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The map label for this gene is mdh [H]

Identifier: 28377875

GI number: 28377875

Start: 982630

End: 983718

Strand: Direct

Name: mdh [H]

Synonym: lp_1082

Alternate gene names: 28377875

Gene position: 982630-983718 (Clockwise)

Preceding gene: 28377872

Following gene: 28377876

Centisome position: 29.7

GC content: 49.04

Gene sequence:

>1089_bases
ATGCGAATTAGTGCGGAAACGGAACGACAATTTTTAGAAGCAGTTTTTAAGGCCCAACGGTTTAGTGCCAAGGATGGGGC
ACTGCTGGCAGACACCCTGGTCGATGCAGATTTACGTGGAATCTCGTCACATGGTATCCAGCGGCTGGCTTGGTATACGC
GGATGATCAAGGATCATACCTTGGAACCGACGCATCAACCGAAGATTTTGAATGAAACACCTACCAGTCTATTGATCGAT
GCGAACCAGAGCATGGGCCAGATTGCGTCGGCGTTTACGATGAATAAACTGATTGAAAAGACTAAGCAACTCGGTGTTTC
ATTAGCGGTTATCCGCAATTCGAATCACTTTGGAACGGCGGGCTATTATTCGCGCATGGCTTGCAAAGCGGGTTTGATCG
GTATTTCAACGACTAATACGCGGCCGTTGGTGGTGCCGACGAATGCGACAGAAGCTTTTTTGGGTTCCAACGCATTAGCT
TTTACTTTTCCAGCCGACCCGCATCCTTTCGTTTTTGACGGCGCGACTGCGGTGGTTTCAAGCGGGAAGATTCAAGTGCT
GGCCAAAAAAGGTGCACAGATTCCGGGTGATTGGGCGGTTGATGAGCATCGTCAAGTCTTGCATGATGCGCAGACGGTGG
AGGATAACTTGACTAAAATTGCGTTTTCTGAGAATCGTCCTGGTGGTGGGGTCCTGACCCTAGGTGGCCAGCAGGAAGTC
AATTCAAATTACAAAGGCTTTGGCAACTCACTAATTATTGAGTTACTCACGGGAATTTTAGCGCAAGGGTCGCTGTCGGC
TGATACGAACACCGGTAAGCATGACTTTAGTCAGTTCTTCATGACGATTAATCCCGCCTTATTTGGCGATCCCGAGGTGT
TGAAGGCCAACGTGACGACTATGTTTGACCGTATTCGGCATTTGAAGCATCTACCAGGTACTAAGATCATGATACCAGGT
GACCGGGAATACCGGCACTATGATGAAAATTTGGTGCAGGGCGTCAGTATTGATCCACAGACGTTGACGGAAATGCAGCA
AGTTGGTGCTGAATTTGGAGTGGCAGTCCCCGCAGCCTTGAAAGCGTAG

Upstream 100 bases:

>100_bases
AACGTGTTCAAGCTGTTTAACAATCTGAATAAAGTGTGATATCCCGGTGCTCGCCAAGTTAGGCGAGTGCTGGCTGTCAA
AAACGGAGGAAAATATAACG

Downstream 100 bases:

>100_bases
TTTGGTGTAGTTGCGGCAATTATTGTGACTAAAATGGGGATCACATAAACTGATGATAGTGTGGCTGGAATCTGCTCTGG
ATGCTGGCGACACTATTTTG

Product: malate / lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHTLEPTHQPKILNETPTSLLID
ANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTAGYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALA
FTFPADPHPFVFDGATAVVSSGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLTKIAFSENRPGGGVLTLGGQQEV
NSNYKGFGNSLIIELLTGILAQGSLSADTNTGKHDFSQFFMTINPALFGDPEVLKANVTTMFDRIRHLKHLPGTKIMIPG
DREYRHYDENLVQGVSIDPQTLTEMQQVGAEFGVAVPAALKA

Sequences:

>Translated_362_residues
MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHTLEPTHQPKILNETPTSLLID
ANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTAGYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALA
FTFPADPHPFVFDGATAVVSSGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLTKIAFSENRPGGGVLTLGGQQEV
NSNYKGFGNSLIIELLTGILAQGSLSADTNTGKHDFSQFFMTINPALFGDPEVLKANVTTMFDRIRHLKHLPGTKIMIPG
DREYRHYDENLVQGVSIDPQTLTEMQQVGAEFGVAVPAALKA
>Mature_362_residues
MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHTLEPTHQPKILNETPTSLLID
ANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTAGYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALA
FTFPADPHPFVFDGATAVVSSGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLTKIAFSENRPGGGVLTLGGQQEV
NSNYKGFGNSLIIELLTGILAQGSLSADTNTGKHDFSQFFMTINPALFGDPEVLKANVTTMFDRIRHLKHLPGTKIMIPG
DREYRHYDENLVQGVSIDPQTLTEMQQVGAEFGVAVPAALKA

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=360, Percent_Identity=27.2222222222222, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786727, Length=346, Percent_Identity=27.7456647398844, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790000, Length=350, Percent_Identity=22.8571428571429, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17507179, Length=361, Percent_Identity=31.0249307479224, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17536633, Length=338, Percent_Identity=31.3609467455621, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI45553211, Length=332, Percent_Identity=32.2289156626506, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24667912, Length=332, Percent_Identity=32.2289156626506, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24667908, Length=332, Percent_Identity=32.2289156626506, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24667904, Length=332, Percent_Identity=32.2289156626506, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24648360, Length=366, Percent_Identity=24.3169398907104, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24658010, Length=359, Percent_Identity=24.7910863509749, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 39320; Mature: 39320

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
LEPTHQPKILNETPTSLLIDANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTA
CCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCH
GYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALAFTFPADPHPFVFDGATAVVS
HHHHHHHHHHCEEEEECCCCCCEEEECCCHHHHHCCCEEEEEECCCCCCEEECCHHHHHC
SGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLTKIAFSENRPGGGVLTLGGQQEV
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCHHHH
NSNYKGFGNSLIIELLTGILAQGSLSADTNTGKHDFSQFFMTINPALFGDPEVLKANVTT
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MFDRIRHLKHLPGTKIMIPGDREYRHYDENLVQGVSIDPQTLTEMQQVGAEFGVAVPAAL
HHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHH
KA
CC
>Mature Secondary Structure
MRISAETERQFLEAVFKAQRFSAKDGALLADTLVDADLRGISSHGIQRLAWYTRMIKDHT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
LEPTHQPKILNETPTSLLIDANQSMGQIASAFTMNKLIEKTKQLGVSLAVIRNSNHFGTA
CCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCH
GYYSRMACKAGLIGISTTNTRPLVVPTNATEAFLGSNALAFTFPADPHPFVFDGATAVVS
HHHHHHHHHHCEEEEECCCCCCEEEECCCHHHHHCCCEEEEEECCCCCCEEECCHHHHHC
SGKIQVLAKKGAQIPGDWAVDEHRQVLHDAQTVEDNLTKIAFSENRPGGGVLTLGGQQEV
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEECCHHHH
NSNYKGFGNSLIIELLTGILAQGSLSADTNTGKHDFSQFFMTINPALFGDPEVLKANVTT
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MFDRIRHLKHLPGTKIMIPGDREYRHYDENLVQGVSIDPQTLTEMQQVGAEFGVAVPAAL
HHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHH
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]