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The map label for this gene is gtcS [H]

Identifier: 28210566

GI number: 28210566

Start: 901222

End: 902664

Strand: Direct

Name: gtcS [H]

Synonym: CTC00849

Alternate gene names: 28210566

Gene position: 901222-902664 (Clockwise)

Preceding gene: 28210565

Following gene: 28210571

Centisome position: 32.2

GC content: 25.64

Gene sequence:

>1443_bases
ATGAAAACTAGAATGAAAAATAAGAAAAAAATATCAAATTTACTCCTAAGAAACTATATTATATCTAATATAATGATGTT
TATAACATTAATTATATTTTTTATAATTACAATAATTATGTGGATTACTTTGTTCCTACCAATAAATAATCTACTTAGTG
AAGAAAAATCAAAATTATTAGCGGAAAACATAATGGCAGATGACTATAAAAAAATAGATGCCTCAGAAGTTTTAAAGGTG
GAAGGATGGGTTGAGGTAGTTGATAGCAACTTTAAAGTAGTTAAGGTGAAAGGTGAACAAAAAAATAAAAGGAACTTTTA
CACAAAGAAAGAATTTTATAAACTAGTTAAAGAAAATAATGATGGTTTATTTGAGAATAAAAACTACATAATAAACATAG
ATTATAATGAAAATAAAGACTTTTTTCTAGTGGTCTATCTACCTAACGATAATTATTTTATTACAACTATAAAAGACCAA
AAGATAAAGCCTAGAACTTTTTTTAGAATTGCAATACTAGGGTATATTATAATATTTGCACTTATTATGATAATGTATGC
AAAATTTACATCTAAGAATTTAACTATGCCTTTAAAAGAGCTTATGAAGGGAGTAAAAAAAATCATAAAGGGCGATTACT
CTACTAGAATATATTTAAAATCTCAAAATGAGTTTGGAGATTTAAGAGATGCCTTTAATTTAATGGTAGAAAAAATAGAA
GAGGAAAGAAAATTAAAGGAAAAATCAGAGGATAATAGAAAAAGATTAATGCTAGACATTTCTCATGATCTAAAAAATCC
ATTAGCAAGCATTAGAGGATATTCAAATTATCTAATAGAAAATAAAGAAATATCTAATAAGGAAAAAGAGAAATATCTAA
AAATAATAGAAAATAATAGTATAAGAGTAAATGATCTTATAACGGATTTATTTGAACTATCTAAGTTTGAAAGCATAGAT
TTTTCTATAGATTTTGAGAAGATGGATATATGTGAATTGATTAGAGAAATAATAGCTAATCATATACCACAAATGGAGGA
CAAAGATATGGTTTATAGCTTTTATTTACCAGAGAATGAAGTGTTTATAATGGGAAATGAGAAAAATTTATATAGGGCTA
TATCCAATCTTTTAGAAAATAGCATAAAATACAATGAAAAAGGTACTAAAATCCAAGTATCCTTAGAAGAGTATGAAGAT
AGTGTGGGAATAGAAGTAGTAGATAATGGAATAGGAATTCCTAAAAAATTAAAACAAGATATTTTTAACCCATTCATAAG
AGTAGACACTTCTAGAAATTCTAAACAAGGCGGAACAGGCTTAGGGTTAGCAATAACTAAGGCTATAGTGGAAAAGCATA
AAGGGGAAATAAAGCTTATAAGTGACATCGATAAAGGAGCAAGATTTAAAATAAAACTTTATAAGATAGTGAACAATGAA
TAG

Upstream 100 bases:

>100_bases
ATAAGTCATATAAGAGATAAAATAGAAGATAATCCAAAAGAGCCTATATATTTAAAAACTATTAGAGGAATAGGATATAA
ATTAGAAAAGGTAGAATAAT

Downstream 100 bases:

>100_bases
TAAAATAAAAAAACTGCATTGCAGTTTTTTTATTTTATCTCTTTATAATTTATTATTTTTAAAGTATTATTTTCAAAATC
CAAGATAAAATTCATCTTTA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MKTRMKNKKKISNLLLRNYIISNIMMFITLIIFFIITIIMWITLFLPINNLLSEEKSKLLAENIMADDYKKIDASEVLKV
EGWVEVVDSNFKVVKVKGEQKNKRNFYTKKEFYKLVKENNDGLFENKNYIINIDYNENKDFFLVVYLPNDNYFITTIKDQ
KIKPRTFFRIAILGYIIIFALIMIMYAKFTSKNLTMPLKELMKGVKKIIKGDYSTRIYLKSQNEFGDLRDAFNLMVEKIE
EERKLKEKSEDNRKRLMLDISHDLKNPLASIRGYSNYLIENKEISNKEKEKYLKIIENNSIRVNDLITDLFELSKFESID
FSIDFEKMDICELIREIIANHIPQMEDKDMVYSFYLPENEVFIMGNEKNLYRAISNLLENSIKYNEKGTKIQVSLEEYED
SVGIEVVDNGIGIPKKLKQDIFNPFIRVDTSRNSKQGGTGLGLAITKAIVEKHKGEIKLISDIDKGARFKIKLYKIVNNE

Sequences:

>Translated_480_residues
MKTRMKNKKKISNLLLRNYIISNIMMFITLIIFFIITIIMWITLFLPINNLLSEEKSKLLAENIMADDYKKIDASEVLKV
EGWVEVVDSNFKVVKVKGEQKNKRNFYTKKEFYKLVKENNDGLFENKNYIINIDYNENKDFFLVVYLPNDNYFITTIKDQ
KIKPRTFFRIAILGYIIIFALIMIMYAKFTSKNLTMPLKELMKGVKKIIKGDYSTRIYLKSQNEFGDLRDAFNLMVEKIE
EERKLKEKSEDNRKRLMLDISHDLKNPLASIRGYSNYLIENKEISNKEKEKYLKIIENNSIRVNDLITDLFELSKFESID
FSIDFEKMDICELIREIIANHIPQMEDKDMVYSFYLPENEVFIMGNEKNLYRAISNLLENSIKYNEKGTKIQVSLEEYED
SVGIEVVDNGIGIPKKLKQDIFNPFIRVDTSRNSKQGGTGLGLAITKAIVEKHKGEIKLISDIDKGARFKIKLYKIVNNE
>Mature_480_residues
MKTRMKNKKKISNLLLRNYIISNIMMFITLIIFFIITIIMWITLFLPINNLLSEEKSKLLAENIMADDYKKIDASEVLKV
EGWVEVVDSNFKVVKVKGEQKNKRNFYTKKEFYKLVKENNDGLFENKNYIINIDYNENKDFFLVVYLPNDNYFITTIKDQ
KIKPRTFFRIAILGYIIIFALIMIMYAKFTSKNLTMPLKELMKGVKKIIKGDYSTRIYLKSQNEFGDLRDAFNLMVEKIE
EERKLKEKSEDNRKRLMLDISHDLKNPLASIRGYSNYLIENKEISNKEKEKYLKIIENNSIRVNDLITDLFELSKFESID
FSIDFEKMDICELIREIIANHIPQMEDKDMVYSFYLPENEVFIMGNEKNLYRAISNLLENSIKYNEKGTKIQVSLEEYED
SVGIEVVDNGIGIPKKLKQDIFNPFIRVDTSRNSKQGGTGLGLAITKAIVEKHKGEIKLISDIDKGARFKIKLYKIVNNE

Specific function: Member of the two-component regulatory system gtcS/gtcR which may act in th control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S. Probably activates gtcR by phosp

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=266, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=30.9090909090909, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=30.4166666666667, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=28.0141843971631, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081816, Length=350, Percent_Identity=22.5714285714286, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=26.0683760683761, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=304, Percent_Identity=24.0131578947368, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=25.8823529411765, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788549, Length=268, Percent_Identity=25.7462686567164, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=28.6885245901639, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=24.3362831858407, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=290, Percent_Identity=25.5172413793103, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788713, Length=262, Percent_Identity=22.1374045801527, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=25.4098360655738, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787894, Length=333, Percent_Identity=24.024024024024, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=332, Percent_Identity=23.4939759036145, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=231, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56347; Mature: 56347

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRMKNKKKISNLLLRNYIISNIMMFITLIIFFIITIIMWITLFLPINNLLSEEKSKLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AENIMADDYKKIDASEVLKVEGWVEVVDSNFKVVKVKGEQKNKRNFYTKKEFYKLVKENN
HHHHHHHHHHHCCHHHHHHHCCHHHEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCC
DGLFENKNYIINIDYNENKDFFLVVYLPNDNYFITTIKDQKIKPRTFFRIAILGYIIIFA
CCCEECCCEEEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
LIMIMYAKFTSKNLTMPLKELMKGVKKIIKGDYSTRIYLKSQNEFGDLRDAFNLMVEKIE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
EERKLKEKSEDNRKRLMLDISHDLKNPLASIRGYSNYLIENKEISNKEKEKYLKIIENNS
HHHHHHHCCCCCHHEEEEEHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHHCCCC
IRVNDLITDLFELSKFESIDFSIDFEKMDICELIREIIANHIPQMEDKDMVYSFYLPENE
EEHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
VFIMGNEKNLYRAISNLLENSIKYNEKGTKIQVSLEEYEDSVGIEVVDNGIGIPKKLKQD
EEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCEEEEECCCCCHHHHHHH
IFNPFIRVDTSRNSKQGGTGLGLAITKAIVEKHKGEIKLISDIDKGARFKIKLYKIVNNE
HCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MKTRMKNKKKISNLLLRNYIISNIMMFITLIIFFIITIIMWITLFLPINNLLSEEKSKLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AENIMADDYKKIDASEVLKVEGWVEVVDSNFKVVKVKGEQKNKRNFYTKKEFYKLVKENN
HHHHHHHHHHHCCHHHHHHHCCHHHEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCC
DGLFENKNYIINIDYNENKDFFLVVYLPNDNYFITTIKDQKIKPRTFFRIAILGYIIIFA
CCCEECCCEEEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHH
LIMIMYAKFTSKNLTMPLKELMKGVKKIIKGDYSTRIYLKSQNEFGDLRDAFNLMVEKIE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
EERKLKEKSEDNRKRLMLDISHDLKNPLASIRGYSNYLIENKEISNKEKEKYLKIIENNS
HHHHHHHCCCCCHHEEEEEHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHHCCCC
IRVNDLITDLFELSKFESIDFSIDFEKMDICELIREIIANHIPQMEDKDMVYSFYLPENE
EEHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCC
VFIMGNEKNLYRAISNLLENSIKYNEKGTKIQVSLEEYEDSVGIEVVDNGIGIPKKLKQD
EEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCEEEEECCCCCHHHHHHH
IFNPFIRVDTSRNSKQGGTGLGLAITKAIVEKHKGEIKLISDIDKGARFKIKLYKIVNNE
HCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7579582 [H]