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The map label for this gene is uvrD [H]

Identifier: 28197981

GI number: 28197981

Start: 46613

End: 48799

Strand: Reverse

Name: uvrD [H]

Synonym: PD0037

Alternate gene names: 28197981

Gene position: 48799-46613 (Counterclockwise)

Preceding gene: 28197985

Following gene: 28197972

Centisome position: 1.94

GC content: 54.64

Gene sequence:

>2187_bases
GTGAACGTCTCTCATGTGCTTTATCACTTAAATCAGAACCAGCGCGAGGCCGTTGCTGCAGCTCCCGGCCACTACCTGAT
CCTCGCCGGTGCCGGATCAGGAAAAACCCGCGTTCTCACTCATCGCATCGTTTGGCTCAACGAGGTAAATGGAGTACCCA
CCCACAGCATGATGGCCGTCACCTTCACGAACAAGGCCGCCGGCGAAATACAACAACGGATTGATCTACAACTGCGCCAC
GGTAAACGCGGCATGTGGATCGGGACCTTCCATAGCCTGGCGCATCGCTTACTGCGCCTGCATTGGAACGACGCAACATT
ACCCGAAAACTTCCAGGTCATAGACAGCGACGATCAATTGCGCCTCGTCAAACGAGTGATCCAGTCCTTGGGATTGAATG
ACACCCTCTTCCCTCCCAAACAGGCGATGTGGTGGATTAATACACAGAAAGATGAAGGACGCCGCCCAGAGCACATCCAA
CCCGAGTCACACGACGACTGGATCGAGACTCAGCGCCGCATCTATACCGAGTATCAGGAGCGCTGCAACCGCGCTGGTTT
GGTCGATTTTTCGGAACTGCTGCTGCGGGCACATGAACTACTACGCGATACCCCTGCACTACTGACACACTACCGTTCGC
GCTTCCGTGAGATTCTGATCGACGAATTCCAAGATACCAACGCCATCCAGTACGCGTTTGTGCGTGTCCTTGCCAATGAC
ACTGGCCACATCTTCGCCGTCGGCGATGACGACCAAGCCATCTACGGCTGGCGTGGTGCCAAAGTTGAGCATGTACAACA
CTTCCTGAAAGATTTTCCAAACGTGCAGACCATCCGCTTGGAGCAAAATTACCGCTCCAGCGCCAATATCCTTGACGCTG
CCAACGCAATCATTGCCCATAACCCAGACCGAATTGGCAAACGCCTCTGGACTGAATCCGGTGTTGGTGAATCCATCGAC
CTATACGCCGCCTACAACGAGATTGATGAAGCCCGCTACATCGTCGAACGCGCCCGCCAGTGGGTACGCGACGGCGGCAG
CTACGGCGAGATCGCAGTGCTTTACCGTAGTAACGCACAGTCCCGCGCATTTGAAGAAGTGCTGCAATCCGAACATATCC
CCTACCGTGTTTACGGCGGCATGCGCTTCTTCGAGCGTGCCGAAATCAAGGATGCCCTAGCCTATCTGCGCCTGCTTGCC
AATCGTAGCGATGATGCTGCGTTCGAACGCGTTGTAAATACCCCCGTACGCGGCATCGGTGAGCGCACCTTAGATGAAGT
AAGACACCTAGCACGTACCCAAGGCTTAGCACTATGGGATGCGGCAATGGCATGTACCCAATCAACCACGCTGACCGCGC
GCGCGCGTAACGCCTTGGCGAGTTTCCTCAATTTACTGCAACAACTTGCGCTGGAAACCAACCAGATGGATTTAGCCGAA
CGAATTGACCATATGCTGCAGCGTTCGGAGTTACGCCAGCACTGGAAGAAAGAAGCGCGTGGTTCTCTGGATGCCGAATC
ACGTCAAGAAAACTTAGACGAACTTGTTTCCGTCGCTTCACGCTTTGTCCTTCCGCAAAACGACGAAGACACACCCATCA
TGACCGAATTAGACGCGTTCCTATCCTACGCGTGCCTGGAAAGTGGTGATGGTCAAGTCCAAGCTGGTGAAGAAGGCGTA
CAACTGATGACCCTACACTCAGCCAAAGGCTTGGAATTCCCCCTAGTCTTCTTGGTGGGCTTGGAAAATGGATTATTCCC
CAGCGCGCGTTCCCTGGATGAACACGGCCGACTAGAGGAAGAACGCCGCTTAGCGTATGTCGGCATCACCCGCGCCCGTC
ACAAACTCATCCTCAGCTATGCCCAAGCACGGCGTATCCACGGTAAAGATAACTACAACGTCCCCTCACGCTTTTTACGC
GAGATCCCGCAGGATCTATTGCATGAAGTACGCCCCACCATCCAGGTCTCACACCAGCCCCCATTAGGAGCAACGCAACG
TCCAGCCCATGATGAACGCGACGCAGCACCTATCAAGCTCGGCGTGAACGTCATACACCCTACATTTGGGTGCGGCGTGG
TTGTCGACTACGAAGGCAGCGGCGTGCACACCCGCGTACAAATCAAATTCGATGACGCCGGTACAAAATGGTTGGTCATG
GCATACGCCAAACTCAGCGTGGTATAG

Upstream 100 bases:

>100_bases
GTATCAGTAACGCTAGCTCCAGCATGACTCTCCTCAATGCCCTCCCGAATGCCCAGACACTTAGAATGAATATCATCCTG
CCACCACGTAGAATCATTGC

Downstream 100 bases:

>100_bases
ACACACATCACCACTGCACTGTGCCTCTCGCACTCTCACTGCAACAGTGCATACCGACGTCATAGACTTTGTCTCCCCCG
ACATCAATACGATGCCGGGG

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 728; Mature: 728

Protein sequence:

>728_residues
MNVSHVLYHLNQNQREAVAAAPGHYLILAGAGSGKTRVLTHRIVWLNEVNGVPTHSMMAVTFTNKAAGEIQQRIDLQLRH
GKRGMWIGTFHSLAHRLLRLHWNDATLPENFQVIDSDDQLRLVKRVIQSLGLNDTLFPPKQAMWWINTQKDEGRRPEHIQ
PESHDDWIETQRRIYTEYQERCNRAGLVDFSELLLRAHELLRDTPALLTHYRSRFREILIDEFQDTNAIQYAFVRVLAND
TGHIFAVGDDDQAIYGWRGAKVEHVQHFLKDFPNVQTIRLEQNYRSSANILDAANAIIAHNPDRIGKRLWTESGVGESID
LYAAYNEIDEARYIVERARQWVRDGGSYGEIAVLYRSNAQSRAFEEVLQSEHIPYRVYGGMRFFERAEIKDALAYLRLLA
NRSDDAAFERVVNTPVRGIGERTLDEVRHLARTQGLALWDAAMACTQSTTLTARARNALASFLNLLQQLALETNQMDLAE
RIDHMLQRSELRQHWKKEARGSLDAESRQENLDELVSVASRFVLPQNDEDTPIMTELDAFLSYACLESGDGQVQAGEEGV
QLMTLHSAKGLEFPLVFLVGLENGLFPSARSLDEHGRLEEERRLAYVGITRARHKLILSYAQARRIHGKDNYNVPSRFLR
EIPQDLLHEVRPTIQVSHQPPLGATQRPAHDERDAAPIKLGVNVIHPTFGCGVVVDYEGSGVHTRVQIKFDDAGTKWLVM
AYAKLSVV

Sequences:

>Translated_728_residues
MNVSHVLYHLNQNQREAVAAAPGHYLILAGAGSGKTRVLTHRIVWLNEVNGVPTHSMMAVTFTNKAAGEIQQRIDLQLRH
GKRGMWIGTFHSLAHRLLRLHWNDATLPENFQVIDSDDQLRLVKRVIQSLGLNDTLFPPKQAMWWINTQKDEGRRPEHIQ
PESHDDWIETQRRIYTEYQERCNRAGLVDFSELLLRAHELLRDTPALLTHYRSRFREILIDEFQDTNAIQYAFVRVLAND
TGHIFAVGDDDQAIYGWRGAKVEHVQHFLKDFPNVQTIRLEQNYRSSANILDAANAIIAHNPDRIGKRLWTESGVGESID
LYAAYNEIDEARYIVERARQWVRDGGSYGEIAVLYRSNAQSRAFEEVLQSEHIPYRVYGGMRFFERAEIKDALAYLRLLA
NRSDDAAFERVVNTPVRGIGERTLDEVRHLARTQGLALWDAAMACTQSTTLTARARNALASFLNLLQQLALETNQMDLAE
RIDHMLQRSELRQHWKKEARGSLDAESRQENLDELVSVASRFVLPQNDEDTPIMTELDAFLSYACLESGDGQVQAGEEGV
QLMTLHSAKGLEFPLVFLVGLENGLFPSARSLDEHGRLEEERRLAYVGITRARHKLILSYAQARRIHGKDNYNVPSRFLR
EIPQDLLHEVRPTIQVSHQPPLGATQRPAHDERDAAPIKLGVNVIHPTFGCGVVVDYEGSGVHTRVQIKFDDAGTKWLVM
AYAKLSVV
>Mature_728_residues
MNVSHVLYHLNQNQREAVAAAPGHYLILAGAGSGKTRVLTHRIVWLNEVNGVPTHSMMAVTFTNKAAGEIQQRIDLQLRH
GKRGMWIGTFHSLAHRLLRLHWNDATLPENFQVIDSDDQLRLVKRVIQSLGLNDTLFPPKQAMWWINTQKDEGRRPEHIQ
PESHDDWIETQRRIYTEYQERCNRAGLVDFSELLLRAHELLRDTPALLTHYRSRFREILIDEFQDTNAIQYAFVRVLAND
TGHIFAVGDDDQAIYGWRGAKVEHVQHFLKDFPNVQTIRLEQNYRSSANILDAANAIIAHNPDRIGKRLWTESGVGESID
LYAAYNEIDEARYIVERARQWVRDGGSYGEIAVLYRSNAQSRAFEEVLQSEHIPYRVYGGMRFFERAEIKDALAYLRLLA
NRSDDAAFERVVNTPVRGIGERTLDEVRHLARTQGLALWDAAMACTQSTTLTARARNALASFLNLLQQLALETNQMDLAE
RIDHMLQRSELRQHWKKEARGSLDAESRQENLDELVSVASRFVLPQNDEDTPIMTELDAFLSYACLESGDGQVQAGEEGV
QLMTLHSAKGLEFPLVFLVGLENGLFPSARSLDEHGRLEEERRLAYVGITRARHKLILSYAQARRIHGKDNYNVPSRFLR
EIPQDLLHEVRPTIQVSHQPPLGATQRPAHDERDAAPIKLGVNVIHPTFGCGVVVDYEGSGVHTRVQIKFDDAGTKWLVM
AYAKLSVV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=736, Percent_Identity=56.1141304347826, Blast_Score=822, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=646, Percent_Identity=38.0804953560372, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1787196, Length=124, Percent_Identity=34.6774193548387, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322369, Length=764, Percent_Identity=25.130890052356, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324477, Length=666, Percent_Identity=21.7717717717718, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 82890; Mature: 82890

