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The map label for this gene is hemN [H]

Identifier: 28210562

GI number: 28210562

Start: 897166

End: 898548

Strand: Direct

Name: hemN [H]

Synonym: CTC00845

Alternate gene names: 28210562

Gene position: 897166-898548 (Clockwise)

Preceding gene: 28210561

Following gene: 28210563

Centisome position: 32.05

GC content: 24.73

Gene sequence:

>1383_bases
TTGAATAGAGAAGAGTTTATAAAAAAGATAGATGAAAAGTTAAAACTTATAAGAAATGAAAAAGGTTTCACTCAAGATAA
AATGAATTATGTGAATAAGGAGAAAAAAATGATTACAGATATATTTAGAAGAATAATACTTGGTAAAAAAGATAAATTTA
TGTTTAAAGGCTATAGTCAAAGTATGGTAGATTTTAGAGAAATAGATGAGAATACAGGCATATATATACATATACCCTTT
TGTAAAAGTATATGTCCATATTGTCCGTATAACAAAGTGCTTTATGAAAAAGAAAAAGCTAAAGATTATAAAAATTCCTT
AATGAAAGAAATTAAAATGTATAAAAAATATCTAAAAAATAAAAATATCACATCTCTATATATAGGGGGAGGTACTCCCA
CACTTTTAGTTGATGAACTAAATGAGGTAATTAATTATATAAAAGATGAATTTGAATTTAATGGGAATATAGGTATAGAA
ATCTATCCAACAGAAGTTTCAGAAGAGCTTTTAACAAAATTGAAATCCTTAGGAGTAAATCTTTTAAGTTTAGGTGTACA
AACTTTTAATGATGATAAGTTAAAATTTTTGGGAAGAAAATATACAGTTAAAGATATAGAAAATGCTTTAGAAAAAATAG
AGAAATTTAACTTTAAATGTGTAGATATAGATATTATGACTAATTTACCTGGACAAACTATAGAAGATATAGAACAGGAT
TTAAGAAAGGTTTATTCTTATAATATTCATCAACTTTCTATATATCCGCTAATAGTATTTCCTATGACACCTATGGATAA
AATTATAAGAGAAAAGAAGTTAAAGAGATTTAGTGAATTAGGGGAGAGAAAAATACTTAATATAATTGATAAAGTATCAA
AAGAGTGTGGTTATGAGAGAAGTTCTATATGGACCTATGGAAAATCAGAGGATAATAGATATACATCTGTCACAAGAGAA
AGTTTCATAGGTATAGGAGCAGGAGCTAGTTCGCTTTTTTCAAATTATTTTTACTTAAATACATTTAATGTTGAAGAATA
TATAAAAGTTTTAAATGAAAACAAACTGCCTATAAATATAGTAAACACTATGAGTAATAGAGAAAAGATGATATTCTGGA
TATTTTGGAGATGCTATGATGGAATTATAGATAAGAATAGATTTTATAAACTATTTAACAAAGATATAAAAAAAGAATTT
AGATTACTTTTTAATTTTTTAAAAATATTTAGTATGTCAAAAGAAGAAGTAGATAAAATCTATCTAACGGAACTAGGAAG
ATTTGCATATCATTATGTGGAAAAACAGTATTCCATATATTATCTAAATCATTTATGGGAAAGCTCTATGAAGAAAGCTT
GGATAGATGAAATAAGTTTATAG

Upstream 100 bases:

>100_bases
GTAGAATGGTATCAAATTTCATTCTGCGATATTTTTTATTTTGCTTAGTTACATTTATGTTATAAAATTACACTATAAGT
GTAATTAAGAAGATGTTTTT

Downstream 100 bases:

>100_bases
ATTAAGGAGGATCATATGAAAAAAAGAGATTTTTTAAAATTAGCTCTATTTGGTATGAAAACAATTATGTTTAAAGAGAA
AAAGCCTATATTAGGTACAA

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNREEFIKKIDEKLKLIRNEKGFTQDKMNYVNKEKKMITDIFRRIILGKKDKFMFKGYSQSMVDFREIDENTGIYIHIPF
CKSICPYCPYNKVLYEKEKAKDYKNSLMKEIKMYKKYLKNKNITSLYIGGGTPTLLVDELNEVINYIKDEFEFNGNIGIE
IYPTEVSEELLTKLKSLGVNLLSLGVQTFNDDKLKFLGRKYTVKDIENALEKIEKFNFKCVDIDIMTNLPGQTIEDIEQD
LRKVYSYNIHQLSIYPLIVFPMTPMDKIIREKKLKRFSELGERKILNIIDKVSKECGYERSSIWTYGKSEDNRYTSVTRE
SFIGIGAGASSLFSNYFYLNTFNVEEYIKVLNENKLPINIVNTMSNREKMIFWIFWRCYDGIIDKNRFYKLFNKDIKKEF
RLLFNFLKIFSMSKEEVDKIYLTELGRFAYHYVEKQYSIYYLNHLWESSMKKAWIDEISL

Sequences:

>Translated_460_residues
MNREEFIKKIDEKLKLIRNEKGFTQDKMNYVNKEKKMITDIFRRIILGKKDKFMFKGYSQSMVDFREIDENTGIYIHIPF
CKSICPYCPYNKVLYEKEKAKDYKNSLMKEIKMYKKYLKNKNITSLYIGGGTPTLLVDELNEVINYIKDEFEFNGNIGIE
IYPTEVSEELLTKLKSLGVNLLSLGVQTFNDDKLKFLGRKYTVKDIENALEKIEKFNFKCVDIDIMTNLPGQTIEDIEQD
LRKVYSYNIHQLSIYPLIVFPMTPMDKIIREKKLKRFSELGERKILNIIDKVSKECGYERSSIWTYGKSEDNRYTSVTRE
SFIGIGAGASSLFSNYFYLNTFNVEEYIKVLNENKLPINIVNTMSNREKMIFWIFWRCYDGIIDKNRFYKLFNKDIKKEF
RLLFNFLKIFSMSKEEVDKIYLTELGRFAYHYVEKQYSIYYLNHLWESSMKKAWIDEISL
>Mature_460_residues
MNREEFIKKIDEKLKLIRNEKGFTQDKMNYVNKEKKMITDIFRRIILGKKDKFMFKGYSQSMVDFREIDENTGIYIHIPF
CKSICPYCPYNKVLYEKEKAKDYKNSLMKEIKMYKKYLKNKNITSLYIGGGTPTLLVDELNEVINYIKDEFEFNGNIGIE
IYPTEVSEELLTKLKSLGVNLLSLGVQTFNDDKLKFLGRKYTVKDIENALEKIEKFNFKCVDIDIMTNLPGQTIEDIEQD
LRKVYSYNIHQLSIYPLIVFPMTPMDKIIREKKLKRFSELGERKILNIIDKVSKECGYERSSIWTYGKSEDNRYTSVTRE
SFIGIGAGASSLFSNYFYLNTFNVEEYIKVLNENKLPINIVNTMSNREKMIFWIFWRCYDGIIDKNRFYKLFNKDIKKEF
RLLFNFLKIFSMSKEEVDKIYLTELGRFAYHYVEKQYSIYYLNHLWESSMKKAWIDEISL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=268, Percent_Identity=23.5074626865672, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI87082341, Length=303, Percent_Identity=25.0825082508251, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789325, Length=194, Percent_Identity=30.4123711340206, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54869; Mature: 54869

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50819 INTEIN_ENDONUCLEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREEFIKKIDEKLKLIRNEKGFTQDKMNYVNKEKKMITDIFRRIILGKKDKFMFKGYSQ
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCH
SMVDFREIDENTGIYIHIPFCKSICPYCPYNKVLYEKEKAKDYKNSLMKEIKMYKKYLKN
HHHHHHHCCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNITSLYIGGGTPTLLVDELNEVINYIKDEFEFNGNIGIEIYPTEVSEELLTKLKSLGVN
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCH
LLSLGVQTFNDDKLKFLGRKYTVKDIENALEKIEKFNFKCVDIDIMTNLPGQTIEDIEQD
HHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHH
LRKVYSYNIHQLSIYPLIVFPMTPMDKIIREKKLKRFSELGERKILNIIDKVSKECGYER
HHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SSIWTYGKSEDNRYTSVTRESFIGIGAGASSLFSNYFYLNTFNVEEYIKVLNENKLPINI
CCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCEEEEECCHHHHHHHHCCCCCCEEE
VNTMSNREKMIFWIFWRCYDGIIDKNRFYKLFNKDIKKEFRLLFNFLKIFSMSKEEVDKI
EECCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YLTELGRFAYHYVEKQYSIYYLNHLWESSMKKAWIDEISL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNREEFIKKIDEKLKLIRNEKGFTQDKMNYVNKEKKMITDIFRRIILGKKDKFMFKGYSQ
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCH
SMVDFREIDENTGIYIHIPFCKSICPYCPYNKVLYEKEKAKDYKNSLMKEIKMYKKYLKN
HHHHHHHCCCCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNITSLYIGGGTPTLLVDELNEVINYIKDEFEFNGNIGIEIYPTEVSEELLTKLKSLGVN
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCH
LLSLGVQTFNDDKLKFLGRKYTVKDIENALEKIEKFNFKCVDIDIMTNLPGQTIEDIEQD
HHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHH
LRKVYSYNIHQLSIYPLIVFPMTPMDKIIREKKLKRFSELGERKILNIIDKVSKECGYER
HHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SSIWTYGKSEDNRYTSVTRESFIGIGAGASSLFSNYFYLNTFNVEEYIKVLNENKLPINI
CCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCEEEEECCHHHHHHHHCCCCCCEEE
VNTMSNREKMIFWIFWRCYDGIIDKNRFYKLFNKDIKKEFRLLFNFLKIFSMSKEEVDKI
EECCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YLTELGRFAYHYVEKQYSIYYLNHLWESSMKKAWIDEISL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]