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The map label for this gene is nox6 [H]

Identifier: 28378092

GI number: 28378092

Start: 1239260

End: 1240375

Strand: Direct

Name: nox6 [H]

Synonym: lp_1350

Alternate gene names: 28378092

Gene position: 1239260-1240375 (Clockwise)

Preceding gene: 28378091

Following gene: 28378093

Centisome position: 37.46

GC content: 43.37

Gene sequence:

>1116_bases
ATGCAAGCTAAATATAAAAAATTGTTTGAGCCCTACACGCTAAATAATGATGTGGTGCTTAAAAATCGGTTAGTTGTTGC
CCCCTTAACAATTTATGACTCAGGGCCGGATGGTGAACTAACGCCGGCAGCGCATAATTTTTGGCGGAATCGCTTTCGGG
GATTTGGTACGTGGATTGTCCCCTTTACGAATGTTCATCCAAGTGGTATTGGTTTTGAGTCACCCAATGCTTTTCATGAG
GAAAACTTACCAACTTTAAAAGCGTATGCAACGATTTCTCATGAGCAAGGCGCTAAAGCAATTATCCAATTAGCACATGC
TGGTATTCATGCTGATCCCGCGATGACTAAAGGCTATGATCTAATGGGACCAAGTAACTTGCCATATATGGGTGTTCGGG
CAATGACGGATTCGGAGGTTCGTGAAATGGTCAATGCATTTGCTTATGCAACGGAATTAGCTATTAGCGCGGGACTTGAT
GGGGTTGAAATTCATGGTGCTAACGGTTGGCTCATCCAACAATTTGTTTCTGAAACGTATAATCAGCGAACAGATCACTG
GGGTGGTAGCGTGGAGAAGCGTTTTAACTTTCCGTTAGCGATTATTGATGCCATTGAGGCTGTTCGCCACAAGTATCACC
GACCAGATTTTATCGTCGGTTATCGTTTTTCTCCTGAGGAACCAGGTGAGGTTGGTTTGACGATGACGGAAACACTTGCT
TTGGTTGATCGTTTATTGGATAAACCACTACAGTATATTCATATTTCACTTTGGAATTTTTATAAGAAGATTCGGCGTGG
TGGTGACGTCAAAAAGACACGAATGGAAGCTGTACATGATCGCATTAATGGCCGTCTGCCATTTATTGGCGTCGGTGACC
TATTTGCCGAGGAACAGGGACTAAAGGCATTTAATACCGGGTGGGCCGATTTACTCGCTGTTGGTGGGTCGGTTGAGCTT
AATCCGAATTTGATTGAGTTAATCAAAACTGGTCAGGAAGATCAGATTCAGAGTGAATTTGACTGGAATGAAATGGATTC
ATACCGTTTTACCCCAGCGATGTTATACGGAACTTTGGCTGGTAATGCGATGTTCCCTAAAGTCAAGCAGAATTAG

Upstream 100 bases:

>100_bases
CCAAAAATAAACGGTACGTTATTACTGGACATTACTGGACTTGACATGGTGATGATTAATGATGTTCTAGTTTGAAGTTT
TTAAAGAGGAGAGATTAGTC

Downstream 100 bases:

>100_bases
GTTTTAAATGTAAGGGCGTGGAAGAATGACACAATTAAAAATTATGACGGTCGCTGATCCGATGATGGGGTTATTATGGG
AAACCTGGCCAACACACCGT

Product: NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MQAKYKKLFEPYTLNNDVVLKNRLVVAPLTIYDSGPDGELTPAAHNFWRNRFRGFGTWIVPFTNVHPSGIGFESPNAFHE
ENLPTLKAYATISHEQGAKAIIQLAHAGIHADPAMTKGYDLMGPSNLPYMGVRAMTDSEVREMVNAFAYATELAISAGLD
GVEIHGANGWLIQQFVSETYNQRTDHWGGSVEKRFNFPLAIIDAIEAVRHKYHRPDFIVGYRFSPEEPGEVGLTMTETLA
LVDRLLDKPLQYIHISLWNFYKKIRRGGDVKKTRMEAVHDRINGRLPFIGVGDLFAEEQGLKAFNTGWADLLAVGGSVEL
NPNLIELIKTGQEDQIQSEFDWNEMDSYRFTPAMLYGTLAGNAMFPKVKQN

Sequences:

>Translated_371_residues
MQAKYKKLFEPYTLNNDVVLKNRLVVAPLTIYDSGPDGELTPAAHNFWRNRFRGFGTWIVPFTNVHPSGIGFESPNAFHE
ENLPTLKAYATISHEQGAKAIIQLAHAGIHADPAMTKGYDLMGPSNLPYMGVRAMTDSEVREMVNAFAYATELAISAGLD
GVEIHGANGWLIQQFVSETYNQRTDHWGGSVEKRFNFPLAIIDAIEAVRHKYHRPDFIVGYRFSPEEPGEVGLTMTETLA
LVDRLLDKPLQYIHISLWNFYKKIRRGGDVKKTRMEAVHDRINGRLPFIGVGDLFAEEQGLKAFNTGWADLLAVGGSVEL
NPNLIELIKTGQEDQIQSEFDWNEMDSYRFTPAMLYGTLAGNAMFPKVKQN
>Mature_371_residues
MQAKYKKLFEPYTLNNDVVLKNRLVVAPLTIYDSGPDGELTPAAHNFWRNRFRGFGTWIVPFTNVHPSGIGFESPNAFHE
ENLPTLKAYATISHEQGAKAIIQLAHAGIHADPAMTKGYDLMGPSNLPYMGVRAMTDSEVREMVNAFAYATELAISAGLD
GVEIHGANGWLIQQFVSETYNQRTDHWGGSVEKRFNFPLAIIDAIEAVRHKYHRPDFIVGYRFSPEEPGEVGLTMTETLA
LVDRLLDKPLQYIHISLWNFYKKIRRGGDVKKTRMEAVHDRINGRLPFIGVGDLFAEEQGLKAFNTGWADLLAVGGSVEL
NPNLIELIKTGQEDQIQSEFDWNEMDSYRFTPAMLYGTLAGNAMFPKVKQN

Specific function: Catalyzes The NADP-Dependent Reduction Of 2,4-Dienoyl- CoA To Yield Trans-2- Enoyl-CoA. [C]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=351, Percent_Identity=25.6410256410256, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1787939, Length=362, Percent_Identity=27.3480662983425, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17559802, Length=305, Percent_Identity=29.1803278688525, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17559804, Length=182, Percent_Identity=31.8681318681319, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17565138, Length=273, Percent_Identity=28.9377289377289, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI72001454, Length=182, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17564188, Length=208, Percent_Identity=28.3653846153846, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540738, Length=211, Percent_Identity=27.9620853080569, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17566914, Length=313, Percent_Identity=24.2811501597444, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321973, Length=217, Percent_Identity=30.4147465437788, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325086, Length=238, Percent_Identity=28.9915966386555, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 41681; Mature: 41681

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAKYKKLFEPYTLNNDVVLKNRLVVAPLTIYDSGPDGELTPAAHNFWRNRFRGFGTWIV
CCCHHHHHCCCCCCCCCEEEECCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
PFTNVHPSGIGFESPNAFHEENLPTLKAYATISHEQGAKAIIQLAHAGIHADPAMTKGYD
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCC
LMGPSNLPYMGVRAMTDSEVREMVNAFAYATELAISAGLDGVEIHGANGWLIQQFVSETY
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
NQRTDHWGGSVEKRFNFPLAIIDAIEAVRHKYHRPDFIVGYRFSPEEPGEVGLTMTETLA
HCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHH
LVDRLLDKPLQYIHISLWNFYKKIRRGGDVKKTRMEAVHDRINGRLPFIGVGDLFAEEQG
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHCC
LKAFNTGWADLLAVGGSVELNPNLIELIKTGQEDQIQSEFDWNEMDSYRFTPAMLYGTLA
CHHHHCCHHHHHHCCCCEEECCHHHHHHHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHC
GNAMFPKVKQN
CCCCCCCCCCC
>Mature Secondary Structure
MQAKYKKLFEPYTLNNDVVLKNRLVVAPLTIYDSGPDGELTPAAHNFWRNRFRGFGTWIV
CCCHHHHHCCCCCCCCCEEEECCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
PFTNVHPSGIGFESPNAFHEENLPTLKAYATISHEQGAKAIIQLAHAGIHADPAMTKGYD
EECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCC
LMGPSNLPYMGVRAMTDSEVREMVNAFAYATELAISAGLDGVEIHGANGWLIQQFVSETY
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
NQRTDHWGGSVEKRFNFPLAIIDAIEAVRHKYHRPDFIVGYRFSPEEPGEVGLTMTETLA
HCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHH
LVDRLLDKPLQYIHISLWNFYKKIRRGGDVKKTRMEAVHDRINGRLPFIGVGDLFAEEQG
HHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHCC
LKAFNTGWADLLAVGGSVELNPNLIELIKTGQEDQIQSEFDWNEMDSYRFTPAMLYGTLA
CHHHHCCHHHHHHCCCCEEECCHHHHHHHCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHC
GNAMFPKVKQN
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]