Click here to switch to the map view.

The map label for this gene is gluP [H]

Identifier: 28210270

GI number: 28210270

Start: 541640

End: 542677

Strand: Direct

Name: gluP [H]

Synonym: CTC00530

Alternate gene names: 28210270

Gene position: 541640-542677 (Clockwise)

Preceding gene: 28210269

Following gene: 28210272

Centisome position: 19.35

GC content: 24.47

Gene sequence:

>1038_bases
ATGCAAATAAATAATAGAAATAACAGATATGCTTTTGATGAAGCAATAAATTTTATTATTGAAAGCTCTGTAAAGGCGTT
AAGATACAGTTTATTTGAATTAAATAATATAGATAATGAAACCATACTAAGTCCATGGATGTTAGTAAGATTTCAAGAAG
ATATAAATGAAGTTATTATATTTTGTAGTGAAAAGTATAATAGTTCATATGACTACGACACTAAATTAAGTGTAGTTAAG
AGTCTACAGAATAAATTTCCTAATTTATCAATATATAATATAACTCTTATAAAAATTAAATTCGTGAGACAGGTCTCAAG
CAATGGTAATTATTTTGAGGAAAATTGTGTCTTAGTAAATTTAAGTGAAAAGAAAATAATTCAGTATAGCAACGGTTTAG
AAGATTTAATTGAAATAATAAGATTTTATATGAATAATACTTATTCTAGGGAAAATGGAAATAAGAAAATAAAGAGATTT
ATTAAGGAAAATACTATAACATTTATATTAATAAGTATGAATATAATTATGTATTTCATAACAGCGTTACTTTCTGGAAA
CATAATCGATAGTAATATAGATGTTCTTATATTTTTAGGTGCCAAGGTAAATCCTCTAATTGATATAGGGCAATACTATA
GATTATTAACTTGTATTTTTTTACATGGAGGATTAATTCATTTAGCTCTTAATATGTATGCTTTATCTGCTATAGGACCA
TTAGTAGAAAAAATATATGGAAAGTTTAAATATTTAGCTATATATTTTTTATCAGGAATATGTTCATCTCTATTAAGTTA
TTTTATGTCATCAAGTATTTCCATCGGAGCTTCTGGAGCAATATTTGGTTTGCTAGGGGCATGTCTTATAATTTCTTTAA
AATATAAAGACAGGGTAGGAAAAGCTTTTGTAAATAATATAATATCAGTAATTTTTGTGAATTTAATTATAGGATTTTCA
ATTTCCAATGTAGATAACTTTGGACATATTGGAGGATTAATTGGAGGAGTAGTAATATCAACATTAATTTGTAAATAA

Upstream 100 bases:

>100_bases
TAGTAGCTGTCTTTGTTAATAAGTTTTTATATACTTATAATAAATTCAAATATAAATGTTATAATAGGTATATAAAAATA
TTCATATAAGGAGGTATTTA

Downstream 100 bases:

>100_bases
AAATGTATTGAATATGTGATAAAAGTTGGGGACAGGTCGCAAAATATAGACTAGTAATTTTTGCGACCTGTCCCCAATAT
ACCCAGCATATCTACTAATT

Product: rhomboid family membrane protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MQINNRNNRYAFDEAINFIIESSVKALRYSLFELNNIDNETILSPWMLVRFQEDINEVIIFCSEKYNSSYDYDTKLSVVK
SLQNKFPNLSIYNITLIKIKFVRQVSSNGNYFEENCVLVNLSEKKIIQYSNGLEDLIEIIRFYMNNTYSRENGNKKIKRF
IKENTITFILISMNIIMYFITALLSGNIIDSNIDVLIFLGAKVNPLIDIGQYYRLLTCIFLHGGLIHLALNMYALSAIGP
LVEKIYGKFKYLAIYFLSGICSSLLSYFMSSSISIGASGAIFGLLGACLIISLKYKDRVGKAFVNNIISVIFVNLIIGFS
ISNVDNFGHIGGLIGGVVISTLICK

