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The map label for this gene is argS

Identifier: 28378123

GI number: 28378123

Start: 1272688

End: 1274376

Strand: Direct

Name: argS

Synonym: lp_1391

Alternate gene names: 28378123

Gene position: 1272688-1274376 (Clockwise)

Preceding gene: 28378122

Following gene: 28378125

Centisome position: 38.47

GC content: 46.18

Gene sequence:

>1689_bases
ATGGATTATAAACAACTCGTCGCAGCGGCCTTAGCGCCAGCACTACCAGATTTAACGCAGGAAGCGATTCTAGACAAGAT
CGAACAACCAAAGACGTCTAAGCAGGGGGACTTGGCCTTTCCGACCTTCACCTTAGCCAAAACGTTACACAAGGCACCTC
AAATGATTGCCAGCGACATCGTCGAAAAAGTCGATAGCAGTGACTTTGAAAAAGTTGTTGCAATGGGCCCGTACGTTAAC
TTCTTCTTCAAGAAGGATGCGTTTGCAGCCGATATTTTAAATCAAGTATTGTCGAATGGTGGCCATTTTGGTGATGCTAA
GCTCGGTGAAGCGGGTCAAGTTCCCATCGATATGTCATCGCCAAACATTGCCAAACCAATCTCAATGGGGCATTTGCGGT
CAACAGTGATTGGGAATTCTTTGGCAAATATTTTAAGTAAGTTGGATTACCAACCCGTTAAGATCAACCACTTAGGTGAC
TGGGGCACGCAGTTCGGTAAGTTGATCACGGCCTACAAAATGTGGGGAAGCGAAGCTGAGGTCAAAGCTGATCCAATCAA
TAACTTATTAAAATACTATGTACGTTTCCATAAAGAAGACGTCGATCATCCTGAAATGGATGACGAGGCGCGTGAATGGT
TCAAGAAATTGGAAAATGGTGATGAAGAAGCCACCCATCTGTGGTCATGGTTCCGCTCAGAATCATTGAAAGCGTTCAAG
AAGATTTACCAACGCTTGGATATCGACTTTGATTCCTTCAAGGGTGAGGCCTTCTACAATGATAAGATGCAAGAAGTTGT
CGACATCTTGGAAGACAAGCACCTCTTGCAAGAAAGTCAAGGCGCCGAAGTGGTGGACTTAAGCAAATATGACTTGAATC
CGGCATTGATTAAAAAATCAGATGGCGCGACTTTATATATCACGCGGGACTTGGCCGCTGCGATCTACCGGAAACGGACT
TATGATTTCGTGCAGTCCCTCTACGTCGTTGGGAATGAACAGACCAACCACTTTAAGCAATTAAAGGCTGTGTTGACCGA
GATGGGCTTTGACTGGGCTGACCAGATCCACCACATTCCATTTGGTTTGATTACTTCTGGTGGTAAGAAGTTGTCAACTC
GGAGTGGCCGGGTCATCCTGCTTGATAAGGTCTTGGACGATGCGGTTGCGTTAGCTCATGAACAAATCGAAGCCAAGAAT
CCGGACTTGCCTAACAAGGATGAAGTTGCGGATGCGGTTGGGATTGGCGCTGTGGTCTTCCATGATTTGAAGAACGAACG
GATGAACAGTTTTGACTTTAACTTGGAAGAAGTTGTTCGTTTCGAGGGTGAGACTGGGCCATACGTGCAGTACGCCCATG
CACGCGCTGAAAGTATCTTACGTAAAGCTGGTAGCCCAGAAATTGCGGCAACCGAGCAAACGTTAAGCGACCCAGCCGCT
TGGGATACCTTGAAGTTATTGAGTGAATTCCCAGCGACTGTAGTACGTGCCAGCACGGAATACGAACCATCCGTTATTGC
TAAGTATGCGATCCACTTAGCCAAGGCATACAACAAGTATTATGCTAACACCAAAATCTTAGTTGAAGATGATGAATTAA
ACGCTCGTCTGGCTTTGGTCAAGAGTGTCAGCATCGTCCTGAAGGAAGCCCTTCGCTTACTTGGCGTTAAGGCTCCAGAT
GAAATGTAA

Upstream 100 bases:

>100_bases
ATATCAATTAGAGTGGTACCGCGGGCACGTCTCGTCTCTTACATGTTTTTAAATATGTGAGGGACTTTTTTTGTCCCGTA
AGACAATCAAGGAGGACAAT

Downstream 100 bases:

>100_bases
TTAGAATTAATTAACAACTGTTCAAATTTGAACGCCACGCATACTAAACCGGCCGTTAAAGCCGGGCGAGAATGCGTGGC
GTTTTTTTGTTGCGGCCGTA

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDYKQLVAAALAPALPDLTQEAILDKIEQPKTSKQGDLAFPTFTLAKTLHKAPQMIASDIVEKVDSSDFEKVVAMGPYVN
FFFKKDAFAADILNQVLSNGGHFGDAKLGEAGQVPIDMSSPNIAKPISMGHLRSTVIGNSLANILSKLDYQPVKINHLGD
WGTQFGKLITAYKMWGSEAEVKADPINNLLKYYVRFHKEDVDHPEMDDEAREWFKKLENGDEEATHLWSWFRSESLKAFK
KIYQRLDIDFDSFKGEAFYNDKMQEVVDILEDKHLLQESQGAEVVDLSKYDLNPALIKKSDGATLYITRDLAAAIYRKRT
YDFVQSLYVVGNEQTNHFKQLKAVLTEMGFDWADQIHHIPFGLITSGGKKLSTRSGRVILLDKVLDDAVALAHEQIEAKN
PDLPNKDEVADAVGIGAVVFHDLKNERMNSFDFNLEEVVRFEGETGPYVQYAHARAESILRKAGSPEIAATEQTLSDPAA
WDTLKLLSEFPATVVRASTEYEPSVIAKYAIHLAKAYNKYYANTKILVEDDELNARLALVKSVSIVLKEALRLLGVKAPD
EM

Sequences:

>Translated_562_residues
MDYKQLVAAALAPALPDLTQEAILDKIEQPKTSKQGDLAFPTFTLAKTLHKAPQMIASDIVEKVDSSDFEKVVAMGPYVN
FFFKKDAFAADILNQVLSNGGHFGDAKLGEAGQVPIDMSSPNIAKPISMGHLRSTVIGNSLANILSKLDYQPVKINHLGD
WGTQFGKLITAYKMWGSEAEVKADPINNLLKYYVRFHKEDVDHPEMDDEAREWFKKLENGDEEATHLWSWFRSESLKAFK
KIYQRLDIDFDSFKGEAFYNDKMQEVVDILEDKHLLQESQGAEVVDLSKYDLNPALIKKSDGATLYITRDLAAAIYRKRT
YDFVQSLYVVGNEQTNHFKQLKAVLTEMGFDWADQIHHIPFGLITSGGKKLSTRSGRVILLDKVLDDAVALAHEQIEAKN
PDLPNKDEVADAVGIGAVVFHDLKNERMNSFDFNLEEVVRFEGETGPYVQYAHARAESILRKAGSPEIAATEQTLSDPAA
WDTLKLLSEFPATVVRASTEYEPSVIAKYAIHLAKAYNKYYANTKILVEDDELNARLALVKSVSIVLKEALRLLGVKAPD
EM
>Mature_562_residues
MDYKQLVAAALAPALPDLTQEAILDKIEQPKTSKQGDLAFPTFTLAKTLHKAPQMIASDIVEKVDSSDFEKVVAMGPYVN
FFFKKDAFAADILNQVLSNGGHFGDAKLGEAGQVPIDMSSPNIAKPISMGHLRSTVIGNSLANILSKLDYQPVKINHLGD
WGTQFGKLITAYKMWGSEAEVKADPINNLLKYYVRFHKEDVDHPEMDDEAREWFKKLENGDEEATHLWSWFRSESLKAFK
KIYQRLDIDFDSFKGEAFYNDKMQEVVDILEDKHLLQESQGAEVVDLSKYDLNPALIKKSDGATLYITRDLAAAIYRKRT
YDFVQSLYVVGNEQTNHFKQLKAVLTEMGFDWADQIHHIPFGLITSGGKKLSTRSGRVILLDKVLDDAVALAHEQIEAKN
PDLPNKDEVADAVGIGAVVFHDLKNERMNSFDFNLEEVVRFEGETGPYVQYAHARAESILRKAGSPEIAATEQTLSDPAA
WDTLKLLSEFPATVVRASTEYEPSVIAKYAIHLAKAYNKYYANTKILVEDDELNARLALVKSVSIVLKEALRLLGVKAPD
EM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI197100773, Length=580, Percent_Identity=32.2413793103448, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI15149476, Length=589, Percent_Identity=28.5229202037351, Blast_Score=213, Evalue=5e-55,
Organism=Escherichia coli, GI1788184, Length=582, Percent_Identity=31.2714776632302, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71985061, Length=591, Percent_Identity=28.2571912013536, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71985068, Length=555, Percent_Identity=28.6486486486486, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17532153, Length=491, Percent_Identity=27.6985743380855, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6320548, Length=559, Percent_Identity=37.0304114490161, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321883, Length=576, Percent_Identity=34.5486111111111, Blast_Score=340, Evalue=2e-94,
Organism=Drosophila melanogaster, GI28571570, Length=468, Percent_Identity=33.974358974359, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI18859963, Length=590, Percent_Identity=28.9830508474576, Blast_Score=223, Evalue=4e-58,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_LACPL (Q88X53)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785015.1
- ProteinModelPortal:   Q88X53
- SMR:   Q88X53
- GeneID:   1062530
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1391
- NMPDR:   fig|220668.1.peg.1149
- HOGENOM:   HBG695395
- OMA:   AYKKWGN
- ProtClustDB:   PRK01611
- BioCyc:   LPLA220668:LP_1391-MONOMER
- BRENDA:   6.1.1.19
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 62910; Mature: 62910

