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The map label for this gene is flp [H]

Identifier: 28378163

GI number: 28378163

Start: 1319557

End: 1320198

Strand: Direct

Name: flp [H]

Synonym: lp_1442

Alternate gene names: 28378163

Gene position: 1319557-1320198 (Clockwise)

Preceding gene: 28378160

Following gene: 28378165

Centisome position: 39.89

GC content: 42.83

Gene sequence:

>642_bases
ATGCATTCAAAAATGGATTGTGTGAGTCGTTCACCATTATTTTCACCGCTAGCGCCAGCGGTGAAAGCCAAATTAATCAC
GGTGACCCATCACCGGAAATTTTATCAAAAAGGGCAGTTGATTCGTCAGCCACTCGACCATCAGGAAGGCATGCTCATTT
TAGATGAGGGAACGGCTAAAATTTATGCCTTAGCTGCTAATGGTAAGGAGAAAATTATTGAGTTGTTGCGTAGTGGTGAT
GTCGTCGGACAACACTGGCTATTTGCACCGCATGAGAATCAGGGATTTATTCAAGCCACGAGTGATGCGTGGGTCTGTTC
CATTCAATATGATGATTTTCAGCGATTATTAGGTGAATCAGCCAGTTTATCATTAGCAATGATCAATAATTTTGGGAACC
AATTGATTGAAGCTGAGAAGAATCAATTGCGACGAGATTTGCTGGATGCTAAAGCGCGTTTGATGGCGTATTTGCGCGAT
TGTGCCGTTGAATCCGGACAAATCGAATTTGAATTGCCGTTGAAGAAGAAGGAATTGGCGAATATTTTGGGGATTACTCC
CGAAACCCTGAGTCGTCAGTTTAAACAATTGGCGGCTGAAGGGCAGATTATCGTCAATAAGCGCCAGATTACAATTTGTT
AG

Upstream 100 bases:

>100_bases
TTTTTTAGTCATGAATAATTCCTCCAGTTCTTCATTATATGGTCAGTATATGCTAGTCTAATCATATAAAAATTGACATA
AATCAAGAAAAGGAGAAATT

Downstream 100 bases:

>100_bases
ACGGTAAAGGGGGGCGTCGCCTGGTTTTGGCTAGTTAAGGGTGACGCTGGTTCAATATTAAAAATAAAGTCTGATTTCCA
ACGCAGTATGGGCTAGGAAA

Product: transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MHSKMDCVSRSPLFSPLAPAVKAKLITVTHHRKFYQKGQLIRQPLDHQEGMLILDEGTAKIYALAANGKEKIIELLRSGD
VVGQHWLFAPHENQGFIQATSDAWVCSIQYDDFQRLLGESASLSLAMINNFGNQLIEAEKNQLRRDLLDAKARLMAYLRD
CAVESGQIEFELPLKKKELANILGITPETLSRQFKQLAAEGQIIVNKRQITIC

Sequences:

>Translated_213_residues
MHSKMDCVSRSPLFSPLAPAVKAKLITVTHHRKFYQKGQLIRQPLDHQEGMLILDEGTAKIYALAANGKEKIIELLRSGD
VVGQHWLFAPHENQGFIQATSDAWVCSIQYDDFQRLLGESASLSLAMINNFGNQLIEAEKNQLRRDLLDAKARLMAYLRD
CAVESGQIEFELPLKKKELANILGITPETLSRQFKQLAAEGQIIVNKRQITIC
>Mature_213_residues
MHSKMDCVSRSPLFSPLAPAVKAKLITVTHHRKFYQKGQLIRQPLDHQEGMLILDEGTAKIYALAANGKEKIIELLRSGD
VVGQHWLFAPHENQGFIQATSDAWVCSIQYDDFQRLLGESASLSLAMINNFGNQLIEAEKNQLRRDLLDAKARLMAYLRD
CAVESGQIEFELPLKKKELANILGITPETLSRQFKQLAAEGQIIVNKRQITIC

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 23985; Mature: 23985

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSKMDCVSRSPLFSPLAPAVKAKLITVTHHRKFYQKGQLIRQPLDHQEGMLILDEGTAK
CCCCCCHHCCCCCCCHHHHHHHHEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEE
IYALAANGKEKIIELLRSGDVVGQHWLFAPHENQGFIQATSDAWVCSIQYDDFQRLLGES
EEEEECCCHHHHHHHHHCCCCCCCCEEECCCCCCCCEEECCCCEEEEEEHHHHHHHHCCC
ASLSLAMINNFGNQLIEAEKNQLRRDLLDAKARLMAYLRDCAVESGQIEFELPLKKKELA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
NILGITPETLSRQFKQLAAEGQIIVNKRQITIC
HHHCCCHHHHHHHHHHHHCCCEEEEEEEEEEEC
>Mature Secondary Structure
MHSKMDCVSRSPLFSPLAPAVKAKLITVTHHRKFYQKGQLIRQPLDHQEGMLILDEGTAK
CCCCCCHHCCCCCCCHHHHHHHHEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEE
IYALAANGKEKIIELLRSGDVVGQHWLFAPHENQGFIQATSDAWVCSIQYDDFQRLLGES
EEEEECCCHHHHHHHHHCCCCCCCCEEECCCCCCCCEEECCCCEEEEEEHHHHHHHHCCC
ASLSLAMINNFGNQLIEAEKNQLRRDLLDAKARLMAYLRDCAVESGQIEFELPLKKKELA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHH
NILGITPETLSRQFKQLAAEGQIIVNKRQITIC
HHHCCCHHHHHHHHHHHHCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]