Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 161501896

GI number: 161501896

Start: 139423

End: 140043

Strand: Direct

Name: pyrE [H]

Synonym: CAB131

Alternate gene names: 161501896

Gene position: 139423-140043 (Clockwise)

Preceding gene: 62184774

Following gene: 62184777

Centisome position: 12.18

GC content: 39.45

Gene sequence:

>621_bases
ATGATGAGCTTTGAAGAAAAGCAACTCCGTGATCATGCTGTAATGAACCTATATCGTATAGGAGCAATACAATTCGGTGA
CTTCAATCTCGCCGATGGTCAGACAACTCCTATTTATGTCGATATGCGGCTAGTGATTTCTTGTCCTAACGTTTTACAAA
CGATAGCTTCTCTGATTTGGTGCTTACGCCCCTCCTTTAATAGTAGCTTATTGTGTGGTGTTCCCTACACTGCCCTTGCT
TTAGCTACCTGCATATCTCTGAAATACAATATCTCTATGGTGTTGAGAAGGAAAGAACTCAAACATTCAAGCCAAACAGA
TAGAATAAAAGTTGAAGGATTGTTTTCCCCAGGGCAAACGTGCTTAGTCATTAACGATGTTGTCGCTTCAGGTCAATCCA
TTTTAGAAACAGCTAAGGCTTTAGAAGATGAAGGTGTAAATATTCGAGAATCTTTAGTTTTTCTAGATCGACAGGTCGGG
GGAGCCGATGCCTTAAAAGATGCAGGGATAAAATTAAGATCCGTATTTACTCTTGAAGAATTAGTGCAGTCTTTACTTTC
CAAATGCGAATTAAAAGAAGCGGACGCGGCCATAGCTTCTACACTTTTAAAAAGTTTATAA

Upstream 100 bases:

>100_bases
CTTAGATAGGGGAATACCAAAAAATAAACGAATAAGCATATCTTTGCGCTTATAATGAGAGTTTTTGTATTTTGTCAAAA
AAACGAGAGGATACTGGGTA

Downstream 100 bases:

>100_bases
TATGATTCGTTTTTTTATTTTGTTAAATAACAAAAGCTTGGTTTTGTTATTAATTTAATATAATTATATTCTAGTTAGTT
TGTGTAGTCTTTTTATTTGA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MMSFEEKQLRDHAVMNLYRIGAIQFGDFNLADGQTTPIYVDMRLVISCPNVLQTIASLIWCLRPSFNSSLLCGVPYTALA
LATCISLKYNISMVLRRKELKHSSQTDRIKVEGLFSPGQTCLVINDVVASGQSILETAKALEDEGVNIRESLVFLDRQVG
GADALKDAGIKLRSVFTLEELVQSLLSKCELKEADAAIASTLLKSL

Sequences:

>Translated_206_residues
MMSFEEKQLRDHAVMNLYRIGAIQFGDFNLADGQTTPIYVDMRLVISCPNVLQTIASLIWCLRPSFNSSLLCGVPYTALA
LATCISLKYNISMVLRRKELKHSSQTDRIKVEGLFSPGQTCLVINDVVASGQSILETAKALEDEGVNIRESLVFLDRQVG
GADALKDAGIKLRSVFTLEELVQSLLSKCELKEADAAIASTLLKSL
>Mature_206_residues
MMSFEEKQLRDHAVMNLYRIGAIQFGDFNLADGQTTPIYVDMRLVISCPNVLQTIASLIWCLRPSFNSSLLCGVPYTALA
LATCISLKYNISMVLRRKELKHSSQTDRIKVEGLFSPGQTCLVINDVVASGQSILETAKALEDEGVNIRESLVFLDRQVG
GADALKDAGIKLRSVFTLEELVQSLLSKCELKEADAAIASTLLKSL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=174, Percent_Identity=44.8275862068966, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17508631, Length=181, Percent_Identity=37.5690607734807, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17554964, Length=182, Percent_Identity=31.3186813186813, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17933654, Length=173, Percent_Identity=39.8843930635838, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22629; Mature: 22629

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSFEEKQLRDHAVMNLYRIGAIQFGDFNLADGQTTPIYVDMRLVISCPNVLQTIASLIW
CCCCHHHHHHHHHHHHHHHHCEEEECCEECCCCCCCEEEEEEEEEEECHHHHHHHHHHHH
CLRPSFNSSLLCGVPYTALALATCISLKYNISMVLRRKELKHSSQTDRIKVEGLFSPGQT
HHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCE
CLVINDVVASGQSILETAKALEDEGVNIRESLVFLDRQVGGADALKDAGIKLRSVFTLEE
EEEEHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHH
LVQSLLSKCELKEADAAIASTLLKSL
HHHHHHHHHCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MMSFEEKQLRDHAVMNLYRIGAIQFGDFNLADGQTTPIYVDMRLVISCPNVLQTIASLIW
CCCCHHHHHHHHHHHHHHHHCEEEECCEECCCCCCCEEEEEEEEEEECHHHHHHHHHHHH
CLRPSFNSSLLCGVPYTALALATCISLKYNISMVLRRKELKHSSQTDRIKVEGLFSPGQT
HHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCE
CLVINDVVASGQSILETAKALEDEGVNIRESLVFLDRQVGGADALKDAGIKLRSVFTLEE
EEEEHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHH
LVQSLLSKCELKEADAAIASTLLKSL
HHHHHHHHHCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]