Sequences:

>Translated_345_residues
MQINNRNNRYAFDEAINFIIESSVKALRYSLFELNNIDNETILSPWMLVRFQEDINEVIIFCSEKYNSSYDYDTKLSVVK
SLQNKFPNLSIYNITLIKIKFVRQVSSNGNYFEENCVLVNLSEKKIIQYSNGLEDLIEIIRFYMNNTYSRENGNKKIKRF
IKENTITFILISMNIIMYFITALLSGNIIDSNIDVLIFLGAKVNPLIDIGQYYRLLTCIFLHGGLIHLALNMYALSAIGP
LVEKIYGKFKYLAIYFLSGICSSLLSYFMSSSISIGASGAIFGLLGACLIISLKYKDRVGKAFVNNIISVIFVNLIIGFS
ISNVDNFGHIGGLIGGVVISTLICK
>Mature_345_residues
MQINNRNNRYAFDEAINFIIESSVKALRYSLFELNNIDNETILSPWMLVRFQEDINEVIIFCSEKYNSSYDYDTKLSVVK
SLQNKFPNLSIYNITLIKIKFVRQVSSNGNYFEENCVLVNLSEKKIIQYSNGLEDLIEIIRFYMNNTYSRENGNKKIKRF
IKENTITFILISMNIIMYFITALLSGNIIDSNIDVLIFLGAKVNPLIDIGQYYRLLTCIFLHGGLIHLALNMYALSAIGP
LVEKIYGKFKYLAIYFLSGICSSLLSYFMSSSISIGASGAIFGLLGACLIISLKYKDRVGKAFVNNIISVIFVNLIIGFS
ISNVDNFGHIGGLIGGVVISTLICK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI190341097, Length=159, Percent_Identity=30.8176100628931, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI301069362, Length=159, Percent_Identity=32.0754716981132, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI93352558, Length=159, Percent_Identity=32.0754716981132, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 39014; Mature: 39014

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINNRNNRYAFDEAINFIIESSVKALRYSLFELNNIDNETILSPWMLVRFQEDINEVII
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHEE
FCSEKYNSSYDYDTKLSVVKSLQNKFPNLSIYNITLIKIKFVRQVSSNGNYFEENCVLVN
EEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHCCCCEEECCEEEEE
LSEKKIIQYSNGLEDLIEIIRFYMNNTYSRENGNKKIKRFIKENTITFILISMNIIMYFI
ECHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHH
TALLSGNIIDSNIDVLIFLGAKVNPLIDIGQYYRLLTCIFLHGGLIHLALNMYALSAIGP
HHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LVEKIYGKFKYLAIYFLSGICSSLLSYFMSSSISIGASGAIFGLLGACLIISLKYKDRVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEHHHHHHH
KAFVNNIISVIFVNLIIGFSISNVDNFGHIGGLIGGVVISTLICK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQINNRNNRYAFDEAINFIIESSVKALRYSLFELNNIDNETILSPWMLVRFQEDINEVII
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHHEE
FCSEKYNSSYDYDTKLSVVKSLQNKFPNLSIYNITLIKIKFVRQVSSNGNYFEENCVLVN
EEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHCCCCEEECCEEEEE
LSEKKIIQYSNGLEDLIEIIRFYMNNTYSRENGNKKIKRFIKENTITFILISMNIIMYFI
ECHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHH
TALLSGNIIDSNIDVLIFLGAKVNPLIDIGQYYRLLTCIFLHGGLIHLALNMYALSAIGP
HHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LVEKIYGKFKYLAIYFLSGICSSLLSYFMSSSISIGASGAIFGLLGACLIISLKYKDRVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEHHHHHHH
KAFVNNIISVIFVNLIIGFSISNVDNFGHIGGLIGGVVISTLICK
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]