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The map label for this gene is upp

Identifier: 28210069

GI number: 28210069

Start: 290828

End: 291457

Strand: Direct

Name: upp

Synonym: CTC00308

Alternate gene names: 28210069

Gene position: 290828-291457 (Clockwise)

Preceding gene: 28210068

Following gene: 28210070

Centisome position: 10.39

GC content: 33.02

Gene sequence:

>630_bases
ATGAGTAAAGTAACACAAATTGCACATCCATTAATACTACATAAATTAACTTTAATAAGGGATAAAAATACAGGTGCAAA
GGATTTTAGAGAATTAGTAGAAGAAGTAGCAATGCTTATGGCTTATGAAGTTACAAGAGATTTTAATTTAAAAGAAGTGG
AAATAGAAACGCCTATATGTAAAACTAAATCTAAGGTATTAGCTGGAAAGAAAGTAGCCATAGTACCAATTTTAAGAGCA
GGTCTTGGAATGGTAGATGGAATTTTAAAACTTATACCAGCAGCTAAAGTTGGTCATATAGGACTTTATAGGGACGAAAA
AACCTTAACGCCAGTAGAATATTTTTGTAAGTTACCACAGGACATAGGAGAAAGAGAAATAATAGTAACAGATCCTATGT
TAGCTACTGGTGGGTCTGCTGCAGATGCTATAGCTCTTTTAAAGAAAAGAGGAGCAAAATATATAAGACTTGTATGTTTA
GTAGCAGCTCCAGAAGGAATAAAAGTAGTAATGGATGCTCATCCAGATGTAGATATATATGTGGCTTCCATAGATGAAAA
ATTAGATGAATCAGGATATATAGTTCCAGGATTAGGAGATGCAGGAGATAGATTATTTGGAACTAAGTAA

Upstream 100 bases:

>100_bases
ATCCTCTGAATTTCAAGGAGGAAGACACCAAAAAAGACTAGATAAAATAAGTGGTATAGAAAATAGTTTTCATAAATAAT
AAAGTTTAGGAGGAAAAAAC

Downstream 100 bases:

>100_bases
TAATAAAAAGTCGGCATATGCCGACTTTTTATATTACTTAGCTATAATTTGTGACTTTAATTTATGTTATTTTTAGTATA
GAATAATAAATAGCATATAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSKVTQIAHPLILHKLTLIRDKNTGAKDFRELVEEVAMLMAYEVTRDFNLKEVEIETPICKTKSKVLAGKKVAIVPILRA
GLGMVDGILKLIPAAKVGHIGLYRDEKTLTPVEYFCKLPQDIGEREIIVTDPMLATGGSAADAIALLKKRGAKYIRLVCL
VAAPEGIKVVMDAHPDVDIYVASIDEKLDESGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MSKVTQIAHPLILHKLTLIRDKNTGAKDFRELVEEVAMLMAYEVTRDFNLKEVEIETPICKTKSKVLAGKKVAIVPILRA
GLGMVDGILKLIPAAKVGHIGLYRDEKTLTPVEYFCKLPQDIGEREIIVTDPMLATGGSAADAIALLKKRGAKYIRLVCL
VAAPEGIKVVMDAHPDVDIYVASIDEKLDESGYIVPGLGDAGDRLFGTK
>Mature_208_residues
SKVTQIAHPLILHKLTLIRDKNTGAKDFRELVEEVAMLMAYEVTRDFNLKEVEIETPICKTKSKVLAGKKVAIVPILRAG
LGMVDGILKLIPAAKVGHIGLYRDEKTLTPVEYFCKLPQDIGEREIIVTDPMLATGGSAADAIALLKKRGAKYIRLVCLV
AAPEGIKVVMDAHPDVDIYVASIDEKLDESGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=195, Percent_Identity=29.2307692307692, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI57863312, Length=195, Percent_Identity=29.2307692307692, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=52.1739130434783, Blast_Score=225, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.3731343283582, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.3731343283582, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550449, Length=196, Percent_Identity=30.6122448979592, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573516, Length=196, Percent_Identity=30.6122448979592, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573514, Length=196, Percent_Identity=30.6122448979592, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573512, Length=196, Percent_Identity=30.6122448979592, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=24.6153846153846, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_CLOTE (Q898X9)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781013.1
- ProteinModelPortal:   Q898X9
- SMR:   Q898X9
- GeneID:   1059884
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00308
- NMPDR:   fig|212717.1.peg.235
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- PhylomeDB:   Q898X9
- ProtClustDB:   PRK00129
- BioCyc:   CTET212717:CTC_00308-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22765; Mature: 22634

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVTQIAHPLILHKLTLIRDKNTGAKDFRELVEEVAMLMAYEVTRDFNLKEVEIETPIC
CCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCH
KTKSKVLAGKKVAIVPILRAGLGMVDGILKLIPAAKVGHIGLYRDEKTLTPVEYFCKLPQ
HCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHCHH
DIGEREIIVTDPMLATGGSAADAIALLKKRGAKYIRLVCLVAAPEGIKVVMDAHPDVDIY
HCCCCEEEEECCCEECCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEECCCCCEEE
VASIDEKLDESGYIVPGLGDAGDRLFGTK
EEECHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SKVTQIAHPLILHKLTLIRDKNTGAKDFRELVEEVAMLMAYEVTRDFNLKEVEIETPIC
CCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCH
KTKSKVLAGKKVAIVPILRAGLGMVDGILKLIPAAKVGHIGLYRDEKTLTPVEYFCKLPQ
HCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHCHH
DIGEREIIVTDPMLATGGSAADAIALLKKRGAKYIRLVCLVAAPEGIKVVMDAHPDVDIY
HCCCCEEEEECCCEECCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEECCCCCEEE
VASIDEKLDESGYIVPGLGDAGDRLFGTK
EEECHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129