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The map label for this gene is argC

Identifier: 28377414

GI number: 28377414

Start: 476966

End: 477991

Strand: Direct

Name: argC

Synonym: lp_0528

Alternate gene names: 28377414

Gene position: 476966-477991 (Clockwise)

Preceding gene: 28377411

Following gene: 28377415

Centisome position: 14.42

GC content: 50.68

Gene sequence:

>1026_bases
ATGCAAGTCGCGCTAGTTGGCGTTACGGGGTACAGTGGCATGGTGTTGTACCGGCTCTTGAAACAACATCCCGAGATCGA
TCGCATCCAATTATACGGGCACGTGGGAGCAACTACGGTGGCATTAAAGACGGTGGCAGCCATGTACCAGAAGGAAACGG
CGGTTATTCGACCATTCGATGCGACGGCAATCATGCGCGATAACGCGATTGTGTTCTTTGCGACATCAGCGGGTATCACG
CGACAATTGGCATTACCATTCATCGCTGCTCATTTTCCAGTCATCGATTTATCTGGTGACTTCCGCTTGCATGATCCAGA
GCAATATCAGCGGTGGTACCAACGTGATCCAGCATCGGCGACCGCTTTGGCGCAGGCGAGCTACGGCTTAGCTGATATGC
CGGCGCCGTTGTCCACCTACATTGCGAATCCCGGCTGCTATGCGACTGCTACGTTATTAGGACTAGCGCCACTTGCTCAG
CAGCAGTTGGTCGAACCGACTTCGATTGTTGTGGATGCTAAGTCCGGCTTATCTGGTGCTGGCAAACGAGCGACAGCTGC
GAGTCATTACGTCGCTGTGAATGATAATTTGAGTTTATATAAGTTGAATCAACATCAACATATCCCTGAAATGATGCAAC
AGTTACAGCAGTGGTGGTCCGCGATTTCTGCGATTGAATTTACTACCACTTTGATTCCAGTAACGCGTGGGATTATGACG
ACGATTTATGCCAAAGCGAAGTCAGCATTGACAACGACGCAGGTCCGCGCTGCTTTTACCGCGACCTATCATGAGCAGCC
GTTCGTGCAAGTGCTACCAACGGGGATGCCGACGCTCAAGGACGTTGTTGGGTCTAATAACTGTGCGTTAGGCGTTGATT
ATAATCCGGTCACGAACACCATCGTGGTTGTGAGCGTCATTGACAATTTGATGAAAGGTGCTGCGGGGCAGGCCGTTCAG
AATTTTAATCGCTATTTTGATTTCGCGGTTACGGCCGGATTACCGACGTTACCTGTATTTCCCTGA

Upstream 100 bases:

>100_bases
TAAAGCTTGCAATTTGAAAGTGATGAGAATATAGTGTGAATCATACTTTCTGCATGAACATGCAGTTAATACACTATTTT
TGAATATTTGAGGTGATTAT

Downstream 100 bases:

>100_bases
TAAGGTGCAATAAGAGAGGAAGTTATGCAGATGCAAGTTTTAACGAATACGAAGTTTGAAACGGTTGCCTTTCAGTGGCC
GGCAGGTTTTTACAGTGATG

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR 2; N-acetyl-glutamate semialdehyde dehydrogenase 2; NAGSA dehydrogenase 2

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFDATAIMRDNAIVFFATSAGIT
RQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASATALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQ
QQLVEPTSIVVDAKSGLSGAGKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMT
TIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNTIVVVSVIDNLMKGAAGQAVQ
NFNRYFDFAVTAGLPTLPVFP

Sequences:

>Translated_341_residues
MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFDATAIMRDNAIVFFATSAGIT
RQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASATALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQ
QQLVEPTSIVVDAKSGLSGAGKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMT
TIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNTIVVVSVIDNLMKGAAGQAVQ
NFNRYFDFAVTAGLPTLPVFP
>Mature_341_residues
MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFDATAIMRDNAIVFFATSAGIT
RQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASATALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQ
QQLVEPTSIVVDAKSGLSGAGKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMT
TIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNTIVVVSVIDNLMKGAAGQAVQ
NFNRYFDFAVTAGLPTLPVFP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=344, Percent_Identity=32.5581395348837, Blast_Score=146, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320913, Length=358, Percent_Identity=26.8156424581006, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC2_LACPL (O08318)

Other databases:

- EMBL:   X99978
- EMBL:   AL935253
- RefSeq:   NP_784306.1
- ProteinModelPortal:   O08318
- GeneID:   1061865
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0528
- NMPDR:   fig|220668.1.peg.440
- HOGENOM:   HBG294213
- OMA:   IGGDHRY
- ProtClustDB:   PRK00436
- BioCyc:   LPLA220668:LP_0528-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 36940; Mature: 36940

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFD
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCC
ATAIMRDNAIVFFATSAGITRQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASA
CEEEEECCEEEEEEECCCCHHHHHHHHHHHHCCEEECCCCCEECCHHHHHHHHHCCCCCH
TALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQQQLVEPTSIVVDAKSGLSGA
HHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
GKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMT
CCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNT
HHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCCHHHHHHCCCCEEEECCCCCCCHH
IVVVSVIDNLMKGAAGQAVQNFNRYFDFAVTAGLPTLPVFP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCCC
>Mature Secondary Structure
MQVALVGVTGYSGMVLYRLLKQHPEIDRIQLYGHVGATTVALKTVAAMYQKETAVIRPFD
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCC
ATAIMRDNAIVFFATSAGITRQLALPFIAAHFPVIDLSGDFRLHDPEQYQRWYQRDPASA
CEEEEECCEEEEEEECCCCHHHHHHHHHHHHCCEEECCCCCEECCHHHHHHHHHCCCCCH
TALAQASYGLADMPAPLSTYIANPGCYATATLLGLAPLAQQQLVEPTSIVVDAKSGLSGA
HHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
GKRATAASHYVAVNDNLSLYKLNQHQHIPEMMQQLQQWWSAISAIEFTTTLIPVTRGIMT
CCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIYAKAKSALTTTQVRAAFTATYHEQPFVQVLPTGMPTLKDVVGSNNCALGVDYNPVTNT
HHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCCHHHHHHCCCCEEEECCCCCCCHH
IVVVSVIDNLMKGAAGQAVQNFNRYFDFAVTAGLPTLPVFP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9098069; 12566566