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The map label for this gene is ipk [H]

Identifier: 28199879

GI number: 28199879

Start: 2373986

End: 2374882

Strand: Reverse

Name: ipk [H]

Synonym: PD2018

Alternate gene names: 28199879

Gene position: 2374882-2373986 (Counterclockwise)

Preceding gene: 28199880

Following gene: 28199878

Centisome position: 94.25

GC content: 54.18

Gene sequence:

>897_bases
ATGGGACGAGTTGATCCCGTGAGTGTCGTCATTGATGACGGTGTGGGCTGGTCGGCGTGGCCGGCACCTGCCAAGTTGAA
TTTATTTTTGCAAATTACCGGGCGACGTGTTGATGGTTACCATGAATTGCAGACTGTTTTTCGTCTGCTTGATTGGGGTG
ATACGATCCATCTGCGGGTGCGTGAAGATGGTCAGATTCATCGCATTGGTGAGTCAGTGACTGGGGTTGTTGAGGCTGAC
GACTTGGTGGTGCGTGCGGCTTATTTGCTAAAACATGCGACTAATGTCTATTTAGGGGCAGATATCTTTGTTGAAAAGCG
AATCCCAGTTGGTGGCGGCTTTGGCGGTGGGTCCTCTGATGCGGCGACTGTGCTTCTTGTGTTGAATGCATTGTGGCACA
CCAGGCTTGACGTTGCGGTTTTGGCGGCTTTGGGGTTACGTTTGGGGGCCGATGTGCCGGTATTTGTACATGGGTGTAAT
GCGTGGGCTGAGGGTGTCGGTGAGTGCTTAACACCGATGATTCTGCCTGGAGCGGCCTACCTGCTATTGGATCCAGGGGT
GTGTGTGCCGACACGGGAGCTGTTCCTTGATCCGGATTTGACGCGCGATGCGTCCCCCGCGACAATAGGCGACTTCATTG
CTGGTACTGCGTTTGGTAATGCATTCGAGCCGGTTCTGAGACGCCGCGAGTCTGCGGTTGCGGGTGCTCTTGATGTGCTC
TCAGAGGTTGGTTTTGCAAGGGTGACTGGCTCTGGCAGCGGTTGCTTTGTGGAATTCAGTACGCGCGATGAGGCTGAGTG
TGCTTTGGAGCGGCTGCCGTACGGGTTGTGTGCTTGGGTTGCTGATGGCGCTTCCCGTTCTCCGCTGCTTGATGTACTGA
AAACAATGGAATTTTGA

Upstream 100 bases:

>100_bases
GGTTTCTGGATTGGTTTCCGTCTTCCGTGGGGCGTCCGATGTTGCCGCGGCAAATTGAGGCTAGTCGCGGTTCGGCTAGG
ATACGTTTGATTGTTGATCA

Downstream 100 bases:

>100_bases
TGCAGGGGCGTCGCCAAGAGGACTAAGGCACCGGGTTTTGATCCCGGCATTCGTAGGTTCGAATCCTACCGCCCCTGCCA
GTTTTTTTATGGTTTTCAAG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGRVDPVSVVIDDGVGWSAWPAPAKLNLFLQITGRRVDGYHELQTVFRLLDWGDTIHLRVREDGQIHRIGESVTGVVEAD
DLVVRAAYLLKHATNVYLGADIFVEKRIPVGGGFGGGSSDAATVLLVLNALWHTRLDVAVLAALGLRLGADVPVFVHGCN
AWAEGVGECLTPMILPGAAYLLLDPGVCVPTRELFLDPDLTRDASPATIGDFIAGTAFGNAFEPVLRRRESAVAGALDVL
SEVGFARVTGSGSGCFVEFSTRDEAECALERLPYGLCAWVADGASRSPLLDVLKTMEF

Sequences:

>Translated_298_residues
MGRVDPVSVVIDDGVGWSAWPAPAKLNLFLQITGRRVDGYHELQTVFRLLDWGDTIHLRVREDGQIHRIGESVTGVVEAD
DLVVRAAYLLKHATNVYLGADIFVEKRIPVGGGFGGGSSDAATVLLVLNALWHTRLDVAVLAALGLRLGADVPVFVHGCN
AWAEGVGECLTPMILPGAAYLLLDPGVCVPTRELFLDPDLTRDASPATIGDFIAGTAFGNAFEPVLRRRESAVAGALDVL
SEVGFARVTGSGSGCFVEFSTRDEAECALERLPYGLCAWVADGASRSPLLDVLKTMEF
>Mature_297_residues
GRVDPVSVVIDDGVGWSAWPAPAKLNLFLQITGRRVDGYHELQTVFRLLDWGDTIHLRVREDGQIHRIGESVTGVVEADD
LVVRAAYLLKHATNVYLGADIFVEKRIPVGGGFGGGSSDAATVLLVLNALWHTRLDVAVLAALGLRLGADVPVFVHGCNA
WAEGVGECLTPMILPGAAYLLLDPGVCVPTRELFLDPDLTRDASPATIGDFIAGTAFGNAFEPVLRRRESAVAGALDVLS
EVGFARVTGSGSGCFVEFSTRDEAECALERLPYGLCAWVADGASRSPLLDVLKTMEF

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol [H]

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787459, Length=278, Percent_Identity=49.6402877697842, Blast_Score=223, Evalue=8e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.148 [H]

Molecular weight: Translated: 31815; Mature: 31684

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVDPVSVVIDDGVGWSAWPAPAKLNLFLQITGRRVDGYHELQTVFRLLDWGDTIHLRV
CCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEE
REDGQIHRIGESVTGVVEADDLVVRAAYLLKHATNVYLGADIFVEKRIPVGGGFGGGSSD
CCCCCEEECCCHHCCEEEHHHHHHHHHHHHHHHCCEEECCEEEEEECCCCCCCCCCCCHH
AATVLLVLNALWHTRLDVAVLAALGLRLGADVPVFVHGCNAWAEGVGECLTPMILPGAAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEE
LLLDPGVCVPTRELFLDPDLTRDASPATIGDFIAGTAFGNAFEPVLRRRESAVAGALDVL
EEECCCCCCCCHHHEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SEVGFARVTGSGSGCFVEFSTRDEAECALERLPYGLCAWVADGASRSPLLDVLKTMEF
HHCCEEEEECCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
GRVDPVSVVIDDGVGWSAWPAPAKLNLFLQITGRRVDGYHELQTVFRLLDWGDTIHLRV
CCCCCEEEEEECCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEE
REDGQIHRIGESVTGVVEADDLVVRAAYLLKHATNVYLGADIFVEKRIPVGGGFGGGSSD
CCCCCEEECCCHHCCEEEHHHHHHHHHHHHHHHCCEEECCEEEEEECCCCCCCCCCCCHH
AATVLLVLNALWHTRLDVAVLAALGLRLGADVPVFVHGCNAWAEGVGECLTPMILPGAAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEE
LLLDPGVCVPTRELFLDPDLTRDASPATIGDFIAGTAFGNAFEPVLRRRESAVAGALDVL
EEECCCCCCCCHHHEECCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SEVGFARVTGSGSGCFVEFSTRDEAECALERLPYGLCAWVADGASRSPLLDVLKTMEF
HHCCEEEEECCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]