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The map label for this gene is lytC [H]

Identifier: 28210263

GI number: 28210263

Start: 533717

End: 535180

Strand: Direct

Name: lytC [H]

Synonym: CTC00521

Alternate gene names: 28210263

Gene position: 533717-535180 (Clockwise)

Preceding gene: 28210262

Following gene: 28210264

Centisome position: 19.07

GC content: 31.15

Gene sequence:

>1464_bases
ATGATAAAGGAGGTATTTACATTAATGAAATATAAAAAAGGCAAAATTAATACTTTTAAATTAGTTATACTATTACTTGT
GATTTCAGCTATAAATATATTCCCAGGAAATAAAGTAGCAGCTGCAGAGATAACAACTAAAAGATTTAATGGAAGAAATA
GATATGAAACAGCAGCTAAAATATGTGAAGATGGTTGGAGTGAAGAAAGTGACTGGGCAGTTGTAGTAAACGGGGATAAT
TTTGTAGATGCTTTAAGTGTTGCACCCCTTGCAAAGAAACATAATGCACCGATACTCTTAACAAATAGCAGAGTTTTGAA
TGTTTATACATCCATGCAGTTAAATAGACTTAAAGTTAAAAATGTATATGTAATTGGAGGAAAAGGGGTAATATCACAGA
ATGTAGAAGATGGCATAAAAGCTAAAGGTATTAAAGTTACAAGGCTTGGAGGGAAGGATAGATATGATACAGCTCTAGAA
ATTGCTAAAAAACTTGGAAGGCCAAAGCAAATAGCTGTTATAAATAGCGCAAGTTTTTATGATGGAGTTTCTATAGCTCC
AATAGCTGCTTTAAAGCAAATGGCAGTAATTCCCGTTGCTAAAAATGATATACCAAAGTCTATTGAAAAGTTTTTAAAAA
GCAATAAAAGAGCTGAACAAATATATGTAATAGGTGGACAAGATCAGATAAGTAACAAGATTTTTAATAAAATACCTAAT
GCAATAAGAGTAGGAAATGGAGATATATATAAAAGAAATATAGATATAATAAATGCATTCCAAAATGAATTGGATTTTGG
TAATGTATATGTAGCTTCCTCAAGGGATTTTGCAGATGCTTTATCTGCATCAGCATTGGCTTGCCAATCATCGTCACCTA
TAGTACTTGCAGGAGGTAATTTAAGTAATAGTACCAAAAGTTTCATGAAGTCAAAAATAATAAATAATGTAAGTATTTTA
GGTGGAAGTGCTTCTGTAAGTTATAACGTAGAACAAATATTAAAATATTTACCTTTAAGAGTGGCAGATACAGAAAATAT
AAGAAAAGAAATATGGCAAAATGAAAGCTTTACACCACCACCAACTATAGTAGTAACAGCAAACAATGGAAATATGGAAG
AGGTTTCAGTAACTTGGAATTTAACAAGAGTTGATACTACTAAGCCAGGAATTTATAGCTTTGTGGGAGAAATAGACGGA
TACAACAGACAGGTTGATTTAATATTAATAGTAAGACCATTACCAGTTAAAATAGAGGATATAAATAAAGAAGCTAAGAG
TAGAGAGAGATTTGTATTACCTGAAAAGGTTGAAGCAGAGATGAGTGATGGTAGTAGAAGTGAACTTTCTGTTATTTGGG
ATTATGGAACAAAACAAAGCAATAAATCAGGAGTTTATGTTTTCTATGGTACTGTAGAAAAGTATGATAAAAAGGTTAAA
TTGACTTTAACAGTAACAGAATAG

Upstream 100 bases:

>100_bases
TACTACATGATTAATAAAAATTTAAAGAAATATGATAAAGATAGAAGTTTCTTTGCAGCTATGGATTCTATATTAGATAA
ATAGTGCTTGTAGATTAATT

Downstream 100 bases:

>100_bases
GGGACAGGTCAAAAAGGTAATAAACAATTAAATTTAAAGTACCAAGAATAAATTTAATATTCTTGGTACTTTAAGTATTA
AATAAAGGGGAATAGGGACA

Product: cwp66 homolog/N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MIKEVFTLMKYKKGKINTFKLVILLLVISAINIFPGNKVAAAEITTKRFNGRNRYETAAKICEDGWSEESDWAVVVNGDN
FVDALSVAPLAKKHNAPILLTNSRVLNVYTSMQLNRLKVKNVYVIGGKGVISQNVEDGIKAKGIKVTRLGGKDRYDTALE
IAKKLGRPKQIAVINSASFYDGVSIAPIAALKQMAVIPVAKNDIPKSIEKFLKSNKRAEQIYVIGGQDQISNKIFNKIPN
AIRVGNGDIYKRNIDIINAFQNELDFGNVYVASSRDFADALSASALACQSSSPIVLAGGNLSNSTKSFMKSKIINNVSIL
GGSASVSYNVEQILKYLPLRVADTENIRKEIWQNESFTPPPTIVVTANNGNMEEVSVTWNLTRVDTTKPGIYSFVGEIDG
YNRQVDLILIVRPLPVKIEDINKEAKSRERFVLPEKVEAEMSDGSRSELSVIWDYGTKQSNKSGVYVFYGTVEKYDKKVK
LTLTVTE

Sequences:

