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The map label for this gene is gyaR [H]

Identifier: 28210561

GI number: 28210561

Start: 895970

End: 897043

Strand: Direct

Name: gyaR [H]

Synonym: CTC00844

Alternate gene names: 28210561

Gene position: 895970-897043 (Clockwise)

Preceding gene: 28210560

Following gene: 28210562

Centisome position: 32.01

GC content: 28.49

Gene sequence:

>1074_bases
TTGAAATATTATAATACAACTTATATTATAATATTAGGAGAAATAAATTATAATGTTTGTTATAAATGGAATATCTATCC
ATTAGGTTATATAACTGCATTATATAAGGAGGGTATTTTTATGAAAATAGTTGTATTAGAACCCCTAGGTGTAAGTGAAG
AGAAAATAAAAAATATAGCATTAAAATTAATGGACAAAGATCATGAGTTAATACTACACAATGAAAAAAGTGAAGATATA
GAAGTACTAAAGAAAAGAGTTGAAACGGCAGATGTATTAATTTTGGCCAATATGCCATTAAAAAAAGAAGTTATAGAAGC
AGCTACAAATTTAAAAATGATTTCTGTTGCTTTTACAGGGATAGATCATATAAATATGGAAACTTGCAGAAAAAATAATA
TAATGGTTTGCAATTCAGCAGGTTACAGTACTTCATCTGTTGTAGAACTTACATTTGGATTGATTTTATCATTATTAAGA
AATATAGTTCCATTAAATGATGAAGTTAGAAATGGAAATACAAAACAAGGATATTCTCAATATGATTTAGCTGGAAAAAC
CTTAGGGGTTATAGGAGCTGGAGATATAGGAACAGAAGTTATCAGAATAGGTAAAGCCTTTGGATGTAATGTTCTAGTAT
ATAATAGAAGTGAAAAGCAACATATTAAAGAATTAGGAGCTACGCAAACTACCTTAGATGAAGTATTAAAAAATAGTGAT
ATAGTTACTCTTCACATTCCGTCCAATAATGAAACAAAAGGACTTATAAATAGTGAAAAATTAGCAATGATGAAGAAAGA
TGCACTATTAATAAATACTGCTAGAGGTCCTGTTGTTGATAATAAAGCATTAGCTGAAGCTTTAAATAAAGGAGAATTAG
GTGGAGCAGGAATAGATGTATTTGATATGGAACCACCTGTACCAGAGGAGTATGAATTATTAAAGACTAATAATTCAGTA
TTAACACCTCATATAGGATTTGCTACAAAAGAAGCAATGGAGAGAAGAGCGGAAATAGTATTTAGAAATATAGAAAAATG
GATAGAAGGAAATCCAGAAAATATAGTAGAATAA

Upstream 100 bases:

>100_bases
AATACTTGTACCTAGAAGCATAAGAATAGTAGATTTATTGACCGAATTAGGCAATATAGAGGAACTAGATAAGGTGTTTT
TAATATAACAATATAATAAC

Downstream 100 bases:

>100_bases
TCTAGTTTAAATAAAAAATATCGTAGAATGGTATCAAATTTCATTCTGCGATATTTTTTATTTTGCTTAGTTACATTTAT
GTTATAAAATTACACTATAA

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKYYNTTYIIILGEINYNVCYKWNIYPLGYITALYKEGIFMKIVVLEPLGVSEEKIKNIALKLMDKDHELILHNEKSEDI
EVLKKRVETADVLILANMPLKKEVIEAATNLKMISVAFTGIDHINMETCRKNNIMVCNSAGYSTSSVVELTFGLILSLLR
NIVPLNDEVRNGNTKQGYSQYDLAGKTLGVIGAGDIGTEVIRIGKAFGCNVLVYNRSEKQHIKELGATQTTLDEVLKNSD
IVTLHIPSNNETKGLINSEKLAMMKKDALLINTARGPVVDNKALAEALNKGELGGAGIDVFDMEPPVPEEYELLKTNNSV
LTPHIGFATKEAMERRAEIVFRNIEKWIEGNPENIVE

Sequences:

>Translated_357_residues
MKYYNTTYIIILGEINYNVCYKWNIYPLGYITALYKEGIFMKIVVLEPLGVSEEKIKNIALKLMDKDHELILHNEKSEDI
EVLKKRVETADVLILANMPLKKEVIEAATNLKMISVAFTGIDHINMETCRKNNIMVCNSAGYSTSSVVELTFGLILSLLR
NIVPLNDEVRNGNTKQGYSQYDLAGKTLGVIGAGDIGTEVIRIGKAFGCNVLVYNRSEKQHIKELGATQTTLDEVLKNSD
IVTLHIPSNNETKGLINSEKLAMMKKDALLINTARGPVVDNKALAEALNKGELGGAGIDVFDMEPPVPEEYELLKTNNSV
LTPHIGFATKEAMERRAEIVFRNIEKWIEGNPENIVE
>Mature_357_residues
MKYYNTTYIIILGEINYNVCYKWNIYPLGYITALYKEGIFMKIVVLEPLGVSEEKIKNIALKLMDKDHELILHNEKSEDI
EVLKKRVETADVLILANMPLKKEVIEAATNLKMISVAFTGIDHINMETCRKNNIMVCNSAGYSTSSVVELTFGLILSLLR
NIVPLNDEVRNGNTKQGYSQYDLAGKTLGVIGAGDIGTEVIRIGKAFGCNVLVYNRSEKQHIKELGATQTTLDEVLKNSD
IVTLHIPSNNETKGLINSEKLAMMKKDALLINTARGPVVDNKALAEALNKGELGGAGIDVFDMEPPVPEEYELLKTNNSV
LTPHIGFATKEAMERRAEIVFRNIEKWIEGNPENIVE

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=238, Percent_Identity=34.8739495798319, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4557497, Length=279, Percent_Identity=32.9749103942652, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=279, Percent_Identity=32.9749103942652, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI6912396, Length=268, Percent_Identity=30.9701492537313, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI145580578, Length=279, Percent_Identity=30.8243727598566, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4557499, Length=279, Percent_Identity=30.8243727598566, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI145580575, Length=279, Percent_Identity=30.8243727598566, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1789279, Length=262, Percent_Identity=36.6412213740458, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI87082289, Length=271, Percent_Identity=33.210332103321, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787645, Length=291, Percent_Identity=26.8041237113402, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87081824, Length=164, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=28.5171102661597, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=295, Percent_Identity=33.2203389830508, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=282, Percent_Identity=28.0141843971631, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=326, Percent_Identity=31.5950920245399, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=30.8868501529052, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=302, Percent_Identity=27.8145695364238, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=300, Percent_Identity=24, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=174, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=263, Percent_Identity=33.4600760456274, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=280, Percent_Identity=33.9285714285714, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646448, Length=280, Percent_Identity=33.9285714285714, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646452, Length=280, Percent_Identity=33.9285714285714, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646450, Length=280, Percent_Identity=33.9285714285714, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI62472511, Length=280, Percent_Identity=33.9285714285714, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571528, Length=339, Percent_Identity=32.4483775811209, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585514, Length=280, Percent_Identity=28.9285714285714, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28574282, Length=280, Percent_Identity=28.9285714285714, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45552429, Length=280, Percent_Identity=28.9285714285714, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28574284, Length=280, Percent_Identity=28.9285714285714, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45551003, Length=280, Percent_Identity=28.9285714285714, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=29.1187739463602, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=24.5161290322581, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 39790; Mature: 39790

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYNTTYIIILGEINYNVCYKWNIYPLGYITALYKEGIFMKIVVLEPLGVSEEKIKNIA
CCEEEEEEEEEEEECCCEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHH
LKLMDKDHELILHNEKSEDIEVLKKRVETADVLILANMPLKKEVIEAATNLKMISVAFTG
HHEECCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCEEEEEEEEC
IDHINMETCRKNNIMVCNSAGYSTSSVVELTFGLILSLLRNIVPLNDEVRNGNTKQGYSQ
CCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCH
YDLAGKTLGVIGAGDIGTEVIRIGKAFGCNVLVYNRSEKQHIKELGATQTTLDEVLKNSD
HCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHHHHHCCCC
IVTLHIPSNNETKGLINSEKLAMMKKDALLINTARGPVVDNKALAEALNKGELGGAGIDV
EEEEEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCEEE
FDMEPPVPEEYELLKTNNSVLTPHIGFATKEAMERRAEIVFRNIEKWIEGNPENIVE
ECCCCCCCCCHHHEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MKYYNTTYIIILGEINYNVCYKWNIYPLGYITALYKEGIFMKIVVLEPLGVSEEKIKNIA
CCEEEEEEEEEEEECCCEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHH
LKLMDKDHELILHNEKSEDIEVLKKRVETADVLILANMPLKKEVIEAATNLKMISVAFTG
HHEECCCCEEEEECCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCEEEEEEEEC
IDHINMETCRKNNIMVCNSAGYSTSSVVELTFGLILSLLRNIVPLNDEVRNGNTKQGYSQ
CCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCH
YDLAGKTLGVIGAGDIGTEVIRIGKAFGCNVLVYNRSEKQHIKELGATQTTLDEVLKNSD
HCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHHHHHCCCC
IVTLHIPSNNETKGLINSEKLAMMKKDALLINTARGPVVDNKALAEALNKGELGGAGIDV
EEEEEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCEEE
FDMEPPVPEEYELLKTNNSVLTPHIGFATKEAMERRAEIVFRNIEKWIEGNPENIVE
ECCCCCCCCCHHHEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA