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The map label for this gene is hppA

Identifier: 28210139

GI number: 28210139

Start: 374053

End: 376074

Strand: Direct

Name: hppA

Synonym: CTC00383

Alternate gene names: 28210139

Gene position: 374053-376074 (Clockwise)

Preceding gene: 28210138

Following gene: 28210140

Centisome position: 13.36

GC content: 36.89

Gene sequence:

>2022_bases
ATGGAGAGTTTTATTGTTTATTCAGTCTTAGCTGGAGTAATAGCATTAATATTTGCTTTCATGCTAAGTAGTTTCATTTC
CAAAGAAAGTGCAGGAAATGAAAGAATGCAAGAAATTGCTGGGCACATTCATGATGGAGCCATGGCTTTCTTGAAAACAG
AATACAAATACTTAACGGGATTTATAGTAATTGTTACAGTAATTTTAGCTATCTTTGTAGGATGGCAAACAGCGGCATGC
TTTATTTTAGGAGCTATATTCTCTATATTTGCAGGATATTTTGGAATGAATGTAGCTACAAAAGCCAATGTTAGAACAGC
AGAGGCAGCAAGACATAGCCAAGGAAAGGCATTAAATATAGCTTTTTCAGGTGGAGCAGTAATGGGAATGTCTGTTGTAG
GACTAGGGGTTGTAGGTATAGGAATTATGTATTACATATTTGGTGGTAATATGGAATTTGTAACAGGCTTTGGTCTTGGA
GCAAGCTCTATTGCACTATTTGCTCGTGTTGGTGGTGGGATATACACCAAGGCGGCAGATGTTGGAGCAGATCTTGTTGG
TAAAGTAGAAGCAGGTATACCAGAAGATGACCCAAGGAACCCAGCGGTAATAGCTGACAACGTAGGGGATAACGTTGGAG
ATGTTGCAGGTATGGGAGCCGACCTTTTTGAATCTTATGTAGGATCAATTATATCTGCATTAACACTTGGAACAGTTGTA
TACGCAAATAAAGAAGGAGTTATGTTTCCTTTAATTTTAAGCTCTATAGGAATAGTAGCGTCTATAATAGGAATATTATT
TTCAAGAAAAAGTAAAGCAAAGGATCCTCAAAAAGCACTTAACACAGGAACTTATATAGGTGGAATTATAGTTATAGTAT
CAGCAGCAATATTAAGTAATACTATATTTGGAAACCTTAAAGCTTTCTTTGCAGTAGCTTCTGGATTAGTTGTTGGAATG
ATTATAGGTAAAATTACAGAAATGTATACATCAGATGCTTATTCATCAGTACAAAAGATTGCTAATCAATCAGAAACAGG
ACCAGCTACTACAATTATTTCGGGTCTTGCAGTAGGAATGTACTCTACATTATGGCCAATAGTTTTAATTTCCATAGGTG
TATTAGTTTCCTTCTTTGTAATGGGCGGAGGATCTAACGCTATGGTGGGACTGTATGGAATATCTTTAGCAGCAGTGGGA
ATGCTTTCAACTACAGGATTAACTGTTGCAGTTGACGCATATGGACCAATTGCAGATAATGCTGGTGGAATAGCTGAAAT
GTCAGAACTACCTCATGAAGTAAGAGAAATCACCGACAAACTTGACTCAGTTGGTAATACTACTGCGGCTATAGGAAAAG
GTTTTGCTATAGGTTCTGCAGCACTTACTGCATTATCTTTATTCGCATCCTATGCACAAGCTACTGAATTGGAAAGTATA
GACATACTTAATACAGTAACTTTAGTAGGTCTATTTATAGGAGCAATGCTTCCATTCTTATTTGGTGCTTTAACAATGGA
ATCAGTTGGTAAGGCTGCAAATGAAATGATAGAAGAGGTTAGAAGACAATTTAAAACTATACCAGGAATAATGGAAGGAA
AAGCTACACCAGACTATAAGAAATGTGTAGATATTTCTACAGCGGCAGCAATAAGAGAAATGATTCTTCCAGGTGTATTA
GCAATAGTAGTACCAGTAGCAATGGGGCTCTTATTAGGTAAAGAAGCCCTTGGTGGACTACTAGCAGGGGCACTTGTGAG
TGGAGTTCTTGTAGGTATACTTATGTCTAATGCTGGTGGAGCATGGGATAATGCTAAAAAATATATTGAAGGTGGAGCTC
ATGGTGGAAAAGGAAGTGAAGCTCATAAAGCAGCTGTAGTTGGAGACACTGTTGGTGACCCATTTAAAGATACTTCAGGA
CCTTCAATGAATATATTAATAAAACTTATGACAATAGTTTCATTAGTATTTGCACCAGTCGTTTTACAATATGGTGGAAT
ATTATTAAACTTAATTAAATAG

Upstream 100 bases:

>100_bases
TAAACCTAGTTTAAATCTTGGGAAAATTTTATATGTTTTTACAAATGTATGAAATTAAAATAAAATAATTAAATTAAAGA
AAGGTTAGGGGGATAAGATC

Downstream 100 bases:

>100_bases
TTATTTATTTAAAAACCCTAGGATAAAATAAATATCCCTAGGGTTTTTTACATTCTTGACTAACAAACAATATTAATATA
GTATTTTATTTAAATATTGG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound sodium-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; Na(+)-PPase

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MESFIVYSVLAGVIALIFAFMLSSFISKESAGNERMQEIAGHIHDGAMAFLKTEYKYLTGFIVIVTVILAIFVGWQTAAC
FILGAIFSIFAGYFGMNVATKANVRTAEAARHSQGKALNIAFSGGAVMGMSVVGLGVVGIGIMYYIFGGNMEFVTGFGLG
ASSIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLFESYVGSIISALTLGTVV
YANKEGVMFPLILSSIGIVASIIGILFSRKSKAKDPQKALNTGTYIGGIIVIVSAAILSNTIFGNLKAFFAVASGLVVGM
IIGKITEMYTSDAYSSVQKIANQSETGPATTIISGLAVGMYSTLWPIVLISIGVLVSFFVMGGGSNAMVGLYGISLAAVG
MLSTTGLTVAVDAYGPIADNAGGIAEMSELPHEVREITDKLDSVGNTTAAIGKGFAIGSAALTALSLFASYAQATELESI
DILNTVTLVGLFIGAMLPFLFGALTMESVGKAANEMIEEVRRQFKTIPGIMEGKATPDYKKCVDISTAAAIREMILPGVL
AIVVPVAMGLLLGKEALGGLLAGALVSGVLVGILMSNAGGAWDNAKKYIEGGAHGGKGSEAHKAAVVGDTVGDPFKDTSG
PSMNILIKLMTIVSLVFAPVVLQYGGILLNLIK

Sequences:

>Translated_673_residues
MESFIVYSVLAGVIALIFAFMLSSFISKESAGNERMQEIAGHIHDGAMAFLKTEYKYLTGFIVIVTVILAIFVGWQTAAC
FILGAIFSIFAGYFGMNVATKANVRTAEAARHSQGKALNIAFSGGAVMGMSVVGLGVVGIGIMYYIFGGNMEFVTGFGLG
ASSIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLFESYVGSIISALTLGTVV
YANKEGVMFPLILSSIGIVASIIGILFSRKSKAKDPQKALNTGTYIGGIIVIVSAAILSNTIFGNLKAFFAVASGLVVGM
IIGKITEMYTSDAYSSVQKIANQSETGPATTIISGLAVGMYSTLWPIVLISIGVLVSFFVMGGGSNAMVGLYGISLAAVG
MLSTTGLTVAVDAYGPIADNAGGIAEMSELPHEVREITDKLDSVGNTTAAIGKGFAIGSAALTALSLFASYAQATELESI
DILNTVTLVGLFIGAMLPFLFGALTMESVGKAANEMIEEVRRQFKTIPGIMEGKATPDYKKCVDISTAAAIREMILPGVL
AIVVPVAMGLLLGKEALGGLLAGALVSGVLVGILMSNAGGAWDNAKKYIEGGAHGGKGSEAHKAAVVGDTVGDPFKDTSG
PSMNILIKLMTIVSLVFAPVVLQYGGILLNLIK
>Mature_673_residues
MESFIVYSVLAGVIALIFAFMLSSFISKESAGNERMQEIAGHIHDGAMAFLKTEYKYLTGFIVIVTVILAIFVGWQTAAC
FILGAIFSIFAGYFGMNVATKANVRTAEAARHSQGKALNIAFSGGAVMGMSVVGLGVVGIGIMYYIFGGNMEFVTGFGLG
ASSIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLFESYVGSIISALTLGTVV
YANKEGVMFPLILSSIGIVASIIGILFSRKSKAKDPQKALNTGTYIGGIIVIVSAAILSNTIFGNLKAFFAVASGLVVGM
IIGKITEMYTSDAYSSVQKIANQSETGPATTIISGLAVGMYSTLWPIVLISIGVLVSFFVMGGGSNAMVGLYGISLAAVG
MLSTTGLTVAVDAYGPIADNAGGIAEMSELPHEVREITDKLDSVGNTTAAIGKGFAIGSAALTALSLFASYAQATELESI
DILNTVTLVGLFIGAMLPFLFGALTMESVGKAANEMIEEVRRQFKTIPGIMEGKATPDYKKCVDISTAAAIREMILPGVL
AIVVPVAMGLLLGKEALGGLLAGALVSGVLVGILMSNAGGAWDNAKKYIEGGAHGGKGSEAHKAAVVGDTVGDPFKDTSG
PSMNILIKLMTIVSLVFAPVVLQYGGILLNLIK

Specific function: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_CLOTE (Q898Q9)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781083.1
- ProteinModelPortal:   Q898Q9
- GeneID:   1059962
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00383
- NMPDR:   fig|212717.1.peg.305
- HOGENOM:   HBG593668
- OMA:   AYLARQY
- ProtClustDB:   PRK00733
- BioCyc:   CTET212717:CTC_00383-MONOMER
- BRENDA:   3.6.1.1
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 69283; Mature: 69283

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb0bc9e4)-; HASH(0xc3c1854)-; HASH(0xb3b946c)-; HASH(0xb54bfe4)-; HASH(0xc150d24)-; HASH(0xbd836cc)-; HASH(0xc308380)-; HASH(0xc0ab32c)-; HASH(0xc8d99f8)-; HASH(0xb3b394c)-; HASH(0xc75e4cc)-; HASH(0xbd151d4)-; HASH(0x40713b90)-; HASH(0xcb1f224)-; HASH(0xc938f64)-; HASH(0xb360224)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFIVYSVLAGVIALIFAFMLSSFISKESAGNERMQEIAGHIHDGAMAFLKTEYKYLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVIVTVILAIFVGWQTAACFILGAIFSIFAGYFGMNVATKANVRTAEAARHSQGKALNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEEE
AFSGGAVMGMSVVGLGVVGIGIMYYIFGGNMEFVTGFGLGASSIALFARVGGGIYTKAAD
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEHHHH
VGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLFESYVGSIISALTLGTVV
HCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHE
YANKEGVMFPLILSSIGIVASIIGILFSRKSKAKDPQKALNTGTYIGGIIVIVSAAILSN
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
TIFGNLKAFFAVASGLVVGMIIGKITEMYTSDAYSSVQKIANQSETGPATTIISGLAVGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
YSTLWPIVLISIGVLVSFFVMGGGSNAMVGLYGISLAAVGMLSTTGLTVAVDAYGPIADN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
AGGIAEMSELPHEVREITDKLDSVGNTTAAIGKGFAIGSAALTALSLFASYAQATELESI
CCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
DILNTVTLVGLFIGAMLPFLFGALTMESVGKAANEMIEEVRRQFKTIPGIMEGKATPDYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
KCVDISTAAAIREMILPGVLAIVVPVAMGLLLGKEALGGLLAGALVSGVLVGILMSNAGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWDNAKKYIEGGAHGGKGSEAHKAAVVGDTVGDPFKDTSGPSMNILIKLMTIVSLVFAPV
CCHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLQYGGILLNLIK
HHHHHHHHHHHCH
>Mature Secondary Structure
MESFIVYSVLAGVIALIFAFMLSSFISKESAGNERMQEIAGHIHDGAMAFLKTEYKYLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVIVTVILAIFVGWQTAACFILGAIFSIFAGYFGMNVATKANVRTAEAARHSQGKALNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEEE
AFSGGAVMGMSVVGLGVVGIGIMYYIFGGNMEFVTGFGLGASSIALFARVGGGIYTKAAD
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEHHHH
VGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDVAGMGADLFESYVGSIISALTLGTVV
HCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHE
YANKEGVMFPLILSSIGIVASIIGILFSRKSKAKDPQKALNTGTYIGGIIVIVSAAILSN
EECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHH
TIFGNLKAFFAVASGLVVGMIIGKITEMYTSDAYSSVQKIANQSETGPATTIISGLAVGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
YSTLWPIVLISIGVLVSFFVMGGGSNAMVGLYGISLAAVGMLSTTGLTVAVDAYGPIADN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
AGGIAEMSELPHEVREITDKLDSVGNTTAAIGKGFAIGSAALTALSLFASYAQATELESI
CCCHHHHHHCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHH
DILNTVTLVGLFIGAMLPFLFGALTMESVGKAANEMIEEVRRQFKTIPGIMEGKATPDYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
KCVDISTAAAIREMILPGVLAIVVPVAMGLLLGKEALGGLLAGALVSGVLVGILMSNAGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AWDNAKKYIEGGAHGGKGSEAHKAAVVGDTVGDPFKDTSGPSMNILIKLMTIVSLVFAPV
CCHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLQYGGILLNLIK
HHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12552129