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The map label for this gene is lpxC [H]

Identifier: 28199729

GI number: 28199729

Start: 2185825

End: 2186739

Strand: Reverse

Name: lpxC [H]

Synonym: PD1860

Alternate gene names: 28199729

Gene position: 2186739-2185825 (Counterclockwise)

Preceding gene: 28199730

Following gene: 28199727

Centisome position: 86.78

GC content: 50.27

Gene sequence:

>915_bases
ATGAGCCAGCAACGTACCCTTAACAACACGATTCGCGCGACTGGCGTTGGTCTGCACAGCGGCAATAAGATCCATATTAC
CCTCCGTCCTGCTCCGGTCAACCACGGTATCGTGTTCCGGCGCGTGGACCTGGATCCTGTGGTTGAAATCCCTGCTAGTG
GGGATTTGGTGACCGAGGTGATCTTATGCACTGGTTTGACGCGCAATGGGGCTAAAGTACAGACGGTCGAACATTTGATG
TCAGCCTTTGCTGGGCTTGGTATCGACAACGCTATTGTGGATCTGTCGTCGGCTGAGTTACCGATTATGGATGGGTCTTC
TGCGCCGTTTGTATTCCTGTTGCAGTCGGCGGGTATCTTAGAGCAGAACGCTGCTAAGCGTTTCATCCGTATTAAGCGTT
CTGTGGAGGTGCGCCAAGGGGATAAGGTGGCCAAGTTTAGCCCTTACGATGGTTATAAATTGGGTTTTACCATTGAGTTC
GATCATCCAATGATCCCGCATAAACAGTCGTATTATGAGATGGAGTTTTCTACTGCGGCTTATATCAAGGAAATTTCTCT
GGCGCGTACTTTTGGTTTTATGCATGACTTGGAAGATATGCGTGAGCGTAACCTTGGACTTGGCGGTTCAATGGACAATG
CGATCTTGCTGGACGACTTCCGTGTGCTCAATGAGGATGGCTTGCGCTATGGCAACGAGTTCGTGCGTCACAAAATACTT
GATGCAATCGGTGATCTTTACTTAATTGGTGGCCCGATTTTGGGGGCTTATGAGGCATTTAAGTCTGGTCATGCGCTGAA
CAATAAGCTGGTTCGTGCTGTACTTGCCGATGAGACTTCTTGGGAGTGGATCAGCTTCCCTAGTCCAGCCGCTGAGCAGC
CGCCTGTCGTCTACACGCATCCCGCTTGCATTTGA

Upstream 100 bases:

>100_bases
CTATGTGCTTGTACTGCTAATATGAGGGCATTCATCATATTGCTACTAAATACGGTGGCGCTAATTTCTTGCCATGCTTC
ATTTTTTCAGACTTCCTCCT

Downstream 100 bases:

>100_bases
ATCATTCTCAGAAAACTTGACTATATGATTATTAATCAATGATTTCTTAATCTGCAAATAACGAATCAAGAGCCGATACC
AGTTACTATGCGCCAGGTCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEVILCTGLTRNGAKVQTVEHLM
SAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEF
DHPMIPHKQSYYEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYGNEFVRHKIL
DAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTHPACI

Sequences:

>Translated_304_residues
MSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEVILCTGLTRNGAKVQTVEHLM
SAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEF
DHPMIPHKQSYYEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYGNEFVRHKIL
DAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTHPACI
>Mature_303_residues
SQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEVILCTGLTRNGAKVQTVEHLMS
AFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGILEQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEFD
HPMIPHKQSYYEMEFSTAAYIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYGNEFVRHKILD
AIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTHPACI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=305, Percent_Identity=53.7704918032787, Blast_Score=354, Evalue=4e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33571; Mature: 33440

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEV
CCCCHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCHHHHHH
ILCTGLTRNGAKVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGIL
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCCEEECCCCCCEEEEEECCCCH
EQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEFDHPMIPHKQSYYEMEFSTAA
HHHHHHHHHHHHHHHEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHHH
YIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYGNEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHH
DAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTH
HHHCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEC
PACI
CCCC
>Mature Secondary Structure 
SQQRTLNNTIRATGVGLHSGNKIHITLRPAPVNHGIVFRRVDLDPVVEIPASGDLVTEV
CCCHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCHHHHHH
ILCTGLTRNGAKVQTVEHLMSAFAGLGIDNAIVDLSSAELPIMDGSSAPFVFLLQSAGIL
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHEEECCCCCCEEECCCCCCEEEEEECCCCH
EQNAAKRFIRIKRSVEVRQGDKVAKFSPYDGYKLGFTIEFDHPMIPHKQSYYEMEFSTAA
HHHHHHHHHHHHHHHEECCCCCEEEECCCCCEEEEEEEEECCCCCCCCCCEEEEEHHHHH
YIKEISLARTFGFMHDLEDMRERNLGLGGSMDNAILLDDFRVLNEDGLRYGNEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHHHHH
DAIGDLYLIGGPILGAYEAFKSGHALNNKLVRAVLADETSWEWISFPSPAAEQPPVVYTH
HHHCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEC
PACI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]