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKQLVAAALAPALPDLTQEAILDKIEQPKTSKQGDLAFPTFTLAKTLHKAPQMIASDI
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VEKVDSSDFEKVVAMGPYVNFFFKKDAFAADILNQVLSNGGHFGDAKLGEAGQVPIDMSS
HHHHCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCC
PNIAKPISMGHLRSTVIGNSLANILSKLDYQPVKINHLGDWGTQFGKLITAYKMWGSEAE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCC
VKADPINNLLKYYVRFHKEDVDHPEMDDEAREWFKKLENGDEEATHLWSWFRSESLKAFK
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KIYQRLDIDFDSFKGEAFYNDKMQEVVDILEDKHLLQESQGAEVVDLSKYDLNPALIKKS
HHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECHHCCCCHHHEECC
DGATLYITRDLAAAIYRKRTYDFVQSLYVVGNEQTNHFKQLKAVLTEMGFDWADQIHHIP
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
FGLITSGGKKLSTRSGRVILLDKVLDDAVALAHEQIEAKNPDLPNKDEVADAVGIGAVVF
HHEEECCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
HDLKNERMNSFDFNLEEVVRFEGETGPYVQYAHARAESILRKAGSPEIAATEQTLSDPAA
HHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHCCCHH
WDTLKLLSEFPATVVRASTEYEPSVIAKYAIHLAKAYNKYYANTKILVEDDELNARLALV
HHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
KSVSIVLKEALRLLGVKAPDEM
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDYKQLVAAALAPALPDLTQEAILDKIEQPKTSKQGDLAFPTFTLAKTLHKAPQMIASDI
CCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VEKVDSSDFEKVVAMGPYVNFFFKKDAFAADILNQVLSNGGHFGDAKLGEAGQVPIDMSS
HHHHCCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCC
PNIAKPISMGHLRSTVIGNSLANILSKLDYQPVKINHLGDWGTQFGKLITAYKMWGSEAE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCC
VKADPINNLLKYYVRFHKEDVDHPEMDDEAREWFKKLENGDEEATHLWSWFRSESLKAFK
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KIYQRLDIDFDSFKGEAFYNDKMQEVVDILEDKHLLQESQGAEVVDLSKYDLNPALIKKS
HHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECHHCCCCHHHEECC
DGATLYITRDLAAAIYRKRTYDFVQSLYVVGNEQTNHFKQLKAVLTEMGFDWADQIHHIP
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCC
FGLITSGGKKLSTRSGRVILLDKVLDDAVALAHEQIEAKNPDLPNKDEVADAVGIGAVVF
HHEEECCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
HDLKNERMNSFDFNLEEVVRFEGETGPYVQYAHARAESILRKAGSPEIAATEQTLSDPAA
HHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHCCCHH
WDTLKLLSEFPATVVRASTEYEPSVIAKYAIHLAKAYNKYYANTKILVEDDELNARLALV
HHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
KSVSIVLKEALRLLGVKAPDEM
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566