Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 28199897

GI number: 28199897

Start: 2392186

End: 2392689

Strand: Reverse

Name: purE [H]

Synonym: PD2036

Alternate gene names: 28199897

Gene position: 2392689-2392186 (Counterclockwise)

Preceding gene: 28199900

Following gene: 28199896

Centisome position: 94.96

GC content: 56.55

Gene sequence:

>504_bases
ATGATCTCCAATCAATCCCCCCCGCTGGTCGGTATTGTCATGGGTTCCTCTTCGGATTGGGGGGCGATGCAGCACGCCGC
ACAAAAGCTCGATGCTCTCAGCGTCGCGTATGAAGTGAAGGTCGTTTCGGCGCATCGTACTCCGGATAAATTGTTTGCTT
ATGCTGAGCAGGCTGAAGGACGTGGTTTGCGTGCCATCATTGCCGGGGCCGGTGGCGCAGCGCACCTTCCAGGTATGTTG
GCTGCTAAGACGATAGTTCCAGTGTTGGGGGTGCCAATGCAGTCCAGGGCTCTGAATGGTTTGGATTCGCTGTTATCAAT
CGTACAGATGCCGGCGGGTATTCCAGTAGCCACATTCGCGATTGGGGAAGCTGGTGCAGTCAATGCCGCCCTGTTTGCCG
CCGCGCTGTTGGTACCCGAAAATCCAGCAATGCGTCGGATGCTGACTGAGTTCCGCCAACGTCAGACGGATCAGGTGAAT
GCTGCGGACGATCCACGCCAATGA

Upstream 100 bases:

>100_bases
TCTGGGGAGCACAGCAAATGAAGTAATTTGCGATCCATAATGAATGTCTGATCTTAACCGGGAAGATGGCTAGAATACGC
GTTTGCGATAGGTTAGGGCC

Downstream 100 bases:

>100_bases
AGACCCTCGGTATTCTTGGCGGTGGGCAACTGGCCCGTATGCTGGCGTTGGCTGCACCCCCATTGGGCGTGCGGGTGTGT
ACCTTTGATCAAACTGTTGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MISNQSPPLVGIVMGSSSDWGAMQHAAQKLDALSVAYEVKVVSAHRTPDKLFAYAEQAEGRGLRAIIAGAGGAAHLPGML
AAKTIVPVLGVPMQSRALNGLDSLLSIVQMPAGIPVATFAIGEAGAVNAALFAAALLVPENPAMRRMLTEFRQRQTDQVN
AADDPRQ

Sequences:

>Translated_167_residues
MISNQSPPLVGIVMGSSSDWGAMQHAAQKLDALSVAYEVKVVSAHRTPDKLFAYAEQAEGRGLRAIIAGAGGAAHLPGML
AAKTIVPVLGVPMQSRALNGLDSLLSIVQMPAGIPVATFAIGEAGAVNAALFAAALLVPENPAMRRMLTEFRQRQTDQVN
AADDPRQ
>Mature_167_residues
MISNQSPPLVGIVMGSSSDWGAMQHAAQKLDALSVAYEVKVVSAHRTPDKLFAYAEQAEGRGLRAIIAGAGGAAHLPGML
AAKTIVPVLGVPMQSRALNGLDSLLSIVQMPAGIPVATFAIGEAGAVNAALFAAALLVPENPAMRRMLTEFRQRQTDQVN
AADDPRQ

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=166, Percent_Identity=61.4457831325301, Blast_Score=173, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324702, Length=152, Percent_Identity=51.9736842105263, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17410; Mature: 17410

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNQSPPLVGIVMGSSSDWGAMQHAAQKLDALSVAYEVKVVSAHRTPDKLFAYAEQAEG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCC
RGLRAIIAGAGGAAHLPGMLAAKTIVPVLGVPMQSRALNGLDSLLSIVQMPAGIPVATFA
CCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
IGEAGAVNAALFAAALLVPENPAMRRMLTEFRQRQTDQVNAADDPRQ
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MISNQSPPLVGIVMGSSSDWGAMQHAAQKLDALSVAYEVKVVSAHRTPDKLFAYAEQAEG
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCC
RGLRAIIAGAGGAAHLPGMLAAKTIVPVLGVPMQSRALNGLDSLLSIVQMPAGIPVATFA
CCEEEEEECCCCHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
IGEAGAVNAALFAAALLVPENPAMRRMLTEFRQRQTDQVNAADDPRQ
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]