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The map label for this gene is gpo [H]

Identifier: 28377153

GI number: 28377153

Start: 202845

End: 203330

Strand: Direct

Name: gpo [H]

Synonym: lp_0220

Alternate gene names: 28377153

Gene position: 202845-203330 (Clockwise)

Preceding gene: 28377149

Following gene: 28377154

Centisome position: 6.13

GC content: 47.94

Gene sequence:

>486_bases
ATGGCAGAATCAGTGTATGATTTTACAGAAACTGAGATGAGTGGTGCGCCACTTGACTTGTCACAATATCGCGGTCAGGT
CTTGCTAATCGTGAATACGGCTAGCAACTGTGGCCTGGCGCCACAGTTTAAAGGATTAGAAGAACTTTATCAGAAGTATC
AGCAGGAGGGCCTAGTGGTCTTGGGATTGCCATCCAATCAATTTCATCAAGAAAAGGCGGATGACGATGAGACCCATGAC
TATTGTCAACGGCACTACGGGGTAACGTTTCCCATGACCAAACGGGTGATGGTTAATGGTGATGACGCTGATCCGTTATT
TACTTACCTCAAACAGGCGGCGGGACATGGTCGAATCAAGTGGAATTTCACAAAATTCCTGATTGGTCGTGATGGCCGTG
TGCTCGAACGCTATGCCCCAACGACACGGCCGGCAACATTTGAAGCAGCGATTCGTGATGCCTTGGCTGATCGTTCAGAA
GATTAA

Upstream 100 bases:

>100_bases
TTTTCCGGAAACTAAAGCAAAGTATGATGAAAAGTCACAATTTTGTGGTTTACTATGGATAAAGCAATGTATTTGGTTAA
TATTCTTAGGAGGGATCTCG

Downstream 100 bases:

>100_bases
CGATAAATTTAACAATGATCGTTTAATTTAAAAGAAAGAAGTGGCTTAAGTTGGAAACTTATACGTTACGTGATGGTTTA
ACAGTACCTAAAATTGGCTT

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MAESVYDFTETEMSGAPLDLSQYRGQVLLIVNTASNCGLAPQFKGLEELYQKYQQEGLVVLGLPSNQFHQEKADDDETHD
YCQRHYGVTFPMTKRVMVNGDDADPLFTYLKQAAGHGRIKWNFTKFLIGRDGRVLERYAPTTRPATFEAAIRDALADRSE
D

Sequences:

>Translated_161_residues
MAESVYDFTETEMSGAPLDLSQYRGQVLLIVNTASNCGLAPQFKGLEELYQKYQQEGLVVLGLPSNQFHQEKADDDETHD
YCQRHYGVTFPMTKRVMVNGDDADPLFTYLKQAAGHGRIKWNFTKFLIGRDGRVLERYAPTTRPATFEAAIRDALADRSE
D
>Mature_160_residues
AESVYDFTETEMSGAPLDLSQYRGQVLLIVNTASNCGLAPQFKGLEELYQKYQQEGLVVLGLPSNQFHQEKADDDETHDY
CQRHYGVTFPMTKRVMVNGDDADPLFTYLKQAAGHGRIKWNFTKFLIGRDGRVLERYAPTTRPATFEAAIRDALADRSED

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=154, Percent_Identity=38.3116883116883, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI90903240, Length=154, Percent_Identity=38.3116883116883, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI15618997, Length=163, Percent_Identity=36.1963190184049, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI192455698, Length=165, Percent_Identity=30.9090909090909, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI90903238, Length=132, Percent_Identity=37.8787878787879, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI41406084, Length=167, Percent_Identity=34.7305389221557, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI32967607, Length=184, Percent_Identity=30.9782608695652, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4557629, Length=178, Percent_Identity=30.8988764044944, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI6006001, Length=163, Percent_Identity=29.4478527607362, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788003, Length=182, Percent_Identity=37.9120879120879, Blast_Score=124, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17506887, Length=160, Percent_Identity=41.25, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17535473, Length=157, Percent_Identity=40.1273885350318, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=37.888198757764, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=31.2101910828025, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550320, Length=165, Percent_Identity=32.7272727272727, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193209493, Length=165, Percent_Identity=32.7272727272727, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=43.421052631579, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=161, Percent_Identity=44.0993788819876, Blast_Score=157, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322228, Length=157, Percent_Identity=43.312101910828, Blast_Score=152, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322826, Length=164, Percent_Identity=39.0243902439024, Blast_Score=140, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24656772, Length=164, Percent_Identity=40.2439024390244, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656777, Length=164, Percent_Identity=40.2439024390244, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656767, Length=164, Percent_Identity=40.2439024390244, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI85726443, Length=147, Percent_Identity=34.6938775510204, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 18231; Mature: 18099

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESVYDFTETEMSGAPLDLSQYRGQVLLIVNTASNCGLAPQFKGLEELYQKYQQEGLVV
CCCCCCCCHHHCCCCCCCCHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCEEE
LGLPSNQFHQEKADDDETHDYCQRHYGVTFPMTKRVMVNGDDADPLFTYLKQAAGHGRIK
EECCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEE
WNFTKFLIGRDGRVLERYAPTTRPATFEAAIRDALADRSED
EEEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AESVYDFTETEMSGAPLDLSQYRGQVLLIVNTASNCGLAPQFKGLEELYQKYQQEGLVV
CCCCCCCHHHCCCCCCCCHHHHCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCEEE
LGLPSNQFHQEKADDDETHDYCQRHYGVTFPMTKRVMVNGDDADPLFTYLKQAAGHGRIK
EECCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEE
WNFTKFLIGRDGRVLERYAPTTRPATFEAAIRDALADRSED
EEEEEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]