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The map label for this gene is uvrA2 [H]

Identifier: 28378106

GI number: 28378106

Start: 1249993

End: 1252263

Strand: Direct

Name: uvrA2 [H]

Synonym: lp_1364

Alternate gene names: 28378106

Gene position: 1249993-1252263 (Clockwise)

Preceding gene: 28378105

Following gene: 28378110

Centisome position: 37.78

GC content: 49.89

Gene sequence:

>2271_bases
TTGATGACCAGTTATTCATTTCCACATGGCGCCATTGACGTATACGACGCTACCCAAAACAATTTAAAGCACGTTAGTCT
TCGCGTTCCTAAATATGCAACCACGGTGTTCGTGGGCTTGTCAGGTTCCGGTAAGTCGTCACTCGTTTTTGATACGATTG
CAGCGGCGTCACGGCGCGAACTGAATGAAACGTTTCCCAGTTTTACGCAACAATATTTACCGAAGTATGGTCAACCACAC
GTCGGGCATATCGAGCACTTGCCCGTTGCGATTGTGATTGCTCAACAACGCCTCGGCAAGAATGCGCGTTCAACCTTGGC
AACCTATACTGGGATTTATTCGTTACTGCGGCTCTTGTTTTCACGGGTTGGGGAACCGTTTATCGGGTATTCGGACAGTT
TTTCGTTTAACTTACCCCAAGGCATGTGCCCAACCTGCCAAGGTTTAGGTTATGTTGACGATATTGATGAGCAGCAATTG
ATTGATCCTGAGAAATCATTAAATGAGGGGGCCATCACGTTTGTGAGTTTTGCACCGGATACGTGGCGTTGGCGCCGTTA
TGCGACGAGTGGTTTGTTTGACAATGATAAACCCATCAAGGATTATAGTGCTGCGGAATACGATTTACTGATGCACGCAC
CGCAACAGAAATTAGCCCATCCTGGAGAAGGTTTTCCTAGAACGGCCCTGTATGAAGGTGTTGTTCCGCGGATCAAGCGC
TCGATTATTGGTAAGAAGGAAGCCGAACACCATCGCGATGCGATTGCGGCGATCGTCACGCGCAAACCGTGCCCAACGTG
TGATGGCACACGACTCAAACCGGTCGTGTTGACCAATCATATTAACGGGGTCAACATTGCTCAGGTGACGGCGATGGATT
TAAAGCATGTTCTGACATTTTTACAAGCGATTGATGCGCCGTTAGCCCAAGATATTGTGCGGGAGCTGACGACCAAGATC
CAATCGTTGGTCGATATTGGTCTGGGCTATCTGACATTGGATCGTGGGACCAGTTCTTTATCTGGTGGTGAAGCGCAACG
GATTAAGATTGCCAAATACTTGACCAGCGCCTTAGTAGATATGGTCTACATTTTGGACGAGCCAAGCGTTGGGCTGCACC
CACATGATATTCAGTTAATCAAGCAAGCGTTAACGAAGCTGAAGGATAAGGGTAACACAATTCTGATTGTTGAACACAAT
CCAGCCATGTTTACGTTAGCCGACTATGTTGTCGAGATGGGGCCTGCAGCTGGTCGCACTGGTGGAAACGTGACCTTTAC
TGGGACTTATGACGAGTTACTGGCTTCTGATACGTTGACGGGCCGGTGGTTGCGACAACCGCATAAATGGGGTCAAGAAC
GACCAGTCCAGGCCCACTTGGCATTACACCATATTAATGAAAATAACCTGCACGATGTCAGTGTCGACGTGCCCCTCGGT
GTGATGACGGTCGTCTCGGGGGTGGCCGGTTCAGGGAAGAGTTCGCTGGTTACCGCGCTAAAACGGCAATTAAAGACGGC
TTATATTGATTTAGCCCAGACACCAGTGGGCCTGAATATTCGCTCAACACCGGCGACTTACTTAGGAGTGCTCGACCAAA
TCCGACAACTATTCGCGAAAGCCAATGGCGTGGCAACTAGTTGGTTCAGCTATAATGGTAAGGGTGCTTGTCCGCGGTGT
AAGGGTAAAGGCGTGACCATCACGAATATGGCCTTTATGGATCCCGTTGTGCAGACATGTGAATTGTGTCATGGGCTGCG
GTATAATGAAACGGCGCTCAGCTATGCTTACCAGGGTAAGACGATTGCCGACGTGCTCCAGATGTCAGTCACAGCGGCGT
TAGCTTTTTTTGCCACGATGGACAAAGTGGCTCAGCCATTGAAGAATTTAGACCGGGTCGGTTTGGGTTACCTAACATTG
GCGCAACCGCTCACCACTTTGTCGGGTGGTGAACTGCAACGGTTGAAGCTGGCGGTTGAGCTAGGCAAGCAGGGAACGGT
GTACTTGTTAGATGAACCGACTGCCGGTCTGCATTTGCAAGACACACAACGCTTATTAAAATTATTCGATGCCTTAGTGG
CCGCTGGTAACTCGTTGATTATTATCGAACATAATCTGGCGGTAATTAGCCAGGCCGATTGGTTGATCGATGTGGGGCCG
GATGCTGGTCAGTATGGCGGCCGAATTCAGTATAGCGGAACCCCACGAGCAGCAGTTGACGTGCCCACTTCACGCACTGG
AGCCGCTTTGAAGGCTTGGCTGACGGCGTGA

Upstream 100 bases:

>100_bases
TATGGGACGGTCGTCAAGCTCGTTGATGAATCAGTCTGATACTTAGGATCTGAATTTTCAGGTCCTTTTTTGATAGCAAA
CAAGTGATAGAAAGGAAGGT

Downstream 100 bases:

>100_bases
TTAGAAAATTTGATTAAATAAAAAGCACGTGCAATTGCACGTGCTTTTTTAGAAGGGCGGTAGGTGGGAATCGAACCCAC
GCGTGCCGGAGCCACAATCC

Product: excinuclease ABC, subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MMTSYSFPHGAIDVYDATQNNLKHVSLRVPKYATTVFVGLSGSGKSSLVFDTIAAASRRELNETFPSFTQQYLPKYGQPH
VGHIEHLPVAIVIAQQRLGKNARSTLATYTGIYSLLRLLFSRVGEPFIGYSDSFSFNLPQGMCPTCQGLGYVDDIDEQQL
IDPEKSLNEGAITFVSFAPDTWRWRRYATSGLFDNDKPIKDYSAAEYDLLMHAPQQKLAHPGEGFPRTALYEGVVPRIKR
SIIGKKEAEHHRDAIAAIVTRKPCPTCDGTRLKPVVLTNHINGVNIAQVTAMDLKHVLTFLQAIDAPLAQDIVRELTTKI
QSLVDIGLGYLTLDRGTSSLSGGEAQRIKIAKYLTSALVDMVYILDEPSVGLHPHDIQLIKQALTKLKDKGNTILIVEHN
PAMFTLADYVVEMGPAAGRTGGNVTFTGTYDELLASDTLTGRWLRQPHKWGQERPVQAHLALHHINENNLHDVSVDVPLG
VMTVVSGVAGSGKSSLVTALKRQLKTAYIDLAQTPVGLNIRSTPATYLGVLDQIRQLFAKANGVATSWFSYNGKGACPRC
KGKGVTITNMAFMDPVVQTCELCHGLRYNETALSYAYQGKTIADVLQMSVTAALAFFATMDKVAQPLKNLDRVGLGYLTL
AQPLTTLSGGELQRLKLAVELGKQGTVYLLDEPTAGLHLQDTQRLLKLFDALVAAGNSLIIIEHNLAVISQADWLIDVGP
DAGQYGGRIQYSGTPRAAVDVPTSRTGAALKAWLTA

Sequences:

>Translated_756_residues
MMTSYSFPHGAIDVYDATQNNLKHVSLRVPKYATTVFVGLSGSGKSSLVFDTIAAASRRELNETFPSFTQQYLPKYGQPH
VGHIEHLPVAIVIAQQRLGKNARSTLATYTGIYSLLRLLFSRVGEPFIGYSDSFSFNLPQGMCPTCQGLGYVDDIDEQQL
IDPEKSLNEGAITFVSFAPDTWRWRRYATSGLFDNDKPIKDYSAAEYDLLMHAPQQKLAHPGEGFPRTALYEGVVPRIKR
SIIGKKEAEHHRDAIAAIVTRKPCPTCDGTRLKPVVLTNHINGVNIAQVTAMDLKHVLTFLQAIDAPLAQDIVRELTTKI
QSLVDIGLGYLTLDRGTSSLSGGEAQRIKIAKYLTSALVDMVYILDEPSVGLHPHDIQLIKQALTKLKDKGNTILIVEHN
PAMFTLADYVVEMGPAAGRTGGNVTFTGTYDELLASDTLTGRWLRQPHKWGQERPVQAHLALHHINENNLHDVSVDVPLG
VMTVVSGVAGSGKSSLVTALKRQLKTAYIDLAQTPVGLNIRSTPATYLGVLDQIRQLFAKANGVATSWFSYNGKGACPRC
KGKGVTITNMAFMDPVVQTCELCHGLRYNETALSYAYQGKTIADVLQMSVTAALAFFATMDKVAQPLKNLDRVGLGYLTL
AQPLTTLSGGELQRLKLAVELGKQGTVYLLDEPTAGLHLQDTQRLLKLFDALVAAGNSLIIIEHNLAVISQADWLIDVGP
DAGQYGGRIQYSGTPRAAVDVPTSRTGAALKAWLTA
>Mature_756_residues
MMTSYSFPHGAIDVYDATQNNLKHVSLRVPKYATTVFVGLSGSGKSSLVFDTIAAASRRELNETFPSFTQQYLPKYGQPH
VGHIEHLPVAIVIAQQRLGKNARSTLATYTGIYSLLRLLFSRVGEPFIGYSDSFSFNLPQGMCPTCQGLGYVDDIDEQQL
IDPEKSLNEGAITFVSFAPDTWRWRRYATSGLFDNDKPIKDYSAAEYDLLMHAPQQKLAHPGEGFPRTALYEGVVPRIKR
SIIGKKEAEHHRDAIAAIVTRKPCPTCDGTRLKPVVLTNHINGVNIAQVTAMDLKHVLTFLQAIDAPLAQDIVRELTTKI
QSLVDIGLGYLTLDRGTSSLSGGEAQRIKIAKYLTSALVDMVYILDEPSVGLHPHDIQLIKQALTKLKDKGNTILIVEHN
PAMFTLADYVVEMGPAAGRTGGNVTFTGTYDELLASDTLTGRWLRQPHKWGQERPVQAHLALHHINENNLHDVSVDVPLG
VMTVVSGVAGSGKSSLVTALKRQLKTAYIDLAQTPVGLNIRSTPATYLGVLDQIRQLFAKANGVATSWFSYNGKGACPRC
KGKGVTITNMAFMDPVVQTCELCHGLRYNETALSYAYQGKTIADVLQMSVTAALAFFATMDKVAQPLKNLDRVGLGYLTL
AQPLTTLSGGELQRLKLAVELGKQGTVYLLDEPTAGLHLQDTQRLLKLFDALVAAGNSLIIIEHNLAVISQADWLIDVGP
DAGQYGGRIQYSGTPRAAVDVPTSRTGAALKAWLTA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=704, Percent_Identity=35.9375, Blast_Score=408, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82377; Mature: 82377

