Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 28210875

GI number: 28210875

Start: 1264288

End: 1265496

Strand: Direct

Name: napA [H]

Synonym: CTC01183

Alternate gene names: 28210875

Gene position: 1264288-1265496 (Clockwise)

Preceding gene: 28210874

Following gene: 28210877

Centisome position: 45.17

GC content: 29.78

Gene sequence:

>1209_bases
ATGGATCCATTAAATTTTATCTTAAGTTTAGCAATTATACTGTTAAGCACTAAATTATTGGGGATTTTAGCACAGCGTTT
TCATATGCCTCAAGTAGTAGGTGCACTTTTAGCAGGTCTTATCTTAGGACCTTCTTGTCTTGCTATAGTTAATAAAACAG
CTACAATAGCTGAATTATCACAACTTGGAGTGATTCTTCTTATGTTTAGTGCAGGACTTGAAACAGATTTAGAGGAGCTT
AAAAAATGCGGAAAAGCTTCTTTTATAATTGCACTTTTAGGATTAATAATTTCATTAATTGGTGGCTTTTTAATAGCAGG
TATATTTAATAATCCAGGTAAAATTTTAACTGGTGATTTTCATAAAGTATTAGAAAACATATTTATTGGAATAATACTTA
CAGCTACATCTGTTAGTATTACAGTAGAAACTCTTCAGGAAATGGGTAAATTAAAAACAGCCTCTGGTACTGCAATACTT
GGAGCAGCTATAATAGATGATATTTTGGGAATAATAGCTTTAACTATAGTAACTAGTTTAGCAGATTCATCTGTAAAATT
ATCTTTTGTTCTTTTAAAAATAGTAGCTTTTTTTATTATTGCTTTTTTTATAAGTTTTGTTTTTGTTTCACTTTTTAAAA
ATATGTGGAATAAAAAGGGCGAGGCAAGAAGAGTTCCTATATTAGCTTTAGGATTTTGTCTTATAATGGCATTTGCAGCT
GAACGTTTTTTTGGTGTTGCAGATATAACAGGTGCCTATGTAGCTGGAATTATTATTTCAAGAACACCTGCTTGTGAGTA
TATTGAGAAAAAGATAGAGGTAGTATCATTTTTGTTCTTATCTCCAATTTTTTTTGCCAATATAGGTATAAGCACTACTA
TAGATCATATGAATAGTACCATGATTATGTTTACTATAGCATTAACAGTTATTGCAATAGTAACAAAGATATATGGATGT
AAATTTGGAGCAAGAATTTGTGGATATACCAAAGAAGAATCTCTTCAAATAGGTATTGGAATGGTATCTAGAGGCGAAGT
TGCTTTAATAATTGCAAATATAGGAGCTTCTACGAATATATTAGAAAGTAAATTCTTTGCTCCTGTTATATTAATGGTAA
TTATTACAACTCTTATTACTCCGGTACTTTTAAAATTAGTATATTCGAAAGATGTAGAGCATAAAAATGTTTTACATAAG
GCTTCCTAG

Upstream 100 bases:

>100_bases
AAAATGTTGTATGAACTTGAAATATATGATAAACTATGTAAATAGAAAACTTTACACAAAGTTCAACACAAAACCAAATA
TAAAAGGAGATGTACTATAA

Downstream 100 bases:

>100_bases
AATAAAAATGTACAGTATCTATTTAAATACTGTACATTTTTATTTTAGTGTGCCCAGCATGGGCAACAACTTGATGGTGA
AAGTCCGTTGTGGCTTGTAG

Product: Na(+)/H(+) antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDPLNFILSLAIILLSTKLLGILAQRFHMPQVVGALLAGLILGPSCLAIVNKTATIAELSQLGVILLMFSAGLETDLEEL
KKCGKASFIIALLGLIISLIGGFLIAGIFNNPGKILTGDFHKVLENIFIGIILTATSVSITVETLQEMGKLKTASGTAIL
GAAIIDDILGIIALTIVTSLADSSVKLSFVLLKIVAFFIIAFFISFVFVSLFKNMWNKKGEARRVPILALGFCLIMAFAA
ERFFGVADITGAYVAGIIISRTPACEYIEKKIEVVSFLFLSPIFFANIGISTTIDHMNSTMIMFTIALTVIAIVTKIYGC
KFGARICGYTKEESLQIGIGMVSRGEVALIIANIGASTNILESKFFAPVILMVIITTLITPVLLKLVYSKDVEHKNVLHK
AS

Sequences:

>Translated_402_residues
MDPLNFILSLAIILLSTKLLGILAQRFHMPQVVGALLAGLILGPSCLAIVNKTATIAELSQLGVILLMFSAGLETDLEEL
KKCGKASFIIALLGLIISLIGGFLIAGIFNNPGKILTGDFHKVLENIFIGIILTATSVSITVETLQEMGKLKTASGTAIL
GAAIIDDILGIIALTIVTSLADSSVKLSFVLLKIVAFFIIAFFISFVFVSLFKNMWNKKGEARRVPILALGFCLIMAFAA
ERFFGVADITGAYVAGIIISRTPACEYIEKKIEVVSFLFLSPIFFANIGISTTIDHMNSTMIMFTIALTVIAIVTKIYGC
KFGARICGYTKEESLQIGIGMVSRGEVALIIANIGASTNILESKFFAPVILMVIITTLITPVLLKLVYSKDVEHKNVLHK
AS
>Mature_402_residues
MDPLNFILSLAIILLSTKLLGILAQRFHMPQVVGALLAGLILGPSCLAIVNKTATIAELSQLGVILLMFSAGLETDLEEL
KKCGKASFIIALLGLIISLIGGFLIAGIFNNPGKILTGDFHKVLENIFIGIILTATSVSITVETLQEMGKLKTASGTAIL
GAAIIDDILGIIALTIVTSLADSSVKLSFVLLKIVAFFIIAFFISFVFVSLFKNMWNKKGEARRVPILALGFCLIMAFAA
ERFFGVADITGAYVAGIIISRTPACEYIEKKIEVVSFLFLSPIFFANIGISTTIDHMNSTMIMFTIALTVIAIVTKIYGC
KFGARICGYTKEESLQIGIGMVSRGEVALIIANIGASTNILESKFFAPVILMVIITTLITPVLLKLVYSKDVEHKNVLHK
AS

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=385, Percent_Identity=23.6363636363636, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786232, Length=398, Percent_Identity=25.3768844221106, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789749, Length=398, Percent_Identity=23.3668341708543, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322367, Length=405, Percent_Identity=28.641975308642, Blast_Score=126, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43186; Mature: 43186

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPLNFILSLAIILLSTKLLGILAQRFHMPQVVGALLAGLILGPSCLAIVNKTATIAELS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
QLGVILLMFSAGLETDLEELKKCGKASFIIALLGLIISLIGGFLIAGIFNNPGKILTGDF
HHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHH
HKVLENIFIGIILTATSVSITVETLQEMGKLKTASGTAILGAAIIDDILGIIALTIVTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ADSSVKLSFVLLKIVAFFIIAFFISFVFVSLFKNMWNKKGEARRVPILALGFCLIMAFAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ERFFGVADITGAYVAGIIISRTPACEYIEKKIEVVSFLFLSPIFFANIGISTTIDHMNST
HHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCH
MIMFTIALTVIAIVTKIYGCKFGARICGYTKEESLQIGIGMVSRGEVALIIANIGASTNI
HHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCEEEEEEEECCCCEEEEEEECCCCCHH
LESKFFAPVILMVIITTLITPVLLKLVYSKDVEHKNVLHKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure
MDPLNFILSLAIILLSTKLLGILAQRFHMPQVVGALLAGLILGPSCLAIVNKTATIAELS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
QLGVILLMFSAGLETDLEELKKCGKASFIIALLGLIISLIGGFLIAGIFNNPGKILTGDF
HHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHH
HKVLENIFIGIILTATSVSITVETLQEMGKLKTASGTAILGAAIIDDILGIIALTIVTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ADSSVKLSFVLLKIVAFFIIAFFISFVFVSLFKNMWNKKGEARRVPILALGFCLIMAFAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
ERFFGVADITGAYVAGIIISRTPACEYIEKKIEVVSFLFLSPIFFANIGISTTIDHMNST
HHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCH
MIMFTIALTVIAIVTKIYGCKFGARICGYTKEESLQIGIGMVSRGEVALIIANIGASTNI
HHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCEEEEEEEECCCCEEEEEEECCCCCHH
LESKFFAPVILMVIITTLITPVLLKLVYSKDVEHKNVLHKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]