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The map label for this gene is mtaD [H]

Identifier: 28199370

GI number: 28199370

Start: 1731991

End: 1733298

Strand: Reverse

Name: mtaD [H]

Synonym: PD1489

Alternate gene names: 28199370

Gene position: 1733298-1731991 (Counterclockwise)

Preceding gene: 28199371

Following gene: 28199369

Centisome position: 68.79

GC content: 58.26

Gene sequence:

>1308_bases
GTGCTGATCGAGGCTGGCTACGTTGTCCCCATCCAACCACATGGCATCGTGCTAGAACAACATGCCGTTGCGGTCCGTGA
GAGTGTCATCGTTGGCCTACTTCCAATTGCCGAGGCCCGCCTGCGCTTTGCCCCCTCGCTCACGGTCAGCCGCCCTCAAG
CCGCCTTATTACCCGGATTGGTCAACGCCCATACCCACAACCCCATGACCCTACTACGTGGCATGGCCGATGACCTGCCA
CTCATGACATGGTTGCAACAACACATCTGGCCCGTGGAGACCGCCGTGATCGGCCCGGAATTTGTGGGCGACGGCACCGC
ACTGGCCATCGCCGAGATGCTGCGTGGTGGCACCACCTGCGCCAACGAGAACTATTTTTTCCCTGATGTCCAAGCCGCCG
TTTACAAACAGCACGGTTTCCGCGCCCTGGTCGGTGCGATCATCATTGATTTTCCGACCGCCTGGGCCAACAGCGATGAT
GAGTACTTTGCCCGTGCCATTGAATTGCACGACCAATGGCGCGGCGATCCCTTAATCGGTACCGCCTTTGCGCCACATGC
CCCCTATACAGTGAGCGATGCGAACTTCGAGCGCATCCGCGTCCTTGCCGATCAACTGGATGTTTTGGTGCATCTGCATA
CCCACGAAACCGCCCAGGAAATTGCTGACTCCATCAAACACCATGGCCAGCGTCCGTTGGCGCGATTGGACCGGCTTGAT
TTGGTCAATGACCGCCTGATTGCGGTACATATGACGCAATTAACAGAAGCCGAGATCCAATTGTGCGCCACACGTGGAGT
TAGCGTAGTGCATTGCCCAGAATCCAACCTCAAACTGGCTTCCGGTTTTTGCCCCGCTTTCGCACTGCACCGCGCTGGTG
TGAACCTCGCCATCGGTACCGATGGCTGTGCAAGCAACAACGACCTAGACATGTTTAGTGAACATCGCATCGCAGCCATG
CTGGCGAAAGCTGTGGCCAACGACCCTACCGCCTTGGACGCAGCGACCACCTTGCGTGCGGCGACCCTGGGCGGTGCCCG
CGCACTCGGTTTCGGCCATCTGATCGGTTCCATTGAAATCGGCAAGCAAGCCGACCTGATCTGCGTGGACTTGAGCGCGC
TCGAAACACAACCCTTGTACCACGTACTCTCGCAACTGGTTTACGCTGCAGGGCGTCAGCACGTCACGGATGTGTGGATT
GCCGGCCAGCCAAAATTGATCCAGCGTGAGCTCATCGGCATTGATACCGCAGCACTGCTGACTAAAGCGCGTCAGTGGCG
CGAGCGCATCCGCGCCATCCGTATTTGA

Upstream 100 bases:

>100_bases
TGGCTGGCCTTTGCTTTACAGACAGGGCCAGATCCTCCTACATCACCTTCTGGCCCCACTTGTCATGACCAATGAATCTC
TCCCTGCTGAACCCTGCGAT

Downstream 100 bases:

>100_bases
ATCCTGCGCACCGCTTCAAGGAGATTCGCCATGCCCTCCTCATATGACCGTGTTTCCAAGAATTACCGCCAAAGTGAACT
GGATAAATTCGCATCCTTCA

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLIEAGYVVPIQPHGIVLEQHAVAVRESVIVGLLPIAEARLRFAPSLTVSRPQAALLPGLVNAHTHNPMTLLRGMADDLP
LMTWLQQHIWPVETAVIGPEFVGDGTALAIAEMLRGGTTCANENYFFPDVQAAVYKQHGFRALVGAIIIDFPTAWANSDD
EYFARAIELHDQWRGDPLIGTAFAPHAPYTVSDANFERIRVLADQLDVLVHLHTHETAQEIADSIKHHGQRPLARLDRLD
LVNDRLIAVHMTQLTEAEIQLCATRGVSVVHCPESNLKLASGFCPAFALHRAGVNLAIGTDGCASNNDLDMFSEHRIAAM
LAKAVANDPTALDAATTLRAATLGGARALGFGHLIGSIEIGKQADLICVDLSALETQPLYHVLSQLVYAAGRQHVTDVWI
AGQPKLIQRELIGIDTAALLTKARQWRERIRAIRI

Sequences:

>Translated_435_residues
MLIEAGYVVPIQPHGIVLEQHAVAVRESVIVGLLPIAEARLRFAPSLTVSRPQAALLPGLVNAHTHNPMTLLRGMADDLP
LMTWLQQHIWPVETAVIGPEFVGDGTALAIAEMLRGGTTCANENYFFPDVQAAVYKQHGFRALVGAIIIDFPTAWANSDD
EYFARAIELHDQWRGDPLIGTAFAPHAPYTVSDANFERIRVLADQLDVLVHLHTHETAQEIADSIKHHGQRPLARLDRLD
LVNDRLIAVHMTQLTEAEIQLCATRGVSVVHCPESNLKLASGFCPAFALHRAGVNLAIGTDGCASNNDLDMFSEHRIAAM
LAKAVANDPTALDAATTLRAATLGGARALGFGHLIGSIEIGKQADLICVDLSALETQPLYHVLSQLVYAAGRQHVTDVWI
AGQPKLIQRELIGIDTAALLTKARQWRERIRAIRI
>Mature_435_residues
MLIEAGYVVPIQPHGIVLEQHAVAVRESVIVGLLPIAEARLRFAPSLTVSRPQAALLPGLVNAHTHNPMTLLRGMADDLP
LMTWLQQHIWPVETAVIGPEFVGDGTALAIAEMLRGGTTCANENYFFPDVQAAVYKQHGFRALVGAIIIDFPTAWANSDD
EYFARAIELHDQWRGDPLIGTAFAPHAPYTVSDANFERIRVLADQLDVLVHLHTHETAQEIADSIKHHGQRPLARLDRLD
LVNDRLIAVHMTQLTEAEIQLCATRGVSVVHCPESNLKLASGFCPAFALHRAGVNLAIGTDGCASNNDLDMFSEHRIAAM
LAKAVANDPTALDAATTLRAATLGGARALGFGHLIGSIEIGKQADLICVDLSALETQPLYHVLSQLVYAAGRQHVTDVWI
AGQPKLIQRELIGIDTAALLTKARQWRERIRAIRI

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=443, Percent_Identity=23.4762979683973, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1789249, Length=333, Percent_Identity=26.4264264264264, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87082177, Length=445, Percent_Identity=24.7191011235955, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540282, Length=381, Percent_Identity=24.1469816272966, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319963, Length=339, Percent_Identity=24.4837758112094, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24643849, Length=382, Percent_Identity=26.4397905759162, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47366; Mature: 47366

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIEAGYVVPIQPHGIVLEQHAVAVRESVIVGLLPIAEARLRFAPSLTVSRPQAALLPGL
CEEECCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCH
VNAHTHNPMTLLRGMADDLPLMTWLQQHIWPVETAVIGPEFVGDGTALAIAEMLRGGTTC
HHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHEEECCHHCCCCHHHHHHHHHCCCCCC
ANENYFFPDVQAAVYKQHGFRALVGAIIIDFPTAWANSDDEYFARAIELHDQWRGDPLIG
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
TAFAPHAPYTVSDANFERIRVLADQLDVLVHLHTHETAQEIADSIKHHGQRPLARLDRLD
CCCCCCCCEEECCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
LVNDRLIAVHMTQLTEAEIQLCATRGVSVVHCPESNLKLASGFCPAFALHRAGVNLAIGT
HCCCCEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCEECCCCCHHHHHHHCCCEEEECC
DGCASNNDLDMFSEHRIAAMLAKAVANDPTALDAATTLRAATLGGARALGFGHLIGSIEI
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCEEE
GKQADLICVDLSALETQPLYHVLSQLVYAAGRQHVTDVWIAGQPKLIQRELIGIDTAALL
CCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCHHHHH
TKARQWRERIRAIRI
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIEAGYVVPIQPHGIVLEQHAVAVRESVIVGLLPIAEARLRFAPSLTVSRPQAALLPGL
CEEECCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCH
VNAHTHNPMTLLRGMADDLPLMTWLQQHIWPVETAVIGPEFVGDGTALAIAEMLRGGTTC
HHCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHEEECCHHCCCCHHHHHHHHHCCCCCC
ANENYFFPDVQAAVYKQHGFRALVGAIIIDFPTAWANSDDEYFARAIELHDQWRGDPLIG
CCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
TAFAPHAPYTVSDANFERIRVLADQLDVLVHLHTHETAQEIADSIKHHGQRPLARLDRLD
CCCCCCCCEEECCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHH
LVNDRLIAVHMTQLTEAEIQLCATRGVSVVHCPESNLKLASGFCPAFALHRAGVNLAIGT
HCCCCEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCEECCCCCHHHHHHHCCCEEEECC
DGCASNNDLDMFSEHRIAAMLAKAVANDPTALDAATTLRAATLGGARALGFGHLIGSIEI
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCEEE
GKQADLICVDLSALETQPLYHVLSQLVYAAGRQHVTDVWIAGQPKLIQRELIGIDTAALL
CCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCHHHHH
TKARQWRERIRAIRI
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA