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The map label for this gene is hemB [H]

Identifier: 62184648

GI number: 62184648

Start: 148

End: 1143

Strand: Direct

Name: hemB [H]

Synonym: CAB001

Alternate gene names: 62184648

Gene position: 148-1143 (Clockwise)

Preceding gene: NA

Following gene: 62184651

Centisome position: 0.01

GC content: 40.96

Gene sequence:

>996_bases
ATGAGCTCATTAGCATTGAGTCGACGACCTCGTAGAAATAGAAGATCCGAGGCGATTCGTGATTTGGTGTCGGAAACTGC
TTTATTACCTCAGGATTTCATCTGTCCTTTTTTTGTTAAGGAAGGAAAAAACATACGCGAGGAAATCGAAAGTCTTACGG
GTGTGTATAGGTGGAGTATAGATCTTCTTTTAAAAGAGATCGAAAGGTTGTGTTCCTTGGGGTTAAGGGCTGTAATTCTT
TTCCCTGTCATTCCGAGTCATCTTAAAGATGCTTATGGCTCATACTCTTCCAATCCTAAAAATATTCTCTGTAAGAGTAT
CTATGAGGTAAAAAAAGCTTTTCCTAACTTGTGTGTAATCAGTGACATTGCTTTAGATCCTTATACCACCCATGGTCATG
ATGGTATTGTTGATCGCGGGGAAGTATTAAACGATGAAAGTGTTCGTATATTTGGAAACATAGCTACGTTGCATGCTGAG
ATGGGTGCTGATGTTGTCGCTCCTAGTGATATGATGGATGGCAGGGTAGCTCATATCCGCTCGAAGTTAGATCAAGCAGG
ATGGACTCAGACGTTGATTCTTTCTTATAGCGTGAAGTATGCCTCGGCTTTGTATCATCCTTTTAGAGATGCTTTAGGAT
CTCATTTGCAATCGGGAGATAAACGAAATTATCAGATGAATCCGACCAATGTCTTAGAAGCTTTACTCGAATGCTCTTTA
GACGAGCAAGAGGGAGCTGACATGCTCATGATCAAACCTGCGGGATTCTATCTTGATGTGTTGCATCGAGTGAAAGCTCT
TACAATGTTACCTTTAGCAGCCTATCAGGTCAGTGGTGAATATGCTATGATAGCCGCGGCTTCTACTTTGGGGTGGTTGG
ATAGAGAAAAGATAGTCTATGAATCTTTGATAGCGATCAAACGAGCAGGAGCTGACATGATCATTTCTTATGCAACCCCG
TTAATATTAGAAATGATAGCTTCTTCGAGAATTTAA

Upstream 100 bases:

>100_bases
GTTTTAAACATTTTCCACACCCCTAAAGAAGAAGAAGTAATATTTATATAAATACTCTATCCTTTTCAGACGTTGTGGAA
AGTGTTGAAGGAATGTAAAC

Downstream 100 bases:

>100_bases
GTTCTTCGAAGAACTTTATTCTACATCGGCGGTATTTTCTGGATTGAGTATCCCTGTTTCTTTTGCGTAATGCTTTAGGG
ATTCTTTAATTATTGTGAGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSSLALSRRPRRNRRSEAIRDLVSETALLPQDFICPFFVKEGKNIREEIESLTGVYRWSIDLLLKEIERLCSLGLRAVIL
FPVIPSHLKDAYGSYSSNPKNILCKSIYEVKKAFPNLCVISDIALDPYTTHGHDGIVDRGEVLNDESVRIFGNIATLHAE
MGADVVAPSDMMDGRVAHIRSKLDQAGWTQTLILSYSVKYASALYHPFRDALGSHLQSGDKRNYQMNPTNVLEALLECSL
DEQEGADMLMIKPAGFYLDVLHRVKALTMLPLAAYQVSGEYAMIAAASTLGWLDREKIVYESLIAIKRAGADMIISYATP
LILEMIASSRI

Sequences:

>Translated_331_residues
MSSLALSRRPRRNRRSEAIRDLVSETALLPQDFICPFFVKEGKNIREEIESLTGVYRWSIDLLLKEIERLCSLGLRAVIL
FPVIPSHLKDAYGSYSSNPKNILCKSIYEVKKAFPNLCVISDIALDPYTTHGHDGIVDRGEVLNDESVRIFGNIATLHAE
MGADVVAPSDMMDGRVAHIRSKLDQAGWTQTLILSYSVKYASALYHPFRDALGSHLQSGDKRNYQMNPTNVLEALLECSL
DEQEGADMLMIKPAGFYLDVLHRVKALTMLPLAAYQVSGEYAMIAAASTLGWLDREKIVYESLIAIKRAGADMIISYATP
LILEMIASSRI
>Mature_330_residues
SSLALSRRPRRNRRSEAIRDLVSETALLPQDFICPFFVKEGKNIREEIESLTGVYRWSIDLLLKEIERLCSLGLRAVILF
PVIPSHLKDAYGSYSSNPKNILCKSIYEVKKAFPNLCVISDIALDPYTTHGHDGIVDRGEVLNDESVRIFGNIATLHAEM
GADVVAPSDMMDGRVAHIRSKLDQAGWTQTLILSYSVKYASALYHPFRDALGSHLQSGDKRNYQMNPTNVLEALLECSLD
EQEGADMLMIKPAGFYLDVLHRVKALTMLPLAAYQVSGEYAMIAAASTLGWLDREKIVYESLIAIKRAGADMIISYATPL
ILEMIASSRI

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=307, Percent_Identity=40.3908794788274, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI87081728, Length=312, Percent_Identity=45.8333333333333, Blast_Score=259, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6321398, Length=313, Percent_Identity=37.6996805111821, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21358291, Length=308, Percent_Identity=35.7142857142857, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36912; Mature: 36781

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLALSRRPRRNRRSEAIRDLVSETALLPQDFICPFFVKEGKNIREEIESLTGVYRWSI
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHCCCCHHHHHHHHHHHHHHHH
DLLLKEIERLCSLGLRAVILFPVIPSHLKDAYGSYSSNPKNILCKSIYEVKKAFPNLCVI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEE
SDIALDPYTTHGHDGIVDRGEVLNDESVRIFGNIATLHAEMGADVVAPSDMMDGRVAHIR
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHHCCHHHHHH
SKLDQAGWTQTLILSYSVKYASALYHPFRDALGSHLQSGDKRNYQMNPTNVLEALLECSL
HHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
DEQEGADMLMIKPAGFYLDVLHRVKALTMLPLAAYQVSGEYAMIAAASTLGWLDREKIVY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHH
ESLIAIKRAGADMIISYATPLILEMIASSRI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLALSRRPRRNRRSEAIRDLVSETALLPQDFICPFFVKEGKNIREEIESLTGVYRWSI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHCCCCHHHHHHHHHHHHHHHH
DLLLKEIERLCSLGLRAVILFPVIPSHLKDAYGSYSSNPKNILCKSIYEVKKAFPNLCVI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEE
SDIALDPYTTHGHDGIVDRGEVLNDESVRIFGNIATLHAEMGADVVAPSDMMDGRVAHIR
ECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHHCCHHHHHH
SKLDQAGWTQTLILSYSVKYASALYHPFRDALGSHLQSGDKRNYQMNPTNVLEALLECSL
HHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
DEQEGADMLMIKPAGFYLDVLHRVKALTMLPLAAYQVSGEYAMIAAASTLGWLDREKIVY
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHH
ESLIAIKRAGADMIISYATPLILEMIASSRI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]