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The map label for this gene is gmuR [H]

Identifier: 28377095

GI number: 28377095

Start: 132004

End: 132756

Strand: Direct

Name: gmuR [H]

Synonym: lp_0152

Alternate gene names: 28377095

Gene position: 132004-132756 (Clockwise)

Preceding gene: 28377089

Following gene: 28377096

Centisome position: 3.99

GC content: 47.54

Gene sequence:

>753_bases
TTGACAAGACCAAATGATGAAGGGGATGTGAGTAGTTTGGCTTATAAGTATGAAACGATTGCGGATAGTCTGCGACAAGA
CATAAAATCCGGTAAATATACGCCGGGCGAATTGATGCCCGACCAGAATAAATTAGCTGAAACTTTTGATACGACACGAA
TTACGATTCACAAGGCCATTCAATTACTGATTATTGAAGGGATGGTTTACTCCAAGCGTGGCGCGGGGACCTTTGTTCGC
AAGGACTTTGGTTTGACTGAACGGCGCCAAGAAACGCTGGTAGACAAGCCCCTGGGAACAACGCAAACGAATGCCGGTAA
AAAGGTGACGAGTAAGGTGTTGGAATTACAAGCTCGCTTGCCTACTAAGCGGGAAGCGGAACAGTTGTTAATCGATGAGA
TGGATCCGGTGTACGTTATTCGGCGGACCCGCTACGTTGATGGTAAGGTGTGGGCGTATGAGCATACGATTATGCCAACG
AGTATCGTGACGTTGACGAAGCAAGTCCTCGAAGGCTCGGTCTACGGTTACTTAGAGCAACATAGTGGCAAGAAAATCGC
GGGTTCACACCGTATTATCTCGGCAGCCCGAGTGACGGCTGATGACGTTGCCGCAATGGGCGCGACTCTGAATGATCCCG
TGTTGGTCATTAATCAGATTAGTTACATGGATGATGGTCAACCCTTTGAAGTCTCCGAATCACATTTCCCATACGAGACA
AGTACGGTCGTAGCGGATGTTCAAATTCATTAA

Upstream 100 bases:

>100_bases
TGACGGATGCTGATGATTAGTTGGATTGGTCGTTAATTAAACAAAGCCAATAAAAGTATATACAAATGATTTCAATTAGC
TACTAAAAGGGGTAAACTAG

Downstream 100 bases:

>100_bases
AGCAATCGGTAACCGCGTTAATCAGTGGCTACCGATTTTTTGTGGAAATTATTCTGGGGAGTTGCATTCAAGAAAACGGT
GGCCCATAATTAAATTGATT

Product: transcription regulator

Products: NA

Alternate protein names: Glucomannan utilization operon repressor; Glucomannan utilization protein R [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTRPNDEGDVSSLAYKYETIADSLRQDIKSGKYTPGELMPDQNKLAETFDTTRITIHKAIQLLIIEGMVYSKRGAGTFVR
KDFGLTERRQETLVDKPLGTTQTNAGKKVTSKVLELQARLPTKREAEQLLIDEMDPVYVIRRTRYVDGKVWAYEHTIMPT
SIVTLTKQVLEGSVYGYLEQHSGKKIAGSHRIISAARVTADDVAAMGATLNDPVLVINQISYMDDGQPFEVSESHFPYET
STVVADVQIH

Sequences:

>Translated_250_residues
MTRPNDEGDVSSLAYKYETIADSLRQDIKSGKYTPGELMPDQNKLAETFDTTRITIHKAIQLLIIEGMVYSKRGAGTFVR
KDFGLTERRQETLVDKPLGTTQTNAGKKVTSKVLELQARLPTKREAEQLLIDEMDPVYVIRRTRYVDGKVWAYEHTIMPT
SIVTLTKQVLEGSVYGYLEQHSGKKIAGSHRIISAARVTADDVAAMGATLNDPVLVINQISYMDDGQPFEVSESHFPYET
STVVADVQIH
>Mature_249_residues
TRPNDEGDVSSLAYKYETIADSLRQDIKSGKYTPGELMPDQNKLAETFDTTRITIHKAIQLLIIEGMVYSKRGAGTFVRK
DFGLTERRQETLVDKPLGTTQTNAGKKVTSKVLELQARLPTKREAEQLLIDEMDPVYVIRRTRYVDGKVWAYEHTIMPTS
IVTLTKQVLEGSVYGYLEQHSGKKIAGSHRIISAARVTADDVAAMGATLNDPVLVINQISYMDDGQPFEVSESHFPYETS
TVVADVQIH

Specific function: Transcriptional repressor of the gmuBACDREFG operon which is involved in the uptake and degradation of glucomannan [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790118, Length=215, Percent_Identity=36.2790697674419, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786950, Length=221, Percent_Identity=28.5067873303167, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082252, Length=223, Percent_Identity=26.0089686098655, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788418, Length=226, Percent_Identity=27.8761061946903, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790540, Length=231, Percent_Identity=25.5411255411255, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27954; Mature: 27823

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPNDEGDVSSLAYKYETIADSLRQDIKSGKYTPGELMPDQNKLAETFDTTRITIHKAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
QLLIIEGMVYSKRGAGTFVRKDFGLTERRQETLVDKPLGTTQTNAGKKVTSKVLELQARL
HHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCC
PTKREAEQLLIDEMDPVYVIRRTRYVDGKVWAYEHTIMPTSIVTLTKQVLEGSVYGYLEQ
CCHHHHHHHHHHCCCCEEEEEEEEEECCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
HSGKKIAGSHRIISAARVTADDVAAMGATLNDPVLVINQISYMDDGQPFEVSESHFPYET
CCCCEECCCCHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCC
STVVADVQIH
CEEEEEEEEC
>Mature Secondary Structure 
TRPNDEGDVSSLAYKYETIADSLRQDIKSGKYTPGELMPDQNKLAETFDTTRITIHKAI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
QLLIIEGMVYSKRGAGTFVRKDFGLTERRQETLVDKPLGTTQTNAGKKVTSKVLELQARL
HHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCC
PTKREAEQLLIDEMDPVYVIRRTRYVDGKVWAYEHTIMPTSIVTLTKQVLEGSVYGYLEQ
CCHHHHHHHHHHCCCCEEEEEEEEEECCEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHH
HSGKKIAGSHRIISAARVTADDVAAMGATLNDPVLVINQISYMDDGQPFEVSESHFPYET
CCCCEECCCCHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCC
STVVADVQIH
CEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377 [H]