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The map label for this gene is gtcR [H]

Identifier: 28210565

GI number: 28210565

Start: 900528

End: 901220

Strand: Direct

Name: gtcR [H]

Synonym: CTC00848

Alternate gene names: 28210565

Gene position: 900528-901220 (Clockwise)

Preceding gene: 28210564

Following gene: 28210566

Centisome position: 32.17

GC content: 27.42

Gene sequence:

>693_bases
ATGAATATATTAATAGCAGAAGATGAACAGGATATAAGAGAACTTTTAGGATTACATCTAATAAAGGAAGATTATAATGT
TTATGAAGCATGTAATGGTATAGAAGCATTAGATGTTTTTAATAAAAATGATATAGATTTAGCAATATTAGATATAATGA
TGCCAGGTTTAGATGGATTTAAAGTTTTAAAAAAAATTAGAGAAAAAAGTAATATACCAGTAATATTTATAACAGCTAGA
GGAGAAGATGAAAATAAAATATTAGGGCTGGGGTTAGGAGCAGATGATTATATAGTAAAGCCGTTTAGTCCTATGGAAGT
AGTAGCAAGAGTAAAAGCTCTTTTTAGAAGGGTTGGAACCTATTCTCAAAATAGCAGTAAAGATATTAATAAAATTGAAA
ATGGAGAGTTATCATTAAACAAAGACTCCTGCACTTTTTACAAAAATGGAAATCCAATTGAATTAAATGCAAAGGAATAT
AAAATAATGGAGTTTCTAATGGAGAATAAAGGCAGAGTACATACAAAAAAACAAATATACGAAAAGGTATGGGGCTATGA
ATACTATGGCGATGCTAATACAATAATGGTACATATAAGTCATATAAGAGATAAAATAGAAGATAATCCAAAAGAGCCTA
TATATTTAAAAACTATTAGAGGAATAGGATATAAATTAGAAAAGGTAGAATAA

Upstream 100 bases:

>100_bases
GAGGAATATAGATGTAAATAATACTAAAATTATTTTTCTATTAAAAGCTATGATATAATTAAAATTAAATTAATTATTTT
TAGAAAGGGAGTTTATTAAT

Downstream 100 bases:

>100_bases
TATGAAAACTAGAATGAAAAATAAGAAAAAAATATCAAATTTACTCCTAAGAAACTATATTATATCTAATATAATGATGT
TTATAACATTAATTATATTT

Product: transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNILIAEDEQDIRELLGLHLIKEDYNVYEACNGIEALDVFNKNDIDLAILDIMMPGLDGFKVLKKIREKSNIPVIFITAR
GEDENKILGLGLGADDYIVKPFSPMEVVARVKALFRRVGTYSQNSSKDINKIENGELSLNKDSCTFYKNGNPIELNAKEY
KIMEFLMENKGRVHTKKQIYEKVWGYEYYGDANTIMVHISHIRDKIEDNPKEPIYLKTIRGIGYKLEKVE

Sequences:

>Translated_230_residues
MNILIAEDEQDIRELLGLHLIKEDYNVYEACNGIEALDVFNKNDIDLAILDIMMPGLDGFKVLKKIREKSNIPVIFITAR
GEDENKILGLGLGADDYIVKPFSPMEVVARVKALFRRVGTYSQNSSKDINKIENGELSLNKDSCTFYKNGNPIELNAKEY
KIMEFLMENKGRVHTKKQIYEKVWGYEYYGDANTIMVHISHIRDKIEDNPKEPIYLKTIRGIGYKLEKVE
>Mature_230_residues
MNILIAEDEQDIRELLGLHLIKEDYNVYEACNGIEALDVFNKNDIDLAILDIMMPGLDGFKVLKKIREKSNIPVIFITAR
GEDENKILGLGLGADDYIVKPFSPMEVVARVKALFRRVGTYSQNSSKDINKIENGELSLNKDSCTFYKNGNPIELNAKEY
KIMEFLMENKGRVHTKKQIYEKVWGYEYYGDANTIMVHISHIRDKIEDNPKEPIYLKTIRGIGYKLEKVE

Specific function: Member of the two-component regulatory system gtcS/gtcR which may act in th control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=36.4035087719298, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=31.25, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=35.5263157894737, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=35.3711790393013, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=33.9130434782609, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=35.2422907488987, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=35.0877192982456, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=31.5555555555556, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=33.6244541484716, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=33.9285714285714, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=32.15859030837, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=32.1739130434783, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.9473684210526, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.5109170305677, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1788550, Length=101, Percent_Identity=38.6138613861386, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=116, Percent_Identity=33.6206896551724, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=124, Percent_Identity=32.258064516129, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788713, Length=135, Percent_Identity=31.1111111111111, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26455; Mature: 26455

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIAEDEQDIRELLGLHLIKEDYNVYEACNGIEALDVFNKNDIDLAILDIMMPGLDGF
CEEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCCCCCCCEEEEEHHHCCCCHH
KVLKKIREKSNIPVIFITARGEDENKILGLGLGADDYIVKPFSPMEVVARVKALFRRVGT
HHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHCC
YSQNSSKDINKIENGELSLNKDSCTFYKNGNPIELNAKEYKIMEFLMENKGRVHTKKQIY
CCCCCCCCHHHCCCCCEEECCCCEEEEECCCEEEECHHHHHHHHHHHHCCCCCHHHHHHH
EKVWGYEYYGDANTIMVHISHIRDKIEDNPKEPIYLKTIRGIGYKLEKVE
HHHCCEEEECCCCEEEEEHHHHHHHHHCCCCCCEEEEEECCCCEEEECCC
>Mature Secondary Structure
MNILIAEDEQDIRELLGLHLIKEDYNVYEACNGIEALDVFNKNDIDLAILDIMMPGLDGF
CEEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCCCCCCCEEEEEHHHCCCCHH
KVLKKIREKSNIPVIFITARGEDENKILGLGLGADDYIVKPFSPMEVVARVKALFRRVGT
HHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHCC
YSQNSSKDINKIENGELSLNKDSCTFYKNGNPIELNAKEYKIMEFLMENKGRVHTKKQIY
CCCCCCCCHHHCCCCCEEECCCCEEEEECCCEEEECHHHHHHHHHHHHCCCCCHHHHHHH
EKVWGYEYYGDANTIMVHISHIRDKIEDNPKEPIYLKTIRGIGYKLEKVE
HHHCCEEEECCCCEEEEEHHHHHHHHHCCCCCCEEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7579582 [H]