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The map label for this gene is pox2 [H]

Identifier: 28377694

GI number: 28377694

Start: 790676

End: 792439

Strand: Direct

Name: pox2 [H]

Synonym: lp_0852

Alternate gene names: 28377694

Gene position: 790676-792439 (Clockwise)

Preceding gene: 28377693

Following gene: 28377696

Centisome position: 23.9

GC content: 48.47

Gene sequence:

>1764_bases
GTGATGACAAAGATGATTGCAGGACAAGCTTTAGTTAAGGTTTTAGAGGCGTGGGGTGTGGACCACATCTACGGGATTCC
CGGCGGTTCAATCAATCATACCGTTGAAGGTTTGTACCTTGAAAAGGCCGATATTGATTATATTCAAGTACGGCATGAAG
AAGTGGGGGCCTTAGCAGCCTCGGCAGATGCCAAGTTTACGGGCAAAATCGGCGTTTCATTTGGTTCTGCGGGTCCTGGT
GCAACGCACTTATTCAACGGTTTGTATGATGCCAAGATGGATCACGTTCCTGTATTAGCACTTGTCGGACAGGTGCCACA
AGCGACGATGAACACGAATTACTTCCAAGAAATGGATGAGACCCCAATGTTTAGTGACGTGGCGGTATATGACCGCACTG
TCACGACGGCCGGACAATTACCATATGTCATTAACCAAGCGATTCGTGAAGCATACCGGCAAAAGGGACCGGCAGTCGTT
ATCATTCCTGAAAATCTCTCAGCGGAAGAAATCGATTATCAGCCGGTATCGACGCCTAACACCGTTTCAGATACGTTTGA
ACAACGGGTCGATCCTCAGGCCATTACGGCAACGTTAAAGATGCTAAAAGCAGCTAAGCATCCATTAGTTTACGCTGGTC
GGGGTCTTCTTGGTGCTAAGGCAGACCTGGTCAAGTTTAGTGAACAATTCAATATTCCAGTCATGAATACGGTCCCGGCG
ACGGGGGTTATTCCAACGAACCACCCGAATGCAATTGGCACGTTTGGCCGGTTGGGTTCCAAATCGGGGTTCGAAGCACT
CCAACACGCTGATTTGATTTTGTTCCTGGGATCTGAATTTCCATTTGCTAGTTTTTGGCCTAAGGGGATTAAGATTATTC
AGGTCAACAATAACAGTTTTGATATCGGCAAGATGGTCCCAATCGATTACGCCGTCATCAGTGACGCCCAAGCTTATTTG
CAAGCGATGATTGCAACTGGCGAAACGTTACCTGAAACAGCGTGGTTAACGACTAACCGGCAAAATAAACGTAATTGGGA
TAAGTGGCTCCAACAATTGGCTGCTGACGACCATGATGGACTAGCGCCGGAAGCGGTCATGCACAAAGTTGCTAGTATGG
TCGGCCCTCGTGATACCTACGGGGTCGACACCGGTAACGTCTCCGAATGGGCTGTCCGGGGGCTCCCAATGGATCAGGAG
CAACGCTTTGCCTTATCTGGCCTCTTCGCAACCATGGGATTTGGACTACCTGCTGGGATGGCTGGTGCCTTAAGTGTTCC
AGACAGCCAAGCGTGGAGTTTCTCAGGCGATGGTGGCTTTGCGATGGTAGCGCCAGATATTATCACGGAAGCACGTTACG
GCTTGCCCGTTATTAACGTGATTTTCAGTAATCAACGGTTTGGTTTCATCTATCGTGAGCAAGTTGATACGAAGCAACAC
TTGTATGGTGTTGATCTAACGGATGCCGACTGGGCCAAAGTTGCAGATGGCCTTGGTGGGATTGGTTTTACTGTTCAAAA
TAATCAAGAGGTCGAAACCGTCTTTGACCAAATCAAGGCGCTCCAAGCGAAGGGCAACAAGCGGCCAATCGTTGTGAACG
CGGTCATCAAGAATGATGATCCAATTGGCACAGCTTACATGCCACTAGATCCTGAATTATATGGTCAAGCAGAAGTTGAC
GCTTATGCCAAAGCCAACCACATTGATATTAAGGAACAGCCATCATTAGGCGCCTTACTACGAGCACAGGGTGATCAGCT
ATAG

Upstream 100 bases:

>100_bases
AGCATATTAATTGCATTTATAATTGAAAGCGATTTATAATACGTTTGTTAAATGAATTGAACCAAGCAGATAAATTGGTT
CTAAGTCGAAGGGATGAATA

Downstream 100 bases:

>100_bases
TTAAAGCCTGAAGGGCTAGTTAGACCACTGGGCAAAGCTTCAGTTAACCTAATATTATTAAGAAGCCGCCAGTATCGGGT
ATGACCTGATACTGGCGGCT

Product: pyruvate oxidase

Products: NA

Alternate protein names: Pyruvic oxidase; POX [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MMTKMIAGQALVKVLEAWGVDHIYGIPGGSINHTVEGLYLEKADIDYIQVRHEEVGALAASADAKFTGKIGVSFGSAGPG
ATHLFNGLYDAKMDHVPVLALVGQVPQATMNTNYFQEMDETPMFSDVAVYDRTVTTAGQLPYVINQAIREAYRQKGPAVV
IIPENLSAEEIDYQPVSTPNTVSDTFEQRVDPQAITATLKMLKAAKHPLVYAGRGLLGAKADLVKFSEQFNIPVMNTVPA
TGVIPTNHPNAIGTFGRLGSKSGFEALQHADLILFLGSEFPFASFWPKGIKIIQVNNNSFDIGKMVPIDYAVISDAQAYL
QAMIATGETLPETAWLTTNRQNKRNWDKWLQQLAADDHDGLAPEAVMHKVASMVGPRDTYGVDTGNVSEWAVRGLPMDQE
QRFALSGLFATMGFGLPAGMAGALSVPDSQAWSFSGDGGFAMVAPDIITEARYGLPVINVIFSNQRFGFIYREQVDTKQH
LYGVDLTDADWAKVADGLGGIGFTVQNNQEVETVFDQIKALQAKGNKRPIVVNAVIKNDDPIGTAYMPLDPELYGQAEVD
AYAKANHIDIKEQPSLGALLRAQGDQL

Sequences:

>Translated_587_residues
MMTKMIAGQALVKVLEAWGVDHIYGIPGGSINHTVEGLYLEKADIDYIQVRHEEVGALAASADAKFTGKIGVSFGSAGPG
ATHLFNGLYDAKMDHVPVLALVGQVPQATMNTNYFQEMDETPMFSDVAVYDRTVTTAGQLPYVINQAIREAYRQKGPAVV
IIPENLSAEEIDYQPVSTPNTVSDTFEQRVDPQAITATLKMLKAAKHPLVYAGRGLLGAKADLVKFSEQFNIPVMNTVPA
TGVIPTNHPNAIGTFGRLGSKSGFEALQHADLILFLGSEFPFASFWPKGIKIIQVNNNSFDIGKMVPIDYAVISDAQAYL
QAMIATGETLPETAWLTTNRQNKRNWDKWLQQLAADDHDGLAPEAVMHKVASMVGPRDTYGVDTGNVSEWAVRGLPMDQE
QRFALSGLFATMGFGLPAGMAGALSVPDSQAWSFSGDGGFAMVAPDIITEARYGLPVINVIFSNQRFGFIYREQVDTKQH
LYGVDLTDADWAKVADGLGGIGFTVQNNQEVETVFDQIKALQAKGNKRPIVVNAVIKNDDPIGTAYMPLDPELYGQAEVD
AYAKANHIDIKEQPSLGALLRAQGDQL
>Mature_587_residues
MMTKMIAGQALVKVLEAWGVDHIYGIPGGSINHTVEGLYLEKADIDYIQVRHEEVGALAASADAKFTGKIGVSFGSAGPG
ATHLFNGLYDAKMDHVPVLALVGQVPQATMNTNYFQEMDETPMFSDVAVYDRTVTTAGQLPYVINQAIREAYRQKGPAVV
IIPENLSAEEIDYQPVSTPNTVSDTFEQRVDPQAITATLKMLKAAKHPLVYAGRGLLGAKADLVKFSEQFNIPVMNTVPA
TGVIPTNHPNAIGTFGRLGSKSGFEALQHADLILFLGSEFPFASFWPKGIKIIQVNNNSFDIGKMVPIDYAVISDAQAYL
QAMIATGETLPETAWLTTNRQNKRNWDKWLQQLAADDHDGLAPEAVMHKVASMVGPRDTYGVDTGNVSEWAVRGLPMDQE
QRFALSGLFATMGFGLPAGMAGALSVPDSQAWSFSGDGGFAMVAPDIITEARYGLPVINVIFSNQRFGFIYREQVDTKQH
LYGVDLTDADWAKVADGLGGIGFTVQNNQEVETVFDQIKALQAKGNKRPIVVNAVIKNDDPIGTAYMPLDPELYGQAEVD
AYAKANHIDIKEQPSLGALLRAQGDQL

Specific function: Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=24.1935483870968, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI21361361, Length=580, Percent_Identity=24.3103448275862, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1787096, Length=540, Percent_Identity=28.1481481481481, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1790104, Length=480, Percent_Identity=28.9583333333333, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI87081685, Length=560, Percent_Identity=26.25, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1786717, Length=567, Percent_Identity=26.984126984127, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1788716, Length=557, Percent_Identity=24.2369838420108, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17531299, Length=570, Percent_Identity=25.7894736842105, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531301, Length=570, Percent_Identity=25.7894736842105, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17542570, Length=595, Percent_Identity=25.7142857142857, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=572, Percent_Identity=25.1748251748252, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320816, Length=565, Percent_Identity=23.3628318584071, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19922626, Length=489, Percent_Identity=26.3803680981595, Blast_Score=138, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014092
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.3.3 [H]

Molecular weight: Translated: 63641; Mature: 63641

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTKMIAGQALVKVLEAWGVDHIYGIPGGSINHTVEGLYLEKADIDYIQVRHEEVGALAA
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHEEE
SADAKFTGKIGVSFGSAGPGATHLFNGLYDAKMDHVPVLALVGQVPQATMNTNYFQEMDE
CCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHCC
TPMFSDVAVYDRTVTTAGQLPYVINQAIREAYRQKGPAVVIIPENLSAEEIDYQPVSTPN
CCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
TVSDTFEQRVDPQAITATLKMLKAAKHPLVYAGRGLLGAKADLVKFSEQFNIPVMNTVPA
HHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCCC
TGVIPTNHPNAIGTFGRLGSKSGFEALQHADLILFLGSEFPFASFWPKGIKIIQVNNNSF
CCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCEEEEECCCCCCHHCCCCCEEEEEECCCCC
DIGKMVPIDYAVISDAQAYLQAMIATGETLPETAWLTTNRQNKRNWDKWLQQLAADDHDG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCC
LAPEAVMHKVASMVGPRDTYGVDTGNVSEWAVRGLPMDQEQRFALSGLFATMGFGLPAGM
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
AGALSVPDSQAWSFSGDGGFAMVAPDIITEARYGLPVINVIFSNQRFGFIYREQVDTKQH
CCCCCCCCCCCEEECCCCCEEEECHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCHHH
LYGVDLTDADWAKVADGLGGIGFTVQNNQEVETVFDQIKALQAKGNKRPIVVNAVIKNDD
EEECCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
PIGTAYMPLDPELYGQAEVDAYAKANHIDIKEQPSLGALLRAQGDQL
CCCEEECCCCHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MMTKMIAGQALVKVLEAWGVDHIYGIPGGSINHTVEGLYLEKADIDYIQVRHEEVGALAA
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEECCCCCEEEEEHHHHHHEEE
SADAKFTGKIGVSFGSAGPGATHLFNGLYDAKMDHVPVLALVGQVPQATMNTNYFQEMDE
CCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHCC
TPMFSDVAVYDRTVTTAGQLPYVINQAIREAYRQKGPAVVIIPENLSAEEIDYQPVSTPN
CCCCCCHHHHCCEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
TVSDTFEQRVDPQAITATLKMLKAAKHPLVYAGRGLLGAKADLVKFSEQFNIPVMNTVPA
HHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCEEECCCC
TGVIPTNHPNAIGTFGRLGSKSGFEALQHADLILFLGSEFPFASFWPKGIKIIQVNNNSF
CCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCEEEEECCCCCCHHCCCCCEEEEEECCCCC
DIGKMVPIDYAVISDAQAYLQAMIATGETLPETAWLTTNRQNKRNWDKWLQQLAADDHDG
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCC
LAPEAVMHKVASMVGPRDTYGVDTGNVSEWAVRGLPMDQEQRFALSGLFATMGFGLPAGM
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
AGALSVPDSQAWSFSGDGGFAMVAPDIITEARYGLPVINVIFSNQRFGFIYREQVDTKQH
CCCCCCCCCCCEEECCCCCEEEECHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCHHH
LYGVDLTDADWAKVADGLGGIGFTVQNNQEVETVFDQIKALQAKGNKRPIVVNAVIKNDD
EEECCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCC
PIGTAYMPLDPELYGQAEVDAYAKANHIDIKEQPSLGALLRAQGDQL
CCCEEECCCCHHHCCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12566566; 8145244; 8438155 [H]