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The map label for this gene is cysC

Identifier: 28378116

GI number: 28378116

Start: 1263732

End: 1264355

Strand: Direct

Name: cysC

Synonym: lp_1379

Alternate gene names: 28378116

Gene position: 1263732-1264355 (Clockwise)

Preceding gene: 28378115

Following gene: 28378117

Centisome position: 38.2

GC content: 45.67

Gene sequence:

>624_bases
ATGGTAAAATCAGATAATATTACTTGGCATCAATCGCAAGTTAGCAAGGCCGAACGGCAAGCGCTGAACCATCATAAGAG
TGTGGTTTTATGGTTTACTGGCCTGTCCGGCTCCGGTAAGTCGACGATTGCGAATGCCGTTGAAAAAGCATTATTTGACC
AACAAGTTGGTAGTTACGTTTTAGACGGCGACAATATGCGTTTTGGCTTGAATAAGAATTTAGGCTTCTCAGCTGAAGAC
CGTGAAGAAAATATTCGCCGAATCGGCGAAGTTGCCAAACTATTTGTCGATGCTGGCGTGATTACGTTGACGGCTTTCAT
TTCACCATATCGGGCCGACCGTGATAAAGTGCGGGCGAACCTTGAGGTCGATGAGTTTATTGAAGTGTTCGTCGACACGC
CGCTTGAAGTTTGTGAACAACGAGATGTGAAACAATTGTACGCGAAGGCGCGTCGTGGTGAAATCACGGGCTTTACAGGC
ATCGATGCACCATACGAAGCACCTATCGATCCTGAGATTACGATTGACACGTCCAAACAACCACTGACCGCTTCCGTCCA
ACAAGTATTGAATTACTTGGCGGAACACCATTATGTCAGTTTGGTTACTGCAAATGAAAACTAA

Upstream 100 bases:

>100_bases
ATGGTGTTGTACCACCAAAGGAAGTTTCACGTCCCGAAGTTGCCCGGGTTCTCATCGACGGGTTGAAACGTAAACGTGAA
CAGCAACAGGAGGTCTAAGC

Downstream 100 bases:

>100_bases
TGCAATCATTACTGACATCACAAAATCGATTGTGAAAATGGACCGAATCTTGGTCTATCGTCATACGAATCCGGATCCCG
ATGCAATCGGGGCACAATTT

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYVLDGDNMRFGLNKNLGFSAED
REENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRANLEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTG
IDAPYEAPIDPEITIDTSKQPLTASVQQVLNYLAEHHYVSLVTANEN

Sequences:

>Translated_207_residues
MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYVLDGDNMRFGLNKNLGFSAED
REENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRANLEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTG
IDAPYEAPIDPEITIDTSKQPLTASVQQVLNYLAEHHYVSLVTANEN
>Mature_207_residues
MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYVLDGDNMRFGLNKNLGFSAED
REENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRANLEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTG
IDAPYEAPIDPEITIDTSKQPLTASVQQVLNYLAEHHYVSLVTANEN

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=212, Percent_Identity=50, Blast_Score=205, Evalue=2e-53,
Organism=Homo sapiens, GI62912492, Length=203, Percent_Identity=48.7684729064039, Blast_Score=194, Evalue=3e-50,
Organism=Homo sapiens, GI34447231, Length=203, Percent_Identity=48.7684729064039, Blast_Score=194, Evalue=3e-50,
Organism=Escherichia coli, GI1789107, Length=192, Percent_Identity=55.7291666666667, Blast_Score=218, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17542422, Length=197, Percent_Identity=53.8071065989848, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322852, Length=193, Percent_Identity=54.4041450777202, Blast_Score=209, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24667040, Length=197, Percent_Identity=46.7005076142132, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24667032, Length=197, Percent_Identity=46.7005076142132, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24667028, Length=197, Percent_Identity=46.7005076142132, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24667036, Length=197, Percent_Identity=46.7005076142132, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI116007838, Length=197, Percent_Identity=46.7005076142132, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24667044, Length=197, Percent_Identity=46.7005076142132, Blast_Score=181, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_LACPL (Q88X60)

Other databases:

- EMBL:   AL935256
- RefSeq:   NP_785008.1
- ProteinModelPortal:   Q88X60
- SMR:   Q88X60
- GeneID:   1062562
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1379
- NMPDR:   fig|220668.1.peg.1142
- HOGENOM:   HBG309946
- OMA:   ITITAFV
- ProtClustDB:   CLSK2520188
- BioCyc:   LPLA220668:LP_1379-MONOMER
- BRENDA:   2.7.1.25
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 23130; Mature: 23130

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYV
CCCCCCCEECHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEE
LDGDNMRFGLNKNLGFSAEDREENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRAN
ECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
LEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTGIDAPYEAPIDPEITIDTSKQ
CCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCC
PLTASVQQVLNYLAEHHYVSLVTANEN
CHHHHHHHHHHHHHHCCEEEEEEECCC
>Mature Secondary Structure
MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYV
CCCCCCCEECHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEE
LDGDNMRFGLNKNLGFSAEDREENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRAN
ECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
LEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTGIDAPYEAPIDPEITIDTSKQ
CCHHHHHHHHHCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCC
PLTASVQQVLNYLAEHHYVSLVTANEN
CHHHHHHHHHHHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566