>Translated_487_residues
MIKEVFTLMKYKKGKINTFKLVILLLVISAINIFPGNKVAAAEITTKRFNGRNRYETAAKICEDGWSEESDWAVVVNGDN
FVDALSVAPLAKKHNAPILLTNSRVLNVYTSMQLNRLKVKNVYVIGGKGVISQNVEDGIKAKGIKVTRLGGKDRYDTALE
IAKKLGRPKQIAVINSASFYDGVSIAPIAALKQMAVIPVAKNDIPKSIEKFLKSNKRAEQIYVIGGQDQISNKIFNKIPN
AIRVGNGDIYKRNIDIINAFQNELDFGNVYVASSRDFADALSASALACQSSSPIVLAGGNLSNSTKSFMKSKIINNVSIL
GGSASVSYNVEQILKYLPLRVADTENIRKEIWQNESFTPPPTIVVTANNGNMEEVSVTWNLTRVDTTKPGIYSFVGEIDG
YNRQVDLILIVRPLPVKIEDINKEAKSRERFVLPEKVEAEMSDGSRSELSVIWDYGTKQSNKSGVYVFYGTVEKYDKKVK
LTLTVTE
>Mature_487_residues
MIKEVFTLMKYKKGKINTFKLVILLLVISAINIFPGNKVAAAEITTKRFNGRNRYETAAKICEDGWSEESDWAVVVNGDN
FVDALSVAPLAKKHNAPILLTNSRVLNVYTSMQLNRLKVKNVYVIGGKGVISQNVEDGIKAKGIKVTRLGGKDRYDTALE
IAKKLGRPKQIAVINSASFYDGVSIAPIAALKQMAVIPVAKNDIPKSIEKFLKSNKRAEQIYVIGGQDQISNKIFNKIPN
AIRVGNGDIYKRNIDIINAFQNELDFGNVYVASSRDFADALSASALACQSSSPIVLAGGNLSNSTKSFMKSKIINNVSIL
GGSASVSYNVEQILKYLPLRVADTENIRKEIWQNESFTPPPTIVVTANNGNMEEVSVTWNLTRVDTTKPGIYSFVGEIDG
YNRQVDLILIVRPLPVKIEDINKEAKSRERFVLPEKVEAEMSDGSRSELSVIWDYGTKQSNKSGVYVFYGTVEKYDKKVK
LTLTVTE

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 53820; Mature: 53820

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKEVFTLMKYKKGKINTFKLVILLLVISAINIFPGNKVAAAEITTKRFNGRNRYETAAK
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCHHHHHHH
ICEDGWSEESDWAVVVNGDNFVDALSVAPLAKKHNAPILLTNSRVLNVYTSMQLNRLKVK
HHHCCCCCCCCEEEEECCCCHHHHHHHCHHHHCCCCCEEEECCEEEEEEECCEECEEEEE
NVYVIGGKGVISQNVEDGIKAKGIKVTRLGGKDRYDTALEIAKKLGRPKQIAVINSASFY
EEEEECCCCEECCCHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
DGVSIAPIAALKQMAVIPVAKNDIPKSIEKFLKSNKRAEQIYVIGGQDQISNKIFNKIPN
CCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCC
AIRVGNGDIYKRNIDIINAFQNELDFGNVYVASSRDFADALSASALACQSSSPIVLAGGN
EEEECCCCEEEECCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHEEECCCCCEEEECCC
LSNSTKSFMKSKIINNVSILGGSASVSYNVEQILKYLPLRVADTENIRKEIWQNESFTPP
CCCHHHHHHHHHHHCCEEEECCCCEEEECHHHHHHHCCEEECCHHHHHHHHHCCCCCCCC
PTIVVTANNGNMEEVSVTWNLTRVDTTKPGIYSFVGEIDGYNRQVDLILIVRPLPVKIED
CEEEEEECCCCCEEEEEEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEEEEECCCEEEEC
INKEAKSRERFVLPEKVEAEMSDGSRSELSVIWDYGTKQSNKSGVYVFYGTVEKYDKKVK
CCCHHHCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEEECHHHCCCEEE
LTLTVTE
EEEEEEC
>Mature Secondary Structure
MIKEVFTLMKYKKGKINTFKLVILLLVISAINIFPGNKVAAAEITTKRFNGRNRYETAAK
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCHHHHHHH
ICEDGWSEESDWAVVVNGDNFVDALSVAPLAKKHNAPILLTNSRVLNVYTSMQLNRLKVK
HHHCCCCCCCCEEEEECCCCHHHHHHHCHHHHCCCCCEEEECCEEEEEEECCEECEEEEE
NVYVIGGKGVISQNVEDGIKAKGIKVTRLGGKDRYDTALEIAKKLGRPKQIAVINSASFY
EEEEECCCCEECCCHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
DGVSIAPIAALKQMAVIPVAKNDIPKSIEKFLKSNKRAEQIYVIGGQDQISNKIFNKIPN
CCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCC
AIRVGNGDIYKRNIDIINAFQNELDFGNVYVASSRDFADALSASALACQSSSPIVLAGGN
EEEECCCCEEEECCHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHEEECCCCCEEEECCC
LSNSTKSFMKSKIINNVSILGGSASVSYNVEQILKYLPLRVADTENIRKEIWQNESFTPP
CCCHHHHHHHHHHHCCEEEECCCCEEEECHHHHHHHCCEEECCHHHHHHHHHCCCCCCCC
PTIVVTANNGNMEEVSVTWNLTRVDTTKPGIYSFVGEIDGYNRQVDLILIVRPLPVKIED
CEEEEEECCCCCEEEEEEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEEEEECCCEEEEC
INKEAKSRERFVLPEKVEAEMSDGSRSELSVIWDYGTKQSNKSGVYVFYGTVEKYDKKVK
CCCHHHCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEEECHHHCCCEEE
LTLTVTE
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]