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The map label for this gene is lipP [H]

Identifier: 28198429

GI number: 28198429

Start: 635643

End: 636620

Strand: Reverse

Name: lipP [H]

Synonym: PD0519

Alternate gene names: 28198429

Gene position: 636620-635643 (Counterclockwise)

Preceding gene: 28198431

Following gene: 28198426

Centisome position: 25.26

GC content: 55.83

Gene sequence:

>978_bases
TTGGCACTGGCATCCACCTCATCCCAAGCCGCCGGCAGCCCTGGTGTCGAACACCGCACCCAAGCCTTCCTCGAAGACTT
AGCGAAGGGAGGGGGAGCACCGATCGAAACCCTGTCGCCTGCCAACGCACGCCAAGTGCTTGTAAACGCACAAAAGGGAG
CCAAACTGCCACCTGCAGACGTGAGCGAAAAGACCATCACCATTGATGGCAAGCAGATTGTGTTGAACATCGTTCGTCCA
GCCGGCGTCAAAGGCATCCTGCCTGGCTTCATGTTCGTCCACGGCGGCGGCTGGGTTCTTGGAGACTTCCAAACCCACGA
ACGCCTTGTACGTGATCTGGTGTCCGATTCCGGCGCAGTAGCCATCTTCGTAAACTACACCCCGTCCCCGGAAGCACGCT
ACCCAGTGGCTATCAATGAAATCTACGCAGCAACCCAGTGGGTAGCCGAACACGGCGCGCAGATCAATGTCGACGGTCAA
CGCCTCGCCATCGTGGGAAACAGCGTCGGCGGCAATATGGCAACCGTGGTAGCACAGATGGCCAAAGAAAAAGGCACACC
AGCGCTACGCGCACAAGTGCTGTTCTGGCCAGTCACTAATGCAAACTTTGAAAACACCTCTTACAACGAATTCGCAAACG
GTCACTTCCTTACAAAAAACATGATGAAATGGTTCTGGGATGCCTATACCACTGATTCCAAACAGCGTCAGGACATCTAC
GCATCACCGCTGCTAGCCACAGCCGAACAATTGAAGGGCCTACCACCCACCCTGATCCAAACCGCTGAGAAAGATGTGCT
CCGTGACGAAGGCGAGGCCTATGCACGCAAACTTGACGCAGCCGGCGTCAACGTCGTCATCACCCGCTACAACGGCATGA
TTCACGACTTCGGGCTCCTCAATGTACTCGCCGACCTACCTGCCACTCGCGCTGCGTTACACCAGGCAAGCGAAGAACTG
AAGATACACCTGCGTTAA

Upstream 100 bases:

>100_bases
ACAACAACATCAACGTGCATTTGAATGTCCCAAATGTACCCACCTATCACTGAGGATCAACCCTATGAAATTCACCCGCA
AACTAGCCACCGCTGCCATC

Downstream 100 bases:

>100_bases
CGTCTGACGCTAGCTGGCCCAACATCCGATTGCTGTTGGGCTAGCCCCCTGAATGTTTTAAAGACGCCTCGAGAAAAATT
CCAAATCCCGCCCCACACAC

Product: lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MALASTSSQAAGSPGVEHRTQAFLEDLAKGGGAPIETLSPANARQVLVNAQKGAKLPPADVSEKTITIDGKQIVLNIVRP
AGVKGILPGFMFVHGGGWVLGDFQTHERLVRDLVSDSGAVAIFVNYTPSPEARYPVAINEIYAATQWVAEHGAQINVDGQ
RLAIVGNSVGGNMATVVAQMAKEKGTPALRAQVLFWPVTNANFENTSYNEFANGHFLTKNMMKWFWDAYTTDSKQRQDIY
ASPLLATAEQLKGLPPTLIQTAEKDVLRDEGEAYARKLDAAGVNVVITRYNGMIHDFGLLNVLADLPATRAALHQASEEL
KIHLR

Sequences:

>Translated_325_residues
MALASTSSQAAGSPGVEHRTQAFLEDLAKGGGAPIETLSPANARQVLVNAQKGAKLPPADVSEKTITIDGKQIVLNIVRP
AGVKGILPGFMFVHGGGWVLGDFQTHERLVRDLVSDSGAVAIFVNYTPSPEARYPVAINEIYAATQWVAEHGAQINVDGQ
RLAIVGNSVGGNMATVVAQMAKEKGTPALRAQVLFWPVTNANFENTSYNEFANGHFLTKNMMKWFWDAYTTDSKQRQDIY
ASPLLATAEQLKGLPPTLIQTAEKDVLRDEGEAYARKLDAAGVNVVITRYNGMIHDFGLLNVLADLPATRAALHQASEEL
KIHLR
>Mature_324_residues
ALASTSSQAAGSPGVEHRTQAFLEDLAKGGGAPIETLSPANARQVLVNAQKGAKLPPADVSEKTITIDGKQIVLNIVRPA
GVKGILPGFMFVHGGGWVLGDFQTHERLVRDLVSDSGAVAIFVNYTPSPEARYPVAINEIYAATQWVAEHGAQINVDGQR
LAIVGNSVGGNMATVVAQMAKEKGTPALRAQVLFWPVTNANFENTSYNEFANGHFLTKNMMKWFWDAYTTDSKQRQDIYA
SPLLATAEQLKGLPPTLIQTAEKDVLRDEGEAYARKLDAAGVNVVITRYNGMIHDFGLLNVLADLPATRAALHQASEELK
IHLR

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68299767, Length=294, Percent_Identity=25.8503401360544, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI157041239, Length=255, Percent_Identity=25.0980392156863, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI21328446, Length=92, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI68051721, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786682, Length=211, Percent_Identity=28.9099526066351, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17567059, Length=301, Percent_Identity=27.5747508305648, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71996133, Length=124, Percent_Identity=37.0967741935484, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17540028, Length=141, Percent_Identity=34.0425531914894, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI72001146, Length=124, Percent_Identity=32.258064516129, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 35070; Mature: 34939

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALASTSSQAAGSPGVEHRTQAFLEDLAKGGGAPIETLSPANARQVLVNAQKGAKLPPAD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCCCCCC
VSEKTITIDGKQIVLNIVRPAGVKGILPGFMFVHGGGWVLGDFQTHERLVRDLVSDSGAV
CCCCEEEECCCEEEEEEECCCCCCHHCCCEEEEECCCEEECCHHHHHHHHHHHHCCCCCE
AIFVNYTPSPEARYPVAINEIYAATQWVAEHGAQINVDGQRLAIVGNSVGGNMATVVAQM
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHH
AKEKGTPALRAQVLFWPVTNANFENTSYNEFANGHFLTKNMMKWFWDAYTTDSKQRQDIY
HHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHH
ASPLLATAEQLKGLPPTLIQTAEKDVLRDEGEAYARKLDAAGVNVVITRYNGMIHDFGLL
HCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
NVLADLPATRAALHQASEELKIHLR
HHHHHCCHHHHHHHHCCHHEEEECC
>Mature Secondary Structure 
ALASTSSQAAGSPGVEHRTQAFLEDLAKGGGAPIETLSPANARQVLVNAQKGAKLPPAD
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCCCCCCCC
VSEKTITIDGKQIVLNIVRPAGVKGILPGFMFVHGGGWVLGDFQTHERLVRDLVSDSGAV
CCCCEEEECCCEEEEEEECCCCCCHHCCCEEEEECCCEEECCHHHHHHHHHHHHCCCCCE
AIFVNYTPSPEARYPVAINEIYAATQWVAEHGAQINVDGQRLAIVGNSVGGNMATVVAQM
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHH
AKEKGTPALRAQVLFWPVTNANFENTSYNEFANGHFLTKNMMKWFWDAYTTDSKQRQDIY
HHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHH
ASPLLATAEQLKGLPPTLIQTAEKDVLRDEGEAYARKLDAAGVNVVITRYNGMIHDFGLL
HCHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
NVLADLPATRAALHQASEELKIHLR
HHHHHCCHHHHHHHHCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]