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The map label for this gene is mutT [H]

Identifier: 28211543

GI number: 28211543

Start: 2032327

End: 2032746

Strand: Direct

Name: mutT [H]

Synonym: CTC01909

Alternate gene names: 28211543

Gene position: 2032327-2032746 (Clockwise)

Preceding gene: 28211538

Following gene: 28211555

Centisome position: 72.6

GC content: 30.48

Gene sequence:

>420_bases
ATGTTATTGGAGGTGAACTGCATGAAAAAATTAATTAAAGTTATTGCCGCTATTATTGAAAATGAAAACAATGAAATCTT
ATGTGCCTTAAGATCAACTAAAATGTCTCTTCCTAATCTATGGGAATTTCCTGGTGGTAAAATCGAAAAAGGTGAATCTT
TAGCTGAGGCTATAACTCGGGAAATTAAAGAAGAGCTAAATTGTACTATAAGTTTTATAGATGTTTTTAATGAAAATACT
CATGAATATGATAAATTTATAGTTAATTTAACAACTGCTAGGTGTAAATTAACAGAAGGACAGCCTACTGCTAATGAGCA
TGATAAACTTATTTGGCTTCCTAAAGAAAATTTAAGTTCTTTAAATTGGGCTCCTGCGGATATTCCTGCTGTAGATCAAT
TGATTAAAGAAAAAGTGTAG

Upstream 100 bases:

>100_bases
AGTCTTCTTTATTCAAAAGCTCTTCTTCTATAACAAATGTATATTAACCAAATGTACATTAAACTTATATTGTTGACTTA
AACAATGTTATTTAGTTAAA

Downstream 100 bases:

>100_bases
CGCCACTAATAATAGTGCTACATCCTTTTCTTTATATGCCTATGCTATTATATGATAATAACCATCCTACTTTTTTTCCT
ATTTTTATTTAGTCATCTTC

Product: 7,8-dihydro-8-oxoguanine-triphosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MLLEVNCMKKLIKVIAAIIENENNEILCALRSTKMSLPNLWEFPGGKIEKGESLAEAITREIKEELNCTISFIDVFNENT
HEYDKFIVNLTTARCKLTEGQPTANEHDKLIWLPKENLSSLNWAPADIPAVDQLIKEKV

Sequences:

>Translated_139_residues
MLLEVNCMKKLIKVIAAIIENENNEILCALRSTKMSLPNLWEFPGGKIEKGESLAEAITREIKEELNCTISFIDVFNENT
HEYDKFIVNLTTARCKLTEGQPTANEHDKLIWLPKENLSSLNWAPADIPAVDQLIKEKV
>Mature_139_residues
MLLEVNCMKKLIKVIAAIIENENNEILCALRSTKMSLPNLWEFPGGKIEKGESLAEAITREIKEELNCTISFIDVFNENT
HEYDKFIVNLTTARCKLTEGQPTANEHDKLIWLPKENLSSLNWAPADIPAVDQLIKEKV

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=126, Percent_Identity=34.9206349206349, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1786288, Length=127, Percent_Identity=33.8582677165354, Blast_Score=76, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15782; Mature: 15782

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLEVNCMKKLIKVIAAIIENENNEILCALRSTKMSLPNLWEFPGGKIEKGESLAEAITR
CEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EIKEELNCTISFIDVFNENTHEYDKFIVNLTTARCKLTEGQPTANEHDKLIWLPKENLSS
HHHHHHCCEEEEEEHHCCCCHHHHHHHEEEEHHEEEECCCCCCCCCCCCEEEECCCCCCC
LNWAPADIPAVDQLIKEKV
CCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLLEVNCMKKLIKVIAAIIENENNEILCALRSTKMSLPNLWEFPGGKIEKGESLAEAITR
CEEEHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
EIKEELNCTISFIDVFNENTHEYDKFIVNLTTARCKLTEGQPTANEHDKLIWLPKENLSS
HHHHHHCCEEEEEEHHCCCCHHHHHHHEEEEHHEEEECCCCCCCCCCCCEEEECCCCCCC
LNWAPADIPAVDQLIKEKV
CCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]