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The map label for this gene is hom [H]

Identifier: 28210599

GI number: 28210599

Start: 940339

End: 941379

Strand: Direct

Name: hom [H]

Synonym: CTC00886

Alternate gene names: 28210599

Gene position: 940339-941379 (Clockwise)

Preceding gene: 28210598

Following gene: 28210600

Centisome position: 33.59

GC content: 29.2

Gene sequence:

>1041_bases
TTGGAATTGGGGGATTTTATGGAAAAAAGGATATTAATATCAGGATATGGTAATATTGGTAGAGAAATAGTGAAACTAAT
ACAGAAAAATAAGGAATATTATAAATATATGTATAATTTAGACCTTGTGATATGCGGTATTGTAGGGAGTAATGGATGTA
TTTTTCAAGATTTAGGATTAAATTTAAATATACTGTTAGAGTGCGGAAAAGGTTCAGAGGCAATTATTAATTATTCAAAG
ATATATATTGATACTTTTTATAATTATCCTGTATTTGAGGGGGATATATTTATAGAGTGCAGTAAAAGTGACATAATGAC
AGAAGGTCACTCATTTGAATATATAATAAATGCCATAGATAGAGAGATGGATATTGTATTAGTATCCAAAGGAGCATTGA
CTAATAATTTTAGTTATCTTAAGGAACTTACTAAAAATAAAAATATAAAACTTAAATACAGTGGTGCTACTTCGGCAGCA
TTACCAACTATAGATACTGCTTATTATAGTTTAGCAGGGGCTAATATTACATCTATATATGGAATATTAAATGGAACAAC
TAATTATATTCTTACGAAAATGTTTGAAGAGTATTGTTCTTTTGAAGAGGCGCTACAAGAAGCAAAGGAGCAAGGGATTG
CAGAAAGTGATGCTTCTTTGGATATAGAAGGAATTGATAGTGCTAGTAAAATGCTTATAATATCAAATAGTGTATTAAAT
ACTGACTTTAGTTTAGAGGATGTAAAAATTCAGGGGATACAAAATATAGATAAAAAGTATATAAAAAGAGCTAAAAAAGA
GGACAAGGTAATAAAACTCATAAGTGAAGTATTTTATGAGAATGGTGAAGCCAACATAAAAGTGTCACCAAAGCTAATAG
AAAAAAACAATGAATTGAATTTTGTAAATGGAACAAATAAAGGTATAGTATTTTGTACCGAAGAAATGGGAAATATATTT
GTTTTTGGAGGGGCGTCAAGTCCTAAAGGAGCAGCTGCTGCAGCGGTGAAAGATGTTATAAATATTTTAAAAGAGAGTTA
A

Upstream 100 bases:

>100_bases
TATATGAATAAAAAAGAAATCATTAATAAAATGGTAATAATATGATATAATTAGAGAAAAAATGAAAAATAAAATAAAGA
AAACGTTTTCTTAAAATTGC

Downstream 100 bases:

>100_bases
TTTAATCTTTACTACACTAATTATATTATATCAAAAGGGGGTGATATGAGTTTTAGCGAGGTATATATTTTTTAGATTAA
TATTGTGAGGGAGGGGATTA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MELGDFMEKRILISGYGNIGREIVKLIQKNKEYYKYMYNLDLVICGIVGSNGCIFQDLGLNLNILLECGKGSEAIINYSK
IYIDTFYNYPVFEGDIFIECSKSDIMTEGHSFEYIINAIDREMDIVLVSKGALTNNFSYLKELTKNKNIKLKYSGATSAA
LPTIDTAYYSLAGANITSIYGILNGTTNYILTKMFEEYCSFEEALQEAKEQGIAESDASLDIEGIDSASKMLIISNSVLN
TDFSLEDVKIQGIQNIDKKYIKRAKKEDKVIKLISEVFYENGEANIKVSPKLIEKNNELNFVNGTNKGIVFCTEEMGNIF
VFGGASSPKGAAAAAVKDVINILKES

Sequences:

>Translated_346_residues
MELGDFMEKRILISGYGNIGREIVKLIQKNKEYYKYMYNLDLVICGIVGSNGCIFQDLGLNLNILLECGKGSEAIINYSK
IYIDTFYNYPVFEGDIFIECSKSDIMTEGHSFEYIINAIDREMDIVLVSKGALTNNFSYLKELTKNKNIKLKYSGATSAA
LPTIDTAYYSLAGANITSIYGILNGTTNYILTKMFEEYCSFEEALQEAKEQGIAESDASLDIEGIDSASKMLIISNSVLN
TDFSLEDVKIQGIQNIDKKYIKRAKKEDKVIKLISEVFYENGEANIKVSPKLIEKNNELNFVNGTNKGIVFCTEEMGNIF
VFGGASSPKGAAAAAVKDVINILKES
>Mature_346_residues
MELGDFMEKRILISGYGNIGREIVKLIQKNKEYYKYMYNLDLVICGIVGSNGCIFQDLGLNLNILLECGKGSEAIINYSK
IYIDTFYNYPVFEGDIFIECSKSDIMTEGHSFEYIINAIDREMDIVLVSKGALTNNFSYLKELTKNKNIKLKYSGATSAA
LPTIDTAYYSLAGANITSIYGILNGTTNYILTKMFEEYCSFEEALQEAKEQGIAESDASLDIEGIDSASKMLIISNSVLN
TDFSLEDVKIQGIQNIDKKYIKRAKKEDKVIKLISEVFYENGEANIKVSPKLIEKNNELNFVNGTNKGIVFCTEEMGNIF
VFGGASSPKGAAAAAVKDVINILKES

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=290, Percent_Identity=24.8275862068966, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 38444; Mature: 38444

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGDFMEKRILISGYGNIGREIVKLIQKNKEYYKYMYNLDLVICGIVGSNGCIFQDLGL
CCHHHHHHHEEEEECCCHHHHHHHHHHHHCHHHHHHHEECEEEEEEEECCCCCEEEECCC
NLNILLECGKGSEAIINYSKIYIDTFYNYPVFEGDIFIECSKSDIMTEGHSFEYIINAID
CEEEEEEECCCCCCEEEEEEEEEEEECCCCEECCCEEEEECCCCCCCCCCCHHHHHHHHC
REMDIVLVSKGALTNNFSYLKELTKNKNIKLKYSGATSAALPTIDTAYYSLAGANITSIY
CCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHH
GILNGTTNYILTKMFEEYCSFEEALQEAKEQGIAESDASLDIEGIDSASKMLIISNSVLN
EECCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCEEC
TDFSLEDVKIQGIQNIDKKYIKRAKKEDKVIKLISEVFYENGEANIKVSPKLIEKNNELN
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHCCCCCCEE
FVNGTNKGIVFCTEEMGNIFVFGGASSPKGAAAAAVKDVINILKES
EEECCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELGDFMEKRILISGYGNIGREIVKLIQKNKEYYKYMYNLDLVICGIVGSNGCIFQDLGL
CCHHHHHHHEEEEECCCHHHHHHHHHHHHCHHHHHHHEECEEEEEEEECCCCCEEEECCC
NLNILLECGKGSEAIINYSKIYIDTFYNYPVFEGDIFIECSKSDIMTEGHSFEYIINAID
CEEEEEEECCCCCCEEEEEEEEEEEECCCCEECCCEEEEECCCCCCCCCCCHHHHHHHHC
REMDIVLVSKGALTNNFSYLKELTKNKNIKLKYSGATSAALPTIDTAYYSLAGANITSIY
CCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHH
GILNGTTNYILTKMFEEYCSFEEALQEAKEQGIAESDASLDIEGIDSASKMLIISNSVLN
EECCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEEECCEEC
TDFSLEDVKIQGIQNIDKKYIKRAKKEDKVIKLISEVFYENGEANIKVSPKLIEKNNELN
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHCCCCCCEE
FVNGTNKGIVFCTEEMGNIFVFGGASSPKGAAAAAVKDVINILKES
EEECCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]