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The map label for this gene is htrA [H]

Identifier: 28377009

GI number: 28377009

Start: 43821

End: 45083

Strand: Direct

Name: htrA [H]

Synonym: lp_0043

Alternate gene names: 28377009

Gene position: 43821-45083 (Clockwise)

Preceding gene: 28377008

Following gene: 28377010

Centisome position: 1.32

GC content: 45.05

Gene sequence:

>1263_bases
ATGGCTAATAAATCATTAATCAAAGTCGCAGTAACCGCACTAGTAGCTGGTTTAATCGGTGGTGGTGTTGCTTACGGCGG
TATTAATTATTTCCAAAACAATAACATCGCAACGTCATCGACCAGTGTACCAACTGGTTCTAATAAATCGGGGTCAACGT
CAACGACGAACGTTAAGGTCAATGTCAGTTCACAGGCGACCAAGGTGTTTGAAAATAACAAGGCGGCCGTTGTATCGGTC
ATTAATCTCCAAAAGAAGAGCTCTTCAAGCAGTTGGAGTGGTATTTTGGGTGGCGATGACTCGTCTGGCAGTGATAGTTC
ATCCAGTTCAGATTCTAGCTCTAGTAAGCTGGAAGAGTACAGTGAAGGTTCTGGGTTGATCTATAAGAAGAGCGGTGACG
CGGCTTATATTGTAACGAATAATCACGTGGTGAGTGGTTCAAGTGCCATTCGAGTGATTATGAGTGATGGGACTAAGTTG
TCAGCTAAAATTGTCGGAACCGATTCTGTGACTGACTTGGCCGTTCTGAAAATCAATTCTTCTAAAGTAACGAAGACGGC
TAGCTTTGGTAACTCAGATAATATCAAGGTTGGTGAAACGGCCTTAGCCATTGGGTCACCGATGGGCTCTAATTACGCAA
CGACCTTGACGCAAGGAATCATTTCAGCGAAGAAGCGGACCGTGGCGACGACGAATACATCTGGTCAAACGACGGGGTAC
GCGACGGTTATCCAAACAGATACGGCAATTAACTCTGGAAACTCTGGTGGTCCGTTGTTCAACATTGCTGGACAAGTTAT
CGGGATCAACTCGATGAAGTTGGCCTCAGATAATTCTGGGACTAGTGTCGAAGGGATGGGCTTTGCAATTCCAAGTAATG
AAGTTGTGAAGATCATCAATGAATTGGTTCAAAAGGGTGAAGTCGTTCGGCCGGCTTTAGGGGTTGCAACCTATGACCTA
TCCAATATTTCTTCTAGTGATCAGAAGTCTGTTCTTAAGTTACCAACCAGTGTGACGAAGGGTGTCGTCATCATGAAGAC
GTACTCAGGTTCACCGGCTAAAGCTGCTGGGTTAACGAAGTACGATGTGATTACGGAGCTAGGTGGCAAGAAAGTGACCA
GCTTAGCCACGTTACGGAGTGCCCTGTATGCCCATTCGGTTAATGATACCGTGACGGTGAAATACTACCATAACGGAAAA
CTCAAGACAGCCAACATGAAGTTGACGGAAACTACCAAAACGTTAACTAAACAAAGTAACTAA

Upstream 100 bases:

>100_bases
ATGTTTCACAACGCTTCAGTCATAAAAAAATCACACTTTTTCGCTAAAATAAACTTAAAATAAGCATTAGTAGGGAGGGA
TCGCGTTTCGACGCGCAATT

Downstream 100 bases:

>100_bases
TAAATGAGAATTTCATAAACGTCCCTGACTGGATAAAGCAGTCGGGGGCGTTTTTTTAGGTTAGTAGCTGAAATCATGAA
AAAACGAAGAATCGATTTTC

Product: serine protease HtrA

Products: NA

Alternate protein names: HtrALl [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MANKSLIKVAVTALVAGLIGGGVAYGGINYFQNNNIATSSTSVPTGSNKSGSTSTTNVKVNVSSQATKVFENNKAAVVSV
INLQKKSSSSSWSGILGGDDSSGSDSSSSSDSSSSKLEEYSEGSGLIYKKSGDAAYIVTNNHVVSGSSAIRVIMSDGTKL
SAKIVGTDSVTDLAVLKINSSKVTKTASFGNSDNIKVGETALAIGSPMGSNYATTLTQGIISAKKRTVATTNTSGQTTGY
ATVIQTDTAINSGNSGGPLFNIAGQVIGINSMKLASDNSGTSVEGMGFAIPSNEVVKIINELVQKGEVVRPALGVATYDL
SNISSSDQKSVLKLPTSVTKGVVIMKTYSGSPAKAAGLTKYDVITELGGKKVTSLATLRSALYAHSVNDTVTVKYYHNGK
LKTANMKLTETTKTLTKQSN

Sequences:

>Translated_420_residues
MANKSLIKVAVTALVAGLIGGGVAYGGINYFQNNNIATSSTSVPTGSNKSGSTSTTNVKVNVSSQATKVFENNKAAVVSV
INLQKKSSSSSWSGILGGDDSSGSDSSSSSDSSSSKLEEYSEGSGLIYKKSGDAAYIVTNNHVVSGSSAIRVIMSDGTKL
SAKIVGTDSVTDLAVLKINSSKVTKTASFGNSDNIKVGETALAIGSPMGSNYATTLTQGIISAKKRTVATTNTSGQTTGY
ATVIQTDTAINSGNSGGPLFNIAGQVIGINSMKLASDNSGTSVEGMGFAIPSNEVVKIINELVQKGEVVRPALGVATYDL
SNISSSDQKSVLKLPTSVTKGVVIMKTYSGSPAKAAGLTKYDVITELGGKKVTSLATLRSALYAHSVNDTVTVKYYHNGK
LKTANMKLTETTKTLTKQSN
>Mature_419_residues
ANKSLIKVAVTALVAGLIGGGVAYGGINYFQNNNIATSSTSVPTGSNKSGSTSTTNVKVNVSSQATKVFENNKAAVVSVI
NLQKKSSSSSWSGILGGDDSSGSDSSSSSDSSSSKLEEYSEGSGLIYKKSGDAAYIVTNNHVVSGSSAIRVIMSDGTKLS
AKIVGTDSVTDLAVLKINSSKVTKTASFGNSDNIKVGETALAIGSPMGSNYATTLTQGIISAKKRTVATTNTSGQTTGYA
TVIQTDTAINSGNSGGPLFNIAGQVIGINSMKLASDNSGTSVEGMGFAIPSNEVVKIINELVQKGEVVRPALGVATYDLS
NISSSDQKSVLKLPTSVTKGVVIMKTYSGSPAKAAGLTKYDVITELGGKKVTSLATLRSALYAHSVNDTVTVKYYHNGKL
KTANMKLTETTKTLTKQSN

Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=282, Percent_Identity=32.6241134751773, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4506141, Length=261, Percent_Identity=33.7164750957854, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI7019477, Length=263, Percent_Identity=35.361216730038, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI22129776, Length=274, Percent_Identity=30.2919708029197, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1786356, Length=291, Percent_Identity=36.7697594501718, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1789629, Length=279, Percent_Identity=37.6344086021505, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789630, Length=272, Percent_Identity=35.2941176470588, Blast_Score=149, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646839, Length=274, Percent_Identity=32.1167883211679, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43102; Mature: 42971

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKSLIKVAVTALVAGLIGGGVAYGGINYFQNNNIATSSTSVPTGSNKSGSTSTTNVKV
CCCHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCCEEECCCCCCCCCCCCCCCEEEEEEE
NVSSQATKVFENNKAAVVSVINLQKKSSSSSWSGILGGDDSSGSDSSSSSDSSSSKLEEY
EECCHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
SEGSGLIYKKSGDAAYIVTNNHVVSGSSAIRVIMSDGTKLSAKIVGTDSVTDLAVLKINS
CCCCCEEEEECCCEEEEEECCEEECCCCEEEEEEECCCEEEEEEEECCCCCEEEEEEECC
SKVTKTASFGNSDNIKVGETALAIGSPMGSNYATTLTQGIISAKKRTVATTNTSGQTTGY
CCEEEEECCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCE
ATVIQTDTAINSGNSGGPLFNIAGQVIGINSMKLASDNSGTSVEGMGFAIPSNEVVKIIN
EEEEEECCEECCCCCCCCEEEECCEEEECCEEEEECCCCCCEECCEEEECCCHHHHHHHH
ELVQKGEVVRPALGVATYDLSNISSSDQKSVLKLPTSVTKGVVIMKTYSGSPAKAAGLTK
HHHHCCCEECCHHCEEEEECCCCCCCCCHHHHCCCCHHHCCEEEEEECCCCCCHHCCCCH
YDVITELGGKKVTSLATLRSALYAHSVNDTVTVKYYHNGKLKTANMKLTETTKTLTKQSN
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCEEEEHHHHHHHCCCC
>Mature Secondary Structure 
ANKSLIKVAVTALVAGLIGGGVAYGGINYFQNNNIATSSTSVPTGSNKSGSTSTTNVKV
CCHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCCEEECCCCCCCCCCCCCCCEEEEEEE
NVSSQATKVFENNKAAVVSVINLQKKSSSSSWSGILGGDDSSGSDSSSSSDSSSSKLEEY
EECCHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
SEGSGLIYKKSGDAAYIVTNNHVVSGSSAIRVIMSDGTKLSAKIVGTDSVTDLAVLKINS
CCCCCEEEEECCCEEEEEECCEEECCCCEEEEEEECCCEEEEEEEECCCCCEEEEEEECC
SKVTKTASFGNSDNIKVGETALAIGSPMGSNYATTLTQGIISAKKRTVATTNTSGQTTGY
CCEEEEECCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCE
ATVIQTDTAINSGNSGGPLFNIAGQVIGINSMKLASDNSGTSVEGMGFAIPSNEVVKIIN
EEEEEECCEECCCCCCCCEEEECCEEEECCEEEEECCCCCCEECCEEEECCCHHHHHHHH
ELVQKGEVVRPALGVATYDLSNISSSDQKSVLKLPTSVTKGVVIMKTYSGSPAKAAGLTK
HHHHCCCEECCHHCEEEEECCCCCCCCCHHHHCCCCHHHCCEEEEEECCCCCCHHCCCCH
YDVITELGGKKVTSLATLRSALYAHSVNDTVTVKYYHNGKLKTANMKLTETTKTLTKQSN
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCEEEEHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10712686; 11337471 [H]