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTSYSFPHGAIDVYDATQNNLKHVSLRVPKYATTVFVGLSGSGKSSLVFDTIAAASRRE
CCCCCCCCCCCEEEEECCCCCCEEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHH
LNETFPSFTQQYLPKYGQPHVGHIEHLPVAIVIAQQRLGKNARSTLATYTGIYSLLRLLF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHH
SRVGEPFIGYSDSFSFNLPQGMCPTCQGLGYVDDIDEQQLIDPEKSLNEGAITFVSFAPD
HHCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHCCCCHHCCCCCCEEEEEECCC
TWRWRRYATSGLFDNDKPIKDYSAAEYDLLMHAPQQKLAHPGEGFPRTALYEGVVPRIKR
CHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHH
SIIGKKEAEHHRDAIAAIVTRKPCPTCDGTRLKPVVLTNHINGVNIAQVTAMDLKHVLTF
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
LQAIDAPLAQDIVRELTTKIQSLVDIGLGYLTLDRGTSSLSGGEAQRIKIAKYLTSALVD
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
MVYILDEPSVGLHPHDIQLIKQALTKLKDKGNTILIVEHNPAMFTLADYVVEMGPAAGRT
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCC
GGNVTFTGTYDELLASDTLTGRWLRQPHKWGQERPVQAHLALHHINENNLHDVSVDVPLG
CCCEEEECCHHHHHHCCCCCHHHHHCHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCHH
VMTVVSGVAGSGKSSLVTALKRQLKTAYIDLAQTPVGLNIRSTPATYLGVLDQIRQLFAK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHH
ANGVATSWFSYNGKGACPRCKGKGVTITNMAFMDPVVQTCELCHGLRYNETALSYAYQGK
CCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCC
TIADVLQMSVTAALAFFATMDKVAQPLKNLDRVGLGYLTLAQPLTTLSGGELQRLKLAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHEEH
LGKQGTVYLLDEPTAGLHLQDTQRLLKLFDALVAAGNSLIIIEHNLAVISQADWLIDVGP
HCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCEEEECCC
DAGQYGGRIQYSGTPRAAVDVPTSRTGAALKAWLTA
CCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHCC
>Mature Secondary Structure
MMTSYSFPHGAIDVYDATQNNLKHVSLRVPKYATTVFVGLSGSGKSSLVFDTIAAASRRE
CCCCCCCCCCCEEEEECCCCCCEEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHH
LNETFPSFTQQYLPKYGQPHVGHIEHLPVAIVIAQQRLGKNARSTLATYTGIYSLLRLLF
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHH
SRVGEPFIGYSDSFSFNLPQGMCPTCQGLGYVDDIDEQQLIDPEKSLNEGAITFVSFAPD
HHCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHCCCCHHCCCCCCEEEEEECCC
TWRWRRYATSGLFDNDKPIKDYSAAEYDLLMHAPQQKLAHPGEGFPRTALYEGVVPRIKR
CHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHH
SIIGKKEAEHHRDAIAAIVTRKPCPTCDGTRLKPVVLTNHINGVNIAQVTAMDLKHVLTF
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
LQAIDAPLAQDIVRELTTKIQSLVDIGLGYLTLDRGTSSLSGGEAQRIKIAKYLTSALVD
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
MVYILDEPSVGLHPHDIQLIKQALTKLKDKGNTILIVEHNPAMFTLADYVVEMGPAAGRT
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCC
GGNVTFTGTYDELLASDTLTGRWLRQPHKWGQERPVQAHLALHHINENNLHDVSVDVPLG
CCCEEEECCHHHHHHCCCCCHHHHHCHHHCCCCCCCEEEEEEEECCCCCCEEEEECCCHH
VMTVVSGVAGSGKSSLVTALKRQLKTAYIDLAQTPVGLNIRSTPATYLGVLDQIRQLFAK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHH
ANGVATSWFSYNGKGACPRCKGKGVTITNMAFMDPVVQTCELCHGLRYNETALSYAYQGK
CCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCC
TIADVLQMSVTAALAFFATMDKVAQPLKNLDRVGLGYLTLAQPLTTLSGGELQRLKLAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHEEH
LGKQGTVYLLDEPTAGLHLQDTQRLLKLFDALVAAGNSLIIIEHNLAVISQADWLIDVGP
HCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCEEEECCC
DAGQYGGRIQYSGTPRAAVDVPTSRTGAALKAWLTA
CCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]