVLAQEAYLITDARYQTAFAGQYDDQHLVITRDYLGAV
CDIIAKTGTGVMGFEAEIPYTAYSYLDENLVSDLVALPDVVDELRITKSVDEIDRLRASARLADAGFEYVTSIVRPGMRE
IDVSNLLDAFMRTHGASGPSFTTIVLGGARAALPHGTASKALLTAGQLVTLDFGYFLDGYTSDMTRTFALGTPDDKLVTA
YQAVQAAQQAVIDQVQAGAATAQLDAVGRDLLTKAGYGDAFNHGMGHGIGLAIHEGPLISKNTTGTLVANSVITVEPGVY
FPDLGGMRIEDDVLVTAEGHERLTTATRDLLIL
>Mature_352_residues
SRVERLQNKFDQLKIDAFLVSDGANLQYLTGMVDMAGDGYLLVLAQEAYLITDARYQTAFAGQYDDQHLVITRDYLGAVC
DIIAKTGTGVMGFEAEIPYTAYSYLDENLVSDLVALPDVVDELRITKSVDEIDRLRASARLADAGFEYVTSIVRPGMREI
DVSNLLDAFMRTHGASGPSFTTIVLGGARAALPHGTASKALLTAGQLVTLDFGYFLDGYTSDMTRTFALGTPDDKLVTAY
QAVQAAQQAVIDQVQAGAATAQLDAVGRDLLTKAGYGDAFNHGMGHGIGLAIHEGPLISKNTTGTLVANSVITVEPGVYF
PDLGGMRIEDDVLVTAEGHERLTTATRDLLIL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=302, Percent_Identity=24.1721854304636, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI93141226, Length=184, Percent_Identity=33.1521739130435, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788728, Length=365, Percent_Identity=37.8082191780822, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789275, Length=257, Percent_Identity=28.7937743190661, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17509539, Length=167, Percent_Identity=37.125748502994, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71989583, Length=258, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=252, Percent_Identity=23.4126984126984, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920384, Length=261, Percent_Identity=30.2681992337165, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357079, Length=307, Percent_Identity=28.3387622149837, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 37871; Mature: 37740

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVERLQNKFDQLKIDAFLVSDGANLQYLTGMVDMAGDGYLLVLAQEAYLITDARYQTA
CCHHHHHHHHHHHEEEEEEEEECCCCEEEEEHHHHCCCCCEEEEEECCEEEEECCCHHHE
FAGQYDDQHLVITRDYLGAVCDIIAKTGTGVMGFEAEIPYTAYSYLDENLVSDLVALPDV
ECCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
VDELRITKSVDEIDRLRASARLADAGFEYVTSIVRPGMREIDVSNLLDAFMRTHGASGPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCC
FTTIVLGGARAALPHGTASKALLTAGQLVTLDFGYFLDGYTSDMTRTFALGTPDDKLVTA
EEEEEECCCHHCCCCCCCCHHHHHCCCEEEEEHHHHHCCCCCCCEEEEECCCCCHHHHHH
YQAVQAAQQAVIDQVQAGAATAQLDAVGRDLLTKAGYGDAFNHGMGHGIGLAIHEGPLIS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCC
KNTTGTLVANSVITVEPGVYFPDLGGMRIEDDVLVTAEGHERLTTATRDLLIL
CCCCCEEEECEEEEECCCEECCCCCCCEEECCEEEEECCCHHHHHHHHCEEEC
>Mature Secondary Structure 
SRVERLQNKFDQLKIDAFLVSDGANLQYLTGMVDMAGDGYLLVLAQEAYLITDARYQTA
CHHHHHHHHHHHEEEEEEEEECCCCEEEEEHHHHCCCCCEEEEEECCEEEEECCCHHHE
FAGQYDDQHLVITRDYLGAVCDIIAKTGTGVMGFEAEIPYTAYSYLDENLVSDLVALPDV
ECCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
VDELRITKSVDEIDRLRASARLADAGFEYVTSIVRPGMREIDVSNLLDAFMRTHGASGPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCC
FTTIVLGGARAALPHGTASKALLTAGQLVTLDFGYFLDGYTSDMTRTFALGTPDDKLVTA
EEEEEECCCHHCCCCCCCCHHHHHCCCEEEEEHHHHHCCCCCCCEEEEECCCCCHHHHHH
YQAVQAAQQAVIDQVQAGAATAQLDAVGRDLLTKAGYGDAFNHGMGHGIGLAIHEGPLIS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEEECCCCCC
KNTTGTLVANSVITVEPGVYFPDLGGMRIEDDVLVTAEGHERLTTATRDLLIL
CCCCCEEEECEEEEECCCEECCCCCCCEEECCEEEEECCCHHHHHHHHCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]