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The map label for this gene is atpA1

Identifier: 28210705

GI number: 28210705

Start: 1069237

End: 1071015

Strand: Direct

Name: atpA1

Synonym: CTC00999

Alternate gene names: 28210705

Gene position: 1069237-1071015 (Clockwise)

Preceding gene: 28210704

Following gene: 28210706

Centisome position: 38.2

GC content: 35.86

Gene sequence:

>1779_bases
GTGGACTTGAAGACTGGTAGAGTTGTAAAAGTGTCAGGACCTTTAGTAGTTGCTGAAGGTATGGAAGAAGCTAATCTATT
TGACGTTGTAAGAGTTGGAGATGAACGTCTTATAGGAGAAATAATAGAAATGAGAGAAGATAAAGCTTCTATTCAGGTTT
ATGAAGAAACTTCAGGTCTTGGTCCTGGAGCACCAGTTGTAACAACTGGAGCACCTTTAAGTGTTGAATTAGGGCCAGGA
TTAATAGAAGCTATGTTTGATGGAATTCAAAGACCTCTTGATGCAATAGAAGCTAAAGCAGGAGATTTTATTACAAGAGG
TATAGATGTGCCATCCTTAAGTAGAGAAAAAGTTTGGCATTTTAACCCCACTAAAAAAGCTGGAGATAAAGTAGAAACGG
GAGATATATTAGGTTTAGTTCAAGAGACTTCCGTTATAGAACACAGAATTATGGTACCTCCTGGAATAAAAGGTGAGATA
ATTTCTTTAAATGAAGGAGATTATACAGTAATTGATAAAATAGGAGAAATAAAAACAGATAAAGGTATAGAAGATTTAAC
ACTTATGCAGAAATGGCCTGTAAGAAGAGGAAGACCTTATAAAAGAAAGCTAAATCCTAGTGCGCCTATGGTAACTGGTC
AAAGAGTAGTAGATACATTTTTCCCAGTTACAAAAGGAGGAACTGCGTGTGTTCCGGGACCTTTTGGAAGTGGTAAAACC
GTTGTTCAACACCAACTTGCAAAATGGGCTGATGCTCAAATAGTTGTGTACATAGGATGTGGAGAACGTGGAAATGAAAT
GACAGACGTTTTAAATGAGTTCCCAGAATTAAAGGATCCTAAAACCGGGGAATCTTTAATGAAAAGAACTGTGTTAATAG
CAAATACATCTAATATGCCTGTTGCAGCTAGAGAAGCATCTATATATACTGGTATAACAATAGGGGAATATTTTAGAGAT
ATGGGATATTCAATAGCACTAATGGCAGATTCGACTTCTAGATGGGCAGAGGCTCTAAGAGAAATGTCTGGAAGACTAGA
GGAGATGCCAGGTGAAGAAGGTTATCCAGCTTATTTAGGATCTAGATTAGCAGAGTTCTATGAAAGAGCAGGTAATGTTA
TATGTTTAGGTCAGGATGGAAGAGAAGGAGCATTAACAGCTATAGGAGCAGTTTCACCTCCAGGGGGAGACTTATCTGAA
CCTGTAACTCAGGCCACATTAAGAATAGTAAAAGTTTTCTGGGGACTGGATTCACAATTGGCTTATAGAAGGCACTTCCC
TGCTATAAACTGGTTAAATTCTTATTCATTATATTTGGATAAAGTTGGTCCTTGGATGAATGAAAATGTAGCAGAAGATT
GGGTAGAATTAAGACAAAAAGCTATGGCTCTTTTACAAGAAGAAGCTAATTTGCAAGAGATAGCCAGACTTGTTGGTATT
GATGCATTATCAGAAGAGGATAGACTTAAACTAGAAGTAGCTAAGTCACTAAGGGAAGATTATTTACAACAAAATGCTTT
CCATGATGTTGATACCTATGCACCATTAAATAAACAATATAGAATGTTAAAAGCCGTTCTTCAATTTGGAGATGAAGCAA
GAAAAGCATTGGAATCTGGTGTTTATTTAAAAGATATATTAAACTTACCAGTTAGAGATAAAATAGCTAGAGCAAAATAT
ATAGATGAAAAAGATATATTAAGTATAGATGAAATATCAAAAGAATTAACAAAAGACATAGAAGATCTAATCAGCAAAGG
GGGGATTTTAGATGCTTAA

Upstream 100 bases:

>100_bases
TATTCCAAGTAATCAAGGTTCACTTAATATAGGTCTAAAAAGAATTAGTGATAATGTAGAAAAGGCAGTTGGAGTTAATA
TTTTATAGGAAGGTAGGTAG

Downstream 100 bases:

>100_bases
AGAATATAGAACAGTTAAAGAAGTAGTTGGTCCTCTAATGCTTGTAGATGGAGTAGAAAATGTAAAGTTTGATGAGCTAG
TAGAAATAGAAATTCAAACT

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A 1

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MDLKTGRVVKVSGPLVVAEGMEEANLFDVVRVGDERLIGEIIEMREDKASIQVYEETSGLGPGAPVVTTGAPLSVELGPG
LIEAMFDGIQRPLDAIEAKAGDFITRGIDVPSLSREKVWHFNPTKKAGDKVETGDILGLVQETSVIEHRIMVPPGIKGEI
ISLNEGDYTVIDKIGEIKTDKGIEDLTLMQKWPVRRGRPYKRKLNPSAPMVTGQRVVDTFFPVTKGGTACVPGPFGSGKT
VVQHQLAKWADAQIVVYIGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIGEYFRD
MGYSIALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLGSRLAEFYERAGNVICLGQDGREGALTAIGAVSPPGGDLSE
PVTQATLRIVKVFWGLDSQLAYRRHFPAINWLNSYSLYLDKVGPWMNENVAEDWVELRQKAMALLQEEANLQEIARLVGI
DALSEEDRLKLEVAKSLREDYLQQNAFHDVDTYAPLNKQYRMLKAVLQFGDEARKALESGVYLKDILNLPVRDKIARAKY
IDEKDILSIDEISKELTKDIEDLISKGGILDA

Sequences:

>Translated_592_residues
MDLKTGRVVKVSGPLVVAEGMEEANLFDVVRVGDERLIGEIIEMREDKASIQVYEETSGLGPGAPVVTTGAPLSVELGPG
LIEAMFDGIQRPLDAIEAKAGDFITRGIDVPSLSREKVWHFNPTKKAGDKVETGDILGLVQETSVIEHRIMVPPGIKGEI
ISLNEGDYTVIDKIGEIKTDKGIEDLTLMQKWPVRRGRPYKRKLNPSAPMVTGQRVVDTFFPVTKGGTACVPGPFGSGKT
VVQHQLAKWADAQIVVYIGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIGEYFRD
MGYSIALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLGSRLAEFYERAGNVICLGQDGREGALTAIGAVSPPGGDLSE
PVTQATLRIVKVFWGLDSQLAYRRHFPAINWLNSYSLYLDKVGPWMNENVAEDWVELRQKAMALLQEEANLQEIARLVGI
DALSEEDRLKLEVAKSLREDYLQQNAFHDVDTYAPLNKQYRMLKAVLQFGDEARKALESGVYLKDILNLPVRDKIARAKY
IDEKDILSIDEISKELTKDIEDLISKGGILDA
>Mature_592_residues
MDLKTGRVVKVSGPLVVAEGMEEANLFDVVRVGDERLIGEIIEMREDKASIQVYEETSGLGPGAPVVTTGAPLSVELGPG
LIEAMFDGIQRPLDAIEAKAGDFITRGIDVPSLSREKVWHFNPTKKAGDKVETGDILGLVQETSVIEHRIMVPPGIKGEI
ISLNEGDYTVIDKIGEIKTDKGIEDLTLMQKWPVRRGRPYKRKLNPSAPMVTGQRVVDTFFPVTKGGTACVPGPFGSGKT
VVQHQLAKWADAQIVVYIGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMPVAAREASIYTGITIGEYFRD
MGYSIALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLGSRLAEFYERAGNVICLGQDGREGALTAIGAVSPPGGDLSE
PVTQATLRIVKVFWGLDSQLAYRRHFPAINWLNSYSLYLDKVGPWMNENVAEDWVELRQKAMALLQEEANLQEIARLVGI
DALSEEDRLKLEVAKSLREDYLQQNAFHDVDTYAPLNKQYRMLKAVLQFGDEARKALESGVYLKDILNLPVRDKIARAKY
IDEKDILSIDEISKELTKDIEDLISKGGILDA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=540, Percent_Identity=53.7037037037037, Blast_Score=596, Evalue=1e-170,
Organism=Homo sapiens, GI32189394, Length=369, Percent_Identity=27.3712737127371, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI19913426, Length=241, Percent_Identity=29.045643153527, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI19913428, Length=241, Percent_Identity=28.6307053941909, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI50345984, Length=280, Percent_Identity=26.4285714285714, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4757810, Length=280, Percent_Identity=26.4285714285714, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1790170, Length=396, Percent_Identity=28.2828282828283, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788251, Length=318, Percent_Identity=27.6729559748428, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790172, Length=232, Percent_Identity=27.1551724137931, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=540, Percent_Identity=52.962962962963, Blast_Score=576, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25144756, Length=301, Percent_Identity=30.2325581395349, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=240, Percent_Identity=31.25, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=241, Percent_Identity=29.4605809128631, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988080, Length=286, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71988063, Length=286, Percent_Identity=26.9230769230769, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71988074, Length=286, Percent_Identity=26.9230769230769, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320016, Length=290, Percent_Identity=53.448275862069, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6322581, Length=379, Percent_Identity=29.8153034300792, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=241, Percent_Identity=30.2904564315353, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319370, Length=235, Percent_Identity=27.2340425531915, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583988, Length=541, Percent_Identity=54.5286506469501, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24583986, Length=541, Percent_Identity=54.5286506469501, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24583984, Length=541, Percent_Identity=54.5286506469501, Blast_Score=605, Evalue=1e-173,
Organism=Drosophila melanogaster, GI20129479, Length=534, Percent_Identity=55.0561797752809, Blast_Score=593, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24583992, Length=539, Percent_Identity=53.4322820037106, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI28574560, Length=299, Percent_Identity=32.1070234113712, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24638766, Length=332, Percent_Identity=28.9156626506024, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI281361666, Length=241, Percent_Identity=28.2157676348548, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646341, Length=241, Percent_Identity=28.2157676348548, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136796, Length=241, Percent_Identity=28.2157676348548, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24658560, Length=281, Percent_Identity=27.0462633451957, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA1_CLOTE (Q896K4)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781649.1
- ProteinModelPortal:   Q896K4
- SMR:   Q896K4
- GeneID:   1059389
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00999
- NMPDR:   fig|212717.1.peg.871
- HOGENOM:   HBG288114
- OMA:   KITWNVI
- ProtClustDB:   PRK04192
- BioCyc:   CTET212717:CTC_00999-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 65365; Mature: 65365

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKTGRVVKVSGPLVVAEGMEEANLFDVVRVGDERLIGEIIEMREDKASIQVYEETSGL
CCCCCCCEEEECCCEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCC
GPGAPVVTTGAPLSVELGPGLIEAMFDGIQRPLDAIEAKAGDFITRGIDVPSLSREKVWH
CCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEE
FNPTKKAGDKVETGDILGLVQETSVIEHRIMVPPGIKGEIISLNEGDYTVIDKIGEIKTD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCHHHHHHCCCCCC
KGIEDLTLMQKWPVRRGRPYKRKLNPSAPMVTGQRVVDTFFPVTKGGTACVPGPFGSGKT
CCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCHH
VVQHQLAKWADAQIVVYIGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMP
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITIGEYFRDMGYSIALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLG
EEECCCCEEECCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRLAEFYERAGNVICLGQDGREGALTAIGAVSPPGGDLSEPVTQATLRIVKVFWGLDSQL
HHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
AYRRHFPAINWLNSYSLYLDKVGPWMNENVAEDWVELRQKAMALLQEEANLQEIARLVGI
HHHHCCCCHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DALSEEDRLKLEVAKSLREDYLQQNAFHDVDTYAPLNKQYRMLKAVLQFGDEARKALESG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCC
VYLKDILNLPVRDKIARAKYIDEKDILSIDEISKELTKDIEDLISKGGILDA
CHHHHHHCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLKTGRVVKVSGPLVVAEGMEEANLFDVVRVGDERLIGEIIEMREDKASIQVYEETSGL
CCCCCCCEEEECCCEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCC
GPGAPVVTTGAPLSVELGPGLIEAMFDGIQRPLDAIEAKAGDFITRGIDVPSLSREKVWH
CCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEE
FNPTKKAGDKVETGDILGLVQETSVIEHRIMVPPGIKGEIISLNEGDYTVIDKIGEIKTD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCCHHHHHHCCCCCC
KGIEDLTLMQKWPVRRGRPYKRKLNPSAPMVTGQRVVDTFFPVTKGGTACVPGPFGSGKT
CCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEECCCCCCCCHH
VVQHQLAKWADAQIVVYIGCGERGNEMTDVLNEFPELKDPKTGESLMKRTVLIANTSNMP
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITIGEYFRDMGYSIALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLG
EEECCCCEEECCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRLAEFYERAGNVICLGQDGREGALTAIGAVSPPGGDLSEPVTQATLRIVKVFWGLDSQL
HHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
AYRRHFPAINWLNSYSLYLDKVGPWMNENVAEDWVELRQKAMALLQEEANLQEIARLVGI
HHHHCCCCHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
DALSEEDRLKLEVAKSLREDYLQQNAFHDVDTYAPLNKQYRMLKAVLQFGDEARKALESG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCC
VYLKDILNLPVRDKIARAKYIDEKDILSIDEISKELTKDIEDLISKGGILDA
CHHHHHHCCCHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129