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The map label for this gene is dapA

Identifier: 28211891

GI number: 28211891

Start: 2419894

End: 2420778

Strand: Direct

Name: dapA

Synonym: CTC02294

Alternate gene names: 28211891

Gene position: 2419894-2420778 (Clockwise)

Preceding gene: 28211890

Following gene: 28211892

Centisome position: 86.45

GC content: 30.85

Gene sequence:

>885_bases
ATGAGTATATTTAAAGGTTCTGGAGTAGCTATAGTAACACCCTTTTGTGAAAATGGTGTTAATTTTAAAAAGCTTGAGGA
GCTTATTGAATGGCATATAGAAAATAGTACCGATGCTATAGTAATATGTGGAACTACTGGAGAAGCATCTACTATGACTG
AAGCTGAAATAAAAGAAACTATTAAGTTTACTGTGGACAAGGTTCAAGGACGAATTCCAGTAATAGCTGGTACTGGCAGT
AATAACACTAGAAAAGCTATTGAGTTAAGTAAGTGGGCTAAATCCATAGGAGTAGATGGTTTACTACTCATAACACCTTA
TTATAATAAAACAACTCAAAAGGGCATTGTTGAGCATTTTAAGGCAATTAACGATGATGTTGATGTGCCTATAATTCTTT
ATAATGTTCCGGGTAGAACTGGACTTAATATACTACCTAAAACACTAGTTAAAATATGTGATACATGTTCAAATGTAGTA
GCTATAAAAGAAGCTAGTGGTGATTTAAGTCAAATTATTGAAATGAAAGCTTTGTTAAAGGATAGAATAGATATTTATTC
AGGTAATGATGACCAAATTATCCCTATACTTTCTATAGGTGGTATTGGTGTAATTTCTGTTTTAGCAAATATTATGCCAA
AAGAAGTTCATGATATGTGTGAACTTTATTTAAAAGGTAAAACAAAAAAAGCTTTAGAAATTCAATTAAATACCCTTTCT
CTTACGAACTCATTATTCATAGAAACTAATCCTATTCCTGTAAAAACAGCAATGAATATTATGGGAATAGATGTAGGTGA
ACTAAGGCTTCCGCTATGTAATATGGATGAAAGTAATTTAAACCTATTAAAAAAAGAGCTATCAAATCATGCTCTTATTA
AGTAA

Upstream 100 bases:

>100_bases
TTGCAGATAATATAAGAAAAGGTGCTGCTCTTAATACAATTCAAATTGCTGAATGTCTAATTAAAAACAAATAACAAATA
ATTTAAAGTGAGGTTTTTAT

Downstream 100 bases:

>100_bases
TAAACTATATTGATGTGGAGGTATATTTAATGGTTAGAATAATGTTAGTTGGTTGCAATGGTAAAATGGGTAGAATAATA
ACTCATTGTTCTAAGGATTT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSIFKGSGVAIVTPFCENGVNFKKLEELIEWHIENSTDAIVICGTTGEASTMTEAEIKETIKFTVDKVQGRIPVIAGTGS
NNTRKAIELSKWAKSIGVDGLLLITPYYNKTTQKGIVEHFKAINDDVDVPIILYNVPGRTGLNILPKTLVKICDTCSNVV
AIKEASGDLSQIIEMKALLKDRIDIYSGNDDQIIPILSIGGIGVISVLANIMPKEVHDMCELYLKGKTKKALEIQLNTLS
LTNSLFIETNPIPVKTAMNIMGIDVGELRLPLCNMDESNLNLLKKELSNHALIK

Sequences:

>Translated_294_residues
MSIFKGSGVAIVTPFCENGVNFKKLEELIEWHIENSTDAIVICGTTGEASTMTEAEIKETIKFTVDKVQGRIPVIAGTGS
NNTRKAIELSKWAKSIGVDGLLLITPYYNKTTQKGIVEHFKAINDDVDVPIILYNVPGRTGLNILPKTLVKICDTCSNVV
AIKEASGDLSQIIEMKALLKDRIDIYSGNDDQIIPILSIGGIGVISVLANIMPKEVHDMCELYLKGKTKKALEIQLNTLS
LTNSLFIETNPIPVKTAMNIMGIDVGELRLPLCNMDESNLNLLKKELSNHALIK
>Mature_293_residues
SIFKGSGVAIVTPFCENGVNFKKLEELIEWHIENSTDAIVICGTTGEASTMTEAEIKETIKFTVDKVQGRIPVIAGTGSN
NTRKAIELSKWAKSIGVDGLLLITPYYNKTTQKGIVEHFKAINDDVDVPIILYNVPGRTGLNILPKTLVKICDTCSNVVA
IKEASGDLSQIIEMKALLKDRIDIYSGNDDQIIPILSIGGIGVISVLANIMPKEVHDMCELYLKGKTKKALEIQLNTLSL
TNSLFIETNPIPVKTAMNIMGIDVGELRLPLCNMDESNLNLLKKELSNHALIK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=292, Percent_Identity=24.3150684931507, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13540533, Length=281, Percent_Identity=25.9786476868327, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=41.296928327645, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI1786463, Length=282, Percent_Identity=29.0780141843972, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082415, Length=276, Percent_Identity=28.2608695652174, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789620, Length=287, Percent_Identity=27.5261324041812, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CLOTE (Q891S3)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_782835.1
- ProteinModelPortal:   Q891S3
- SMR:   Q891S3
- GeneID:   1060459
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC02294
- NMPDR:   fig|212717.1.peg.2057
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- PhylomeDB:   Q891S3
- ProtClustDB:   PRK03170
- BioCyc:   CTET212717:CTC_02294-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32152; Mature: 32021

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 163-163 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFKGSGVAIVTPFCENGVNFKKLEELIEWHIENSTDAIVICGTTGEASTMTEAEIKET
CCEECCCCCEEEEEHHCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
IKFTVDKVQGRIPVIAGTGSNNTRKAIELSKWAKSIGVDGLLLITPYYNKTTQKGIVEHF
HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH
KAINDDVDVPIILYNVPGRTGLNILPKTLVKICDTCSNVVAIKEASGDLSQIIEMKALLK
HHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH
DRIDIYSGNDDQIIPILSIGGIGVISVLANIMPKEVHDMCELYLKGKTKKALEIQLNTLS
HCCEEECCCCCCEEEEEEECCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
LTNSLFIETNPIPVKTAMNIMGIDVGELRLPLCNMDESNLNLLKKELSNHALIK
ECCEEEEECCCCCHHHHHHHHCCCHHHEECCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIFKGSGVAIVTPFCENGVNFKKLEELIEWHIENSTDAIVICGTTGEASTMTEAEIKET
CEECCCCCEEEEEHHCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHH
IKFTVDKVQGRIPVIAGTGSNNTRKAIELSKWAKSIGVDGLLLITPYYNKTTQKGIVEHF
HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH
KAINDDVDVPIILYNVPGRTGLNILPKTLVKICDTCSNVVAIKEASGDLSQIIEMKALLK
HHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHH
DRIDIYSGNDDQIIPILSIGGIGVISVLANIMPKEVHDMCELYLKGKTKKALEIQLNTLS
HCCEEECCCCCCEEEEEEECCHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEEEEEEEEEE
LTNSLFIETNPIPVKTAMNIMGIDVGELRLPLCNMDESNLNLLKKELSNHALIK
ECCEEEEECCCCCHHHHHHHHCCCHHHEECCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129