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The map label for this gene is npr1 [H]

Identifier: 28378165

GI number: 28378165

Start: 1321113

End: 1322429

Strand: Direct

Name: npr1 [H]

Synonym: lp_1445

Alternate gene names: 28378165

Gene position: 1321113-1322429 (Clockwise)

Preceding gene: 28378163

Following gene: 28378174

Centisome position: 39.93

GC content: 48.22

Gene sequence:

>1317_bases
ATGGCAAAAATTATTATTGTCGGGGCTGCACATGGCGGCCGCGAAACGGTCAATGGCTTATTAGCAGCTAATACGGATAA
TGAGATTCATTGGTACGAGCACGGGCAATTCGCGACGGCTTTGGATTGGGCTCCGGCGGATGCTGAAAAAGAGCGGTTGG
CCTTGTCCCAGCAGGTGACTCTATTCGACCAAACGACGGTCACAAGAATTACCCCAGCGACCCACACGATTACTGCTCGT
AATCAACGGGGGCAATTACAGACTGATCATTACGATCGATTGGTATTGAGCGTTGGATCGTTACCAATCCAGTTACCGAT
TCCCGGAGCCGAATTATCTGGTGTTCGATCGATTCAAAACCGTGCCAGCATCAATGAGTTAAAATTGGCCGCTAAGTCAG
CAGCCATTAAAAACGTGGTCGTGATTGGAGGCGGCTATATTGGGATGAATTTTGCAGCCTTATTTAAACAAACCGGCAAG
CAAGTAACTGTTATTGATGTGAACGCTCGGCCATTCAGTCACAATCTTGATTCAGAATTTACGCAAATTTTAGCTGCAGC
GAGTGTTGAGAATGGGCTGCAATTAAAGATGGAAGAGCGGGTGACGGCCGTATTAGGTTCAACACACGTGACAGCGGTAC
AAACGAATCGTGGTCAGTATGCTGCCGACTTAGTCCTTGTCGCAGTCGGCAATCGACCGAATACTGCATGGCTACGGGGA
ACTTTGGCGCTAGATTCTGAGGGATTAATTGAGACGGATGATTATTTTCAAACAAGTGTTCCAGATATTTACGCGATTGG
CGATGCGACTAAAGTTCGGTTTACGCCCACGGGTACTAAAGAGCGGATCACTTTAGGCAGCGCGGCCAGTCATGCCGGTC
GGTTATTAGCGCATAACTTGTTAACGGATCAGCGAATTGTGTTTCCCGGCGTTCAGGCAACGTCCGCGCTTAATGCGGCG
GGATATTACTTTGCTGCTACGGGCCTAAACACGCAACTAGCTGTCCGTATGCAACAACCGGTGTTAGCAACTTACATCGC
GGTTCCCCGATTGGTGGCATCCGCACCAGCTCGATTGAATGCGACCGTTCATTTTAAGTTGTTTTATGATAAAACTCATC
GGATACTAGGTGCACAAATAATGTCTACAGCAGAATTAACGGCGGTCATCAATACCGTTTCGCTCGCAATCCAGATGGGA
GCAACGCTCGAGCAATTAGCCTATGGTGACTTTTTCTTTCAACCGGGATTAAGCCAGCCGGTGGATGTACTCAGTACGGC
TAGTTTACAGGCGTTACAAACTTTAGCCACTAACTAG

Upstream 100 bases:

>100_bases
TAATAGTGATTTCCGTAGCCAAACGATTGTTGTAGTTAAAGACAACGTGTATCTTAAATAGCGTTGTTAACAATAATTTA
AGTAATCAGAGGCGGAAAAT

Downstream 100 bases:

>100_bases
GTTGATTATTGCCAAGCCCATTATACGGACTTGGCAATTTTAAGTTGATGTGTTGCTTAAGCTCAGTATATGACATGGAA
AACTAGTGGTTACTGATGAT

Product: NADH peroxidase

Products: NA

Alternate protein names: NPXase; Npx [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MAKIIIVGAAHGGRETVNGLLAANTDNEIHWYEHGQFATALDWAPADAEKERLALSQQVTLFDQTTVTRITPATHTITAR
NQRGQLQTDHYDRLVLSVGSLPIQLPIPGAELSGVRSIQNRASINELKLAAKSAAIKNVVVIGGGYIGMNFAALFKQTGK
QVTVIDVNARPFSHNLDSEFTQILAAASVENGLQLKMEERVTAVLGSTHVTAVQTNRGQYAADLVLVAVGNRPNTAWLRG
TLALDSEGLIETDDYFQTSVPDIYAIGDATKVRFTPTGTKERITLGSAASHAGRLLAHNLLTDQRIVFPGVQATSALNAA
GYYFAATGLNTQLAVRMQQPVLATYIAVPRLVASAPARLNATVHFKLFYDKTHRILGAQIMSTAELTAVINTVSLAIQMG
ATLEQLAYGDFFFQPGLSQPVDVLSTASLQALQTLATN

Sequences:

>Translated_438_residues
MAKIIIVGAAHGGRETVNGLLAANTDNEIHWYEHGQFATALDWAPADAEKERLALSQQVTLFDQTTVTRITPATHTITAR
NQRGQLQTDHYDRLVLSVGSLPIQLPIPGAELSGVRSIQNRASINELKLAAKSAAIKNVVVIGGGYIGMNFAALFKQTGK
QVTVIDVNARPFSHNLDSEFTQILAAASVENGLQLKMEERVTAVLGSTHVTAVQTNRGQYAADLVLVAVGNRPNTAWLRG
TLALDSEGLIETDDYFQTSVPDIYAIGDATKVRFTPTGTKERITLGSAASHAGRLLAHNLLTDQRIVFPGVQATSALNAA
GYYFAATGLNTQLAVRMQQPVLATYIAVPRLVASAPARLNATVHFKLFYDKTHRILGAQIMSTAELTAVINTVSLAIQMG
ATLEQLAYGDFFFQPGLSQPVDVLSTASLQALQTLATN
>Mature_437_residues
AKIIIVGAAHGGRETVNGLLAANTDNEIHWYEHGQFATALDWAPADAEKERLALSQQVTLFDQTTVTRITPATHTITARN
QRGQLQTDHYDRLVLSVGSLPIQLPIPGAELSGVRSIQNRASINELKLAAKSAAIKNVVVIGGGYIGMNFAALFKQTGKQ
VTVIDVNARPFSHNLDSEFTQILAAASVENGLQLKMEERVTAVLGSTHVTAVQTNRGQYAADLVLVAVGNRPNTAWLRGT
LALDSEGLIETDDYFQTSVPDIYAIGDATKVRFTPTGTKERITLGSAASHAGRLLAHNLLTDQRIVFPGVQATSALNAAG
YYFAATGLNTQLAVRMQQPVLATYIAVPRLVASAPARLNATVHFKLFYDKTHRILGAQIMSTAELTAVINTVSLAIQMGA
TLEQLAYGDFFFQPGLSQPVDVLSTASLQALQTLATN

Specific function: Peroxidase whose active site is a redox-active cysteine- sulfenic acid [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=281, Percent_Identity=26.6903914590747, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI65787454, Length=281, Percent_Identity=26.6903914590747, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226437568, Length=281, Percent_Identity=26.6903914590747, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI91199540, Length=372, Percent_Identity=22.8494623655914, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789065, Length=289, Percent_Identity=29.0657439446367, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786307, Length=344, Percent_Identity=26.7441860465116, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17559934, Length=217, Percent_Identity=23.963133640553, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=357, Percent_Identity=22.96918767507, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358499, Length=371, Percent_Identity=25.3369272237197, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24639257, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281359715, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281359713, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639250, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18543267, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639252, Length=219, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585130, Length=221, Percent_Identity=24.4343891402715, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.11.1.1 [H]

Molecular weight: Translated: 46984; Mature: 46853

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIIVGAAHGGRETVNGLLAANTDNEIHWYEHGQFATALDWAPADAEKERLALSQQVT
CEEEEEEECCCCCHHHHCEEEEECCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHEEE
LFDQTTVTRITPATHTITARNQRGQLQTDHYDRLVLSVGSLPIQLPIPGAELSGVRSIQN
EEECCEEEEECCCEEEEEECCCCCCCCCCCHHEEEEEECCCEEEECCCCCHHHHHHHHHH
RASINELKLAAKSAAIKNVVVIGGGYIGMNFAALFKQTGKQVTVIDVNARPFSHNLDSEF
HCCHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHH
TQILAAASVENGLQLKMEERVTAVLGSTHVTAVQTNRGQYAADLVLVAVGNRPNTAWLRG
HHHHHHHHCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEEECCCCCCEEEEE
TLALDSEGLIETDDYFQTSVPDIYAIGDATKVRFTPTGTKERITLGSAASHAGRLLAHNL
EEEECCCCCEECCCCCCCCCCCEEEECCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHH
LTDQRIVFPGVQATSALNAAGYYFAATGLNTQLAVRMQQPVLATYIAVPRLVASAPARLN
CCCCEEEECCCCHHHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEE
ATVHFKLFYDKTHRILGAQIMSTAELTAVINTVSLAIQMGATLEQLAYGDFFFQPGLSQP
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCCC
VDVLSTASLQALQTLATN
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIIIVGAAHGGRETVNGLLAANTDNEIHWYEHGQFATALDWAPADAEKERLALSQQVT
EEEEEEECCCCCHHHHCEEEEECCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHEEE
LFDQTTVTRITPATHTITARNQRGQLQTDHYDRLVLSVGSLPIQLPIPGAELSGVRSIQN
EEECCEEEEECCCEEEEEECCCCCCCCCCCHHEEEEEECCCEEEECCCCCHHHHHHHHHH
RASINELKLAAKSAAIKNVVVIGGGYIGMNFAALFKQTGKQVTVIDVNARPFSHNLDSEF
HCCHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHH
TQILAAASVENGLQLKMEERVTAVLGSTHVTAVQTNRGQYAADLVLVAVGNRPNTAWLRG
HHHHHHHHCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEEECCCCCCEEEEE
TLALDSEGLIETDDYFQTSVPDIYAIGDATKVRFTPTGTKERITLGSAASHAGRLLAHNL
EEEECCCCCEECCCCCCCCCCCEEEECCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHH
LTDQRIVFPGVQATSALNAAGYYFAATGLNTQLAVRMQQPVLATYIAVPRLVASAPARLN
CCCCEEEECCCCHHHHHCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEE
ATVHFKLFYDKTHRILGAQIMSTAELTAVINTVSLAIQMGATLEQLAYGDFFFQPGLSQP
EEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCCC
VDVLSTASLQALQTLATN
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1719212; 12663927; 2501302; 1942054; 8425532; 8756456; 9214307 [H]