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSHVLYHLNQNQREAVAAAPGHYLILAGAGSGKTRVLTHRIVWLNEVNGVPTHSMMAV
CCHHHEEEECCCCCHHHHEECCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCEEEE
TFTNKAAGEIQQRIDLQLRHGKRGMWIGTFHSLAHRLLRLHWNDATLPENFQVIDSDDQL
EECCHHHHHHHHHHHHHEECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHH
RLVKRVIQSLGLNDTLFPPKQAMWWINTQKDEGRRPEHIQPESHDDWIETQRRIYTEYQE
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RCNRAGLVDFSELLLRAHELLRDTPALLTHYRSRFREILIDEFQDTNAIQYAFVRVLAND
HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
TGHIFAVGDDDQAIYGWRGAKVEHVQHFLKDFPNVQTIRLEQNYRSSANILDAANAIIAH
CCEEEEECCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHCHHEEC
NPDRIGKRLWTESGVGESIDLYAAYNEIDEARYIVERARQWVRDGGSYGEIAVLYRSNAQ
CHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
SRAFEEVLQSEHIPYRVYGGMRFFERAEIKDALAYLRLLANRSDDAAFERVVNTPVRGIG
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCC
ERTLDEVRHLARTQGLALWDAAMACTQSTTLTARARNALASFLNLLQQLALETNQMDLAE
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RIDHMLQRSELRQHWKKEARGSLDAESRQENLDELVSVASRFVLPQNDEDTPIMTELDAF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LSYACLESGDGQVQAGEEGVQLMTLHSAKGLEFPLVFLVGLENGLFPSARSLDEHGRLEE
HHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCH
ERRLAYVGITRARHKLILSYAQARRIHGKDNYNVPSRFLREIPQDLLHEVRPTIQVSHQP
HHEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
PLGATQRPAHDERDAAPIKLGVNVIHPTFGCGVVVDYEGSGVHTRVQIKFDDAGTKWLVM
CCCCCCCCCCCCCCCCCEEECCEEECCCCCCCEEEEECCCCEEEEEEEEECCCCCEEEEE
AYAKLSVV
EHHHHHCC
>Mature Secondary Structure
MNVSHVLYHLNQNQREAVAAAPGHYLILAGAGSGKTRVLTHRIVWLNEVNGVPTHSMMAV
CCHHHEEEECCCCCHHHHEECCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCEEEE
TFTNKAAGEIQQRIDLQLRHGKRGMWIGTFHSLAHRLLRLHWNDATLPENFQVIDSDDQL
EECCHHHHHHHHHHHHHEECCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHH
RLVKRVIQSLGLNDTLFPPKQAMWWINTQKDEGRRPEHIQPESHDDWIETQRRIYTEYQE
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RCNRAGLVDFSELLLRAHELLRDTPALLTHYRSRFREILIDEFQDTNAIQYAFVRVLAND
HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
TGHIFAVGDDDQAIYGWRGAKVEHVQHFLKDFPNVQTIRLEQNYRSSANILDAANAIIAH
CCEEEEECCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHCHHEEC
NPDRIGKRLWTESGVGESIDLYAAYNEIDEARYIVERARQWVRDGGSYGEIAVLYRSNAQ
CHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCH
SRAFEEVLQSEHIPYRVYGGMRFFERAEIKDALAYLRLLANRSDDAAFERVVNTPVRGIG
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCC
ERTLDEVRHLARTQGLALWDAAMACTQSTTLTARARNALASFLNLLQQLALETNQMDLAE
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RIDHMLQRSELRQHWKKEARGSLDAESRQENLDELVSVASRFVLPQNDEDTPIMTELDAF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LSYACLESGDGQVQAGEEGVQLMTLHSAKGLEFPLVFLVGLENGLFPSARSLDEHGRLEE
HHHHHHCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCH
ERRLAYVGITRARHKLILSYAQARRIHGKDNYNVPSRFLREIPQDLLHEVRPTIQVSHQP
HHEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCC
PLGATQRPAHDERDAAPIKLGVNVIHPTFGCGVVVDYEGSGVHTRVQIKFDDAGTKWLVM
CCCCCCCCCCCCCCCCCEEECCEEECCCCCCCEEEEECCCCEEEEEEEEECCCCCEEEEE
AYAKLSVV
EHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]