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The map label for this gene is mntH1

Identifier: 28377200

GI number: 28377200

Start: 250642

End: 252036

Strand: Direct

Name: mntH1

Synonym: lp_0275

Alternate gene names: 28377200

Gene position: 250642-252036 (Clockwise)

Preceding gene: 28377199

Following gene: 28377205

Centisome position: 7.58

GC content: 44.37

Gene sequence:

>1395_bases
ATGAAATCAGCAAAAACGAAGGATCACGCTAAGATGAAAGCTGCCGAAGAAAAGGCGATTCATTCAACGGGTGCCGATAG
TAAGAGCTTGGACGAAGTCAATGGGAGTGTCCGGGTCCCTAAGGATGCCAGCTTCTGGCGAACTTTAATTGCCTACACTG
GACCGGGTGCACTAGTTGCAGTTGGGTACATGGATCCTGGGAACTGGATCACATCAATCGCAGGTGGATCACAGTACAAA
TATGCATTACTTTCTGTGATCCTGTTATCAAGTTTAATTGCCATGTTGCTACAAGCCATGGCCGCTCGTCTGGGAATTGT
GACGGGTAAAGATTTAGCACAATTGACGCGGGAACGAACGTCAAAAGGAATGGGGATTTTTCTCTGGATTATTACTGAAC
TAGCGATTATGGCGACCGATGTTGCTGAAATCATTGGTTCTGGGATTGCTTTGAAGTTATTATTCGGATTTCCATTAATT
GTCGGTATTTTGATTACCACTGCCGATGTCTTGATTCTGTTATTATTAATGAAACTTGGTTTCCGGAAAATCGAAGCAAT
TGTGGCAACGCTGGTTGCCGTGATTCTCTTCGTCTTCCTGTATGAAGTTATTATTTCACAACCTAATATTCCAGAAATGT
TAAAAGGGTATGTCCCAACTAGTCGGATTGTCAGCAACCGTTCTATGCTATTTCTAGCACTCGGAATTGTTGGGGCAACC
GTTATGCCGCATAACTTGTACTTGGGATCATCAATCTCACAAACACGTCAAGTTGACCGGAGTGACGAAAAAGAAGTTGC
CAAGGCTGTTAAGTTCACGACAATCGACTCCAATATTCAATTGTCAGTCGCGTTCGTTGTTAATAGTTTGCTATTAATTC
TTGGCGCCGCACTGTTCTTTGGAACTAAGGGGGATCTTGGCCGGTTCGTTGACTTGTACAATGCACTTGGCGATAGTAAG
GTCGTTGGCTCGATTGCGAGTCCGTTACTCAGTATGCTCTTTGCCATTGCGCTGTTGTCTTCTGGTCAAAGTTCTACGAT
TACGGGGACGTTATCTGGTCAGATTATCATGGAAGGGTTTATCCGTTTGAAGATGCCACTCTGGGCACAACGGTTACTAA
CTCGGTTAATCTCGGTTACACCAGTGTTGGCTTTTGCGATTTATTATCATGGCAATGAAGCGAAAATTGAAGATCTGCTG
ACGATGTCGCAAGTCTTCCTGAGTATCGCGTTACCATTTGCCATGATTCCGCTAGTCATGTTCACGAGTAATCGGGCGCT
GATGGGGAACTTCACCAACCGTGTCTGGGTCAAGTGGACGGCTTGGATCGTGACGGTGATTCTAATCATCTTAAACATTT
ACCTTATTTTACAGACTGTCGGTCTGGTTAAATAA

Upstream 100 bases:

>100_bases
TTGGAATTAAAGTGAGTGCTCAATTAAGGGGACGCACTGTTGAGGATCACGTAGTAGTCCACAACCTGAATTCTAAACCA
ATAGAAGAGAGGGTTTCATA

Downstream 100 bases:

>100_bases
TCAAACATTAAAATGAGCTTTCCAGGGATTGCAAAGAATTCCTGGAAAGCTCATTTTGTGTTTTGGGAATAGCGGCAATG
CAAGATACCGATTCAAAGCG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKSAKTKDHAKMKAAEEKAIHSTGADSKSLDEVNGSVRVPKDASFWRTLIAYTGPGALVAVGYMDPGNWITSIAGGSQYK
YALLSVILLSSLIAMLLQAMAARLGIVTGKDLAQLTRERTSKGMGIFLWIITELAIMATDVAEIIGSGIALKLLFGFPLI
VGILITTADVLILLLLMKLGFRKIEAIVATLVAVILFVFLYEVIISQPNIPEMLKGYVPTSRIVSNRSMLFLALGIVGAT
VMPHNLYLGSSISQTRQVDRSDEKEVAKAVKFTTIDSNIQLSVAFVVNSLLLILGAALFFGTKGDLGRFVDLYNALGDSK
VVGSIASPLLSMLFAIALLSSGQSSTITGTLSGQIIMEGFIRLKMPLWAQRLLTRLISVTPVLAFAIYYHGNEAKIEDLL
TMSQVFLSIALPFAMIPLVMFTSNRALMGNFTNRVWVKWTAWIVTVILIILNIYLILQTVGLVK

Sequences:

>Translated_464_residues
MKSAKTKDHAKMKAAEEKAIHSTGADSKSLDEVNGSVRVPKDASFWRTLIAYTGPGALVAVGYMDPGNWITSIAGGSQYK
YALLSVILLSSLIAMLLQAMAARLGIVTGKDLAQLTRERTSKGMGIFLWIITELAIMATDVAEIIGSGIALKLLFGFPLI
VGILITTADVLILLLLMKLGFRKIEAIVATLVAVILFVFLYEVIISQPNIPEMLKGYVPTSRIVSNRSMLFLALGIVGAT
VMPHNLYLGSSISQTRQVDRSDEKEVAKAVKFTTIDSNIQLSVAFVVNSLLLILGAALFFGTKGDLGRFVDLYNALGDSK
VVGSIASPLLSMLFAIALLSSGQSSTITGTLSGQIIMEGFIRLKMPLWAQRLLTRLISVTPVLAFAIYYHGNEAKIEDLL
TMSQVFLSIALPFAMIPLVMFTSNRALMGNFTNRVWVKWTAWIVTVILIILNIYLILQTVGLVK
>Mature_464_residues
MKSAKTKDHAKMKAAEEKAIHSTGADSKSLDEVNGSVRVPKDASFWRTLIAYTGPGALVAVGYMDPGNWITSIAGGSQYK
YALLSVILLSSLIAMLLQAMAARLGIVTGKDLAQLTRERTSKGMGIFLWIITELAIMATDVAEIIGSGIALKLLFGFPLI
VGILITTADVLILLLLMKLGFRKIEAIVATLVAVILFVFLYEVIISQPNIPEMLKGYVPTSRIVSNRSMLFLALGIVGAT
VMPHNLYLGSSISQTRQVDRSDEKEVAKAVKFTTIDSNIQLSVAFVVNSLLLILGAALFFGTKGDLGRFVDLYNALGDSK
VVGSIASPLLSMLFAIALLSSGQSSTITGTLSGQIIMEGFIRLKMPLWAQRLLTRLISVTPVLAFAIYYHGNEAKIEDLL
TMSQVFLSIALPFAMIPLVMFTSNRALMGNFTNRVWVKWTAWIVTVILIILNIYLILQTVGLVK

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI295293167, Length=453, Percent_Identity=36.4238410596026, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI295293175, Length=453, Percent_Identity=36.4238410596026, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI295293173, Length=453, Percent_Identity=36.4238410596026, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI10835169, Length=453, Percent_Identity=36.4238410596026, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI295293178, Length=453, Percent_Identity=36.4238410596026, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI295293171, Length=453, Percent_Identity=36.4238410596026, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI295293169, Length=453, Percent_Identity=36.4238410596026, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI109255241, Length=432, Percent_Identity=33.7962962962963, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI1788736, Length=418, Percent_Identity=37.0813397129187, Blast_Score=246, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17569473, Length=407, Percent_Identity=36.3636363636364, Blast_Score=261, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI193210616, Length=473, Percent_Identity=34.0380549682875, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71999499, Length=459, Percent_Identity=33.7690631808279, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71993856, Length=256, Percent_Identity=36.328125, Blast_Score=161, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6323062, Length=398, Percent_Identity=40.4522613065327, Blast_Score=256, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6324450, Length=451, Percent_Identity=32.5942350332594, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6321841, Length=422, Percent_Identity=36.7298578199052, Blast_Score=226, Evalue=6e-60,
Organism=Drosophila melanogaster, GI24648607, Length=458, Percent_Identity=35.8078602620087, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI281362176, Length=458, Percent_Identity=35.8078602620087, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24648609, Length=458, Percent_Identity=35.8078602620087, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI45553443, Length=431, Percent_Identity=36.6589327146172, Blast_Score=266, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_LACPL (Q8GH68)

