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The map label for this gene is tlpA [H]

Identifier: 28210899

GI number: 28210899

Start: 1297044

End: 1298759

Strand: Direct

Name: tlpA [H]

Synonym: CTC01211

Alternate gene names: 28210899

Gene position: 1297044-1298759 (Clockwise)

Preceding gene: 28210898

Following gene: 28210900

Centisome position: 46.34

GC content: 29.78

Gene sequence:

>1716_bases
GTGGTGAAGTTGCGTAAAAATCTAAAATTGGCACAAAAATTAATTTTAAGTTATATATTAATAGCTTTATTAATTGCTAT
TGTAGGGTTTATTGGCGTATTTAATATGCAAAAAGTAAATAATAGCGGAGAAAGACTATATCATGAAGGTTTGTTGGGAA
TAAATAGTGTAAGAAATATAAAAGAAAATTTTTTAACCATAGGAGCTAATACGCTTCTTATGGCGTCCCAGGAAAACTTA
GGGCGAGTATCTTATTTAGAAAATGATGTAAAAAAATTATTTAACCATAATAATGAGCTTTTTAACATATATGAAAAAAC
AATAATCACCAGGGAGAATAAAGGTATATATAACAGGTTGAGGAAATCTTCGAGTGACTATAGAAGTATTCATAATGAAA
TTATGAATGCAGTTAAGAAAAATGATTATAAAAAAGCTAAATTTCATGTAAATCAAATTTCTGAAGTTAGGGATATTATG
TTTAGTCAGTTAAATGAATTAATAGATTTAAATATTAAAATGTCTAGGGAAGCTAAAGCAGTAAGTACTTCAACTTATGA
TAAATCTTTTAAAATAATTATAATGTCTATAGTTTTAGGTTTTATTTTATCTATTACTATGGGATGGGTTACATCTTCTA
AAATAATAAAAAATATAAAAAAGACAGAGGATTTTGCAAAGGCTATTGGAAAAGGAGATTTAACAAAGGATATAGATATA
AAAGCAGATGATGAAATAGGAGAGATTGCTAAATCTTTAAATAATGCAAAGGAGAATATAAGGACAATTATAAATGAAAT
AGAAATCAGTGCAAGGGATATAGGAGTTGGGAGTGAAGAACTATCGGCTATTACAGAAGAAGTTTATTCAAAGGTGGAAG
CTGCAAATGAATCACTAACTGAAATAACTAAAGGTTCCCAAGATTTAAGTGCTACTGCAGAGGAGGTAAGTGCTTCTACA
GAAGATATAGGATCAACTATTAGGGAGTTAGCTCAAAGGTCTGATAATTTTCATGAAACTGTAGAGAATATAAAAAACAG
AGCGGTAGATATAAAGAATAAAGCTACAGAAGCAATTGAAAATAGTGAAATGATATACAATAAGCATGAAAAAGATTTAA
TTAAATCTATTGAAGAAGGTGAGATAGTAGAAGATATTAAGATCATGGCAGAATCTATAGGAAATATTGCAGAACAAACC
AATTTACTTGCTTTAAATGCTGCAATTGAAGCAGCTAGAGCAGGAGAGCATGGAAGAGGGTTTGCTGTGGTTGCAGAAGA
AGTTCGAAAGCTTGCAGAGGAGTCTACTAACGCTGTAGCAGAGATTCAAACTATGGTAAATAAAATACAAGGTGCTTTTT
ATAGTTTATCTGAAAATGGTAAAAGTATACTTGAATTTATGGAAACTAATGTTAAACCAACTTATGAATTATTAAAAGAT
ACAGGGGAAAATTATGAAATAGATGCTGAAATGATAGAAGAAATAATGGAGTACATATCACTGTCTTCAAATCAAATATC
AGCATCTATTGAACAAGTAAATGTAGCTATACGAAATGTTTCAGACACAGCAGAGGAATCGGCAGCAGGATCTAAAGAAA
TAATGGCAGGAGCTAATGAGACAGCTATAGCAATGGAAGAGGTATCAACTTCTACAGAAACACAATCTGAATTAGCAAGT
AAACTTAATAATGTAATTAGTAAATTTAAAATATAA

Upstream 100 bases:

>100_bases
GCAAAGGTGGATTTGGCTCTACAGGAAAATAAAGCATATAAATATGAGAAGGTTATTTTATTTAATTTATATTTAGTTTT
AGAATGTTAAGGGGGAGACA

Downstream 100 bases:

>100_bases
TATTTATGTATTGAATAAAGAAAAGGTAAAGTATATTATAAAATGTGTAGTATTAAAATAGTAAAGTTTAAAAACTTTAC
TATTTTAATTTTATGGTAAA

Product: methyl-accepting chemotaxis protein tlpA

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MVKLRKNLKLAQKLILSYILIALLIAIVGFIGVFNMQKVNNSGERLYHEGLLGINSVRNIKENFLTIGANTLLMASQENL
GRVSYLENDVKKLFNHNNELFNIYEKTIITRENKGIYNRLRKSSSDYRSIHNEIMNAVKKNDYKKAKFHVNQISEVRDIM
FSQLNELIDLNIKMSREAKAVSTSTYDKSFKIIIMSIVLGFILSITMGWVTSSKIIKNIKKTEDFAKAIGKGDLTKDIDI
KADDEIGEIAKSLNNAKENIRTIINEIEISARDIGVGSEELSAITEEVYSKVEAANESLTEITKGSQDLSATAEEVSAST
EDIGSTIRELAQRSDNFHETVENIKNRAVDIKNKATEAIENSEMIYNKHEKDLIKSIEEGEIVEDIKIMAESIGNIAEQT
NLLALNAAIEAARAGEHGRGFAVVAEEVRKLAEESTNAVAEIQTMVNKIQGAFYSLSENGKSILEFMETNVKPTYELLKD
TGENYEIDAEMIEEIMEYISLSSNQISASIEQVNVAIRNVSDTAEESAAGSKEIMAGANETAIAMEEVSTSTETQSELAS
KLNNVISKFKI

Sequences:

>Translated_571_residues
MVKLRKNLKLAQKLILSYILIALLIAIVGFIGVFNMQKVNNSGERLYHEGLLGINSVRNIKENFLTIGANTLLMASQENL
GRVSYLENDVKKLFNHNNELFNIYEKTIITRENKGIYNRLRKSSSDYRSIHNEIMNAVKKNDYKKAKFHVNQISEVRDIM
FSQLNELIDLNIKMSREAKAVSTSTYDKSFKIIIMSIVLGFILSITMGWVTSSKIIKNIKKTEDFAKAIGKGDLTKDIDI
KADDEIGEIAKSLNNAKENIRTIINEIEISARDIGVGSEELSAITEEVYSKVEAANESLTEITKGSQDLSATAEEVSAST
EDIGSTIRELAQRSDNFHETVENIKNRAVDIKNKATEAIENSEMIYNKHEKDLIKSIEEGEIVEDIKIMAESIGNIAEQT
NLLALNAAIEAARAGEHGRGFAVVAEEVRKLAEESTNAVAEIQTMVNKIQGAFYSLSENGKSILEFMETNVKPTYELLKD
TGENYEIDAEMIEEIMEYISLSSNQISASIEQVNVAIRNVSDTAEESAAGSKEIMAGANETAIAMEEVSTSTETQSELAS
KLNNVISKFKI
>Mature_571_residues
MVKLRKNLKLAQKLILSYILIALLIAIVGFIGVFNMQKVNNSGERLYHEGLLGINSVRNIKENFLTIGANTLLMASQENL
GRVSYLENDVKKLFNHNNELFNIYEKTIITRENKGIYNRLRKSSSDYRSIHNEIMNAVKKNDYKKAKFHVNQISEVRDIM
FSQLNELIDLNIKMSREAKAVSTSTYDKSFKIIIMSIVLGFILSITMGWVTSSKIIKNIKKTEDFAKAIGKGDLTKDIDI
KADDEIGEIAKSLNNAKENIRTIINEIEISARDIGVGSEELSAITEEVYSKVEAANESLTEITKGSQDLSATAEEVSAST
EDIGSTIRELAQRSDNFHETVENIKNRAVDIKNKATEAIENSEMIYNKHEKDLIKSIEEGEIVEDIKIMAESIGNIAEQT
NLLALNAAIEAARAGEHGRGFAVVAEEVRKLAEESTNAVAEIQTMVNKIQGAFYSLSENGKSILEFMETNVKPTYELLKD
TGENYEIDAEMIEEIMEYISLSSNQISASIEQVNVAIRNVSDTAEESAAGSKEIMAGANETAIAMEEVSTSTETQSELAS
KLNNVISKFKI

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=394, Percent_Identity=25.6345177664975, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI2367378, Length=346, Percent_Identity=28.0346820809249, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787690, Length=387, Percent_Identity=25.0645994832041, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788195, Length=323, Percent_Identity=27.5541795665635, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1789453, Length=275, Percent_Identity=26.9090909090909, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 63501; Mature: 63501

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLRKNLKLAQKLILSYILIALLIAIVGFIGVFNMQKVNNSGERLYHEGLLGINSVRNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KENFLTIGANTLLMASQENLGRVSYLENDVKKLFNHNNELFNIYEKTIITRENKGIYNRL
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHH
RKSSSDYRSIHNEIMNAVKKNDYKKAKFHVNQISEVRDIMFSQLNELIDLNIKMSREAKA
HCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHH
VSTSTYDKSFKIIIMSIVLGFILSITMGWVTSSKIIKNIKKTEDFAKAIGKGDLTKDIDI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KADDEIGEIAKSLNNAKENIRTIINEIEISARDIGVGSEELSAITEEVYSKVEAANESLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EITKGSQDLSATAEEVSASTEDIGSTIRELAQRSDNFHETVENIKNRAVDIKNKATEAIE
HHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
NSEMIYNKHEKDLIKSIEEGEIVEDIKIMAESIGNIAEQTNLLALNAAIEAARAGEHGRG
CCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FAVVAEEVRKLAEESTNAVAEIQTMVNKIQGAFYSLSENGKSILEFMETNVKPTYELLKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHC
TGENYEIDAEMIEEIMEYISLSSNQISASIEQVNVAIRNVSDTAEESAAGSKEIMAGANE
CCCCCEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCC
TAIAMEEVSTSTETQSELASKLNNVISKFKI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVKLRKNLKLAQKLILSYILIALLIAIVGFIGVFNMQKVNNSGERLYHEGLLGINSVRNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KENFLTIGANTLLMASQENLGRVSYLENDVKKLFNHNNELFNIYEKTIITRENKGIYNRL
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHH
RKSSSDYRSIHNEIMNAVKKNDYKKAKFHVNQISEVRDIMFSQLNELIDLNIKMSREAKA
HCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHH
VSTSTYDKSFKIIIMSIVLGFILSITMGWVTSSKIIKNIKKTEDFAKAIGKGDLTKDIDI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KADDEIGEIAKSLNNAKENIRTIINEIEISARDIGVGSEELSAITEEVYSKVEAANESLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EITKGSQDLSATAEEVSASTEDIGSTIRELAQRSDNFHETVENIKNRAVDIKNKATEAIE
HHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHH
NSEMIYNKHEKDLIKSIEEGEIVEDIKIMAESIGNIAEQTNLLALNAAIEAARAGEHGRG
CCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FAVVAEEVRKLAEESTNAVAEIQTMVNKIQGAFYSLSENGKSILEFMETNVKPTYELLKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHC
TGENYEIDAEMIEEIMEYISLSSNQISASIEQVNVAIRNVSDTAEESAAGSKEIMAGANE
CCCCCEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCCC
TAIAMEEVSTSTETQSELASKLNNVISKFKI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]