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The map label for this gene is tmk

Identifier: 28199448

GI number: 28199448

Start: 1817194

End: 1817820

Strand: Reverse

Name: tmk

Synonym: PD1569

Alternate gene names: 28199448

Gene position: 1817820-1817194 (Counterclockwise)

Preceding gene: 28199450

Following gene: 28199442

Centisome position: 72.14

GC content: 56.14

Gene sequence:

>627_bases
ATGCTCGTCGCCATCGAGGGGATTGATGGTGCCGGAAAGACCACGTTAGCTCGGAGTTTGGCGCTTAAGTTACGAGGTGT
CGGGTTGGAAACGGTGGTCAGTAAGGAGCCGACCAACGGTCCATGGGGCACGCTGTTGCGGCAGTCTGCTGTGACCGGGC
GTTTTTCCCCCGAGGAGGAGGTTGATGTGTTGTTGCGTGATCGTCGCCAGCATGTTGAAGATCTTATTGTTCCGATGATC
GGCCGTGGTGCGGTGGTGATCTTGGACCGCTATTTCCCGTCGATGGTGGCTTATCAGGGCGCTGCCGGGTTACCAGTGGA
TGCTTTGCTTGAGGCCAATGCGTTTGCTCCACGTCCGGATGTTCTGTTGTTGCTGGATGTGCCGCCAGTGATTGGTTTGC
AGCGTATCTGGGAGCGGGGGAGCACGCCAAATCACTTTGAAACTACGGAAAATCTGTCGCGTTGCCGTGACATTTTCCTA
GCATTGGAACTGCCATCTAAACGGGTGATTGATGCAACGGCCAATGCTGAAACGGTGTTCTCTGCGGCACTGGGCTTGGT
GATGGAGGTATTGCGGGTGCGTCTGGGCGCATTAGGTGCGGTGGTGTTGGAGCGTCTTGCTGGCTAA

Upstream 100 bases:

>100_bases
TGTGCGACTCATGGGATGGTTGTTCATGGTAGGAGGCTTATTAGGATGGCCCGTGGTCGGTTAAAGTAGCCCGATGCACG
ATCAGATCATTCCATGTGGG

Downstream 100 bases:

>100_bases
GGTGTGTGATGTTGTAGGGGCATCGTTCTAAATAAACAACGTATCAGAGGTAGGTGTGTTGTTGGATGCGCGTGTTGACA
GCTTAGGTCTATCAATGGGT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQHVEDLIVPMI
GRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFL
ALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG

Sequences:

>Translated_208_residues
MLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQHVEDLIVPMI
GRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFL
ALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG
>Mature_208_residues
MLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEEVDVLLRDRRQHVEDLIVPMI
GRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPDVLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFL
ALELPSKRVIDATANAETVFSAALGLVMEVLRVRLGALGAVVLERLAG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=196, Percent_Identity=33.6734693877551, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_XYLF2 (B2I7G4)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830335.1
- GeneID:   6202015
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1654
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   PRK00698
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22455; Mature: 22455

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEE
CEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHH
VDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPD
HHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCC
VLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFLALELPSKRVIDATANAETVF
EEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEECCCCHHHHH
SAALGLVMEVLRVRLGALGAVVLERLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGTLLRQSAVTGRFSPEEE
CEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHH
VDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEANAFAPRPD
HHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCC
VLLLLDVPPVIGLQRIWERGSTPNHFETTENLSRCRDIFLALELPSKRVIDATANAETVF
EEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEECCCCCEEECCCCHHHHH
SAALGLVMEVLRVRLGALGAVVLERLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA