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The map label for this gene is galK

Identifier: 28210581

GI number: 28210581

Start: 919221

End: 920399

Strand: Direct

Name: galK

Synonym: CTC00865

Alternate gene names: 28210581

Gene position: 919221-920399 (Clockwise)

Preceding gene: 28210580

Following gene: 28210582

Centisome position: 32.84

GC content: 28.84

Gene sequence:

>1179_bases
ATGGTGAAATGGAGGAATAATATGAATATAAATGAACTTAAAAAAGAATTTATAAAGATTTACGGAGAAGGTTCCATGAG
AAACTTTTTTTCACCAGGGAGGGTAAATCTCATAGGAGAACATATAGACTATAACGGAGGACATGTTTTTCCATGTGCTT
TGAACTTTGGAACTCTAGGATGTGTAAGAAAAAGAAAAGATAATAAAGTGAATTTAGCATCTACTAATATACCATTAAAA
GTTTCAATAAATTTAGAGGATATAAAATATGAAAAGAAACATGGATGGGGTAATTATCCTAAGGGTGTTATAAAAGAAAT
CATTGATAAAGGGTATAAAGTTGGAGGAATGGATATATTGATAAGTGGAAACATACCAAATGGTTCAGGATTGTCCTCTT
CAGCTTCTTTAGAACTTTTAATCGCAATTATGATAAATAATATATTTAACGATGGAAAATTAGATAAGGTAGAATTAATT
AAGTTGAGTCAAAAAGCAGAGAATGATTTTGTTGGATTAAATTGTGGAATAATGGATCAATTTGCAGTGGCTATGGGAAA
AAAAGATATGGCTATACTATTAGATTGTAATACCCTAGAATATAAATATGCTCCTGTAGATTTAGGGAATTATGTTATAA
CTATAATGAATACTAATAAAAGAAGAGAGTTAAGTGATTCTAAATATAATGAAAGAAGATTAGAATGTGAAAAGGCTCTT
AAATTAATTAACAAAGAAAAGAAAATAAACTATTTATGCGAACTTTCTTTAGAGGAATTTGAAAGCTTAAAATATTTAAT
AAAAGATAACAGGGTATTAAACAGGGCAACTCATGTAGTGTATGAAAATGAAAGAGTTAAAAGAGCTTACTATCTTTTAT
CAAAAAGAAATCTAAAAGAATTTGGAAAGCTTTTAGCAGAATCTCATTTTTCACTACGGGATTTATATGAAGTAACAGGA
AAAGAATTAGATGCCATAGTAGGTGAAGCACTAAATGTTTCAGGTTGTATTGGTGCTAGAATGATTGGAGCTGGATTTGG
AGGATGTGCTATAGCTTTAGTAGAAAAGAGTAAATTAGATTTATTTAAGAAAAAGGTTTCAAATAATTATAATAAAATAA
TAGGGTACAAGCCAGGGTTTTACACAAGTGAAATAGGAGAAGGCACTTATGAAATATAA

Upstream 100 bases:

>100_bases
TTACAAATATATTAAAAAATACAGGAGTATTTAAAAGAGATGAAAAGGGTAAATATGGATTCATAAAATTTATAAGATCT
ATGGGATTTATCAAACATTA

Downstream 100 bases:

>100_bases
TTGTGCTTTAGAGACAACTAATGGATATTACGATACTATAGATATGGCTAAAAAGAATAATAAGTTAAAAGTTTTAGAAT
CAAAAGAAGAATTGAATTTT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MVKWRNNMNINELKKEFIKIYGEGSMRNFFSPGRVNLIGEHIDYNGGHVFPCALNFGTLGCVRKRKDNKVNLASTNIPLK
VSINLEDIKYEKKHGWGNYPKGVIKEIIDKGYKVGGMDILISGNIPNGSGLSSSASLELLIAIMINNIFNDGKLDKVELI
KLSQKAENDFVGLNCGIMDQFAVAMGKKDMAILLDCNTLEYKYAPVDLGNYVITIMNTNKRRELSDSKYNERRLECEKAL
KLINKEKKINYLCELSLEEFESLKYLIKDNRVLNRATHVVYENERVKRAYYLLSKRNLKEFGKLLAESHFSLRDLYEVTG
KELDAIVGEALNVSGCIGARMIGAGFGGCAIALVEKSKLDLFKKKVSNNYNKIIGYKPGFYTSEIGEGTYEI

Sequences:

>Translated_392_residues
MVKWRNNMNINELKKEFIKIYGEGSMRNFFSPGRVNLIGEHIDYNGGHVFPCALNFGTLGCVRKRKDNKVNLASTNIPLK
VSINLEDIKYEKKHGWGNYPKGVIKEIIDKGYKVGGMDILISGNIPNGSGLSSSASLELLIAIMINNIFNDGKLDKVELI
KLSQKAENDFVGLNCGIMDQFAVAMGKKDMAILLDCNTLEYKYAPVDLGNYVITIMNTNKRRELSDSKYNERRLECEKAL
KLINKEKKINYLCELSLEEFESLKYLIKDNRVLNRATHVVYENERVKRAYYLLSKRNLKEFGKLLAESHFSLRDLYEVTG
KELDAIVGEALNVSGCIGARMIGAGFGGCAIALVEKSKLDLFKKKVSNNYNKIIGYKPGFYTSEIGEGTYEI
>Mature_392_residues
MVKWRNNMNINELKKEFIKIYGEGSMRNFFSPGRVNLIGEHIDYNGGHVFPCALNFGTLGCVRKRKDNKVNLASTNIPLK
VSINLEDIKYEKKHGWGNYPKGVIKEIIDKGYKVGGMDILISGNIPNGSGLSSSASLELLIAIMINNIFNDGKLDKVELI
KLSQKAENDFVGLNCGIMDQFAVAMGKKDMAILLDCNTLEYKYAPVDLGNYVITIMNTNKRRELSDSKYNERRLECEKAL
KLINKEKKINYLCELSLEEFESLKYLIKDNRVLNRATHVVYENERVKRAYYLLSKRNLKEFGKLLAESHFSLRDLYEVTG
KELDAIVGEALNVSGCIGARMIGAGFGGCAIALVEKSKLDLFKKKVSNNYNKIIGYKPGFYTSEIGEGTYEI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=387, Percent_Identity=36.4341085271318, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4503897, Length=402, Percent_Identity=29.6019900497512, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI48527957, Length=402, Percent_Identity=29.6019900497512, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1786972, Length=377, Percent_Identity=37.1352785145889, Blast_Score=254, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI71989053, Length=434, Percent_Identity=26.2672811059908, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319494, Length=257, Percent_Identity=28.7937743190661, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320212, Length=234, Percent_Identity=27.3504273504274, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24661292, Length=421, Percent_Identity=27.3159144893112, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21355577, Length=421, Percent_Identity=27.3159144893112, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24661285, Length=421, Percent_Identity=27.3159144893112, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_CLOTE (Q896X8)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781525.1
- ProteinModelPortal:   Q896X8
- SMR:   Q896X8
- GeneID:   1060886
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00865
- NMPDR:   fig|212717.1.peg.747
- HOGENOM:   HBG725121
- OMA:   EYVGAPT
- PhylomeDB:   Q896X8
- ProtClustDB:   PRK05322
- BioCyc:   CTET212717:CTC_00865-MONOMER
- BRENDA:   2.7.1.6
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 44228; Mature: 44228

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKWRNNMNINELKKEFIKIYGEGSMRNFFSPGRVNLIGEHIDYNGGHVFPCALNFGTLG
CCEECCCCCHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECEECCCCEEEEEEECCCCHH
CVRKRKDNKVNLASTNIPLKVSINLEDIKYEKKHGWGNYPKGVIKEIIDKGYKVGGMDIL
HHHCCCCCEEEEEECCCCEEEEEEHHHHEEEHHCCCCCCCHHHHHHHHHCCCEECCEEEE
ISGNIPNGSGLSSSASLELLIAIMINNIFNDGKLDKVELIKLSQKAENDFVGLNCGIMDQ
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHEEEHHHHCCCCEEEECCCHHHH
FAVAMGKKDMAILLDCNTLEYKYAPVDLGNYVITIMNTNKRRELSDSKYNERRLECEKAL
HHHHHCCCCEEEEEECCCCEEEECCEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
KLINKEKKINYLCELSLEEFESLKYLIKDNRVLNRATHVVYENERVKRAYYLLSKRNLKE
HHHCCCHHCCEEEECCHHHHHHHHHHHHCCHHHHHHHHEEECCCHHHHHHHHHHHCCHHH
FGKLLAESHFSLRDLYEVTGKELDAIVGEALNVSGCIGARMIGAGFGGCAIALVEKSKLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEHHHHH
LFKKKVSNNYNKIIGYKPGFYTSEIGEGTYEI
HHHHHHCCCCCEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVKWRNNMNINELKKEFIKIYGEGSMRNFFSPGRVNLIGEHIDYNGGHVFPCALNFGTLG
CCEECCCCCHHHHHHHHHHHHCCCCHHCCCCCCCEEEEEECEECCCCEEEEEEECCCCHH
CVRKRKDNKVNLASTNIPLKVSINLEDIKYEKKHGWGNYPKGVIKEIIDKGYKVGGMDIL
HHHCCCCCEEEEEECCCCEEEEEEHHHHEEEHHCCCCCCCHHHHHHHHHCCCEECCEEEE
ISGNIPNGSGLSSSASLELLIAIMINNIFNDGKLDKVELIKLSQKAENDFVGLNCGIMDQ
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHEEEHHHHCCCCEEEECCCHHHH
FAVAMGKKDMAILLDCNTLEYKYAPVDLGNYVITIMNTNKRRELSDSKYNERRLECEKAL
HHHHHCCCCEEEEEECCCCEEEECCEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
KLINKEKKINYLCELSLEEFESLKYLIKDNRVLNRATHVVYENERVKRAYYLLSKRNLKE
HHHCCCHHCCEEEECCHHHHHHHHHHHHCCHHHHHHHHEEECCCHHHHHHHHHHHCCHHH
FGKLLAESHFSLRDLYEVTGKELDAIVGEALNVSGCIGARMIGAGFGGCAIALVEKSKLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEHHHHH
LFKKKVSNNYNKIIGYKPGFYTSEIGEGTYEI
HHHHHHCCCCCEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129