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The map label for this gene is greA [H]

Identifier: 62184651

GI number: 62184651

Start: 3147

End: 5300

Strand: Direct

Name: greA [H]

Synonym: CAB004

Alternate gene names: 62184651

Gene position: 3147-5300 (Clockwise)

Preceding gene: 62184648

Following gene: 62184652

Centisome position: 0.27

GC content: 37.98

Gene sequence:

>2154_bases
GTGGACTATCTAGAAAAGTTGCAAGTCTTAATAGACGAAGAGCAACCCTCAAGTTTCTTTAATTTGTGGGAAGAATATTG
TTTTAACGATGTGGTGAGGGGGACGGAGCTTGTTCAGATCTTAGAGAAGGTAAGACATTCATCTTTAGCCCCTTTGTTTG
GCAAGATAGCAGACACTGTCCTTCCTTTGTGGGAAAGAATACCTGAGGGCAAAGAAAAAGATCAGGTTCTTAGATTAGTT
TTGGATATACAAAACACTAACGCTAAGCCGTTTTATGATGCGGCTATGGATTACGTAAATAGGAAGTACCATGGTAGGCA
AAATTTTAATGAGGCTTTAAGAGTTGTTGGTCTTCGTGATGGTCGTGAGTTTCAGTATAGTTTAAGCCGTTTTGACTTCT
TGATGCACTTGAAAGAGGGAAATTTCGTCTTTCATTCTGGGGGATGGGGTGTTGGAGAGGTGATGAGTGTTTCCTTTCTT
CAACAGAAGGTTCTCATAGAGTTTGAAGGCGTGATGATGGCTAAGGATATCTCCTTTGAAACAGCCTTTAAAAGTTTGAT
TCCTTTAGATAACGATCATTTTCTATCACGAAGATTTGGAGATCCAGATGGGTTTGAGGCTTATGCTAAAGATCATCCGT
CCGAGGTGATAGAAATTCTACTTAAGGATTTAGGTCCGAAAACAGCTAAAGAGATCAAGGATGAGCTTGTAGATTTGGTT
ATTCCCGAGGTGGACTGGCACCGTTGGTGGCAAGCAACTAAGAGTAAAATTAAGAAAAACACTCGTATTGTATCCCCTAA
AACCATAAAAGACCCTTATCGATATAATCCTGGAGGGGATTCTTTAATTTCTCAGTTAGAAACGCGACTTTCTCAAATCG
AAGAGACTCAGAGAAAGATTATCGAGATTTATCAATTTATTAGAGATTTGCATAGTGAATTAAAGAAACCTGAAAACAGG
GAAATCATACTGAAGGTTTTACAAACACTTCCTATAGAAGATAACCAATCTTTAGAAATCCAAAGGGATTTGTTACTTTC
TGATTTTTTAGGTGAAAAATCTAATAAGTTAGACAGTAAATTTGTAGCTTCGCTTTCTGAAGAAGGGATTATCACTATAG
TTAATGACATTTCTATAGCCGCCTTACAGAAGGCTTTCTTAATGTTAATCAAGAAGTATTCTCCTGTTTGGGAAAATGTC
TTTATGAAGATCTTTTTCTCGACAACGTTTCCAGCCCTCAGAGAGCTGAGTTTTAAAGTATTAAAAGGAGAGGAGTCGTG
TTGCCAGAAAATTAAAGAAAAGCTTCTTGGATTTATAGAGCATCCTATGATGTATCCAGAGGTTTTTGTCTGGTTTTTCT
TAAAGTTCGGTTCGCACGATGACGGTCTTTTTGATCCTAAAGATAAGGAAATCGAAAGGCTGTTTTTAGAGGCGGCTATG
GTGTTTATGTACTATATTGCTTCAACGCCGCAGAAAGAGTTAGGGAAAAAGATTTACAACTTCCTTGTGAGAGAACGTTA
CCTGGTGATTCGTAATATGATAGAGGGGGCTCCTTTATCTTATTTGAAAGAGATTCTGTTGCTCTCAACGAAATGTAGTC
AATTTTCCTCTAGTGATCTCAGTGTTTTACAAAGCCTTGCCGAGGTTGTACAACCTGATCTGAAGAAAAACACTGTAGCT
GTGAAAGAAGATATTCTTTGGACAACACCAGAAAGCTTTACGAAAATGAAAAACAAGCTTCAATCTCTTGTGGGTAAGGA
AATGGTGGATAACGCCAAGGAAATAGAGGATGCTAGAGCTTTAGGGGACCTTAGGGAGAACTCTGAGTATAAATTTGCTT
TGGAAAAACGAGCACGTTTACAAGAAGAAATTCGTGTGCTTTCTGAAGAAGTAAATCGAGCTAGAATATTAACTAAGGAT
ATTGTTTTTACTGATACGGTAGGCGTTGGTTGCAAAGTTTCTTTAGAAGATGAACAAGGAAATCTTATCACCTATTCCAT
TCTTGGTCCTTGGGACGCTGACCCCGACAACTATATTCTATCTTTAAAATCTAAGCTTGCTCAAGAAATGCTAAACAAGA
GCGTTGGAGCTAGTCTACAGTTTCAAGGAAAGAAATATAAGATTAGCCGAATACAATCTATTTGGGATGCATAA

Upstream 100 bases:

>100_bases
GATTTTAATTTATTATAAAATAAATATTATTATTTTTGTGTTGTGATATTGCTCTTTTTTATAGTTAAGCGTATATTTCC
CGTTAAAAACGGGAGACATC

Downstream 100 bases:

>100_bases
AGCAATGGAGTATAGCGGAATCGAACCGCTGACCTCAACAATGCCATTGTTGCGCTCTACCAATTGAGCTAATACCCCAA
GTAGATAAAATTATCATGAG

Product: transcript cleavage factor/unknown domain fusion protein

Products: NA

Alternate protein names: Transcript cleavage factor greA [H]

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MDYLEKLQVLIDEEQPSSFFNLWEEYCFNDVVRGTELVQILEKVRHSSLAPLFGKIADTVLPLWERIPEGKEKDQVLRLV
LDIQNTNAKPFYDAAMDYVNRKYHGRQNFNEALRVVGLRDGREFQYSLSRFDFLMHLKEGNFVFHSGGWGVGEVMSVSFL
QQKVLIEFEGVMMAKDISFETAFKSLIPLDNDHFLSRRFGDPDGFEAYAKDHPSEVIEILLKDLGPKTAKEIKDELVDLV
IPEVDWHRWWQATKSKIKKNTRIVSPKTIKDPYRYNPGGDSLISQLETRLSQIEETQRKIIEIYQFIRDLHSELKKPENR
EIILKVLQTLPIEDNQSLEIQRDLLLSDFLGEKSNKLDSKFVASLSEEGIITIVNDISIAALQKAFLMLIKKYSPVWENV
FMKIFFSTTFPALRELSFKVLKGEESCCQKIKEKLLGFIEHPMMYPEVFVWFFLKFGSHDDGLFDPKDKEIERLFLEAAM
VFMYYIASTPQKELGKKIYNFLVRERYLVIRNMIEGAPLSYLKEILLLSTKCSQFSSSDLSVLQSLAEVVQPDLKKNTVA
VKEDILWTTPESFTKMKNKLQSLVGKEMVDNAKEIEDARALGDLRENSEYKFALEKRARLQEEIRVLSEEVNRARILTKD
IVFTDTVGVGCKVSLEDEQGNLITYSILGPWDADPDNYILSLKSKLAQEMLNKSVGASLQFQGKKYKISRIQSIWDA

Sequences:

>Translated_717_residues
MDYLEKLQVLIDEEQPSSFFNLWEEYCFNDVVRGTELVQILEKVRHSSLAPLFGKIADTVLPLWERIPEGKEKDQVLRLV
LDIQNTNAKPFYDAAMDYVNRKYHGRQNFNEALRVVGLRDGREFQYSLSRFDFLMHLKEGNFVFHSGGWGVGEVMSVSFL
QQKVLIEFEGVMMAKDISFETAFKSLIPLDNDHFLSRRFGDPDGFEAYAKDHPSEVIEILLKDLGPKTAKEIKDELVDLV
IPEVDWHRWWQATKSKIKKNTRIVSPKTIKDPYRYNPGGDSLISQLETRLSQIEETQRKIIEIYQFIRDLHSELKKPENR
EIILKVLQTLPIEDNQSLEIQRDLLLSDFLGEKSNKLDSKFVASLSEEGIITIVNDISIAALQKAFLMLIKKYSPVWENV
FMKIFFSTTFPALRELSFKVLKGEESCCQKIKEKLLGFIEHPMMYPEVFVWFFLKFGSHDDGLFDPKDKEIERLFLEAAM
VFMYYIASTPQKELGKKIYNFLVRERYLVIRNMIEGAPLSYLKEILLLSTKCSQFSSSDLSVLQSLAEVVQPDLKKNTVA
VKEDILWTTPESFTKMKNKLQSLVGKEMVDNAKEIEDARALGDLRENSEYKFALEKRARLQEEIRVLSEEVNRARILTKD
IVFTDTVGVGCKVSLEDEQGNLITYSILGPWDADPDNYILSLKSKLAQEMLNKSVGASLQFQGKKYKISRIQSIWDA
>Mature_717_residues
MDYLEKLQVLIDEEQPSSFFNLWEEYCFNDVVRGTELVQILEKVRHSSLAPLFGKIADTVLPLWERIPEGKEKDQVLRLV
LDIQNTNAKPFYDAAMDYVNRKYHGRQNFNEALRVVGLRDGREFQYSLSRFDFLMHLKEGNFVFHSGGWGVGEVMSVSFL
QQKVLIEFEGVMMAKDISFETAFKSLIPLDNDHFLSRRFGDPDGFEAYAKDHPSEVIEILLKDLGPKTAKEIKDELVDLV
IPEVDWHRWWQATKSKIKKNTRIVSPKTIKDPYRYNPGGDSLISQLETRLSQIEETQRKIIEIYQFIRDLHSELKKPENR
EIILKVLQTLPIEDNQSLEIQRDLLLSDFLGEKSNKLDSKFVASLSEEGIITIVNDISIAALQKAFLMLIKKYSPVWENV
FMKIFFSTTFPALRELSFKVLKGEESCCQKIKEKLLGFIEHPMMYPEVFVWFFLKFGSHDDGLFDPKDKEIERLFLEAAM
VFMYYIASTPQKELGKKIYNFLVRERYLVIRNMIEGAPLSYLKEILLLSTKCSQFSSSDLSVLQSLAEVVQPDLKKNTVA
VKEDILWTTPESFTKMKNKLQSLVGKEMVDNAKEIEDARALGDLRENSEYKFALEKRARLQEEIRVLSEEVNRARILTKD
IVFTDTVGVGCKVSLEDEQGNLITYSILGPWDADPDNYILSLKSKLAQEMLNKSVGASLQFQGKKYKISRIQSIWDA

Specific function: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary

COG id: COG1747

COG function: function code S; Uncharacterized N-terminal domain of the transcription elongation factor GreA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GRAD1 (greA associated 1) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018151
- InterPro:   IPR006359
- InterPro:   IPR001437
- InterPro:   IPR022691 [H]

Pfam domain/function: PF01272 GreA_GreB; PF03449 GreA_GreB_N [H]

EC number: NA

Molecular weight: Translated: 82898; Mature: 82898

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00829 GREAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLEKLQVLIDEEQPSSFFNLWEEYCFNDVVRGTELVQILEKVRHSSLAPLFGKIADTV
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LPLWERIPEGKEKDQVLRLVLDIQNTNAKPFYDAAMDYVNRKYHGRQNFNEALRVVGLRD
HHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
GREFQYSLSRFDFLMHLKEGNFVFHSGGWGVGEVMSVSFLQQKVLIEFEGVMMAKDISFE
CCHHHHHHHHHHHHHEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCHH
TAFKSLIPLDNDHFLSRRFGDPDGFEAYAKDHPSEVIEILLKDLGPKTAKEIKDELVDLV
HHHHHHCCCCCCHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IPEVDWHRWWQATKSKIKKNTRIVSPKTIKDPYRYNPGGDSLISQLETRLSQIEETQRKI
CCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IEIYQFIRDLHSELKKPENREIILKVLQTLPIEDNQSLEIQRDLLLSDFLGEKSNKLDSK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
FVASLSEEGIITIVNDISIAALQKAFLMLIKKYSPVWENVFMKIFFSTTFPALRELSFKV
HHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGEESCCQKIKEKLLGFIEHPMMYPEVFVWFFLKFGSHDDGLFDPKDKEIERLFLEAAM
HCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
VFMYYIASTPQKELGKKIYNFLVRERYLVIRNMIEGAPLSYLKEILLLSTKCSQFSSSDL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHH
SVLQSLAEVVQPDLKKNTVAVKEDILWTTPESFTKMKNKLQSLVGKEMVDNAKEIEDARA
HHHHHHHHHHCCCCCCCCEEHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLRENSEYKFALEKRARLQEEIRVLSEEVNRARILTKDIVFTDTVGVGCKVSLEDEQG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCC
NLITYSILGPWDADPDNYILSLKSKLAQEMLNKSVGASLQFQGKKYKISRIQSIWDA
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDYLEKLQVLIDEEQPSSFFNLWEEYCFNDVVRGTELVQILEKVRHSSLAPLFGKIADTV
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LPLWERIPEGKEKDQVLRLVLDIQNTNAKPFYDAAMDYVNRKYHGRQNFNEALRVVGLRD
HHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
GREFQYSLSRFDFLMHLKEGNFVFHSGGWGVGEVMSVSFLQQKVLIEFEGVMMAKDISFE
CCHHHHHHHHHHHHHEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCHH
TAFKSLIPLDNDHFLSRRFGDPDGFEAYAKDHPSEVIEILLKDLGPKTAKEIKDELVDLV
HHHHHHCCCCCCHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IPEVDWHRWWQATKSKIKKNTRIVSPKTIKDPYRYNPGGDSLISQLETRLSQIEETQRKI
CCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IEIYQFIRDLHSELKKPENREIILKVLQTLPIEDNQSLEIQRDLLLSDFLGEKSNKLDSK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
FVASLSEEGIITIVNDISIAALQKAFLMLIKKYSPVWENVFMKIFFSTTFPALRELSFKV
HHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGEESCCQKIKEKLLGFIEHPMMYPEVFVWFFLKFGSHDDGLFDPKDKEIERLFLEAAM
HCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
VFMYYIASTPQKELGKKIYNFLVRERYLVIRNMIEGAPLSYLKEILLLSTKCSQFSSSDL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHH
SVLQSLAEVVQPDLKKNTVAVKEDILWTTPESFTKMKNKLQSLVGKEMVDNAKEIEDARA
HHHHHHHHHHCCCCCCCCEEHHHCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDLRENSEYKFALEKRARLQEEIRVLSEEVNRARILTKDIVFTDTVGVGCKVSLEDEQG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCC
NLITYSILGPWDADPDNYILSLKSKLAQEMLNKSVGASLQFQGKKYKISRIQSIWDA
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]