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The map label for this gene is htpX

Identifier: 28199861

GI number: 28199861

Start: 2348670

End: 2349539

Strand: Reverse

Name: htpX

Synonym: PD1995

Alternate gene names: 28199861

Gene position: 2349539-2348670 (Counterclockwise)

Preceding gene: 28199862

Following gene: 28199859

Centisome position: 93.24

GC content: 48.39

Gene sequence:

>870_bases
ATGTTGACTCGTATTGTCTTATTTGCCATCACCAATATTGCAGTATTGATTTTAGCTAGCATCGTGATGTCGTTGCTGGG
TGTCAATCCGACACAAATGAGTGGGCTGTTGGTTATGGCTTTAATTTTGGGTTTTGGTGGTTCGCTTATCTCGCTATTGA
TGTCTAAAGCCATCGCTAAGCATACGACTGGTGCCTATGTGATTGAGCAACCCAGGAATCCAAGTCAGCGCTGGTTACTA
GACACTGTAAGGCGGCAAGCCGAGATTGTTGGCATCGGCATGCCTGAGGTAGCTATCTATGAGGGACCTGAGATCAATGC
TTTTGCAACTGGTGCTGATCGCAACAATGCGCTGGTGGCAGTATCTACCGGTTTGTTGCAGAACATGAGTCAGGATGAGG
CCGAGGCAGTGTTGGGGCATGAGATCGCACATGTTGCCAACGGTGACATGGTGACTATGGCGTTGCTGCAGGGTGTGCTT
AATACATTTGTGATCGTACTAGCGCGGGTCGTTGGAGGGTTTATTGACAGTCTGCTTTCCGGAAATCGTGGTGGTGGTCG
TGGTGTTGCTTACTACGGGATTGTATTGGTATTGGAATTATTGTTTGGTCTTTTTGCGACGATAATTACCATGTGGTTTT
CGCGTCGTCGTGAGTTTCGTGCTGATGAGGGCGGTGCATACTTGGCCGGCCGCAATAAAATGATTGCTGCATTAGAGCGG
CTTGGGATTAACCATGGCCAAAGTACGTTACCGACGCAGGTGCAAGCTTTTGGTATTTATGGTGGTATCGGTGAAGGGCT
GCGTAAGCTTTTCTTGAGTCATCCGCCTTTGAGTGAGCGTATTGCTGCGCTTCGTATGGCTAGAGAGTAA

Upstream 100 bases:

>100_bases
TGATCCCCTTAATATCAATCAGTTTTATCGCTTGATATTCAGTGATACTGACCACACATTGTGATGTATATTCTTTTCTA
TATTTTGGAATATTCGTTAT

Downstream 100 bases:

>100_bases
TGTACACTCTCGCTTTGGTTGCTGCTTAATTATCTGATTCTAATTTGGATTTTAACTAATTATGTAATGCAGTTATTAGC
CAACTTTAGTAATTGATTGT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MLTRIVLFAITNIAVLILASIVMSLLGVNPTQMSGLLVMALILGFGGSLISLLMSKAIAKHTTGAYVIEQPRNPSQRWLL
DTVRRQAEIVGIGMPEVAIYEGPEINAFATGADRNNALVAVSTGLLQNMSQDEAEAVLGHEIAHVANGDMVTMALLQGVL
NTFVIVLARVVGGFIDSLLSGNRGGGRGVAYYGIVLVLELLFGLFATIITMWFSRRREFRADEGGAYLAGRNKMIAALER
LGINHGQSTLPTQVQAFGIYGGIGEGLRKLFLSHPPLSERIAALRMARE

Sequences:

>Translated_289_residues
MLTRIVLFAITNIAVLILASIVMSLLGVNPTQMSGLLVMALILGFGGSLISLLMSKAIAKHTTGAYVIEQPRNPSQRWLL
DTVRRQAEIVGIGMPEVAIYEGPEINAFATGADRNNALVAVSTGLLQNMSQDEAEAVLGHEIAHVANGDMVTMALLQGVL
NTFVIVLARVVGGFIDSLLSGNRGGGRGVAYYGIVLVLELLFGLFATIITMWFSRRREFRADEGGAYLAGRNKMIAALER
LGINHGQSTLPTQVQAFGIYGGIGEGLRKLFLSHPPLSERIAALRMARE
>Mature_289_residues
MLTRIVLFAITNIAVLILASIVMSLLGVNPTQMSGLLVMALILGFGGSLISLLMSKAIAKHTTGAYVIEQPRNPSQRWLL
DTVRRQAEIVGIGMPEVAIYEGPEINAFATGADRNNALVAVSTGLLQNMSQDEAEAVLGHEIAHVANGDMVTMALLQGVL
NTFVIVLARVVGGFIDSLLSGNRGGGRGVAYYGIVLVLELLFGLFATIITMWFSRRREFRADEGGAYLAGRNKMIAALER
LGINHGQSTLPTQVQAFGIYGGIGEGLRKLFLSHPPLSERIAALRMARE

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=289, Percent_Identity=54.3252595155709, Blast_Score=313, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_XYLF2 (B2IA62)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830772.1
- ProteinModelPortal:   B2IA62
- SMR:   B2IA62
- GeneID:   6203579
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2100
- HOGENOM:   HBG739460
- OMA:   NRFLTAN
- ProtClustDB:   PRK05457
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 31001; Mature: 31001

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0xed2b0f4)-; HASH(0xf16e084)-; HASH(0xf329954)-; HASH(0xf84f1a4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRIVLFAITNIAVLILASIVMSLLGVNPTQMSGLLVMALILGFGGSLISLLMSKAIAK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
HTTGAYVIEQPRNPSQRWLLDTVRRQAEIVGIGMPEVAIYEGPEINAFATGADRNNALVA
HCCCCEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCEEEECCCCCCEEEE
VSTGLLQNMSQDEAEAVLGHEIAHVANGDMVTMALLQGVLNTFVIVLARVVGGFIDSLLS
EEHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNRGGGRGVAYYGIVLVLELLFGLFATIITMWFSRRREFRADEGGAYLAGRNKMIAALER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHH
LGINHGQSTLPTQVQAFGIYGGIGEGLRKLFLSHPPLSERIAALRMARE
HCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCH
>Mature Secondary Structure
MLTRIVLFAITNIAVLILASIVMSLLGVNPTQMSGLLVMALILGFGGSLISLLMSKAIAK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
HTTGAYVIEQPRNPSQRWLLDTVRRQAEIVGIGMPEVAIYEGPEINAFATGADRNNALVA
HCCCCEEEECCCCCHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCEEEECCCCCCEEEE
VSTGLLQNMSQDEAEAVLGHEIAHVANGDMVTMALLQGVLNTFVIVLARVVGGFIDSLLS
EEHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNRGGGRGVAYYGIVLVLELLFGLFATIITMWFSRRREFRADEGGAYLAGRNKMIAALER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHH
LGINHGQSTLPTQVQAFGIYGGIGEGLRKLFLSHPPLSERIAALRMARE
HCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA