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The map label for this gene is ndk

Identifier: 62184765

GI number: 62184765

Start: 125197

End: 125622

Strand: Direct

Name: ndk

Synonym: CAB120

Alternate gene names: 62184765

Gene position: 125197-125622 (Clockwise)

Preceding gene: 161501897

Following gene: 62184769

Centisome position: 10.94

GC content: 38.26

Gene sequence:

>426_bases
ATGGAACAAACGCTATCAATTATCAAACCTGATTCTGTTGGTAAGGCTCATATTGGTGAGATTATTGCTATCTTTGAAAA
ATCAGGATTTCGCATAGCTGCTATGAAAATGTTGCATTTATCAGTGAAAGAGGCAGAAGGCTTTTACGCTGTTCATAAAT
CGCGTCCATTTTTCCAAGAGTTAGTGGATTTTATGATTTCTGGTCCTGTAGTGGTTATGGTTCTTGAAGGGAATAATGCT
GTAGCTCGTAATAGAGAAATTATGGGAGCAACAAATCCTCAAGAAGCTGCTCCAGGAACTATCCGCGCTCAGTTTGGTGA
GTCTATAGGAATTAATGCAGTTCATGGTTCTGATAGTTTGGAAAACGCTGCGATAGAAATTAACTATTTCTTCAGCAAAG
TCGAAATAGTGAATTCTGCTGCTTAA

Upstream 100 bases:

>100_bases
AAGAATTTACAGGGGTTGAACAAGATCTAGACTTTCCTGAAGATCGTGGTATAATTTCCTCCACCATTTACTACATGTTG
TTTAAGGAGATTATATATAC

Downstream 100 bases:

>100_bases
TCAGAAATACTTTTACAGTAAGATTGTGGATTTCCTGTGTGGTTTTTCTAAGATGTCTTTCAGTTCATTCTTTGAAAGAG
TTTCCCAGACAAAACGACTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MEQTLSIIKPDSVGKAHIGEIIAIFEKSGFRIAAMKMLHLSVKEAEGFYAVHKSRPFFQELVDFMISGPVVVMVLEGNNA
VARNREIMGATNPQEAAPGTIRAQFGESIGINAVHGSDSLENAAIEINYFFSKVEIVNSAA

Sequences:

>Translated_141_residues
MEQTLSIIKPDSVGKAHIGEIIAIFEKSGFRIAAMKMLHLSVKEAEGFYAVHKSRPFFQELVDFMISGPVVVMVLEGNNA
VARNREIMGATNPQEAAPGTIRAQFGESIGINAVHGSDSLENAAIEINYFFSKVEIVNSAA
>Mature_141_residues
MEQTLSIIKPDSVGKAHIGEIIAIFEKSGFRIAAMKMLHLSVKEAEGFYAVHKSRPFFQELVDFMISGPVVVMVLEGNNA
VARNREIMGATNPQEAAPGTIRAQFGESIGINAVHGSDSLENAAIEINYFFSKVEIVNSAA

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=47.1014492753623, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=47.1014492753623, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=47.1014492753623, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=47.1014492753623, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=47.1014492753623, Blast_Score=129, Evalue=7e-31,
Organism=Homo sapiens, GI4557797, Length=140, Percent_Identity=45, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI38045913, Length=140, Percent_Identity=45, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=43.3823529411765, Blast_Score=124, Evalue=2e-29,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=42.4460431654676, Blast_Score=116, Evalue=5e-27,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=43.609022556391, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=43.609022556391, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=37.2262773722628, Blast_Score=86, Evalue=8e-18,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=36.4963503649635, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=34.0579710144928, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30023828, Length=142, Percent_Identity=33.0985915492958, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=56.2043795620438, Blast_Score=162, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17506807, Length=140, Percent_Identity=42.8571428571429, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=44.5255474452555, Blast_Score=133, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=45.2554744525547, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645457, Length=140, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CHLAB (Q5L6Z2)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219550.1
- ProteinModelPortal:   Q5L6Z2
- SMR:   Q5L6Z2
- GeneID:   3337465
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB120
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q5L6Z2
- ProtClustDB:   PRK00668
- BioCyc:   CABO218497:CAB120-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15281; Mature: 15281

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTLSIIKPDSVGKAHIGEIIAIFEKSGFRIAAMKMLHLSVKEAEGFYAVHKSRPFFQE
CCCCCCEECCCCCCCHHHHHEEEEEECCCCEEEEHHHHHHHECCCCCEEEEECCCCHHHH
LVDFMISGPVVVMVLEGNNAVARNREIMGATNPQEAAPGTIRAQFGESIGINAVHGSDSL
HHHHHHCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEECCCCCCCCEEEECCCCC
ENAAIEINYFFSKVEIVNSAA
CCEEEEEEEEEEEEEEECCCC
>Mature Secondary Structure
MEQTLSIIKPDSVGKAHIGEIIAIFEKSGFRIAAMKMLHLSVKEAEGFYAVHKSRPFFQE
CCCCCCEECCCCCCCHHHHHEEEEEECCCCEEEEHHHHHHHECCCCCEEEEECCCCHHHH
LVDFMISGPVVVMVLEGNNAVARNREIMGATNPQEAAPGTIRAQFGESIGINAVHGSDSL
HHHHHHCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEECCCCCCCCEEEECCCCC
ENAAIEINYFFSKVEIVNSAA
CCEEEEEEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA