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The map label for this gene is mmuM [H]

Identifier: 28378054

GI number: 28378054

Start: 1186080

End: 1187009

Strand: Direct

Name: mmuM [H]

Synonym: lp_1298

Alternate gene names: 28378054

Gene position: 1186080-1187009 (Clockwise)

Preceding gene: 28378048

Following gene: 28378055

Centisome position: 35.85

GC content: 52.58

Gene sequence:

>930_bases
ATGCTTTCATTAACTGAACAATTGAACCGGGGCCCAGTCGTCTCGGACGGTGCGATGGCTACGGAATTAGAAAAACGGGG
CGTGGCAACCAATAGCGCACTGTGGTCAGCCACGGCAATGTTGGACCATCCGGATGCGATTCAAGCGGTCCATCAGAGCT
ATCTGGATGCGGGCGCAAAAATCATGACAACTAATACATACCAGGCCAACGTCCCTGCATTTGAGCAGGCTGGTATTGCT
GCCGTACAAGCGCGTCAATTGATACAACAGGCGGTGACAATTGCTCATACGGCGCGTGATGCTAGTCATGTCACGGATGC
TGTGATTGCTGGTAGTATTGGCCCGTACGGTGCTTACTTAGCGGATGGTAGTGAGTACACGGGTGCATATCAGTTAACGC
CGAGTGCCTATCAAGACTTTCACCGCGAACGCCTGGCGTTGATCATGGCCGCCGGGGTGGACGTGCTTGCATTAGAAACG
ATGCCACGTTTAGACGAAGTACAGGCTTTGGTACAACTAATCACAACCACTTGGCCGCAACAACCATACTGGGTAAGCTT
TAGTATCAAGGATCCACAGACATTATGTGATGGGACGTCATTAGCTGTGGCCGCAAAGTGGGTGGCGGCCCAGCCGAACG
TGGTCGCTGTGGGGGTCAATTGCACTACGCTGGAAAACATTGCACCAGCGTTAACCACTTTGAAGGCTGCTGTAGCGGTT
CCGTTGATCGTTTATCCTAATTCTGGTGATCAATATGATCCCGTGACGAAGACTTGGCAAGAAACTCATTTGAGTCATCA
ATTTGCATCCTTTGTCCCCCAGTGGTTAGCCGCCGGGGCCCGCATTATCGGCGGCTGTTGTCGCACAACGCCGAAGGATA
TTGCGACGGTGGCACGGGCTCTCAGTGTTTCGGATTCCGCCAAGCTTTGA

Upstream 100 bases:

>100_bases
TCCTTACTTGCAGAATTAATATGATTAGACTATGATTAGAAAATCAACAATGTTATTAGAATAACATAATTTATAAGTAG
AAAGGAAGGCAATTATTGCA

Downstream 100 bases:

>100_bases
AAAATGTTAAGAAATGACGGTGTTTTAGTTCATGGTGGGCGTGTCTCAGAGATCTAAGTTGTCTTGGGGTGTTCGTTACA
CACTAATTATTGATTTAATT

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MLSLTEQLNRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQANVPAFEQAGIA
AVQARQLIQQAVTIAHTARDASHVTDAVIAGSIGPYGAYLADGSEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALET
MPRLDEVQALVQLITTTWPQQPYWVSFSIKDPQTLCDGTSLAVAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAV
PLIVYPNSGDQYDPVTKTWQETHLSHQFASFVPQWLAAGARIIGGCCRTTPKDIATVARALSVSDSAKL

Sequences:

>Translated_309_residues
MLSLTEQLNRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQANVPAFEQAGIA
AVQARQLIQQAVTIAHTARDASHVTDAVIAGSIGPYGAYLADGSEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALET
MPRLDEVQALVQLITTTWPQQPYWVSFSIKDPQTLCDGTSLAVAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAV
PLIVYPNSGDQYDPVTKTWQETHLSHQFASFVPQWLAAGARIIGGCCRTTPKDIATVARALSVSDSAKL
>Mature_309_residues
MLSLTEQLNRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAKIMTTNTYQANVPAFEQAGIA
AVQARQLIQQAVTIAHTARDASHVTDAVIAGSIGPYGAYLADGSEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALET
MPRLDEVQALVQLITTTWPQQPYWVSFSIKDPQTLCDGTSLAVAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAV
PLIVYPNSGDQYDPVTKTWQETHLSHQFASFVPQWLAAGARIIGGCCRTTPKDIATVARALSVSDSAKL

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI13162290, Length=318, Percent_Identity=26.1006289308176, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI157266337, Length=329, Percent_Identity=24.9240121580547, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI169790923, Length=325, Percent_Identity=24, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786456, Length=292, Percent_Identity=46.5753424657534, Blast_Score=273, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI17569783, Length=264, Percent_Identity=28.030303030303, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322966, Length=314, Percent_Identity=31.8471337579618, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324982, Length=316, Percent_Identity=28.7974683544304, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323983, Length=93, Percent_Identity=38.7096774193548, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI20129603, Length=317, Percent_Identity=36.2776025236593, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24585077, Length=287, Percent_Identity=35.5400696864112, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 32892; Mature: 32892

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLTEQLNRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAK
CCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCE
IMTTNTYQANVPAFEQAGIAAVQARQLIQQAVTIAHTARDASHVTDAVIAGSIGPYGAYL
EEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
ADGSEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALETMPRLDEVQALVQLITTTWPQ
ECCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHHHHCCCC
QPYWVSFSIKDPQTLCDGTSLAVAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAV
CCEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHC
PLIVYPNSGDQYDPVTKTWQETHLSHQFASFVPQWLAAGARIIGGCCRTTPKDIATVARA
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LSVSDSAKL
HHCCCCCCC
>Mature Secondary Structure
MLSLTEQLNRGPVVSDGAMATELEKRGVATNSALWSATAMLDHPDAIQAVHQSYLDAGAK
CCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCE
IMTTNTYQANVPAFEQAGIAAVQARQLIQQAVTIAHTARDASHVTDAVIAGSIGPYGAYL
EEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
ADGSEYTGAYQLTPSAYQDFHRERLALIMAAGVDVLALETMPRLDEVQALVQLITTTWPQ
ECCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHHHHCCCC
QPYWVSFSIKDPQTLCDGTSLAVAAKWVAAQPNVVAVGVNCTTLENIAPALTTLKAAVAV
CCEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHC
PLIVYPNSGDQYDPVTKTWQETHLSHQFASFVPQWLAAGARIIGGCCRTTPKDIATVARA
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LSVSDSAKL
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]