Other databases:

- EMBL:   AF416709
- EMBL:   AL935252
- RefSeq:   NP_784092.1
- GeneID:   1061171
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0275
- NMPDR:   fig|220668.1.peg.226
- HOGENOM:   HBG312498
- OMA:   NWITSVV
- ProtClustDB:   PRK00701
- BioCyc:   LPLA220668:LP_0275-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 50353; Mature: 50353

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbfca34c)-; HASH(0xba1d49c)-; HASH(0xc46eb38)-; HASH(0xc6229d0)-; HASH(0xae279d0)-; HASH(0xc74b480)-; HASH(0xc3e1ba4)-; HASH(0xc1243a4)-; HASH(0xaf3e7bc)-; HASH(0xc0b474c)-; HASH(0xc32b434)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAKTKDHAKMKAAEEKAIHSTGADSKSLDEVNGSVRVPKDASFWRTLIAYTGPGALVA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEECCCCHHHHHHHHHHCCCCCEEE
VGYMDPGNWITSIAGGSQYKYALLSVILLSSLIAMLLQAMAARLGIVTGKDLAQLTRERT
EEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SKGMGIFLWIITELAIMATDVAEIIGSGIALKLLFGFPLIVGILITTADVLILLLLMKLG
CCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRKIEAIVATLVAVILFVFLYEVIISQPNIPEMLKGYVPTSRIVSNRSMLFLALGIVGAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHH
VMPHNLYLGSSISQTRQVDRSDEKEVAKAVKFTTIDSNIQLSVAFVVNSLLLILGAALFF
HCCCCEEECCCHHHHHHCCCCCHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHHHH
GTKGDLGRFVDLYNALGDSKVVGSIASPLLSMLFAIALLSSGQSSTITGTLSGQIIMEGF
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
IRLKMPLWAQRLLTRLISVTPVLAFAIYYHGNEAKIEDLLTMSQVFLSIALPFAMIPLVM
HHHHCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTSNRALMGNFTNRVWVKWTAWIVTVILIILNIYLILQTVGLVK
HCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKSAKTKDHAKMKAAEEKAIHSTGADSKSLDEVNGSVRVPKDASFWRTLIAYTGPGALVA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEECCCCHHHHHHHHHHCCCCCEEE
VGYMDPGNWITSIAGGSQYKYALLSVILLSSLIAMLLQAMAARLGIVTGKDLAQLTRERT
EEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
SKGMGIFLWIITELAIMATDVAEIIGSGIALKLLFGFPLIVGILITTADVLILLLLMKLG
CCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRKIEAIVATLVAVILFVFLYEVIISQPNIPEMLKGYVPTSRIVSNRSMLFLALGIVGAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHHHH
VMPHNLYLGSSISQTRQVDRSDEKEVAKAVKFTTIDSNIQLSVAFVVNSLLLILGAALFF
HCCCCEEECCCHHHHHHCCCCCHHHHHHHHHHEEECCCCEEHHHHHHHHHHHHHHHHHHH
GTKGDLGRFVDLYNALGDSKVVGSIASPLLSMLFAIALLSSGQSSTITGTLSGQIIMEGF
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
IRLKMPLWAQRLLTRLISVTPVLAFAIYYHGNEAKIEDLLTMSQVFLSIALPFAMIPLVM
HHHHCHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTSNRALMGNFTNRVWVKWTAWIVTVILIILNIYLILQTVGLVK
HCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12566566