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The map label for this gene is lytC [H]

Identifier: 28210262

GI number: 28210262

Start: 531085

End: 533700

Strand: Direct

Name: lytC [H]

Synonym: CTC00520

Alternate gene names: 28210262

Gene position: 531085-533700 (Clockwise)

Preceding gene: 28210261

Following gene: 28210263

Centisome position: 18.97

GC content: 27.14

Gene sequence:

>2616_bases
ATGATTAAAAGTAAATGTGAAAAAAGAATTGCAAAGATTTTATGTGGTACTTTTTTAGTTACTACTATGATTTTACAACC
TCTAACTGCTGTTAAGGCAGCTAAGAAAGATAGCGATAAGGAAAAAAAATATGTTAGAAAACCAGCTAAAGTAAGAATTT
ATGGTAAAGACAGATATGAAACGTCATCAAAGATAGCAAAAGAAGGATGGAGTAGTTCCTATTATGCAATAATAGCATCT
GGCGAAGATTTCCCGGATTCTCTAAGTGCAGTTACATTATCTAAAAGGCATGATGCTCCTATCTTATTAACTAATAGTAA
AAGTTTAAATAGAAATACAAGAGAAGAATTAACTAGAATGAGAGTAAAAAAGGTATTTATAATTGGAGGACAGGTCGCAA
TTTCTCCTAAAGTAGAACAAGATATAAAAGCTATGGGAATTACTACAGAAAGGCTGGGGGGCAAGGATAGATACGAAACA
TCTATTAAAGTTGCAGAAAGACTGGGAAACCCAGGAACATTATTTGTAGTTACATCTAATCATTTTGCAGATGCATTATC
TGCAGGACCAATTGCTGCTAAAAAAGGAGCACCTATAATATTAACTTCTAAAGATCGTTTAGCGGATGTTACTAAAAAAT
ATCTAAATAAAAAAGTGTTCAATAAAGTGTATATAGTGGGGGACAGGTCACAAATAAGTGATAAAGTAGCAAGTGAATTT
GAAATACATGTACGAAATCATAAAAATGGTTTAGAAAGAATAGATTCTAAAGCTAGTGAATATGTTAAAAATTCCACTGT
ATATGAAAGGAATATAAACATAATCAATAAATTTCCGAATGAGTTAAATTCATATAAAGAAATATTTGTAGCTTCTGGTG
TTGCATTTGCGGATGCTCTTTCTGTAAATGCATTAGCTGCTAAAAGAGAAGCACCTATTGTAATAGGAAATACATCTGAT
GGAAACTTATTAAAGAGTTTTATATCTGACAATTTTTCAAAAATAGCTACAATGAATATTGTAGGTGGACAGGGTGTTAT
ATCTGAAAACTATGTAAATAATATAGTAGATTATATAGAAGATGAAGAAATTAAATTTAAAGATGGCAATATGGAAAGAG
CTGTTAGAGAAAAGCTAGGTATAACAAATGAAAATGAAAGAATTTATAAATCTAAAGTAAGGGATGTTAAAATATTAGAT
TTATCAGGATTCAACATATCAAAAATAGATGGAATTCAATTGTTTGAAGGTCTTAAAGAGTTAAATTTAAGTAATAATAA
AATAAAGAATCTAGAACCTTTAGAAGATATGTTTTATTTAGAAAGTCTAAATCTATCAGAAAATAAAGTAGAAGATTTAG
AACCTCTAGAAGAGCTTCGTAGTTTAAATTATTTGAATTTAAATAACAATAATGTAAGGTATGTGGATTCTCTTAAAAAA
TTAGAGTACCTAAAATATTTAAATTTAGGTAAGAATGATATAAGCTATATTGAAGATTTTAAAGATTTAACTTATCTTTA
TTATTTAGATTTATCACATAATAACAACATAGGTGGGTTAAGTGATTTATCTGATTTAAAGAATTTAACTACATTAAAAT
TAAGCAATACAGGTATATCAAGTTTAGGATTTTTAGAAGATTTAAAGAGATTAACAGAGTTAGATTTAGCTAAAAATAGC
ATAAGTAATTTAGATAGCTTAAAGAAGCTAGATAATTTAAAAACTTTATATTTAAATGATAATAACATATCTTATATAGA
GGATTTAAAAGATTTAAAGGATTTAGAAGAGTTAAATGTATGGGGAAATAATATAAAGGATGTTGAGAAGTTTAAAAAGT
TTAAGACACTTAGAAAGTTGACAATACAGAGATCATTATTAGGGGATGATGATAGAAAACAGTTAGATTTAATATCAAAT
ATTCCACATGTTTTTGACAAGAAGAATACTTATGTAGCATCTAAAAATGATATAGATAGTAATTTTAAGGATATACCAGG
AAAAACTTATAAGGACAAGGAATTAGATGATATTTCAAAGGAATCTAAAGATCTTAAAGATACTTATAAACATGAATACA
ATCCTTATGAGGTGATATATAAATCTAACTCTGGATATAGCAATGCGTTTACAGCTAGAGAACTTCTTAACCGTGAAAAA
GATCTTAAATCTATGATAGAAGATTCTACCTACTCTATGCAAGTTAGAAAAATGATGCAAGAAGATTTAGAGAAAGTAAT
AAATCGATATGGAATGGTTAATAAAACTAATAGAATGAATGATAAAGTCATGGAATTAGAAGCTAAAATTAATATGTACT
TTGAAGAAAAAGAAAAGAGAAAAGCAAGAAATAGAATAAACTATGTGTATTCAGATTATAAATATGACTTTTATAAAAAT
GCAGCTATAGAATGTGAAAGGGACATGTCACAATTAAAATCACAAATTGGACAACTAGAATATAGCAATAGCTATAGTAA
TAATGAAAAGGCTAGACTTTTAAAAGGTGAGTTAAGAAACAAGGAAATAGAATACTACATGATTAATAAAAATTTAAAGA
AATATGATAAAGATAGAAGTTTCTTTGCAGCTATGGATTCTATATTAGATAAATAG

Upstream 100 bases:

>100_bases
GAAAAATGGAGTATTGGTCTGGGAACACATATAAATATTATAAGTTACTTAATATTGTGTTCATGATCATCTGATTATAT
TAAGAAGGAAGGATAGGTTT

Downstream 100 bases:

>100_bases
TGCTTGTAGATTAATTATGATAAAGGAGGTATTTACATTAATGAAATATAAAAAAGGCAAAATTAATACTTTTAAATTAG
TTATACTATTACTTGTGATT

Product: cwp66 homolog/N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 871; Mature: 871

Protein sequence:

>871_residues
MIKSKCEKRIAKILCGTFLVTTMILQPLTAVKAAKKDSDKEKKYVRKPAKVRIYGKDRYETSSKIAKEGWSSSYYAIIAS
GEDFPDSLSAVTLSKRHDAPILLTNSKSLNRNTREELTRMRVKKVFIIGGQVAISPKVEQDIKAMGITTERLGGKDRYET
SIKVAERLGNPGTLFVVTSNHFADALSAGPIAAKKGAPIILTSKDRLADVTKKYLNKKVFNKVYIVGDRSQISDKVASEF
EIHVRNHKNGLERIDSKASEYVKNSTVYERNINIINKFPNELNSYKEIFVASGVAFADALSVNALAAKREAPIVIGNTSD
GNLLKSFISDNFSKIATMNIVGGQGVISENYVNNIVDYIEDEEIKFKDGNMERAVREKLGITNENERIYKSKVRDVKILD
LSGFNISKIDGIQLFEGLKELNLSNNKIKNLEPLEDMFYLESLNLSENKVEDLEPLEELRSLNYLNLNNNNVRYVDSLKK
LEYLKYLNLGKNDISYIEDFKDLTYLYYLDLSHNNNIGGLSDLSDLKNLTTLKLSNTGISSLGFLEDLKRLTELDLAKNS
ISNLDSLKKLDNLKTLYLNDNNISYIEDLKDLKDLEELNVWGNNIKDVEKFKKFKTLRKLTIQRSLLGDDDRKQLDLISN
IPHVFDKKNTYVASKNDIDSNFKDIPGKTYKDKELDDISKESKDLKDTYKHEYNPYEVIYKSNSGYSNAFTARELLNREK
DLKSMIEDSTYSMQVRKMMQEDLEKVINRYGMVNKTNRMNDKVMELEAKINMYFEEKEKRKARNRINYVYSDYKYDFYKN
AAIECERDMSQLKSQIGQLEYSNSYSNNEKARLLKGELRNKEIEYYMINKNLKKYDKDRSFFAAMDSILDK

Sequences:

>Translated_871_residues
MIKSKCEKRIAKILCGTFLVTTMILQPLTAVKAAKKDSDKEKKYVRKPAKVRIYGKDRYETSSKIAKEGWSSSYYAIIAS
GEDFPDSLSAVTLSKRHDAPILLTNSKSLNRNTREELTRMRVKKVFIIGGQVAISPKVEQDIKAMGITTERLGGKDRYET
SIKVAERLGNPGTLFVVTSNHFADALSAGPIAAKKGAPIILTSKDRLADVTKKYLNKKVFNKVYIVGDRSQISDKVASEF
EIHVRNHKNGLERIDSKASEYVKNSTVYERNINIINKFPNELNSYKEIFVASGVAFADALSVNALAAKREAPIVIGNTSD
GNLLKSFISDNFSKIATMNIVGGQGVISENYVNNIVDYIEDEEIKFKDGNMERAVREKLGITNENERIYKSKVRDVKILD
LSGFNISKIDGIQLFEGLKELNLSNNKIKNLEPLEDMFYLESLNLSENKVEDLEPLEELRSLNYLNLNNNNVRYVDSLKK
LEYLKYLNLGKNDISYIEDFKDLTYLYYLDLSHNNNIGGLSDLSDLKNLTTLKLSNTGISSLGFLEDLKRLTELDLAKNS
ISNLDSLKKLDNLKTLYLNDNNISYIEDLKDLKDLEELNVWGNNIKDVEKFKKFKTLRKLTIQRSLLGDDDRKQLDLISN
IPHVFDKKNTYVASKNDIDSNFKDIPGKTYKDKELDDISKESKDLKDTYKHEYNPYEVIYKSNSGYSNAFTARELLNREK
DLKSMIEDSTYSMQVRKMMQEDLEKVINRYGMVNKTNRMNDKVMELEAKINMYFEEKEKRKARNRINYVYSDYKYDFYKN
AAIECERDMSQLKSQIGQLEYSNSYSNNEKARLLKGELRNKEIEYYMINKNLKKYDKDRSFFAAMDSILDK
>Mature_871_residues
MIKSKCEKRIAKILCGTFLVTTMILQPLTAVKAAKKDSDKEKKYVRKPAKVRIYGKDRYETSSKIAKEGWSSSYYAIIAS
GEDFPDSLSAVTLSKRHDAPILLTNSKSLNRNTREELTRMRVKKVFIIGGQVAISPKVEQDIKAMGITTERLGGKDRYET
SIKVAERLGNPGTLFVVTSNHFADALSAGPIAAKKGAPIILTSKDRLADVTKKYLNKKVFNKVYIVGDRSQISDKVASEF
EIHVRNHKNGLERIDSKASEYVKNSTVYERNINIINKFPNELNSYKEIFVASGVAFADALSVNALAAKREAPIVIGNTSD
GNLLKSFISDNFSKIATMNIVGGQGVISENYVNNIVDYIEDEEIKFKDGNMERAVREKLGITNENERIYKSKVRDVKILD
LSGFNISKIDGIQLFEGLKELNLSNNKIKNLEPLEDMFYLESLNLSENKVEDLEPLEELRSLNYLNLNNNNVRYVDSLKK
LEYLKYLNLGKNDISYIEDFKDLTYLYYLDLSHNNNIGGLSDLSDLKNLTTLKLSNTGISSLGFLEDLKRLTELDLAKNS
ISNLDSLKKLDNLKTLYLNDNNISYIEDLKDLKDLEELNVWGNNIKDVEKFKKFKTLRKLTIQRSLLGDDDRKQLDLISN
IPHVFDKKNTYVASKNDIDSNFKDIPGKTYKDKELDDISKESKDLKDTYKHEYNPYEVIYKSNSGYSNAFTARELLNREK
DLKSMIEDSTYSMQVRKMMQEDLEKVINRYGMVNKTNRMNDKVMELEAKINMYFEEKEKRKARNRINYVYSDYKYDFYKN
AAIECERDMSQLKSQIGQLEYSNSYSNNEKARLLKGELRNKEIEYYMINKNLKKYDKDRSFFAAMDSILDK

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Homo sapiens, GI4506013, Length=234, Percent_Identity=34.1880341880342, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI21389483, Length=219, Percent_Identity=32.8767123287671, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI209862903, Length=303, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI55743114, Length=167, Percent_Identity=31.1377245508982, Blast_Score=70, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17554124, Length=235, Percent_Identity=33.6170212765957, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17536161, Length=220, Percent_Identity=31.8181818181818, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531555, Length=247, Percent_Identity=31.9838056680162, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71984630, Length=292, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21358617, Length=211, Percent_Identity=31.2796208530806, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17933612, Length=219, Percent_Identity=32.4200913242009, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330678, Length=189, Percent_Identity=30.1587301587302, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI85726404, Length=189, Percent_Identity=30.1587301587302, Blast_Score=70, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355407, Length=209, Percent_Identity=33.0143540669856, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 100041; Mature: 100041

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSKCEKRIAKILCGTFLVTTMILQPLTAVKAAKKDSDKEKKYVRKPAKVRIYGKDRYE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCHH
TSSKIAKEGWSSSYYAIIASGEDFPDSLSAVTLSKRHDAPILLTNSKSLNRNTREELTRM
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHEEECCCCCCCEEEECCCCCCCCHHHHHHHH
RVKKVFIIGGQVAISPKVEQDIKAMGITTERLGGKDRYETSIKVAERLGNPGTLFVVTSN
HHHEEEEECCEEEECCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECC
HFADALSAGPIAAKKGAPIILTSKDRLADVTKKYLNKKVFNKVYIVGDRSQISDKVASEF
HHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCEEEEEECHHHHHHHHHHHE
EIHVRNHKNGLERIDSKASEYVKNSTVYERNINIINKFPNELNSYKEIFVASGVAFADAL
EEEEECCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHCHHHHHHHHHHHHHCCHHHHHHH
SVNALAAKREAPIVIGNTSDGNLLKSFISDNFSKIATMNIVGGQGVISENYVNNIVDYIE
HHHHHHHCCCCCEEEECCCCHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHC
DEEIKFKDGNMERAVREKLGITNENERIYKSKVRDVKILDLSGFNISKIDGIQLFEGLKE
CCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHH
LNLSNNKIKNLEPLEDMFYLESLNLSENKVEDLEPLEELRSLNYLNLNNNNVRYVDSLKK
CCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHH
LEYLKYLNLGKNDISYIEDFKDLTYLYYLDLSHNNNIGGLSDLSDLKNLTTLKLSNTGIS
HHHHHHHCCCCCHHHHHHHHHHCEEEEEEEECCCCCCCCCHHHHHHCCCEEEEECCCCCC
SLGFLEDLKRLTELDLAKNSISNLDSLKKLDNLKTLYLNDNNISYIEDLKDLKDLEELNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
WGNNIKDVEKFKKFKTLRKLTIQRSLLGDDDRKQLDLISNIPHVFDKKNTYVASKNDIDS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCCEEECCCCCCC
NFKDIPGKTYKDKELDDISKESKDLKDTYKHEYNPYEVIYKSNSGYSNAFTARELLNREK
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
DLKSMIEDSTYSMQVRKMMQEDLEKVINRYGMVNKTNRMNDKVMELEAKINMYFEEKEKR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KARNRINYVYSDYKYDFYKNAAIECERDMSQLKSQIGQLEYSNSYSNNEKARLLKGELRN
HHHHHHHEEHCCCEECHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHCC
KEIEYYMINKNLKKYDKDRSFFAAMDSILDK
CCEEEEEECCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKSKCEKRIAKILCGTFLVTTMILQPLTAVKAAKKDSDKEKKYVRKPAKVRIYGKDRYE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCHH
TSSKIAKEGWSSSYYAIIASGEDFPDSLSAVTLSKRHDAPILLTNSKSLNRNTREELTRM
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHEEECCCCCCCEEEECCCCCCCCHHHHHHHH
RVKKVFIIGGQVAISPKVEQDIKAMGITTERLGGKDRYETSIKVAERLGNPGTLFVVTSN
HHHEEEEECCEEEECCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECC
HFADALSAGPIAAKKGAPIILTSKDRLADVTKKYLNKKVFNKVYIVGDRSQISDKVASEF
HHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCEEEEEECHHHHHHHHHHHE
EIHVRNHKNGLERIDSKASEYVKNSTVYERNINIINKFPNELNSYKEIFVASGVAFADAL
EEEEECCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHCHHHHHHHHHHHHHCCHHHHHHH
SVNALAAKREAPIVIGNTSDGNLLKSFISDNFSKIATMNIVGGQGVISENYVNNIVDYIE
HHHHHHHCCCCCEEEECCCCHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHHHHHHHHHC
DEEIKFKDGNMERAVREKLGITNENERIYKSKVRDVKILDLSGFNISKIDGIQLFEGLKE
CCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHH
LNLSNNKIKNLEPLEDMFYLESLNLSENKVEDLEPLEELRSLNYLNLNNNNVRYVDSLKK
CCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHH
LEYLKYLNLGKNDISYIEDFKDLTYLYYLDLSHNNNIGGLSDLSDLKNLTTLKLSNTGIS
HHHHHHHCCCCCHHHHHHHHHHCEEEEEEEECCCCCCCCCHHHHHHCCCEEEEECCCCCC
SLGFLEDLKRLTELDLAKNSISNLDSLKKLDNLKTLYLNDNNISYIEDLKDLKDLEELNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
WGNNIKDVEKFKKFKTLRKLTIQRSLLGDDDRKQLDLISNIPHVFDKKNTYVASKNDIDS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCCCCEEECCCCCCC
NFKDIPGKTYKDKELDDISKESKDLKDTYKHEYNPYEVIYKSNSGYSNAFTARELLNREK
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
DLKSMIEDSTYSMQVRKMMQEDLEKVINRYGMVNKTNRMNDKVMELEAKINMYFEEKEKR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KARNRINYVYSDYKYDFYKNAAIECERDMSQLKSQIGQLEYSNSYSNNEKARLLKGELRN
HHHHHHHEEHCCCEECHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHCC
KEIEYYMINKNLKKYDKDRSFFAAMDSILDK
CCEEEEEECCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]