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The map label for this gene is lytC [H]

Identifier: 28210491

GI number: 28210491

Start: 813005

End: 815008

Strand: Direct

Name: lytC [H]

Synonym: CTC00774

Alternate gene names: 28210491

Gene position: 813005-815008 (Clockwise)

Preceding gene: 28210490

Following gene: 28210492

Centisome position: 29.04

GC content: 27.94

Gene sequence:

>2004_bases
GTGAAAAAGAGAATTAAGTCTATTTTGTCTTTTATTATAACATTTATGTTTATGTTCACATATATAAGCATAATTCCAGT
AAAGGCAAGTAGTAATAATGAAGAACTATTGAAAAAAGTAAATACGTCTATAAACAATGTTCATAAATTTATAGTTAAAA
ATGGTACATGGAGTAGTGATTGGAAGACAGTAGCCTTTAATAAATCAGGACTTCAATTACCTAAAAATTATAATTATAAG
TATTTAGAAGATACTAAAAAATTATTAAAAGATTCTAAAGGATATTTTTATAAAGTAACTGACTATGAAAGAATAACTTT
AGGGGTTGTGGCAGCAGGGGGAGATCCAAGAAATGTAGGAGGATACAATATTTTAGATAAAATATATAATTTCCATGATC
CTAAAAATCCGAATAGAAAAATTGATTTTCAGGGATTAAATGGAGTTATATATGCTCTCATAGCTTTAGACACCAAAAAT
TATGAAATACCAGCTGGAGCTAAGTTTACAAGAGAATATATGTTAGATTATGTTTTAGAAAACAGAAATACTGATGGTGG
ATGGGACCTAAATATGAGTGGAAATAAAAGTGATGTAGATATAACTTCTATGACACTTATAGCTTTAGCACCACATCATG
ATTATGTAAGTAAAAATGGTAAAAAAGTTACAGATGCTATTAAAGGTGCTATAGATTGGTTATCAAAGGTTCAAAGACAA
GATGGAGGATTTAATTCTTGGTTTACGGAAAATAATAGTGAAAGTTGTGCTCAAACTATAATAGGACTTTGTGCCAATGG
AATAGATCCTACAAGTGCTAAATTTACTAAAAACAGAAATTTGGTGGAAAATCTATTAAGATTTCAACAATCAAATGGTG
AATTTTATCATTTGATGGATGGTAGTGAAGGTGTAAATGGAATGTCAACGGAGCAAGCATACCAAGCTATACTTGCATAT
AGAGATTTTGCAAAAGAAAAAGGTTCAATATATTGGTTTGATAATAAGAAGGTTCCAACTACATTTAAAGATTTAAATGG
AGAATCAAATAATAAATCAGAAGATTTAAAGGATGTAGAAAATAATAAAGTACAAAGAATTAAAGGAAAAGATAGGTTTG
AAACTTCAGTAAAAATTGGTAACAAATTTAGATTAGAAAATGGAGAAGAAAAATTAAAAAATGTAATAGTATCTTCAGCT
TTTGGATTTGCAGATTCATTAAGTGGAAGTATCTTATCTAAAAAATTAGATGCTCCAATAATGTTAACAGGAAATAATGA
AAGTAGTAGTAAAGAAGCTATTGAATATATAAAAAATAATGTTGATAAAAAGGGAAATGTCTATATATTAGGTGGAATAG
CTTCTGTAAATAGCACTATAGAAAACACCATAAAAAACAATGGATATAATATAAAAAGATTGAGTGGAGAAGATAGATAT
GGAACATGTAACTCAATTGTAAAAGAATTTGGAGTAAAAGAAGGTACCCCAGTAGTAATAGTAAATGGATTAAATTTTGC
AGATGCATTAAGTGTAAGTGCACCGGCAAGTATAAAAGGATATCCTGTATTACTAAGTGGAAATGGAGCATTACCTGAAT
ATGCTAAAAGTATTATAAAAACTGCAAAACCTTCAGAAGTTTTTATAATTGGAGGAGAAGGTGCATTAAGTAAGAACATA
GAAGATGAAGTTAAAAAAATACATTCATCATCGAAAATAACTAGATTAAGTGGAAAAGATAGATATGAAACTTCATTAAA
GGTAAATAAATATTTTGATAACAATGAAACAGTAATAATGGCTTCAGGAATAAATTATCCAGATGCCCTATCAGGAAGTG
CACTAGCAGGAAAGTTAAACGCCTCTTTACTTTTAATAAATGCTGGAAGTTTAAATAATCAAATTAAATTTATTAATAAG
GAAAAAACAAAAGAGGTAATTCTATTAGGAGGAGAAGGTGTATTAAGTAAAAAAGTAGAAAATTCTATAAAAAAATCTTT
CTAA

Upstream 100 bases:

>100_bases
CATTATCAGCAGAACGAATTAATAATAAAAACTTAAGAGACATAGTAAGACCACAACCAATTACTATAACTGTTAAGTAA
TAAAAAGGAAGGGTGATATT

Downstream 100 bases:

>100_bases
TATATGAACAGTTTAAAATAAAGTTAAATTACAGAAGAAGGGTGATCTTGTGAGAAAAAGGATTAAATCAATTATAGTTT
TAGCTATGACAGTTATGCTA

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MKKRIKSILSFIITFMFMFTYISIIPVKASSNNEELLKKVNTSINNVHKFIVKNGTWSSDWKTVAFNKSGLQLPKNYNYK
YLEDTKKLLKDSKGYFYKVTDYERITLGVVAAGGDPRNVGGYNILDKIYNFHDPKNPNRKIDFQGLNGVIYALIALDTKN
YEIPAGAKFTREYMLDYVLENRNTDGGWDLNMSGNKSDVDITSMTLIALAPHHDYVSKNGKKVTDAIKGAIDWLSKVQRQ
DGGFNSWFTENNSESCAQTIIGLCANGIDPTSAKFTKNRNLVENLLRFQQSNGEFYHLMDGSEGVNGMSTEQAYQAILAY
RDFAKEKGSIYWFDNKKVPTTFKDLNGESNNKSEDLKDVENNKVQRIKGKDRFETSVKIGNKFRLENGEEKLKNVIVSSA
FGFADSLSGSILSKKLDAPIMLTGNNESSSKEAIEYIKNNVDKKGNVYILGGIASVNSTIENTIKNNGYNIKRLSGEDRY
GTCNSIVKEFGVKEGTPVVIVNGLNFADALSVSAPASIKGYPVLLSGNGALPEYAKSIIKTAKPSEVFIIGGEGALSKNI
EDEVKKIHSSSKITRLSGKDRYETSLKVNKYFDNNETVIMASGINYPDALSGSALAGKLNASLLLINAGSLNNQIKFINK
EKTKEVILLGGEGVLSKKVENSIKKSF

Sequences:

>Translated_667_residues
MKKRIKSILSFIITFMFMFTYISIIPVKASSNNEELLKKVNTSINNVHKFIVKNGTWSSDWKTVAFNKSGLQLPKNYNYK
YLEDTKKLLKDSKGYFYKVTDYERITLGVVAAGGDPRNVGGYNILDKIYNFHDPKNPNRKIDFQGLNGVIYALIALDTKN
YEIPAGAKFTREYMLDYVLENRNTDGGWDLNMSGNKSDVDITSMTLIALAPHHDYVSKNGKKVTDAIKGAIDWLSKVQRQ
DGGFNSWFTENNSESCAQTIIGLCANGIDPTSAKFTKNRNLVENLLRFQQSNGEFYHLMDGSEGVNGMSTEQAYQAILAY
RDFAKEKGSIYWFDNKKVPTTFKDLNGESNNKSEDLKDVENNKVQRIKGKDRFETSVKIGNKFRLENGEEKLKNVIVSSA
FGFADSLSGSILSKKLDAPIMLTGNNESSSKEAIEYIKNNVDKKGNVYILGGIASVNSTIENTIKNNGYNIKRLSGEDRY
GTCNSIVKEFGVKEGTPVVIVNGLNFADALSVSAPASIKGYPVLLSGNGALPEYAKSIIKTAKPSEVFIIGGEGALSKNI
EDEVKKIHSSSKITRLSGKDRYETSLKVNKYFDNNETVIMASGINYPDALSGSALAGKLNASLLLINAGSLNNQIKFINK
EKTKEVILLGGEGVLSKKVENSIKKSF
>Mature_667_residues
MKKRIKSILSFIITFMFMFTYISIIPVKASSNNEELLKKVNTSINNVHKFIVKNGTWSSDWKTVAFNKSGLQLPKNYNYK
YLEDTKKLLKDSKGYFYKVTDYERITLGVVAAGGDPRNVGGYNILDKIYNFHDPKNPNRKIDFQGLNGVIYALIALDTKN
YEIPAGAKFTREYMLDYVLENRNTDGGWDLNMSGNKSDVDITSMTLIALAPHHDYVSKNGKKVTDAIKGAIDWLSKVQRQ
DGGFNSWFTENNSESCAQTIIGLCANGIDPTSAKFTKNRNLVENLLRFQQSNGEFYHLMDGSEGVNGMSTEQAYQAILAY
RDFAKEKGSIYWFDNKKVPTTFKDLNGESNNKSEDLKDVENNKVQRIKGKDRFETSVKIGNKFRLENGEEKLKNVIVSSA
FGFADSLSGSILSKKLDAPIMLTGNNESSSKEAIEYIKNNVDKKGNVYILGGIASVNSTIENTIKNNGYNIKRLSGEDRY
GTCNSIVKEFGVKEGTPVVIVNGLNFADALSVSAPASIKGYPVLLSGNGALPEYAKSIIKTAKPSEVFIIGGEGALSKNI
EDEVKKIHSSSKITRLSGKDRYETSLKVNKYFDNNETVIMASGINYPDALSGSALAGKLNASLLLINAGSLNNQIKFINK
EKTKEVILLGGEGVLSKKVENSIKKSF

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 73862; Mature: 73862

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRIKSILSFIITFMFMFTYISIIPVKASSNNEELLKKVNTSINNVHKFIVKNGTWSSD
CHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCHHHHHHHHEEECCCCCCC
WKTVAFNKSGLQLPKNYNYKYLEDTKKLLKDSKGYFYKVTDYERITLGVVAAGGDPRNVG
CEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCCC
GYNILDKIYNFHDPKNPNRKIDFQGLNGVIYALIALDTKNYEIPAGAKFTREYMLDYVLE
CHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
NRNTDGGWDLNMSGNKSDVDITSMTLIALAPHHDYVSKNGKKVTDAIKGAIDWLSKVQRQ
CCCCCCCEEECCCCCCCCCEEEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHC
DGGFNSWFTENNSESCAQTIIGLCANGIDPTSAKFTKNRNLVENLLRFQQSNGEFYHLMD
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCEEEEEC
GSEGVNGMSTEQAYQAILAYRDFAKEKGSIYWFDNKKVPTTFKDLNGESNNKSEDLKDVE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHH
NNKVQRIKGKDRFETSVKIGNKFRLENGEEKLKNVIVSSAFGFADSLSGSILSKKLDAPI
CCCEEECCCCCHHHHEEECCCEEECCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHCCCCE
MLTGNNESSSKEAIEYIKNNVDKKGNVYILGGIASVNSTIENTIKNNGYNIKRLSGEDRY
EEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCC
GTCNSIVKEFGVKEGTPVVIVNGLNFADALSVSAPASIKGYPVLLSGNGALPEYAKSIIK
CCHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
TAKPSEVFIIGGEGALSKNIEDEVKKIHSSSKITRLSGKDRYETSLKVNKYFDNNETVIM
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCEEEE
ASGINYPDALSGSALAGKLNASLLLINAGSLNNQIKFINKEKTKEVILLGGEGVLSKKVE
ECCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCEEEEECCCCCEEEEECCCCHHHHHHH
NSIKKSF
HHHHHCC
>Mature Secondary Structure
MKKRIKSILSFIITFMFMFTYISIIPVKASSNNEELLKKVNTSINNVHKFIVKNGTWSSD
CHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHCCHHHHHHHHEEECCCCCCC
WKTVAFNKSGLQLPKNYNYKYLEDTKKLLKDSKGYFYKVTDYERITLGVVAAGGDPRNVG
CEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCCC
GYNILDKIYNFHDPKNPNRKIDFQGLNGVIYALIALDTKNYEIPAGAKFTREYMLDYVLE
CHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
NRNTDGGWDLNMSGNKSDVDITSMTLIALAPHHDYVSKNGKKVTDAIKGAIDWLSKVQRQ
CCCCCCCEEECCCCCCCCCEEEEEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHC
DGGFNSWFTENNSESCAQTIIGLCANGIDPTSAKFTKNRNLVENLLRFQQSNGEFYHLMD
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHCCCCEEEEEC
GSEGVNGMSTEQAYQAILAYRDFAKEKGSIYWFDNKKVPTTFKDLNGESNNKSEDLKDVE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHHH
NNKVQRIKGKDRFETSVKIGNKFRLENGEEKLKNVIVSSAFGFADSLSGSILSKKLDAPI
CCCEEECCCCCHHHHEEECCCEEECCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHCCCCE
MLTGNNESSSKEAIEYIKNNVDKKGNVYILGGIASVNSTIENTIKNNGYNIKRLSGEDRY
EEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEECCCCCC
GTCNSIVKEFGVKEGTPVVIVNGLNFADALSVSAPASIKGYPVLLSGNGALPEYAKSIIK
CCHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
TAKPSEVFIIGGEGALSKNIEDEVKKIHSSSKITRLSGKDRYETSLKVNKYFDNNETVIM
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCEEEE
ASGINYPDALSGSALAGKLNASLLLINAGSLNNQIKFINKEKTKEVILLGGEGVLSKKVE
ECCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCEEEEECCCCCEEEEECCCCHHHHHHH
NSIKKSF
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]