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The map label for this gene is tkt2 [H]

Identifier: 28377876

GI number: 28377876

Start: 984596

End: 986608

Strand: Direct

Name: tkt2 [H]

Synonym: lp_1083

Alternate gene names: 28377876

Gene position: 984596-986608 (Clockwise)

Preceding gene: 28377875

Following gene: 28377877

Centisome position: 29.76

GC content: 53.1

Gene sequence:

>2013_bases
ATGCAAGCATTTGATGAAATTGATGAATTAGCGGTGAATAATCTACGAGTACTGAGTGCGGAAATGATTGAACGGGCCGG
TTCTGGTCATCCAGGATTGCCACTCGGCGCGGCTCCAATGATGTGGGCACTGTGGAGCCGACAATTACGGGTCGATCCAC
AGCAGTCTCAATGGGCTAATCGCGATCGCTTTGTCTTATCAGCCGGACACGGGTCGGCGTTGTTGTACAGTCTGCTACAT
GTGAGTGGCTTCAACGTGACAATGGGCGAGTTACAACGTTTTCGTCAATTCGGCAGTCATACGCCAGGCCACCCTGAACT
GGGAATCGTGGATGGTGTGGAAGCCACGACCGGTCCACTGGGACAGGGATTAGGGATGGCGGTGGGCATGGCCCTGGCTG
AACGGCAACTAGCGGCTCAGTTCTCCGAGTCACCGCAGTTGGTGGATCACTATACTTACGCGTTAGTCGGTGATGGTGAT
TTGATGGAAGGCGTCTCCCACGAAGCTGCCAGCTTTGCCGGTAATCAACAATTGCAAAAATTAATTGTATTGTACGACGA
TAACGCTGTTTCGCTTGATGGCCCCACCAGCCGGTCGTTTCGTACCGATGTGAACCAGCGCTTCGCTAGTTATGGTTGGG
ATACACAAACGGTAGGTGATGGCAATGATTTAACGGCGATTAATGCCGCCATTGAGCGTGCCAAACACAGTTCACGTCCA
AGCCTGATCGCTGTTAAAACGACGATTGGATTTGGCGCACCACAAGCGGGTACGAATGCGGTGCATGGCAATCCGTTGGG
AACGGCCGGTTTAACTAGTTTGCGGCAACAATTAGGGTGGCAAGCCGCGCCATTTACGGTAATGCCGGCCGTTGCTAAAC
GCGCACAGCAACTAATCTTGCAACGTGGTCAGCGTGCACATCGCCGGTGGCAGTCACAACGAGAGGCTTTACCACAAGCC
GTACAACACCGTTTCGAACAACAGCTCAGTATGCGTCTGCCAGTTGACTTAGCCACCAGTTTACCGATCTTTGATGAAGG
CGCCCAAGCTTCGCGGATCACGAGTCATACCGTCATTCAGAAGCTAGCCGCTCAGTTACCAGGATTAGTCGGGGGCGCGG
CTGATTTAGCCAGTTCGAATAAAACGACCATTGAGCAGGATCAATTGTCGACTCCGGTGACCCCGGATCAGCGCAACGTT
GCCTTTGGTGTCCGGGAGTTTGGTATGGGCACCATTTTGAATGGGATGACTTTACACGGTGGCTTGCGGGTCTTTGGTGG
CACCTTCCTTGTCTTTTCCGATTACACGCGTGCGGCTATTCGATTGGCGGCGATGATGAAGTTACCAGTCACTTACGTTT
TCACGCATGACTCGATTGCAGTCGGCGAGGACGGTCCGACTCATCAGCCAATTGAACAGCTAATGAGTTTACGATTGATT
CCGAATCTAACGGTGATCCGGCCCGCTGACCCGAATGAAACGGTCGCAGCTTGGTGGCAAGCCATCAACGCGACGGATCA
TCCAACCGTGCTCGTCTTGACCCGTCAGAATTTGGCAGTGCTATCCGGATCTAAGACTAAGGCCATGACTGGTGTGGCTC
GTGGCGGTTATGTTCTCTCACCGCAGCGTGGCCGCCAGCCAATGGGAATCTTGATTGCAAGCGGGTCAGAAGTTGCTTTA
GCTCTTCAGGCCCAGGCGAAACTAGCTACGTTAGGTGAAGATGTCAGTGTCGTTTCAATGCCGTCGATGGAAAACTTTGC
GCGCCAATCAACGAATTACCAAGCTCAGGTCTTGCCACCTCAAATTCGGCGGCGAGTTGCAGTCGAAATGGGCGCAACAT
CTGGCTGGGAACGTTACGTTGGGTTAGATGGGGCGGTACTAGGCTTGGACCACTTTGGCGCCAGTGGAGCGGCCGACCAA
GTATTAGCCGCTAACCAGTTCACGGTAGCAGACCTAGTGCGGACGTATCAACAAACGCACGTGGATCTTGGTCAACAATT
GCGAGTCATTTAG

Upstream 100 bases:

>100_bases
GTAGCGGTGTTTTTCGGGCACCCTGCGAAGAATTAGTGGACTCACAGTTGGTGTAACTGCGAGTCTTTTTTATTAGCCAA
AATGAGAGGGAGCGAAGTTA

Downstream 100 bases:

>100_bases
AAAGGAAGTTAGTTAAAGCATGATTGATGGACAAACGGCACTCTTTGGATTTATCGCGCACCCCGCGCGGCACAGTCGCT
CACCGCGAATGCATAATTTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MQAFDEIDELAVNNLRVLSAEMIERAGSGHPGLPLGAAPMMWALWSRQLRVDPQQSQWANRDRFVLSAGHGSALLYSLLH
VSGFNVTMGELQRFRQFGSHTPGHPELGIVDGVEATTGPLGQGLGMAVGMALAERQLAAQFSESPQLVDHYTYALVGDGD
LMEGVSHEAASFAGNQQLQKLIVLYDDNAVSLDGPTSRSFRTDVNQRFASYGWDTQTVGDGNDLTAINAAIERAKHSSRP
SLIAVKTTIGFGAPQAGTNAVHGNPLGTAGLTSLRQQLGWQAAPFTVMPAVAKRAQQLILQRGQRAHRRWQSQREALPQA
VQHRFEQQLSMRLPVDLATSLPIFDEGAQASRITSHTVIQKLAAQLPGLVGGAADLASSNKTTIEQDQLSTPVTPDQRNV
AFGVREFGMGTILNGMTLHGGLRVFGGTFLVFSDYTRAAIRLAAMMKLPVTYVFTHDSIAVGEDGPTHQPIEQLMSLRLI
PNLTVIRPADPNETVAAWWQAINATDHPTVLVLTRQNLAVLSGSKTKAMTGVARGGYVLSPQRGRQPMGILIASGSEVAL
ALQAQAKLATLGEDVSVVSMPSMENFARQSTNYQAQVLPPQIRRRVAVEMGATSGWERYVGLDGAVLGLDHFGASGAADQ
VLAANQFTVADLVRTYQQTHVDLGQQLRVI

Sequences:

>Translated_670_residues
MQAFDEIDELAVNNLRVLSAEMIERAGSGHPGLPLGAAPMMWALWSRQLRVDPQQSQWANRDRFVLSAGHGSALLYSLLH
VSGFNVTMGELQRFRQFGSHTPGHPELGIVDGVEATTGPLGQGLGMAVGMALAERQLAAQFSESPQLVDHYTYALVGDGD
LMEGVSHEAASFAGNQQLQKLIVLYDDNAVSLDGPTSRSFRTDVNQRFASYGWDTQTVGDGNDLTAINAAIERAKHSSRP
SLIAVKTTIGFGAPQAGTNAVHGNPLGTAGLTSLRQQLGWQAAPFTVMPAVAKRAQQLILQRGQRAHRRWQSQREALPQA
VQHRFEQQLSMRLPVDLATSLPIFDEGAQASRITSHTVIQKLAAQLPGLVGGAADLASSNKTTIEQDQLSTPVTPDQRNV
AFGVREFGMGTILNGMTLHGGLRVFGGTFLVFSDYTRAAIRLAAMMKLPVTYVFTHDSIAVGEDGPTHQPIEQLMSLRLI
PNLTVIRPADPNETVAAWWQAINATDHPTVLVLTRQNLAVLSGSKTKAMTGVARGGYVLSPQRGRQPMGILIASGSEVAL
ALQAQAKLATLGEDVSVVSMPSMENFARQSTNYQAQVLPPQIRRRVAVEMGATSGWERYVGLDGAVLGLDHFGASGAADQ
VLAANQFTVADLVRTYQQTHVDLGQQLRVI
>Mature_670_residues
MQAFDEIDELAVNNLRVLSAEMIERAGSGHPGLPLGAAPMMWALWSRQLRVDPQQSQWANRDRFVLSAGHGSALLYSLLH
VSGFNVTMGELQRFRQFGSHTPGHPELGIVDGVEATTGPLGQGLGMAVGMALAERQLAAQFSESPQLVDHYTYALVGDGD
LMEGVSHEAASFAGNQQLQKLIVLYDDNAVSLDGPTSRSFRTDVNQRFASYGWDTQTVGDGNDLTAINAAIERAKHSSRP
SLIAVKTTIGFGAPQAGTNAVHGNPLGTAGLTSLRQQLGWQAAPFTVMPAVAKRAQQLILQRGQRAHRRWQSQREALPQA
VQHRFEQQLSMRLPVDLATSLPIFDEGAQASRITSHTVIQKLAAQLPGLVGGAADLASSNKTTIEQDQLSTPVTPDQRNV
AFGVREFGMGTILNGMTLHGGLRVFGGTFLVFSDYTRAAIRLAAMMKLPVTYVFTHDSIAVGEDGPTHQPIEQLMSLRLI
PNLTVIRPADPNETVAAWWQAINATDHPTVLVLTRQNLAVLSGSKTKAMTGVARGGYVLSPQRGRQPMGILIASGSEVAL
ALQAQAKLATLGEDVSVVSMPSMENFARQSTNYQAQVLPPQIRRRVAVEMGATSGWERYVGLDGAVLGLDHFGASGAADQ
VLAANQFTVADLVRTYQQTHVDLGQQLRVI

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=484, Percent_Identity=28.7190082644628, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4507521, Length=484, Percent_Identity=28.7190082644628, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI133778974, Length=496, Percent_Identity=25, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI48994911, Length=659, Percent_Identity=45.5235204855842, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI1788808, Length=654, Percent_Identity=44.1896024464832, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17539652, Length=578, Percent_Identity=26.8166089965398, Blast_Score=145, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=678, Percent_Identity=42.4778761061947, Blast_Score=507, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319593, Length=685, Percent_Identity=42.6277372262774, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45551847, Length=514, Percent_Identity=27.431906614786, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45550715, Length=514, Percent_Identity=27.431906614786, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24666278, Length=520, Percent_Identity=26.3461538461538, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645119, Length=488, Percent_Identity=27.2540983606557, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72115; Mature: 72115

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAFDEIDELAVNNLRVLSAEMIERAGSGHPGLPLGAAPMMWALWSRQLRVDPQQSQWAN
CCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCC
RDRFVLSAGHGSALLYSLLHVSGFNVTMGELQRFRQFGSHTPGHPELGIVDGVEATTGPL
CCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCC
GQGLGMAVGMALAERQLAAQFSESPQLVDHYTYALVGDGDLMEGVSHEAASFAGNQQLQK
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEECCHHHHHCCHHHHHHHCCHHHEE
LIVLYDDNAVSLDGPTSRSFRTDVNQRFASYGWDTQTVGDGNDLTAINAAIERAKHSSRP
EEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
SLIAVKTTIGFGAPQAGTNAVHGNPLGTAGLTSLRQQLGWQAAPFTVMPAVAKRAQQLIL
CEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
QRGQRAHRRWQSQREALPQAVQHRFEQQLSMRLPVDLATSLPIFDEGAQASRITSHTVIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
KLAAQLPGLVGGAADLASSNKTTIEQDQLSTPVTPDQRNVAFGVREFGMGTILNGMTLHG
HHHHHCCCCCCCHHHHCCCCCCEECHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCEEECC
GLRVFGGTFLVFSDYTRAAIRLAAMMKLPVTYVFTHDSIAVGEDGPTHQPIEQLMSLRLI
CEEEECCEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHC
PNLTVIRPADPNETVAAWWQAINATDHPTVLVLTRQNLAVLSGSKTKAMTGVARGGYVLS
CCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCHHHHHHHCCCCEEEC
PQRGRQPMGILIASGSEVALALQAQAKLATLGEDVSVVSMPSMENFARQSTNYQAQVLPP
CCCCCCCCEEEEECCCCEEEEEEHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEECCH
QIRRRVAVEMGATSGWERYVGLDGAVLGLDHFGASGAADQVLAANQFTVADLVRTYQQTH
HHHHHHHHHCCCCCCCHHHCCCCCEEEEHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
VDLGQQLRVI
HHHHHHCCCC
>Mature Secondary Structure
MQAFDEIDELAVNNLRVLSAEMIERAGSGHPGLPLGAAPMMWALWSRQLRVDPQQSQWAN
CCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCC
RDRFVLSAGHGSALLYSLLHVSGFNVTMGELQRFRQFGSHTPGHPELGIVDGVEATTGPL
CCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCC
GQGLGMAVGMALAERQLAAQFSESPQLVDHYTYALVGDGDLMEGVSHEAASFAGNQQLQK
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEEECCHHHHHCCHHHHHHHCCHHHEE
LIVLYDDNAVSLDGPTSRSFRTDVNQRFASYGWDTQTVGDGNDLTAINAAIERAKHSSRP
EEEEECCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
SLIAVKTTIGFGAPQAGTNAVHGNPLGTAGLTSLRQQLGWQAAPFTVMPAVAKRAQQLIL
CEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
QRGQRAHRRWQSQREALPQAVQHRFEQQLSMRLPVDLATSLPIFDEGAQASRITSHTVIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
KLAAQLPGLVGGAADLASSNKTTIEQDQLSTPVTPDQRNVAFGVREFGMGTILNGMTLHG
HHHHHCCCCCCCHHHHCCCCCCEECHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCEEECC
GLRVFGGTFLVFSDYTRAAIRLAAMMKLPVTYVFTHDSIAVGEDGPTHQPIEQLMSLRLI
CEEEECCEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHC
PNLTVIRPADPNETVAAWWQAINATDHPTVLVLTRQNLAVLSGSKTKAMTGVARGGYVLS
CCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCHHHHHHHCCCCEEEC
PQRGRQPMGILIASGSEVALALQAQAKLATLGEDVSVVSMPSMENFARQSTNYQAQVLPP
CCCCCCCCEEEEECCCCEEEEEEHHHHHHHCCCCCEEEECCCHHHHHHHCCCCEEEECCH
QIRRRVAVEMGATSGWERYVGLDGAVLGLDHFGASGAADQVLAANQFTVADLVRTYQQTH
HHHHHHHHHCCCCCCCHHHCCCCCEEEEHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
VDLGQQLRVI
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]