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The map label for this gene is iolC

Identifier: 28210250

GI number: 28210250

Start: 514978

End: 515997

Strand: Direct

Name: iolC

Synonym: CTC00508

Alternate gene names: 28210250

Gene position: 514978-515997 (Clockwise)

Preceding gene: 28210249

Following gene: 28210251

Centisome position: 18.4

GC content: 31.18

Gene sequence:

>1020_bases
GTGAATTATATTAAGTTTGACGAAAAAAAACCACTAGATGTAATTCCTATTGGAAGGGTAACCATAGATTTTAATCCTAA
TGAGATTAATAGACCTTTAGAGGAAAGTAGAACCTTTACTAAATACTTAGGAGGATCTCCAGGAAATATAGCAGTTGGAT
TAGCAAGACTTGGGAAAAAGGTAGGTTTTTTAAGTACAGTATCTGATGATCAATTTGGAAATTTTGTGGTAAATTATTTA
AAAAATGAAGGAATAGATATATCTCAAATAAATAGAGCTAAAAACGGGGAAAAATTAGGTCTTACATTTACAGAAATTTT
AAGTCCTAAAGAAAGTAGTATATTAATGTATAGAAAAGGAATAGCAGATTTACAGCTATCATCTAAAGAAGTAAGTGAGG
ACTATATAAAAAGTGCAAAAGCTATAGTTATATCTGGTACAGCTTTATCAAAAAGTCCATCAAGAGAAGCAGCTTTTGTT
GCATTAGAATATGCTAAAAAACATAATACTAGGATAATATTTGACTTGGATTATAGAGAATATACATGGAATTGCAAGGA
AGAAATAGCTATTTATTATTCATTAGCAGCAAGAATGAGTGACGTTATAATGGGTTCAAGAGAAGAATTTAATCTTATGG
AAGGTCTTATAAGTCCAGAGGAAAGTAATGATAAAGAAACAGCAGAAAGATGGATAGGATATGGAAACAAAATTGTTGTA
ATAAAACATGGAAAAGATGGTTCAACTGCATATTTACATGATGGTACAAGCTATAAAATAAAACCATTTCCAGTAAAACT
ATTAAAATCCTTTGGTGGTGGAGACGCATATGCTTCAGCATTTATATATGGAATTATGGAAGGATGGGATGTTATAGATG
CATTAGAATTTGGCAGTGCTTCAGCAGCTATGCTTGTAGCAAGTCACAGTTGTTCTGAGGCTATGCCTAAAGTAGAAGAA
ATTAAACAATTTATAAAAGAAAAAAAAGAAGAACATGGTGAGATGGTAGTAAGGGGGTAA

Upstream 100 bases:

>100_bases
TATCATGATGTTGTTATTAATGCAGCCTATGATAACGTAAAAAAACATATAGACATATTTGGTAGTAGTAACAAAGCATA
AATTTTAAGGGGGTATTTTA

Downstream 100 bases:

>100_bases
TAATTAATGCTTGAAAAACTTAAAGAACTAGAGAAAGGGCATAATATTTTAGTAGAATCTAATGGAAAACATAGTGAAAT
GATGATGGATATAAGTATAT

Product: 5-dehydro-2-deoxygluconokinase

Products: NA

Alternate protein names: 2-deoxy-5-keto-D-gluconate kinase; DKG kinase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNYIKFDEKKPLDVIPIGRVTIDFNPNEINRPLEESRTFTKYLGGSPGNIAVGLARLGKKVGFLSTVSDDQFGNFVVNYL
KNEGIDISQINRAKNGEKLGLTFTEILSPKESSILMYRKGIADLQLSSKEVSEDYIKSAKAIVISGTALSKSPSREAAFV
ALEYAKKHNTRIIFDLDYREYTWNCKEEIAIYYSLAARMSDVIMGSREEFNLMEGLISPEESNDKETAERWIGYGNKIVV
IKHGKDGSTAYLHDGTSYKIKPFPVKLLKSFGGGDAYASAFIYGIMEGWDVIDALEFGSASAAMLVASHSCSEAMPKVEE
IKQFIKEKKEEHGEMVVRG

Sequences:

>Translated_339_residues
MNYIKFDEKKPLDVIPIGRVTIDFNPNEINRPLEESRTFTKYLGGSPGNIAVGLARLGKKVGFLSTVSDDQFGNFVVNYL
KNEGIDISQINRAKNGEKLGLTFTEILSPKESSILMYRKGIADLQLSSKEVSEDYIKSAKAIVISGTALSKSPSREAAFV
ALEYAKKHNTRIIFDLDYREYTWNCKEEIAIYYSLAARMSDVIMGSREEFNLMEGLISPEESNDKETAERWIGYGNKIVV
IKHGKDGSTAYLHDGTSYKIKPFPVKLLKSFGGGDAYASAFIYGIMEGWDVIDALEFGSASAAMLVASHSCSEAMPKVEE
IKQFIKEKKEEHGEMVVRG
>Mature_339_residues
MNYIKFDEKKPLDVIPIGRVTIDFNPNEINRPLEESRTFTKYLGGSPGNIAVGLARLGKKVGFLSTVSDDQFGNFVVNYL
KNEGIDISQINRAKNGEKLGLTFTEILSPKESSILMYRKGIADLQLSSKEVSEDYIKSAKAIVISGTALSKSPSREAAFV
ALEYAKKHNTRIIFDLDYREYTWNCKEEIAIYYSLAARMSDVIMGSREEFNLMEGLISPEESNDKETAERWIGYGNKIVV
IKHGKDGSTAYLHDGTSYKIKPFPVKLLKSFGGGDAYASAFIYGIMEGWDVIDALEFGSASAAMLVASHSCSEAMPKVEE
IKQFIKEKKEEHGEMVVRG

Specific function: Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family

Homologues:

Organism=Escherichia coli, GI87081971, Length=324, Percent_Identity=24.0740740740741, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IOLC_CLOTE (Q898F0)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781194.1
- ProteinModelPortal:   Q898F0
- GeneID:   1060112
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00508
- NMPDR:   fig|212717.1.peg.416
- HOGENOM:   HBG466006
- OMA:   RPMFWSS
- PhylomeDB:   Q898F0
- ProtClustDB:   CLSK873289
- BioCyc:   CTET212717:CTC_00508-MONOMER
- HAMAP:   MF_01668
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR022841

Pfam domain/function: PF00294 PfkB

EC number: =2.7.1.92

Molecular weight: Translated: 37754; Mature: 37754

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYIKFDEKKPLDVIPIGRVTIDFNPNEINRPLEESRTFTKYLGGSPGNIAVGLARLGKK
CCCCCCCCCCCCCEEECCEEEEEECCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VGFLSTVSDDQFGNFVVNYLKNEGIDISQINRAKNGEKLGLTFTEILSPKESSILMYRKG
HCEEEECCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEECEEHHHHCCCCCCCEEEEECC
IADLQLSSKEVSEDYIKSAKAIVISGTALSKSPSREAAFVALEYAKKHNTRIIFDLDYRE
CCCEEECHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHEEEEEHHHHCCCEEEEEECCCE
YTWNCKEEIAIYYSLAARMSDVIMGSREEFNLMEGLISPEESNDKETAERWIGYGNKIVV
ECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEE
IKHGKDGSTAYLHDGTSYKIKPFPVKLLKSFGGGDAYASAFIYGIMEGWDVIDALEFGSA
EEECCCCCEEEEECCCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHCCCC
SAAMLVASHSCSEAMPKVEEIKQFIKEKKEEHGEMVVRG
CEEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MNYIKFDEKKPLDVIPIGRVTIDFNPNEINRPLEESRTFTKYLGGSPGNIAVGLARLGKK
CCCCCCCCCCCCCEEECCEEEEEECCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VGFLSTVSDDQFGNFVVNYLKNEGIDISQINRAKNGEKLGLTFTEILSPKESSILMYRKG
HCEEEECCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEECEEHHHHCCCCCCCEEEEECC
IADLQLSSKEVSEDYIKSAKAIVISGTALSKSPSREAAFVALEYAKKHNTRIIFDLDYRE
CCCEEECHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHEEEEEHHHHCCCEEEEEECCCE
YTWNCKEEIAIYYSLAARMSDVIMGSREEFNLMEGLISPEESNDKETAERWIGYGNKIVV
ECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEE
IKHGKDGSTAYLHDGTSYKIKPFPVKLLKSFGGGDAYASAFIYGIMEGWDVIDALEFGSA
EEECCCCCEEEEECCCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHCCCC
SAAMLVASHSCSEAMPKVEEIKQFIKEKKEEHGEMVVRG
CEEEEEECCCHHHHCCCHHHHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129